Lithium Orotate Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Lithium Orotate against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Lithium Orotate is a dietary supplement by Global Healing Center with 1 active ingredient. Its ingredients are commonly taken for mood support, bipolar disorder (prescription), healthy mental function.Based on those ingredients, 515 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Lithium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Lithium Orotate by Global Healing Center
Ask about any prescription or over-the-counter medication and we check it for interactions with Lithium Orotate by Global Healing Center — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Lithium Orotate by Global Healing Center
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: lithium. Lithium is a mineral that has been studied for mood and neurological conditions, though the evidence in our data is insufficient for most uses listed here.
The supplement also includes vegetable capsule material, organic gum acacia, and organic rice as inactive ingredients.
Does it work?
Not established
The evidence in our data for lithium's effectiveness is insufficient to rate for the conditions listed — alcohol use disorder, Alzheimer disease, ALS (Lou Gehrig's disease), and anorexia nervosa. That means we don't have strong enough data to say whether it works or doesn't.
If you're considering this supplement for a specific condition, talk with your doctor about what the broader research shows and whether it's right for you.
How safe is it?
Well-documented data
Prescription lithium is generally well tolerated when properly dosed and monitored with blood tests, but it has a narrow safety margin — the gap between an effective dose and a toxic one is small. Supplement forms are not well studied, so it's unclear how lower supplement doses affect side effects.
Common adverse effects with prescription lithium include tremor, fatigue, weight gain, increased thirst and urination, muscle weakness, and gastrointestinal symptoms. Lithium can also worsen or trigger skin problems like acne, psoriasis, and hair loss.
If you're pregnant, the safety data advises against lithium — it can cross the placenta and has been linked to birth defects. If you're breastfeeding, the safety data advises against it too, as lithium passes into breast milk and may affect the infant.
Both of these recommendations apply unless your doctor has specifically directed and monitored use. Also, don't stop lithium suddenly; abrupt discontinuation can trigger a return of bipolar symptoms.
It should be tapered gradually over at least 14 days.
Meds to double-check
Major interaction found
Before you take this product, double-check with your doctor or pharmacist if you're on serotonergic drugs (antidepressants, especially SSRIs), diuretics (water pills), NSAIDs (pain relievers like ibuprofen), ACE inhibitors or calcium channel blockers (blood pressure medications), antipsychotics, skeletal muscle relaxants, or anticonvulsants. Lithium interacts with all of these, and some interactions are Major severity.
The bottom line
Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Major medication interactions have been identified, and safety information is well characterized.
Lithium Orotate carries Major-severity risks with serotonergic drugs and diuretics, and Moderate risks with several other common medication classes. Prescription lithium requires careful blood monitoring because of its narrow safety window, and supplement forms are not well studied.
If you take any medications — especially antidepressants, blood pressure drugs, or water pills — check with your doctor or pharmacist before starting this product, and do not take it during pregnancy or while breastfeeding without medical supervision.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 23, 2020.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Lithium Orotate, straight from the product label.
| Brand | Global Healing Center |
|---|---|
| Barcode (UPC) | 769173635951 |
| Net contents | 60 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Jul 23, 2020 |
| DSLD ID | 231200 |
| Product type | Mineral |
| Supplement form | Capsule |
| Dietary claims / uses | Nutrient, All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Lithium Orotate by Global Healing Center, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Lithium | 10 mg | -- |
Other ingredients: Vegetable Capsule, organic Gum Acacia, Nu-Flow organic Rice
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Suggested Use Take one capsule twice daily or as recommended by your healthcare practitioner.
Formula
Lithium is a trace mineral used to nutritionally support mood, focus, and a healthy response to stress. Lithium orotate is a form of lithium bonded with orotic acid for optimal cellular transport and use.
Elemental lithium trace mineral
Precautions
Warning: Keep out of reach of children.
