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Dietary supplement

Lipo Hesperidin Ingredients & Drug Interactions

by Renue By Science

Lipo Hesperidin label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Lipo Hesperidin against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Lipo Hesperidin is a dietary supplement by Renue By Science with 1 active ingredient. Its ingredients are commonly taken for hemorrhoids, varicose veins and poor circulation, leg swelling (venous insufficiency).Based on those ingredients, 702 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Hesperdin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Lipo Hesperidin by Renue By Science

Ask about any prescription or over-the-counter medication and we check it for interactions with Lipo Hesperidin by Renue By Science — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Lipo Hesperidin by Renue By Science

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Oct 1, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Lipo Hesperidin contains one active ingredient: hesperidin, a compound extracted from citrus that's being studied for effects on weight and cholesterol. The capsule itself is made from cellulose, with added sunflower lecithin, rice flour, and microcrystalline cellulose as inactive ingredients.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Hesperidin's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Circulatory health and vein support.
  • We looked for evidence on: Chronic venous insufficiency (CVI), Hemorrhoids, Varicose veins, Venous leg ulcers, Poor circulation, Leg swelling — and 1 related terms.
  • The closest evidence on file: Hesperidin is rated "Insufficient Reliable Evidence To Rate" for Chronic venous insufficiency (CVI) (Natural Medicines).
  • Also on file: Hesperidin is rated "Insufficient Reliable Evidence To Rate" for Hemorrhoids, Lymphedema, Varicose veins, Venous leg ulcers.

The evidence for hesperidin in this product doesn't support its use for weight loss — studies rate it as possibly ineffective for obesity. For high cholesterol (hypercholesterolemia), the data is mixed enough that it's also rated possibly ineffective.

For nonalcoholic fatty liver disease, there simply isn't enough reliable evidence to say either way. If you're looking at this supplement to address any of those concerns, the research doesn't back a strong claim that it'll work.

The evidence, ingredient by ingredient Hesperidin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Hesperidin is generally well tolerated in food amounts and during short-term supplement use, but long-term safety data is thin. One case of an allergic skin reaction was reported, though it was rare and happened with a topical form in someone who'd never had allergies before.

Because there isn't enough safety information for pregnancy and breastfeeding, the data advises against use during those times — talk with your doctor or pharmacist about whether this product is right for you if you're pregnant, planning to become pregnant, or nursing.

Side effects, ingredient by ingredient Hesperidin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Hesperidin.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 702 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your pharmacist or doctor if you're on blood thinners or antiplatelet drugs (like warfarin or clopidogrel), blood pressure medications, heart medications (especially verapamil or diltiazem), sleep aids or sedatives, or any drug metabolized by P-glycoprotein. Hesperidin may also affect celiprolol (a blood pressure drug) by making it less effective.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Lipo Hesperidin is a single-ingredient supplement with a long list of potential drug interactions, especially with blood thinners, blood pressure medications, and certain heart drugs. The evidence doesn't support it for weight loss or cholesterol, and it's not recommended in pregnancy or while breastfeeding.

If you're on any prescription medication, check it against your meds with your pharmacist or doctor before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Lipo Hesperidin, straight from the product label.

Brand Renue By Science
Barcode (UPC) 850055685093
Net contents 90 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Sep 25, 2024
DSLD ID 318993
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Lipo Hesperidin by Renue By Science, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vegetarian Capsule(s)
Maximum serving Sizes:
1 Vegetarian Capsule(s)
Servings per container
90
UPC/BARCODE
850055685093
IngredientAmount% DV
Hesperdin300 mg--

Other ingredients: Cellulose, Sunflower Lecithin, Rice Flour, Microcrystalline Cellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use Take one (1) capsule daily with or without food. May be taken with or without food.

Precautions

Pregnant or nursing mothers, children under the age of 18, and individuals with a known medical condition should consult a physician before using.

Pregnant or nursing mothers, children under the age of 18, and individuals with a known medical condition should consult a physician before using.

Do not use if safety seal is broken or missing.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formulation

This product is manufactured in the United States at a FDA registered facility under strict GMP standards.

No artificial colors, flavors or preservatives. Non-GMO.

Suitable for vegans.

Seals/Symbols

GMP Good Manufacturing practice certified.

