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Dietary supplement

Liposomal Citicoline with Cognizin Ingredients & Drug Interactions

by DaVinci Laboratories

Liposomal Citicoline with Cognizin label
See full label image
Liquid Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Liposomal Citicoline with Cognizin against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Liposomal Citicoline with Cognizin is a dietary supplement by DaVinci Laboratories with 2 active ingredients. Its ingredients are commonly taken for sugar substitute / sweetener, blood sugar support in diabetes, weight management.Based on those ingredients, 259 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Stevia leaf extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Liposomal Citicoline with Cognizin by DaVinci Laboratories

Ask about any prescription or over-the-counter medication and we check it for interactions with Liposomal Citicoline with Cognizin by DaVinci Laboratories — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Liposomal Citicoline with Cognizin by DaVinci Laboratories

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains 2 active ingredients. Citicoline (branded as Cognizin) is a compound your brain naturally produces; it plays a role in cell membrane health and nerve signaling.

Stevia leaf extract is a natural sweetener derived from stevia plant leaves. The rest of the formula—glycerin, water, oils, lecithin, and other compounds—are inactive ingredients that make the liquid drinkable and stable.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: memory and brain health support.
  • We looked for evidence on: Age-related cognitive decline, Alzheimer disease, Attention deficit-hyperactivity disorder (ADHD), Cerebrovascular disease, Stroke, Traumatic brain injury (TBI) — and 4 related terms.
  • The strongest evidence on file: Citicoline is rated "Possibly Effective" for Age-related cognitive decline (Natural Medicines).
  • Also on file: Citicoline is rated "Possibly Ineffective" for Stroke.
  • Also on file: Citicoline is rated "Insufficient Reliable Evidence To Rate" for Alzheimer disease, Attention deficit-hyperactivity disorder (ADHD), Cerebrovascular disease, Vascular dementia, and more.

Citicoline has the strongest evidence for age-related cognitive decline and glaucoma, where it's rated possibly effective. Evidence for Alzheimer disease, traumatic brain injury, and cardiac arrest is insufficient to rate.

For stroke, preliminary research suggests it may be ineffective. Stevia's effectiveness for diabetes, high blood pressure, and weight management is not well established in our data.

The evidence, ingredient by ingredient Stevia Citicoline

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Citicoline is generally well tolerated in studies, though long-term safety isn't fully established. Common side effects from oral citicoline include abdominal pain, back pain, blurred vision, constipation, diarrhea, headache, insomnia, and nausea.

Stevia leaf extract at supplement doses lacks good safety data, so caution is warranted—though purified stevia at food amounts is generally recognized as safe. Minor stevia side effects like bloating, dizziness, headache, muscle pain, nausea, and numbness tend to resolve within the first week.

Allergic reactions are rare but possible. Neither citicoline nor stevia has sufficient pregnancy or breastfeeding safety data; talk with your doctor or pharmacist if you're pregnant, trying to conceive, or nursing.

Side effects, ingredient by ingredient Stevia Citicoline

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Stevia.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications; lithium.
  • For scale: 259 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this, double-check if you're on lithium—stevia may raise its level (Moderate concern). Also flag any blood pressure medications or diabetes drugs with your pharmacist, since stevia could slightly boost their effects (Minor concerns).

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product may help with age-related memory changes if citicoline is your main concern. If you take lithium, blood pressure medications, or diabetes drugs, check your specific medications with the tool below before starting.

Pregnant or breastfeeding? Skip it and talk to your pharmacist first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 20, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Liposomal Citicoline with Cognizin, straight from the product label.

