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Dietary supplement

Liquid Vitamin D3 Drops 2000 IU Natural Citrus Flavor Ingredients & Drug Interactions

by Bluebonnet

Liquid Category: Vitamin
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Liquid Vitamin D3 Drops 2000 IU Natural Citrus Flavor is a dietary supplement by Bluebonnet with 1 active ingredient. Its ingredients are commonly taken for bone health and osteoporosis, correcting vitamin d deficiency, immune system support.Based on those ingredients, 715 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Vitamin D3. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Liquid Vitamin D3 Drops 2000 IU Natural Citrus Flavor by Bluebonnet

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: vitamin D3 (cholecalciferol), the form of vitamin D your body naturally makes from sunlight. The inactive ingredients are medium chain triglycerides (a carrier oil), orange essential oil, and lemon essential oil for flavor.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: building strong bones and teeth.
  • We looked for evidence on: Corticosteroid-induced osteoporosis, Dental caries, Familial hypophosphatemia, Fall prevention, Fractures, Hyperparathyroidism-related bone loss — and 4 related terms.
  • The strongest evidence on file: Vitamin D is rated "Effective" for Familial hypophosphatemia (Natural Medicines).
  • Also on file: Vitamin D is rated "Effective" for Osteomalacia, Renal osteodystrophy, Hypoparathyroidism.
  • Also on file: Vitamin D is rated "Likely Effective" for Corticosteroid-induced osteoporosis.

Vitamin D3 is effective for treating rickets, osteomalacia (soft bone disease), renal bone disease, familial hypophosphatemia, and hypoparathyroidism—conditions where your body doesn't have enough vitamin D or can't use it properly. For general bone health and vitamin D deficiency prevention, speak with your doctor or pharmacist about whether supplementation is right for you.

The evidence, ingredient by ingredient Vitamin D

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin D3 is generally well tolerated at recommended doses. However, very high doses taken over time can cause vitamin D toxicity, with symptoms including high blood calcium (hypercalcemia), bone loss, and in children, slowed growth.

The product facts note that at recommended amounts, vitamin D is often used during pregnancy and breastfeeding, but you should use it only under your doctor's guidance. We don't hold detailed safety data on how much is safe in pregnancy or breastfeeding—talk with your doctor about what's right for you.

Side effects, ingredient by ingredient Vitamin D

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Vitamin D.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: heart-rhythm medications.
  • For scale: 716 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check if you use thiazide diuretics (water pills), verapamil or diltiazem (heart medications), digoxin (Lanoxin), atorvastatin (Lipitor), calcipotriene (Dovonex, a psoriasis treatment), or aluminum-containing medications—all documented to interact moderately with vitamin D. There's also a minor concern with many other medications your liver processes.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This vitamin D3 supplement is appropriate for treating vitamin D deficiency and related bone disorders under medical supervision. If you take thiazide diuretics, heart rhythm medications (verapamil, diltiazem), digoxin, atorvastatin, or psoriasis treatments like calcipotriene, check with your pharmacist before starting.

Even at this 2000 IU dose, it's worth confirming your medications won't interact with it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 25, 2018.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Liquid Vitamin D3 Drops 2000 IU Natural Citrus Flavor, straight from the product label.

Brand Bluebonnet
Barcode (UPC) 743715003767
Net contents 1 fl. Oz.; 30 mL
Market status On market
Date entered into DSLD Jun 25, 2018
DSLD ID 177870
Product type Vitamin
Supplement form Liquid
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Kosher, Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Liquid Vitamin D3 Drops 2000 IU Natural Citrus Flavor by Bluebonnet, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Drop(s)
Maximum serving Sizes:
1 Drop(s)
Servings per container
900
UPC/BARCODE
743715003767
IngredientAmount% DV
Vitamin D32000 IU500%

Other ingredients: Medium Chain Triglycerides, Orange essential Oil, Lemon essential Oil

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Shaking not required to dispense drop. Turn bottle upside down and in a few seconds a drop will fall.

Directions: As a dietary supplement, take 1 drop daily or as directed by a healthcare practitioner.

General Statements

Building strong bones and teeth require the effort of more than just calcium.

Highly-concentrated

30% more free

Available in liquid drops for maximum assimilation and absorption.

Formula

Vitamin D3, a fat-soluble nutrient sourced from the sun and from dietary sources like fish oil or lanolin, helps facilitate calcium and phosphorus absorption in the body. Bluebonnet’s Liquid Vitamin D3 Drops 2000 IU specifically sourced from lanolin helps support bone mineralization, a biological process where minerals build up in the bones, causing them to harden and remain strong.