Formula

Powdered Liposomal

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Lipo Hesperidin by Renue By Science label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Lipo Hesperidin label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Lipo Hesperidin by Renue By Science

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Vegetarian Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

Hesperdin

Interacts with
702 drugs
300 mg per serving

Hesperidin is a flavonoid found in citrus fruits that is often combined with diosmin and used for vein and circulation problems like hemorrhoids and v...

Hesperdin monograph & interactions

Other (inactive) ingredients: Cellulose, Sunflower Lecithin, Rice Flour, Microcrystalline Cellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Lipo Hesperidin by Renue By Science Drug Interactions

Want to check YOUR meds against Lipo Hesperidin?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
702Drugs
702 Moderate

Ingredients driving the most interactions

Hesperdin 702

Individual Drug Interactions

The ingredients in Lipo Hesperidin interact with 702 drugs. Click any drug to see the details.

1 of the 1 ingredient in Lipo Hesperidin interact with drugs. Each result below shows which ingredient is responsible. Hesperdin

Each ingredient & the kinds of drugs it affects

For each ingredient in Lipo Hesperidin with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Hesperdin7 drug types · 702 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, hesperidin may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Animal research suggests that hesperetin, a bioflavonoid aglycone derivative of hesperidin, may have antiplatelet activity.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, taking hesperidin with antihypertensive drugs might increase the risk of hypotension.
Some clinical and animal research shows that hesperidin can decrease blood pressure. However, other clinical research shows that hesperidin does not affect blood pressure.

Likelihood Possible Evidence D
Celiprolol (Celicard)

Theoretically, hesperidin may decrease the levels and clinical effects of celiprolol.
Animal research shows that concomitant use of hesperidin may reduce the plasma area under the curve of celiprolol by up to 75%. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, concomitant use with CNS depressants may cause additive sedative effects.
Animal studies show that hesperidin has sedative effects, due to opioid receptor activity and can increase sedation when used with diazepam. This effect has not been reported in humans.

Likelihood Possible Evidence D
Diltiazem (Cardizem, Others)

Theoretically, hesperidin may increase the levels and clinical effects of diltiazem.
Animal research suggests that hesperidin may enhance the bioavailability of diltiazem, increasing the plasma area under the curve of diltiazem by up to 65.3%. This effect has not been reported in humans.

Likelihood Possible Evidence D
P-Glycoprotein Substrates

Theoretically, hesperidin might inhibit P-glycoprotein-mediated drug efflux and potentially increase levels of drugs that are substrates of P-glycoprotein.
In vitro research shows that hesperidin can inhibit P-glycoprotein efflux. This effect has not been reported in humans.

Likelihood Possible Evidence D
Verapamil (Calan, Others)

Theoretically, hesperidin might increase the levels and clinical effects of verapamil.
Animal research suggests that hesperidin may enhance the bioavailability of verapamil, increasing the plasma area under the curve of verapamil by 96.8%. This effect has not been reported in humans

Likelihood Possible Evidence D
Hesperdin full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Lipo Hesperidin, from the product label.

Renue By Science

See all Renue By Science products
Name
Renue By Science
City
Jacksonville
State
FL
ZipCode
32204
Phone Number
1-800-810-1935
Web Address
renuebyscience.com
Pharmacist Counseling Corner

Lipo Hesperidin by Renue By Science: Common Questions

Does Lipo Hesperidin by Renue By Science interact with any medications?
Yes. Based on its ingredients, Lipo Hesperidin has a known interaction with 702 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Lipo Hesperidin contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Lipo Hesperidin if I'm pregnant or breastfeeding?
No — there isn't enough safety information, so the data advises against it during pregnancy and while breastfeeding. Talk with your doctor or pharmacist about what's right for your situation.
Does hesperidin actually help you lose weight?
The research rates it as possibly ineffective for weight loss, so there's no strong evidence it works for that purpose.
What is hesperidin, and why is it in this supplement?
Hesperidin is a compound from citrus that's being studied for possible effects on weight and cholesterol, though current evidence is weak. It's the only active ingredient in this product.
Are there any reported side effects?
One case of an allergic skin reaction was reported with a topical form of a hesperidin derivative, but it's rare. The supplement is generally well tolerated in short-term use, though long-term safety data is limited.
Does this product interact with a lot of medications?
Yes — hesperidin interacts with over 700 individual medications across several types, including blood thinners, blood pressure drugs, and certain heart medications. Always check your specific prescriptions before starting.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Lipo Hesperidin is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Lipo Hesperidin label
Go deeper

The Full Monographs Behind Lipo Hesperidin’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Hesperidin

Interacts with 702 drugs

Hesperidin is a flavonoid found in citrus fruits that is often combined with diosmin and used for vein and circulation problems like hemorrhoids and varicose veins. Some evidence supports th...