Brand DaVinci Laboratories
Barcode (UPC) 026664014948
Net contents 2 Fluid Ounce(s); 60 mL
Market status On market
Date entered into DSLD Jun 20, 2024
DSLD ID 313209
Product type Other Combinations
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Liposomal Citicoline with Cognizin by DaVinci Laboratories, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 mL
Maximum serving Sizes:
1 mL
Servings per container
60
UPC/BARCODE
026664014948
IngredientAmount% DV
Total Carbohydrates1 Gram(s)--
Stevia leaf extract1 mg--
Cognizin250 mg--

Other ingredients: Glycerin, Water, Oleic Acid Polyglyceride, Lemon Oil, Sunflower Lecithin, Sunflower Oil, Xanthan Gum, Potassium Citrate, Rosmarinic Acid, Mixed Tocopherols, Natural

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Color, flavor and sweetness of this product may vary due to variations of natural ingredients.

A Dietary supplement for Mental Energy, Focus, & Attention

Vegetarian

Gluten free Soy free

Precautions

Warning: If pregnant or nursing, consult your healthcare practitioner before taking this product.

Keep out of reach of children.

To obtain product information or report a serious adverse event, call 1-800-325-1776.

Storage

Store in a cool, dry place.

Best if used within 60 days of opening.

Brand IP Statement(s)

Cognizin is a registered trademark of Kyowa Hakko Bio Co., Ltd.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formula

Liposomal Citicoline with Cognizin

FDA Statement of Identity

A Dietary supplement for Mental Energy, Focus, & Attention

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take 1 ml once or twice daily, or as directed by your healthcare practitioner. Shake well before each use.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Liposomal Citicoline with Cognizin by DaVinci Laboratories label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Liposomal Citicoline with Cognizin label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Liposomal Citicoline with Cognizin by DaVinci Laboratories

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 mL Dosage formLiquid Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Stevia leaf extract

Interacts with
259 drugs
1 mg per serving

Stevia is a plant-based, calorie-free sweetener that is widely used as a sugar alternative and is considered safe in normal food amounts by major regu...

Stevia leaf extract monograph & interactions

Cognizin

No known
interactions
250 mg per serving Form: Citicoline

Citicoline is a naturally occurring compound involved in making brain cell membranes and the messenger chemical acetylcholine. It is popularly taken f...

Cognizin monograph & interactions

Other (inactive) ingredients: Glycerin, Water, Oleic Acid Polyglyceride, Lemon Oil, Sunflower Lecithin, Sunflower Oil, Xanthan Gum, Potassium Citrate, Rosmarinic Acid, Mixed Tocopherols, Natural. These complete the product’s ingredient list but are not active constituents.

Interaction report

Liposomal Citicoline with Cognizin by DaVinci Laboratories Drug Interactions

Want to check YOUR meds against Liposomal Citicoline with Cognizin?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
259Drugs
1 Moderate 258 Minor

Ingredients driving the most interactions

Stevia leaf extract 259

Individual Drug Interactions

The ingredients in Liposomal Citicoline with Cognizin interact with 259 drugs. Click any drug to see the details.

1 of the 2 ingredients in Liposomal Citicoline with Cognizin interact with drugs. Each result below shows which ingredient is responsible. Stevia leaf extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Liposomal Citicoline with Cognizin with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Stevia leaf extract3 drug types · 259 drugs

Lithium

Theoretically, stevia might decrease clearance and increase levels of lithium.
Animal research suggests that stevia extracts might have diuretic activity. Theoretically, increased reabsorption of lithium along with sodium might reduce excretion and increase levels of lithium.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, stevia might increase the risk for hypoglycemia when combined with antidiabetes drugs.
Preliminary clinical research in patients with type 2 diabetes suggests that taking a single dose of stevia extract 1000 mg reduces postprandial blood glucose levels when taken with a meal. However, other clinical research in patients with type 1 or type 2 diabetes suggests that taking stevioside 250 mg three times daily does not significantly affect blood glucose levels or glycated hemoglobin (HbA1C) after three months of treatment.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, combining stevia or stevia constituents with antihypertensive agents might increase the risk of hypotension.
Stevia extract and stevioside might lower blood pressure in patients with hypertension. However, other clinical research suggests that stevioside does not significantly lower blood pressure in patients with hypertension.