Kosher certified

Bluebonnet’s Liquid Vitamin D3 Drops 2000 IU contain natural vitamin D3 (cholecalciferol) from lanolin. Each drop of this sunshine vitamin is flavored using a hint of orange and lemon essential oils.

KOF-K Certification #K-0001604

Formulation

Gluten-free

Made with non GMO ingredients

Free of milk, egg, fish, crustacean shellfish, tree nuts, peanuts, wheat and soybeans. Also free of yeast, gluten, barley, rice, sodium and sugar.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

Made with non GMO ingredients

K Parve

Gluten free

Brand IP Statement(s)

A taste of the sun

FDA Statement of Identity

Dietary Supplement

Precautions

Warning: Keep out of the reach of children and do not go over the recommended dose in the directions or the dose provided by your healthcare practitioner.

General

0376C

See for yourself

Liquid Vitamin D3 Drops 2000 IU Natural Citrus Flavor by Bluebonnet label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Liquid Vitamin D3 Drops 2000 IU Natural Citrus Flavor by Bluebonnet

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Drop(s) Dosage formLiquid Servings per container900 Amounts shown are per serving.

Vitamin D3

Interacts with
715 drugs
2000 IU per serving Form: Lanolin

Vitamin D is a fat-soluble vitamin that helps your body absorb calcium and is important for healthy bones, muscles, and immune function. Many people,...

Vitamin D3 monograph & interactions

Other (inactive) ingredients: Medium Chain Triglycerides, Orange essential Oil, Lemon essential Oil. These complete the product’s ingredient list but are not active constituents.

Interaction report

Liquid Vitamin D3 Drops 2000 IU Natural Citrus Flavor by Bluebonnet Drug Interactions

Want to check YOUR meds against Liquid Vitamin D3 Drops 2000 IU Natural Citrus Flavor?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
715Drugs
80 Moderate 635 Minor

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in Liquid Vitamin D3 Drops 2000 IU Natural Citrus Flavor with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin D38 drug types · 715 drugs

Aluminum

Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
The protein that transports calcium across the intestinal wall can also bind and transport aluminum. This protein is stimulated by vitamin D, which may therefore increase aluminum absorption. This mechanism may contribute to increased aluminum levels and toxicity in people with renal failure, when they take vitamin D and aluminum-containing phosphate binders chronically.

Likelihood Probable Evidence B
Atorvastatin (Lipitor)

Vitamin D might reduce absorption of atorvastatin.
A small, low-quality clinical study shows that taking vitamin D reduces levels of atorvastatin and its active metabolites by up to 55%. However, while atorvastatin levels decreased, total cholesterol, low-density lipoprotein (LDL) cholesterol, and high-density lipoprotein (HDL) cholesterol levels did not substantially change. Atorvastatin is metabolized in the gut by CYP3A4 enzymes, and researchers theorized that vitamin D might induce CYP3A4, causing reduced levels of atorvastatin. However, this proposed mechanism was not specifically studied.

Likelihood Probable Evidence B
Calcipotriene (Dovonex)

Taking calcipotriene with vitamin D increases the risk for hypercalcemia.
Calcipotriene is a vitamin D analog used topically for psoriasis. It can be absorbed in sufficient amounts to cause systemic effects, including hypercalcemia. Theoretically, combining calcipotriene with vitamin D supplements might increase the risk of hypercalcemia.

Likelihood Probable Evidence D
Digoxin (Lanoxin)

Theoretically, hypercalcemia induced by high-dose vitamin D can increase the risk of arrhythmia from digoxin.
High doses of vitamin D can cause hypercalcemia. Hypercalcemia increases the risk of fatal cardiac arrhythmias with digoxin. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and digoxin concurrently.

Likelihood Possible Evidence D
Diltiazem (Cardizem, Others)

Theoretically, hypercalcemia induced by high-dose vitamin D can reduce the therapeutic effects of diltiazem for arrhythmia.
High doses of vitamin D can cause hypercalcemia. Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically this could also occur with diltiazem. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and diltiazem concurrently.

Likelihood Probable Evidence B
Thiazide Diuretics

Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Thiazide diuretics decrease urinary calcium excretion, which could lead to hypercalcemia if vitamin D supplements are taken concurrently. This has been reported in people being treated with vitamin D for hypoparathyroidism, and also in elderly people with normal parathyroid function who were taking a thiazide, vitamin D, and calcium-containing antacids daily.

