Lung Tonic Non-Alcohol Ingredients & Drug Interactions
by Herbs, Etc.
What is this page for?
First and foremost: checking Lung Tonic Non-Alcohol against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Lung Tonic Non-Alcohol is a dietary supplement by Herbs, Etc. with 10 active ingredients. Its ingredients are commonly taken for cough and chest congestion, sore throat, bronchitis.Based on those ingredients, 1,267 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Passionflower Herb Extract, Fresh, Echinacea angustifolia Root Extract, Horehound herb extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Lung Tonic Non-Alcohol by Herbs, Etc.
Ask about any prescription or over-the-counter medication and we check it for interactions with Lung Tonic Non-Alcohol by Herbs, Etc. — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Lung Tonic Non-Alcohol by Herbs, Etc.
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
Lung Tonic Non-Alcohol contains ten active ingredients in a non-alcohol liquid base. The main components are extracts of horehound herb, osha root, mullein leaf, elecampane root, yerba santa leaf, echinacea root, passionflower herb, pleurisy root, grindelia flower, and lobelia.
The product also contains inactive ingredients—glycerin, purified water, citric acid, and gums (arabic and tragacanth)—that serve as preservatives, thickeners, and stabilizers.
Does it work?
Not established
The evidence supporting these ingredients is limited. Passionflower shows possibly effective ratings for insomnia and pre-procedural anxiety based on available studies.
For the other ingredients—osha root, mullein leaf, elecampane root, yerba santa, echinacea, pleurisy root, and lobelia—the data we hold either shows insufficient reliable evidence or, in lobelia's case, possibly ineffective for smoking cessation. No effectiveness data are on file for horehound herb or grindelia flower.
How safe is it?
Well-documented data
Most ingredients are generally well tolerated for short-term use, but several carry important cautions. Elecampane and pleurisy root contain potentially toxic compounds and require cautious use.
Lobelia is particularly concerning—it can be toxic at higher doses (600 mg or more of the leaf), causing serious symptoms including rapid heartbeat, low blood pressure, and in extreme cases, death. Common mild side effects across ingredients include nausea, vomiting, diarrhea, and dizziness.
Echinacea can trigger allergic reactions, especially in people sensitive to ragweed or related plants; rare cases of liver inflammation have been reported. Passionflower may cause drowsiness or confusion.
Pleurisy root can cause digitalis-like poisoning at high doses with symptoms like irregular heartbeat, muscle weakness, and tremors.
Meds to double-check
Major interaction found
Before you take this, double-check your medications against these types: heart drugs like digoxin (Major severity); sedatives and CNS depressants, immune-suppressing drugs, and diuretics (Moderate); and blood thinners like warfarin, caffeine-containing products, and certain chemotherapy or HIV drugs (Minor). No interactions are documented for horehound herb or grindelia flower, which we could not fully check.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Major medication interactions have been identified, and safety information is well characterized.
This is a traditional respiratory blend, but it's not a simple product. If you're on digoxin, a heart medication, do not take this without talking to your pharmacist or doctor first—the pleurisy root interaction is serious.
If you take any other prescription medications, especially sedatives, blood thinners, lithium, or immune suppressants, check with us before you start. The product is not recommended in pregnancy or while breastfeeding.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 9 of 10 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Lung Tonic Non-Alcohol, straight from the product label.
| Brand | Herbs, Etc. |
|---|---|
| Barcode (UPC) | 765704323014 |
| Net contents | 1 Fluid Ounce(s); 30 mL |
| Market status | On market |
| Date entered into DSLD | Nov 22, 2023 |
| DSLD ID | 300024 |
| Product type | Botanical |
| Supplement form | Liquid |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Lung Tonic Non-Alcohol by Herbs, Etc., sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Proprietary Extract Blend | 0.75 mL | -- |
| Horehound herb extract | 0 NP | -- |
| Osha root extract | 0 NP | -- |
| Mullein Leaf Extract, Fresh | 0 NP | -- |
| Elecampane Root Extract | 0 NP | -- |
| Yerba Santa leaf extract | 0 NP | -- |
| Echinacea angustifolia Root Extract | 0 NP | -- |
| Passionflower Herb Extract, Fresh | 0 NP | -- |
| Pleurisy Root Extract | 0 NP | -- |
| Grindelia Flower Extract, Fresh | 0 NP | -- |
| Lobelia Extract, Fresh | 0 NP | -- |
Other ingredients: Glycerin, Water, Purified, Citric Acid, Gum Arabic, Gum Tragacanth
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
Supports lung and bronchial health
Gluten free
Vegan
Made in Santa Fe, NM.