Likelihood Possible Evidence D
Stevia leaf extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Liposomal Citicoline with Cognizin, from the product label.

DaVinci Laboratories

See all DaVinci Laboratories products
Name
DaVinci Laboratories a division of FoodScience LLC
Street Address
929 Harvest Lane
City
Williston
State
VT
ZipCode
05495
Phone Number
1-800-325-1776
Web Address
www.davincilabs.com
Pharmacist Counseling Corner

Liposomal Citicoline with Cognizin by DaVinci Laboratories: Common Questions

Does Liposomal Citicoline with Cognizin by DaVinci Laboratories interact with any medications?
Yes. Based on its ingredients, Liposomal Citicoline with Cognizin has a known interaction with 259 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Liposomal Citicoline with Cognizin contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What does citicoline actually do in the brain?
Citicoline is a compound your brain makes naturally. It supports the health of cell membranes and helps with nerve cell communication, which is why it's being studied for memory and cognitive function as you age.
Is stevia in this product safe?
Purified stevia at typical food amounts is generally recognized as safe. However, stevia at supplement doses—like what's in this product—hasn't been studied enough long-term, so we recommend caution. If you experience bloating, dizziness, or headache, those often go away within the first week.
Will this help my memory?
Citicoline is possibly effective for age-related cognitive decline based on current evidence. For Alzheimer disease or other brain conditions, the evidence isn't strong enough to say either way. Talk with your doctor about whether this makes sense for your situation.
Can I take this while pregnant or nursing?
There isn't enough safety data on either ingredient during pregnancy or breastfeeding. If you're pregnant, trying to conceive, or nursing, talk with your doctor or pharmacist before starting—they can help you weigh the risks and benefits for your situation.
What are the most common side effects?
From citicoline: abdominal pain, back pain, headache, insomnia, and nausea. From stevia: bloating, dizziness, headache, muscle pain, and nausea. Most stevia side effects fade within the first week of use.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Liposomal Citicoline with Cognizin is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Liposomal Citicoline with Cognizin label
Go deeper

The Full Monographs Behind Liposomal Citicoline with Cognizin’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Stevia

Interacts with 259 drugs

Stevia is a plant-based, calorie-free sweetener that is widely used as a sugar alternative and is considered safe in normal food amounts by major regulators. Purified stevia extracts have a...

Read the full Stevia monograph → Herb & supplement monograph

Citicoline

Citicoline is a naturally occurring compound involved in making brain cell membranes and the messenger chemical acetylcholine. It is popularly taken for memory, focus, and brain aging, and s...

Read the full Citicoline monograph →
Sources

Sources & How We Checked

Liposomal Citicoline with Cognizin's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 21 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Stevia 10 references
  1. Chan P, Xu DY, Liu JC, et al. The effect of stevioside on blood pressure and plasma catecholamines in spontaneously hypertensive rats. Life Sci 1998;63:1679-84. PubMed
  2. Melis MS. A crude extract of Stevia rebaudiana increases the renal plasma flow of normal and hypertensive rats. Braz J Med Biol Res 1996;29:669-75.
  3. Melis MS. Chronic administration of aqueous extract of Stevia rebaudiana in rats: renal effects. J Ethnopharmacol 1995;47:129-34. PubMed
  4. Melis MS, Sainati AR. Effect of calcium and verapamil on renal function of rats during treatment with stevioside. J Ethnopharmacol 1991;33:257-622. PubMed
  5. Hsieh MH, Chan P, Sue YM, et al. Efficacy and tolerability of oral stevioside in patients with mild essential hypertension: a two-year, randomized, placebo-controlled study. Clin Ther 2003;25:2797-808. PubMed
  6. Chan P, Tomlinson B, Chen YJ, et al. A double-blind placebo-controlled study of the effectiveness and tolerability of oral stevioside in human hypertension. Br J Clin Pharmacol 2000;50:215-20. PubMed
  7. Gregersen S, Jeppesen PB, Holst JJ, Hermansen K. Antihyperglycemic effects of stevioside in type 2 diabetic subjects. Metabolism 2004;53:73-6. PubMed
  8. Barriocanal LA, Palacios M, Benitez G, et al. Apparent lack of pharmacological effect of steviol glycosides used as sweeteners in humans. A pilot study of repeated exposures in some normotensive and hypotensive individuals and in Type 1 and Type 2 diabeti
  9. Ferri LA, Alves-Do-Prado W, Yamada SS, et al. Investigation of the antihypertensive effect of oral crude stevioside in patients with mild essential hypertension. Phytother Res 2006;20:732-6. PubMed
  10. Almiron-Roig E, Navas-Carretero S, Castelnuovo G, et al. Impact of acute consumption of beverages containing plant-based or alternative sweetener blends on postprandial appetite, food intake, metabolism, and gastro-intestinal symptoms: Results of the SWEE