Likelihood Probable Evidence D
Verapamil (Calan, Others)

Hypercalcemia induced by high-dose vitamin D can reduce the therapeutic effects of verapamil for arrhythmia.
Hypercalcemia due to high doses of vitamin D can reduce the effectiveness of verapamil in atrial fibrillation. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and verapamil concurrently.

Likelihood Probable Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
There is some concern that vitamin D might induce CYP3A4. In vitro research suggests that vitamin D induces CYP3A4 transcription. Additionally, observational research has found that increased UV light exposure and serum vitamin D levels are associated with decreased serum levels of CYP3A4 substrates such as tacrolimus and sirolimus, while no association between UV light exposure or vitamin D levels and levels of mycophenolic acid, a non-CYP3A4 substrate, was found. A small, low-quality clinical study shows that taking vitamin D reduces levels of the CYP3A4 substrate atorvastatin and its active metabolites by up to 55%; however, the clinical effects of atorvastatin were not reduced. While researchers theorized that vitamin D might induce CYP3A4, this proposed mechanism was not specifically studied.

Likelihood Possible Evidence D
The maker

Brand information

Manufacturer and brand details for Liquid Vitamin D3 Drops 2000 IU Natural Citrus Flavor, from the product label.

Bluebonnet

Name
Bluebonnet Nutrition Corporation
Street Address
12915 Dairy Ashford
City
Sugar Land
State
TX
ZipCode
77478
Web Address
www.bluebonnetnutrition.com
Pharmacist Counseling Corner

Liquid Vitamin D3 Drops 2000 IU Natural Citrus Flavor by Bluebonnet: Common Questions

Does Liquid Vitamin D3 Drops 2000 IU Natural Citrus Flavor by Bluebonnet interact with any medications?
Yes. Based on its ingredients, Liquid Vitamin D3 Drops 2000 IU Natural Citrus Flavor has a known interaction with 715 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Liquid Vitamin D3 Drops 2000 IU Natural Citrus Flavor contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is 2000 IU of vitamin D3 a safe daily dose?
Yes—2000 IU is well below the daily upper limit of 4000 IU for adults. However, 'safe' depends on your overall vitamin D intake from food and sun, and on your medications. If you take heart or blood-pressure medications, check with your pharmacist first.
Can I take this while pregnant or breastfeeding?
Vitamin D is often used at recommended doses during pregnancy and breastfeeding, but we don't hold detailed safety data for higher amounts. Use only under your doctor's guidance, and talk with them about what dose is right for you.
What is vitamin D3, and why do I need it?
Vitamin D3 (cholecalciferol) is the form of vitamin D your body makes naturally when your skin is exposed to sunlight. Your body uses it to absorb calcium, support bone health, and regulate immune function. If you don't get enough from sun or food, supplementation may help.
What are the symptoms of taking too much vitamin D?
Very high doses over time can cause vitamin D toxicity with symptoms including high blood calcium (nausea, weakness, bone loss), and in children, slowed growth. Stick to recommended doses and talk with your doctor if you're considering high-dose supplementation.
Will vitamin D3 drops interact with my atorvastatin (Lipitor)?
Yes, there's a documented moderate interaction—vitamin D may reduce how well your body absorbs atorvastatin. Talk with your pharmacist about whether you should take them at different times or if your cholesterol levels need monitoring while using both.
Why is this product liquid instead of a pill?
The product facts don't explain the form choice, but liquid drops are easier for some people to dose and absorb. Ask your pharmacist if liquid or solid form would work better for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Liquid Vitamin D3 Drops 2000 IU Natural Citrus Flavor is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Liquid Vitamin D3 Drops 2000 IU Natural Citrus Flavor label
Go deeper

The Full Monographs Behind Liquid Vitamin D3 Drops 2000 IU Natural Citrus Flavor’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Sources