No artificial preservatives.
We apply our company philosophy to Lung Tonic, as we do to all of our herbal medicines. That philosophy is to do what's right, which extends to choosing the right herbs, using the right processes and making the right formulations that support your health needs.
FDA Statement of Identity
Herbal Supplement
Formula
Lung tonic is made with lung and bronchial supporting herbs, including mullein, horehound and grindelia.
Brand IP Statement(s)
We do all of this to bring you herbal medicines made right.
We do all of this to bring you herbal medicines made right.
Suggested/Recommended/Usage/Directions
Suggested use: Take 30 drops in water three times a day. Specific for long-term use.
FDA Disclaimer Statement
This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Lung Tonic Non-Alcohol by Herbs, Etc. label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Lung Tonic Non-Alcohol by Herbs, Etc.
These are the 10 active ingredients this product is made of. Select any to open its full monograph.
Serving size30 Drop(s) Dosage formLiquid Servings per container40 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Proprietary Extract Blend
- › Horehound herb extract
- › Osha root extract
- › Mullein Leaf Extract, Fresh
- › Elecampane Root Extract
- › Yerba Santa leaf extract
- › Echinacea angustifolia Root Extract
- › Passionflower Herb Extract, Fresh
- › Pleurisy Root Extract
- › Grindelia Flower Extract, Fresh
- › Lobelia Extract, Fresh
Other (inactive) ingredients: Glycerin, Water, Purified, Citric Acid, Gum Arabic, Gum Tragacanth. These complete the product’s ingredient list but are not active constituents.
Lung Tonic Non-Alcohol by Herbs, Etc. Drug Interactions
HelloPharmacist Interaction Report
Lung Tonic Non-Alcohol by Herbs, Etc. has documented interactions with a number of medication types.
The most serious concern is pleurisy root, one of its ten active ingredients, which contains heart-active compounds (digitalis-like cardenolides) that can raise the risk of toxicity if you're taking digoxin, a heart medication. This is a Major interaction.
Read the full breakdown — every affected drug type, severity by severity
Several ingredients carry Moderate interactions. Elecampane and passionflower may cause extra drowsiness with sedating drugs like benzodiazepines or sleep aids.
Echinacea can increase levels of certain medications by affecting liver enzymes (CYP1A2 and CYP3A4 substrates), raise caffeine levels by about 30%, and may interfere with drugs that suppress the immune system. Yerba santa and lobelia may increase lithium levels if you're on that mood stabilizer.
Pleurisy root may also reduce the effect of estrogen-based birth control and pose a risk with potassium-depleting water pills (diuretics).
Mullein leaf shows a Minor interaction with blood thinners (anticoagulants) — lab tests suggest mild blood-thinning effects, though they appear weak. Echinacea also has Minor interactions with warfarin and certain other drugs.
We could not check horehound herb extract or grindelia flower extract because we hold no interaction data for them.
Altogether, these interactions span 1,108 individual medications. Use the search tool on this page to check your specific medications before starting this product.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Lung Tonic Non-Alcohol?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Lung Tonic Non-Alcohol interact with 1,267 drugs. Click any drug to see the details.
8 of the 10 ingredients in Lung Tonic Non-Alcohol interact with drugs. Each result below shows which ingredient is responsible. Passionflower Herb Extract, Fresh Echinacea angustifolia Root Extract Horehound herb extract Elecampane Root Extract Mullein Leaf Extract, Fresh Pleurisy Root Extract Yerba Santa leaf extract Lobelia Extract, Fresh
DigoxinDigitek, Lanoxicaps, Lanoxin
How Digoxin interacts with Lung Tonic Non-Alcohol — through 1 ingredient. Tap an ingredient for the detail:
Pleurisy Root ExtractDigoxin (lanoxin) Major
Interaction Summary
Pleurisy root contains digitalis-like cardenolide glycosides.