Consult your healthcare practitioner if you are pregnant or nursing; if you take an SSRI, MAOI, or other similar medication; if you have kidney problems of take an ACE inhibitor or diuretic; if you have a thyroid condition; of for any additional concerns.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
General Statements
Global Healing Center since 1998
FDA Statement of Identity
Dietary Supplement
Formulation
GMO free Gluten free
Vegan
Seals/Symbols
No Animal Testing
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Lithium Orotate by Global Healing Center label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Lithium Orotate by Global Healing Center
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.
Lithium
Interacts with515 drugs
Lithium is a naturally occurring metal that, in prescription form (lithium carbonate or citrate), is an FDA-approved, well-proven treatment for bipola...
Lithium monograph & interactionsOther (inactive) ingredients: Vegetable Capsule, Organic Gum Acacia, Nu-Flow organic Rice. These complete the product’s ingredient list but are not active constituents.
Lithium Orotate by Global Healing Center Drug Interactions
HelloPharmacist Interaction Report
Lithium Orotate by Global Healing Center contains lithium, which has significant documented interactions with multiple medication types.
The most serious concern is with serotonergic drugs (antidepressants like SSRIs) — combining them with lithium may both mask and increase the risk of serotonin syndrome, a potentially dangerous condition. A case report documented this in a patient taking both lithium and SSRIs together.
Read the full breakdown — every affected drug type, severity by severity
Lithium also interacts Major-severity with diuretics (water pills, including loop and thiazide types), which can increase lithium levels in your body and raise the risk of side effects. You should be especially cautious if you're on a sodium-restricted diet, as that can compound the effect.
Moderate-severity interactions are documented with skeletal muscle relaxants, NSAIDs (like ibuprofen and naproxen), antipsychotic drugs, ACE inhibitors (blood pressure medications), calcium channel blockers (another blood pressure class), and anticonvulsants. With NSAIDs and ACE inhibitors, lithium levels may rise; with calcium channel blockers, they may fall — and some of these effects are unclear at supplement doses.
Antipsychotics carry a risk of encephalopathic syndrome (a serious brain inflammation). Altogether, these interactions span 515 individual medications.
Before you start this supplement, check your exact medications with your doctor or pharmacist using the search tool on this page.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Lithium Orotate?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Lithium Orotate interact with 515 drugs. Click any drug to see the details.
1 of the 1 ingredient in Lithium Orotate interact with drugs. Each result below shows which ingredient is responsible. Lithium
Acetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Lithium Orotate — through 1 ingredient. Tap an ingredient for the detail:
LithiumMethylxanthines, Diuretic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with methylxanthines might decrease lithium levels.
Read the full Lithium + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Lithium Orotate — through 1 ingredient. Tap an ingredient for the detail:
LithiumSerotonergic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.
Read the full Lithium + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Lithium Orotate — through 1 ingredient. Tap an ingredient for the detail:
LithiumSerotonergic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.
Read the full Lithium + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Lithium Orotate — through 1 ingredient. Tap an ingredient for the detail:
LithiumSerotonergic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.
Read the full Lithium + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with Lithium Orotate — through 1 ingredient. Tap an ingredient for the detail:
LithiumSerotonergic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.
Read the full Lithium + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with Lithium Orotate — through 1 ingredient. Tap an ingredient for the detail:
LithiumSerotonergic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.
Read the full Lithium + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interacts with Lithium Orotate — through 1 ingredient. Tap an ingredient for the detail:
LithiumSerotonergic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.
Read the full Lithium + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionAcetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, SalicylamideRhinogesic GG
How Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interacts with Lithium Orotate — through 1 ingredient. Tap an ingredient for the detail:
LithiumSerotonergic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.
Read the full Lithium + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylephrineAlka-Seltzer PLUS, Histex SR, Protid
How Acetaminophen, Chlorpheniramine, Phenylephrine interacts with Lithium Orotate — through 1 ingredient. Tap an ingredient for the detail:
LithiumSerotonergic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.
Read the full Lithium + Acetaminophen, Chlorpheniramine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, Phenylephrine, SalicylamideRhinogesic, Rhinogesic JR
How Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interacts with Lithium Orotate — through 1 ingredient. Tap an ingredient for the detail:
LithiumSerotonergic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.