Read the full Hesperidin monograph →
Sources

Sources & How We Checked

Lipo Hesperidin's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 14 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Hesperidin 14 references
  1. Fernandez, S. P., Wasowski, C., Paladini, A. C., and Marder, M. Synergistic interaction between hesperidin, a natural flavonoid, and diazepam. Eur.J.Pharmacol. 4-11-2005;512(2-3):189-198. PubMed
  2. Jin, Y. R., Han, X. H., Zhang, Y. H., Lee, J. J., Lim, Y., Chung, J. H., and Yun, Y. P. Antiplatelet activity of hesperetin, a bioflavonoid, is mainly mediated by inhibition of PLC-gamma2 phosphorylation and cyclooxygenase-1 activity. Atherosclerosis 200
  3. Loscalzo, L. M., Wasowski, C., Paladini, A. C., and Marder, M. Opioid receptors are involved in the sedative and antinociceptive effects of hesperidin as well as in its potentiation with benzodiazepines. Eur.J.Pharmacol. 2-12-2008;580(3):306-313. PubMed
  4. Yamamoto, M., Suzuki, A., Jokura, H., Yamamoto, N., and Hase, T. Glucosyl hesperidin prevents endothelial dysfunction and oxidative stress in spontaneously hypertensive rats. Nutrition 2008;24(5):470-476. PubMed
  5. El-Readi, M. Z., Hamdan, D., Farrag, N., El-Shazly, A., and Wink, M. Inhibition of P-glycoprotein activity by limonin and other secondary metabolites from Citrus species in human colon and leukaemia cell lines. Eur.J.Pharmacol. 1-25-2010;626(2-3):139-145 PubMed
  6. Buckshee, K., Takkar, D., and Aggarwal, N. Micronized flavonoid therapy in internal hemorrhoids of pregnancy. Int J Gynaecol Obstet 1997;57(2):145-151. PubMed
  7. Uesawa, Y. and Mohri, K. Hesperidin in orange juice reduces the absorption of celiprolol in rats. Biopharm Drug Dispos. 2008;29(3):185-188. PubMed
  8. Cho, YA, Choi, DH, and Choi, JS. Effect of hesperidin on the oral pharmacokinetics of diltiazem and its main metabolite, desacetyldiltiazem, in rats. J Pharm Pharmacol. 2009;61(6):825-829. PubMed
  9. Piao, YJ and Choi, JS. Enhanced bioavailability of verapamil after oral administration with hesperidin in rats. Arch Pharm Res. 2008;31(4):518-522. PubMed
  10. Andersen KE. Hesperidin methyl chalcone?-?a new cosmetic contact allergen. Contact Dermatitis. 2015;72(6):402-4. PubMed
  11. Morand C, Dubray C, Milenkovic D, et al. Hesperidin contributes to the vascular protective effects of orange juice: a randomized crossover study in healthy volunteers. Am J Clin Nutr 2011;93(1):73-80. PubMed
  12. Homayouni F, Haidari F, Hedayati M, Zakerkish M, Ahmadi K. Blood pressure lowering and anti-inflammatory effects of hesperidin in type 2 diabetes; a randomized double-blind controlled clinical trial. Phytother Res. 2018;32(6):1073-1079. PubMed
  13. Mohammadi M, Ramezani-Jolfaie N, Lorzadeh E, Khoshbakht Y, Salehi-Abargouei A. Hesperidin, a major flavonoid in orange juice, might not affect lipid profile and blood pressure: A systematic review and meta-analysis of randomized controlled clinical trials PubMed
  14. Valls RM, Pedret A, Calderón-Pérez L, et al. Effects of hesperidin in orange juice on blood and pulse pressures in mildly hypertensive individuals: a randomized controlled trial (Citrus study). Eur J Nutr. 2021;60(3):1277-1288. PubMed

See these in context on the Hesperidin monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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