Read the full Pleurisy Root Extract + Digoxin interaction6-mercaptopurinePurinethol
How 6-mercaptopurine interacts with Lung Tonic Non-Alcohol — through 1 ingredient. Tap an ingredient for the detail:
Echinacea Angustifolia Root ExtractImmunosuppressants Moderate
Interaction Summary
Echinacea has immunostimulant activity which may interfere with immunosuppressant therapy.
Read the full Echinacea Angustifolia Root Extract + 6-mercaptopurine interactionAdo-trastuzumab EmtansineKadcyla
How Ado-trastuzumab Emtansine interacts with Lung Tonic Non-Alcohol — through 2 ingredients. Tap an ingredient for the detail:
Echinacea Angustifolia Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Echinacea may induce hepatic CYP3A4 and inhibit intestinal CYP3A4.
Read the full Echinacea Angustifolia Root Extract + Ado-trastuzumab Emtansine interactionPassionflower Herb Extract, FreshCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, passion flower might decrease the effects of CYP3A4 substrates.
Read the full Passionflower Herb Extract, Fresh + Ado-trastuzumab Emtansine interactionAbemaciclibVerzenio
How Abemaciclib interacts with Lung Tonic Non-Alcohol — through 2 ingredients. Tap an ingredient for the detail:
Echinacea Angustifolia Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Echinacea may induce hepatic CYP3A4 and inhibit intestinal CYP3A4.
Read the full Echinacea Angustifolia Root Extract + Abemaciclib interactionPassionflower Herb Extract, FreshCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, passion flower might decrease the effects of CYP3A4 substrates.
Read the full Passionflower Herb Extract, Fresh + Abemaciclib interactionAbiraterone
How Abiraterone interacts with Lung Tonic Non-Alcohol — through 2 ingredients. Tap an ingredient for the detail:
Echinacea Angustifolia Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Echinacea may induce hepatic CYP3A4 and inhibit intestinal CYP3A4.
Read the full Echinacea Angustifolia Root Extract + Abiraterone interactionPassionflower Herb Extract, FreshCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, passion flower might decrease the effects of CYP3A4 substrates.
Read the full Passionflower Herb Extract, Fresh + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with Lung Tonic Non-Alcohol — through 2 ingredients. Tap an ingredient for the detail:
Echinacea Angustifolia Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Echinacea may induce hepatic CYP3A4 and inhibit intestinal CYP3A4.
Read the full Echinacea Angustifolia Root Extract + Abiraterone Acetate interactionPassionflower Herb Extract, FreshCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, passion flower might decrease the effects of CYP3A4 substrates.
Read the full Passionflower Herb Extract, Fresh + Abiraterone Acetate interactionAbrocitinibCibinqo
How Abrocitinib interacts with Lung Tonic Non-Alcohol — through 2 ingredients. Tap an ingredient for the detail:
Echinacea Angustifolia Root ExtractImmunosuppressants Moderate
Interaction Summary
Echinacea has immunostimulant activity which may interfere with immunosuppressant therapy.
Read the full Echinacea Angustifolia Root Extract + Abrocitinib interactionMullein Leaf Extract, FreshAnticoagulant/antiplatelet Drugs Minor
Interaction Summary
Lab tests on extracts from different parts of common and dense-flowered mullein plants show that they do have some blood-thinning effects, as they increase the time it takes for blood to clot.
Read the full Mullein Leaf Extract, Fresh + Abrocitinib interactionAcalabrutinibCalquence
How Acalabrutinib interacts with Lung Tonic Non-Alcohol — through 2 ingredients. Tap an ingredient for the detail:
Echinacea Angustifolia Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Echinacea may induce hepatic CYP3A4 and inhibit intestinal CYP3A4.
Read the full Echinacea Angustifolia Root Extract + Acalabrutinib interactionPassionflower Herb Extract, FreshCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, passion flower might decrease the effects of CYP3A4 substrates.
Read the full Passionflower Herb Extract, Fresh + Acalabrutinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Lung Tonic Non-Alcohol — through 1 ingredient. Tap an ingredient for the detail:
Horehound Herb ExtractAntidiabetes Drugs Moderate
Interaction Summary
Evidence from animal research suggests that white horehound might lower blood glucose.