Read the full Lithium + Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylpropanolamineAlumadrine, Conex, Sinadrin Max Strength, Sinulin
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine interacts with Lithium Orotate — through 1 ingredient. Tap an ingredient for the detail:
LithiumSerotonergic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.
Read the full Lithium + Acetaminophen, Chlorpheniramine, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, OpiumHista-Derfule
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interacts with Lithium Orotate — through 1 ingredient. Tap an ingredient for the detail:
LithiumSerotonergic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.
Read the full Lithium + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, PhenyltoloxamineNorel Plus
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interacts with Lithium Orotate — through 1 ingredient. Tap an ingredient for the detail:
LithiumSerotonergic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.
Read the full Lithium + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interactionAcetaminophen, Chlorpheniramine, PseudoephedrineAlka-Seltzer PLUS Liquid Gels, Children's Tylenol Cold, Codimal, Comtrex, Extra Strength Tylenol Allergy Sinus, Lorsin +3 more
How Acetaminophen, Chlorpheniramine, Pseudoephedrine interacts with Lithium Orotate — through 1 ingredient. Tap an ingredient for the detail:
LithiumSerotonergic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.
Read the full Lithium + Acetaminophen, Chlorpheniramine, Pseudoephedrine interactionAcetaminophen, DextromethorphanTylenol Cough Ex Strength
How Acetaminophen, Dextromethorphan interacts with Lithium Orotate — through 1 ingredient. Tap an ingredient for the detail:
LithiumSerotonergic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.
Read the full Lithium + Acetaminophen, Dextromethorphan interactionAcetaminophen, Dextromethorphan, Doxylamine, PseudoephedrineVicks NyQuil
How Acetaminophen, Dextromethorphan, Doxylamine, Pseudoephedrine interacts with Lithium Orotate — through 1 ingredient. Tap an ingredient for the detail:
LithiumSerotonergic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.
Read the full Lithium + Acetaminophen, Dextromethorphan, Doxylamine, Pseudoephedrine interactionAcetaminophen, Dextromethorphan, Guaifenesin, PhenylephrineConar-A
How Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine interacts with Lithium Orotate — through 1 ingredient. Tap an ingredient for the detail:
LithiumSerotonergic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.
Read the full Lithium + Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine interactionAcetaminophen, Dextromethorphan, Guaifenesin, PhenylpropanolamineAnatuss
How Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine interacts with Lithium Orotate — through 1 ingredient. Tap an ingredient for the detail:
LithiumSerotonergic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.
Read the full Lithium + Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine interactionAcetaminophen, Dextromethorphan, Guaifenesin, PseudoephedrineRobitussin Cold, Severe Cold, Suphedrine Cold/Cough
How Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine interacts with Lithium Orotate — through 1 ingredient. Tap an ingredient for the detail:
LithiumSerotonergic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.
Read the full Lithium + Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine interactionAcetaminophen, Dextromethorphan, Phenylpropanolamine, PyrilamineTheracaps
How Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interacts with Lithium Orotate — through 1 ingredient. Tap an ingredient for the detail:
LithiumSerotonergic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.
Read the full Lithium + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionAcetaminophen, Dextromethorphan, PseudoephedrineAlka-Seltzer PLUS Flu Liquid Gels, Non Aspirin Cold Caps, Tylenol Cold, Tylenol Flu Daytime Ex Strength, Tylenol Flu Ex Strength
How Acetaminophen, Dextromethorphan, Pseudoephedrine interacts with Lithium Orotate — through 1 ingredient. Tap an ingredient for the detail:
LithiumSerotonergic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.
Read the full Lithium + Acetaminophen, Dextromethorphan, Pseudoephedrine interactionAcetaminophen, MeperidineDemerol APAP
How Acetaminophen, Meperidine interacts with Lithium Orotate — through 1 ingredient. Tap an ingredient for the detail:
LithiumSerotonergic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.