See these in context on the Stevia monograph →

Citicoline 11 references
  1. Spiers PA, Myers D, Hochanadel GS, et al. Citicoline improves verbal memory in aging. Arch Neurol 1996;53:441-8. PubMed
  2. Fioravanti M, Yanagi M. Cytidinediphosphocholine (CDP-choline) for cognitive and behavioural disturbances associated with chronic cerebral disorders in the elderly. Cochrane Database Syst Rev 2005;(2):CD000269. PubMed
  3. Conant R, Schauss AG. Therapeutic applications of citicoline for stroke and cognitive function in the elderly: A review of the literature. Altern Med Rev 2004;9:17-31.
  4. Warach, S., Pettigrew, L. C., Dashe, J. F., Pullicino, P., Lefkowitz, D. M., Sabounjian, L., Harnett, K., Schwiderski, U., and Gammans, R. Effect of citicoline on ischemic lesions as measured by diffusion-weighted magnetic resonance imaging. Citicoline 0 DOI
  5. Lukas, S. E., Kouri, E. M., Rhee, C., Madrid, A., and Renshaw, P. F. Effects of short-term citicoline treatment on acute cocaine intoxication and cardiovascular effects. Psychopharmacology.(Berl.) 2001;157(2):163-167. PubMed
  6. Dinsdale, J. R., Griffiths, G. K., Castello, J., Maddock, J., Ortiz, J. A., and Aylward, M. CDP-choline: repeated oral dose tolerance studies in adult healthy volunteers. Arzneimittelforschung. 1983;33(7A):1061-1065.
  7. Clark BC, Georgekutty J, Berul CI. Myocardial ischemia secondary to synthetic cannabinoid (K2) use in pediatric patients. J Pediatr 2015;167(3):757-61.e1. PubMed
  8. Ghajar A, Gholamian F, Tabatabei-Motlagh M, et al. Citicoline (CDP-choline) add-on therapy to risperidone for treatment of negative symptoms in patients with stable schizophrenia: a double-blind, randomized placebo-controlled trial. Hum Psychopharmacol. 2
  9. Castagna A, Manzo C, Fabbo A, Lacava R, Ruberto C, Ruotolo G. The CITIMERIVA Study: CITIcoline plus MEmantina plus RIVAstigmine in Older Patients Affected with Alzheimer's Disease. Clin Drug Investig. 2021 Feb;41(2):177-182. PubMed
  10. Jeong H, Yoon S, Sung YH, et al. Effects of cytidine-5'-diphosphate choline on gray matter volumes in methamphetamine-dependent patients: A randomized, double-blind, placebo-controlled study. J Psychiatr Res 2021;143:215-221. PubMed
  11. Nakazaki E, Mah E, Sanoshy K, Citrolo D, Watanabe F. Citicoline and Memory Function in Healthy Older Adults: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. J Nutr 2021;151(8):2153-2160. PubMed

See these in context on the Citicoline monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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