Read the full Horehound Herb Extract + Acarbose interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Lung Tonic Non-Alcohol — through 1 ingredient. Tap an ingredient for the detail:
Horehound Herb ExtractAntihypertensive Drugs Moderate
Interaction Summary
Evidence from animal research suggests that taking white horehound extract lowers blood pressure.
Read the full Horehound Herb Extract + Acebutolol interactionAcepromazineAtravet
How Acepromazine interacts with Lung Tonic Non-Alcohol — through 2 ingredients. Tap an ingredient for the detail:
Elecampane Root ExtractCns Depressants Moderate
Interaction Summary
Theoretically, elecampane may cause additive sedative effects when taken with CNS depressants.
Read the full Elecampane Root Extract + Acepromazine interactionPassionflower Herb Extract, FreshCns Depressants Moderate
Interaction Summary
Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.
Read the full Passionflower Herb Extract, Fresh + Acepromazine interactionAcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength
How Acetaminophen interacts with Lung Tonic Non-Alcohol — through 1 ingredient. Tap an ingredient for the detail:
Echinacea Angustifolia Root ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Echinacea might inhibit the metabolism of CYP1A2 and increase plasma levels of some drugs.
Read the full Echinacea Angustifolia Root Extract + Acetaminophen interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Lung Tonic Non-Alcohol — through 2 ingredients. Tap an ingredient for the detail:
Echinacea Angustifolia Root ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Echinacea might inhibit the metabolism of CYP1A2 and increase plasma levels of some drugs.
Read the full Echinacea Angustifolia Root Extract + Acetaminophen, Aspirin interactionMullein Leaf Extract, FreshAnticoagulant/antiplatelet Drugs Minor
Interaction Summary
Lab tests on extracts from different parts of common and dense-flowered mullein plants show that they do have some blood-thinning effects, as they increase the time it takes for blood to clot.
Read the full Mullein Leaf Extract, Fresh + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Lung Tonic Non-Alcohol — through 3 ingredients. Tap an ingredient for the detail:
Echinacea Angustifolia Root ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Echinacea might inhibit the metabolism of CYP1A2 and increase plasma levels of some drugs.
Read the full Echinacea Angustifolia Root Extract + Acetaminophen, Aspirin, Caffeine interactionMullein Leaf Extract, FreshAnticoagulant/antiplatelet Drugs Minor
Interaction Summary
Lab tests on extracts from different parts of common and dense-flowered mullein plants show that they do have some blood-thinning effects, as they increase the time it takes for blood to clot.
Read the full Mullein Leaf Extract, Fresh + Acetaminophen, Aspirin, Caffeine interactionPassionflower Herb Extract, FreshCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, passion flower might decrease the effects of CYP3A4 substrates.
Read the full Passionflower Herb Extract, Fresh + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with Lung Tonic Non-Alcohol — through 1 ingredient. Tap an ingredient for the detail:
Echinacea Angustifolia Root ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Echinacea might inhibit the metabolism of CYP1A2 and increase plasma levels of some drugs.
Read the full Echinacea Angustifolia Root Extract + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more
How Acetaminophen, Butalbital interacts with Lung Tonic Non-Alcohol — through 1 ingredient. Tap an ingredient for the detail:
Echinacea Angustifolia Root ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Echinacea might inhibit the metabolism of CYP1A2 and increase plasma levels of some drugs.
Read the full Echinacea Angustifolia Root Extract + Acetaminophen, Butalbital interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Lung Tonic Non-Alcohol — through 2 ingredients. Tap an ingredient for the detail:
Echinacea Angustifolia Root ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Caffeine +1 Moderate
Interaction Summary
Echinacea might inhibit the metabolism of CYP1A2 and increase plasma levels of some drugs.
Read the full Echinacea Angustifolia Root Extract + Acetaminophen, Butalbital, Caffeine interactionPassionflower Herb Extract, FreshCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, passion flower might decrease the effects of CYP3A4 substrates.
Read the full Passionflower Herb Extract, Fresh + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Lung Tonic Non-Alcohol — through 3 ingredients. Tap an ingredient for the detail:
Echinacea Angustifolia Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Caffeine +1 Moderate
Interaction Summary
Echinacea may induce hepatic CYP3A4 and inhibit intestinal CYP3A4.