Read the full Lithium + Acetaminophen, Meperidine interactionAcetaminophen, Pamabrom, PyrilamineMidol Max Strength PMS, Pamprin, Pamprin ES
How Acetaminophen, Pamabrom, Pyrilamine interacts with Lithium Orotate — through 1 ingredient. Tap an ingredient for the detail:
LithiumDiuretic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with loop diuretics might increase lithium levels and adverse effects.
Read the full Lithium + Acetaminophen, Pamabrom, Pyrilamine interactionAcetaminophen, Phenylephrine, ChlorpheniramineSuper Cold Tabs
How Acetaminophen, Phenylephrine, Chlorpheniramine interacts with Lithium Orotate — through 1 ingredient. Tap an ingredient for the detail:
LithiumSerotonergic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.
Read the full Lithium + Acetaminophen, Phenylephrine, Chlorpheniramine interactionAcetazolamideAk-Zol, Diamox
How Acetazolamide interacts with Lithium Orotate — through 1 ingredient. Tap an ingredient for the detail:
LithiumDiuretic Drugs, Anticonvulsants Major
Interaction Summary
Theoretically, taking lithium supplements with loop diuretics might increase lithium levels and adverse effects.
Read the full Lithium + Acetazolamide interactionAlmotriptanAlmogran, Axert
How Almotriptan interacts with Lithium Orotate — through 1 ingredient. Tap an ingredient for the detail:
LithiumSerotonergic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.
Read the full Lithium + Almotriptan interactionAlosetronLotronex
How Alosetron interacts with Lithium Orotate — through 1 ingredient. Tap an ingredient for the detail:
LithiumSerotonergic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.
Read the full Lithium + Alosetron interactionAmiloride, HydrochlorothiazideAmil-Co, Amilzide, Moduret 25, Moduretic
How Amiloride, Hydrochlorothiazide interacts with Lithium Orotate — through 1 ingredient. Tap an ingredient for the detail:
LithiumDiuretic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with loop diuretics might increase lithium levels and adverse effects.
Read the full Lithium + Amiloride, Hydrochlorothiazide interactionAmitriptylineElavil
How Amitriptyline interacts with Lithium Orotate — through 1 ingredient. Tap an ingredient for the detail:
LithiumSerotonergic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.
Read the full Lithium + Amitriptyline interactionAmitriptyline, ChlordiazepoxideLimbitrol DS
How Amitriptyline, Chlordiazepoxide interacts with Lithium Orotate — through 1 ingredient. Tap an ingredient for the detail:
LithiumSerotonergic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.
Read the full Lithium + Amitriptyline, Chlordiazepoxide interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Lithium Orotate with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Lithium
Diuretic Drugs
Theoretically, taking lithium supplements with loop diuretics might increase lithium levels and adverse effects.
Thiazide diuretics and loop diuretics might reduce lithium excretion, particularly in sodium-restricted patients. If lithium is clinically indicated and other treatment options are unavailable or inadequate in patients using diuretics, lithium treatment can be initiated with extreme caution. Serum lithium should be measured frequently and the doses used should be the lowest dose ordinarily tolerated. It is unclear if this interaction would be clinically significant with the smaller doses found in lithium supplements.
Serotonergic Drugs
Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.
In a case report, a 67-year-old female with depression and bipolar disorder using lithium in combination with selective serotonin reuptake inhibitors (SSRIs) and other medications developed serotonin syndrome with symptoms of deep tendon hyperreflexia, muscle rigidity, tremor, and hyperthermia. However, agitation, one classical symptom of serotonin syndrome, was lacking. This was thought to be due to masking by lithium toxicity. Lithium can increase serotonin levels, thus, combining serotonergic drugs with lithium might increase the risk of serotonergic side effects including serotonin syndrome and cerebral vasoconstrictive disorders. It is unclear if this interaction would occur with the smaller doses found in lithium supplements.
Ace Inhibitors (Aceis)
Theoretically, taking lithium supplements with ACEIs might increase levels and adverse effects of lithium.
Concomitant administration of ACEIs with lithium may increase lithium concentrations. It is unclear if this interaction would be clinically significant with the smaller doses found in lithium supplements.