Sources & How We Checked

Liquid Vitamin D3 Drops 2000 IU Natural Citrus Flavor's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 26 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin D 26 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Tatro DS, ed. Drug Interactions Facts. Facts and Comparisons Inc., St. Louis, MO. 1999.
  3. Koutkia P, Chen TC, Holick MF. Vitamin D intoxication associated with an over-the-counter supplement. N Engl J Med 2001;345:66-7. PubMed
  4. Bar-Or D, Yoel G. Calcium and calciferol antagonize effect of verapamil in atrial fibrillation. Br Med J 1981;282:1585-6.
  5. Demontis R, Leflon A, Fournier A, et al. 1 alpha(OH) vitamin D3 increases plasma aluminum in hemodialyzed patients taking AI(OH)3. Clin Nephrol 1986;26:146-9.
  6. Crowe M, Wollner L, Griffiths RA. Hypercalcemia following vitamin D and thiazide therapy in the elderly. Practitioner 1984;228:312-3.
  7. Parfitt AM. Thiazide-induced hypercalcemia in vitamin D-treated hypoparathyroidism. Ann Intern Med 1972;77:557-63. PubMed
  8. Thiazide diuretics and the risk of osteoporosis. Pharmacist's Letter/Prescriber's Letter 2003;19(11):191105.
  9. Moon J. The role of vitamin D in toxic metal absorption. J Am Coll Nutr 1994;13:559-64.
  10. Demontis R, Reissi D, Noel C, et al. Indirect clinical evidence that 1alphaOH vitamin D<SUB>3</SUB> increases the intestinal absorption of aluminum. Clin Nephrol 1989;31:123-7.
  11. Adler AJ, Berlyne GM. Duodenal aluminum absorption in the rat: effect of vitamin D. Am J Physiol 1985;249:G209-13. PubMed
  12. Schwartz JB. Effects of vitamin D supplementation in atorvastatin-treated patients: A new drug interaction with an unexpected consequence. Clin Pharmacol Ther 2009;85:198-203. PubMed
  13. Dietary reference intakes for calcium and vitamin D. Institute of Medicine, November 30, 2010. Available at: http://www.iom.edu/~/media/Files/Report%20Files/2010/Dietary-Reference-Intakes-for-Calcium-and-Vitamin-D/Vitamin%20D%20and%20Calcium%202010%20Repo
  14. Cox KA, Dunn MA. Aluminum toxicity alters the regulation of calbindin-D28k protein and mRNA expression in chick intestine. J Nutr 2001;131:2007-13. PubMed
  15. Escribano, J., Balaguer, A., Pagone, F., Feliu, A., and Roque, I. Figuls. Pharmacological interventions for preventing complications in idiopathic hypercalciuria. Cochrane.Database.Syst.Rev. 2009;(1):CD004754. PubMed
  16. Carlton, S., Clopton, D., and Cappuzzo, K. A. Vitamin D deficiency: appropriate replenishment therapies and the effects of vitamin D toxicity. Consult Pharm 2010;25(3):171-177. PubMed
  17. Wang, H., Xia, N., Yang, Y., and Peng, D. Q. Influence of vitamin D supplementation on plasma lipid profiles: a meta-analysis of randomized controlled trials. Lipids Health Dis. 2012;11:42. PubMed
  18. Turner AN, Carr Reese P, Fields KS, Anderson J, Ervin M, Davis JA, Fichorova RN, Roberts MW, Klebanoff MA, Jackson RD. A blinded, randomized controlled trial of high-dose vitamin D supplementation to reduce recurrence of bacterial vaginosis. Am J Obstet G PubMed
  19. Weiner M, Epstein FH. Signs and symptoms of electrolyte disorders. Yale J Biol Med. 1970;43(2):76-109.
  20. Lappe J, Watson P, Travers-Gustafson D, Recker R, Garland C, Gorham E, Baggerly K, McDonnell SL. Effect of Vitamin D and Calcium Supplementation on Cancer Incidence in Older Women: A Randomized Clinical Trial. JAMA. 2017 Mar 28;317(12):1234-1243. PubMed
  21. Roth DE, Leung M, Mesfin E, Qamar H, Watterworth J, Papp E. Vitamin D supplementation during pregnancy: state of the evidence from a systematic review of randomised trials. BMJ. 2017;359:j5237. PubMed
  22. Murai IH, Fernandes AL, Sales LP, et al. Effect of a single high dose of vitamin D3 on hospital length of stay in patients with moderate to severe COVID-19: A randomized clinical trial. JAMA. 2021.
  23. Wang Z, Schuetz EG, Xu Y, Thummel KE. Interplay between vitamin D and the drug metabolizing enzyme CYP3A4. J Steroid Biochem Mol Biol 2013;136:54-8. PubMed
  24. Doyle D, Browne U, Brickley A, Murphy D. Vitamin D-induced hypercalcaemia and acute kidney injury in sarcoidosis. BMJ Case Rep 2023;16(1):e250580. PubMed
  25. Williamson A, Martineau AR, Sheikh A, Jolliffe D, Griffiths CJ. Vitamin D for the management of asthma. Cochrane Database Syst Rev 2023;2(2):CD011511. PubMed
  26. Kinesya E, Santoso D, Gde Arya N, et al. Vitamin D as adjuvant therapy for diabetic foot ulcers: Systematic review and meta-analysis approach. Clin Nutr ESPEN 2023;54:137-143. PubMed

See these in context on the Vitamin D monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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