Anticonvulsants
Theoretically, taking lithium supplements with anticonvulsants might increase the risk of neurotoxicity.
Drugs such as carbamazepine and phenytoin seem to increase the risk of neurotoxicity. It is unclear if this interaction would occur with the smaller doses found in lithium supplements.
Antipsychotic Drugs
Theoretically, taking lithium supplements with antipsychotic drugs might increase the risk of encephalopathic syndrome.
Encephalopathic syndrome has been reported in multiple patients taking prescription lithium and antipsychotics concomitantly. Symptoms have included weakness and lethargy, fever, confusion, and extrapyramidal symptoms. In some patients, resulting brain damage was irreversible. Although there is no established causal relationship between these symptoms and the combination of lithium and antipsychotic medications, there is a theoretical relationship. It is unclear if this interaction would occur with the smaller doses found in lithium supplements.
Calcium Channel Blockers
Theoretically, taking lithium supplements with calcium channel blockers might reduce lithium levels and might also increase the risk of certain adverse effects.
Calcium channel blockers might reduce lithium concentrations. Monitor lithium levels with concurrent use. Calcium channel blockers might also increase the adverse neurological and gastrointestinal adverse effects of lithium. It is unclear if these interactions would occur with the smaller doses found in lithium supplements.
Methyldopa (Aldomet)
Theoretically, taking lithium supplements with methyldopa might increase the risk of lithium toxicity.
Concurrent use of methyldopa with lithium increases the risk of lithium toxicity. It is unclear if this interaction would be clinically significant with the smaller doses found in lithium supplements.
Methylxanthines
Theoretically, taking lithium supplements with methylxanthines might decrease lithium levels.
Xanthines such as aminophylline, caffeine, and theophylline (Theo-Dur, Theo-24, others) might increase the clearance of lithium. It is unclear if this interaction would be clinically significant with the smaller doses found in lithium supplements.
Nonsteroidal Anti-Inflammatory Drugs (Nsaids)
Theoretically, taking lithium supplements with NSAIDs might increase lithium levels and adverse effects.
NSAIDs can decrease the renal clearance of lithium and increase lithium levels. It is unclear if this interaction would be clinically significant with the smaller doses found in lithium supplements.
Phenothiazines
Theoretically, taking lithium supplements with phenothiazines might decrease the levels and clinical effects of phenothiazines.
Concomitant use of lithium with phenothiazines might reduce lithium concentrations. Lithium might also reduce phenothiazine concentrations, making the pharmacokinetic effect unpredictable. It is unclear if these interactions would occur with the smaller doses found in lithium supplements.
Skeletal Muscle Relaxants
Theoretically, taking lithium supplements with skeletal muscle relaxants might prolong neuromuscular blockade.
Lithium might prolong neuromuscular blockade. It is unclear if this interaction would occur with the smaller doses found in lithium supplements.
Brand information
Manufacturer and brand details for Lithium Orotate, from the product label.
Global Healing Center
See all Global Healing Center products- Name
- Global Healing Center, LP.
- City
- Houston
- State
- Texas
- ZipCode
- 77018
- Phone Number
- 1.800.476.0016
- Web Address
- www.globalhealingcenter.com
Lithium Orotate by Global Healing Center: Common Questions
Does Lithium Orotate by Global Healing Center interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take this if I'm pregnant or breastfeeding?
What are the most common side effects?
Does lithium actually work for depression or bipolar disorder?
Is this supplement monitored the way prescription lithium is?
If I stop taking lithium, can I just quit cold turkey?
What does the vegetable capsule contain?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Lithium Orotate is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Lithium Orotate’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Lithium Orotate's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 26 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Lithium 26 references
- Martindale W. Martindale the Extra Pharmacopoeia. Pharmaceutical Press, 1999.
- McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
- Perlis RH, Sachs GS, Lafer B, et al. Effect of abrupt change from standard to low serum levels of lithium: a reanalysis of double-blind lithium maintenance data. Am J Psychiatry 2002;159:1155-9.. PubMed
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