Read the full Echinacea Angustifolia Root Extract + Acetaminophen, Butalbital, Caffeine, Codeine interactionPassionflower Herb Extract, FreshCytochrome P450 3a4 (cyp3a4) Substrates, Cns Depressants Moderate
Interaction Summary
Theoretically, passion flower might decrease the effects of CYP3A4 substrates.
Read the full Passionflower Herb Extract, Fresh + Acetaminophen, Butalbital, Caffeine, Codeine interactionElecampane Root ExtractCns Depressants Moderate
Interaction Summary
Theoretically, elecampane may cause additive sedative effects when taken with CNS depressants.
Read the full Elecampane Root Extract + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Lung Tonic Non-Alcohol — through 3 ingredients. Tap an ingredient for the detail:
Elecampane Root ExtractCns Depressants Moderate
Interaction Summary
Theoretically, elecampane may cause additive sedative effects when taken with CNS depressants.
Read the full Elecampane Root Extract + Acetaminophen, Butalbital, Codeine interactionPassionflower Herb Extract, FreshCns Depressants Moderate
Interaction Summary
Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.
Read the full Passionflower Herb Extract, Fresh + Acetaminophen, Butalbital, Codeine interactionEchinacea Angustifolia Root ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Echinacea might inhibit the metabolism of CYP1A2 and increase plasma levels of some drugs.
Read the full Echinacea Angustifolia Root Extract + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Lung Tonic Non-Alcohol — through 3 ingredients. Tap an ingredient for the detail:
Echinacea Angustifolia Root ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Echinacea might inhibit the metabolism of CYP1A2 and increase plasma levels of some drugs.
Read the full Echinacea Angustifolia Root Extract + Acetaminophen, Butalbital, Codeine Phosphate interactionPassionflower Herb Extract, FreshCns Depressants Moderate
Interaction Summary
Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.
Read the full Passionflower Herb Extract, Fresh + Acetaminophen, Butalbital, Codeine Phosphate interactionElecampane Root ExtractCns Depressants Moderate
Interaction Summary
Theoretically, elecampane may cause additive sedative effects when taken with CNS depressants.
Read the full Elecampane Root Extract + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Lung Tonic Non-Alcohol — through 3 ingredients. Tap an ingredient for the detail:
Elecampane Root ExtractCns Depressants Moderate
Interaction Summary
Theoretically, elecampane may cause additive sedative effects when taken with CNS depressants.
Read the full Elecampane Root Extract + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionEchinacea Angustifolia Root ExtractCaffeine, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Echinacea can increase plasma levels of caffeine by inhibiting its metabolism.
Read the full Echinacea Angustifolia Root Extract + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionPassionflower Herb Extract, FreshCns Depressants, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.
Read the full Passionflower Herb Extract, Fresh + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Lung Tonic Non-Alcohol — through 3 ingredients. Tap an ingredient for the detail:
Passionflower Herb Extract, FreshCytochrome P450 3a4 (cyp3a4) Substrates, Cns Depressants Moderate
Interaction Summary
Theoretically, passion flower might decrease the effects of CYP3A4 substrates.
Read the full Passionflower Herb Extract, Fresh + Acetaminophen, Caffeine, Codeine interactionEchinacea Angustifolia Root ExtractCaffeine, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Echinacea can increase plasma levels of caffeine by inhibiting its metabolism.
Read the full Echinacea Angustifolia Root Extract + Acetaminophen, Caffeine, Codeine interactionElecampane Root ExtractCns Depressants Moderate
Interaction Summary
Theoretically, elecampane may cause additive sedative effects when taken with CNS depressants.
Read the full Elecampane Root Extract + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Lung Tonic Non-Alcohol — through 3 ingredients. Tap an ingredient for the detail:
Echinacea Angustifolia Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Caffeine +1 Moderate
Interaction Summary
Echinacea may induce hepatic CYP3A4 and inhibit intestinal CYP3A4.
Read the full Echinacea Angustifolia Root Extract + Acetaminophen, Caffeine, Codeine, Salicylamide interactionPassionflower Herb Extract, FreshCytochrome P450 3a4 (cyp3a4) Substrates, Cns Depressants Moderate
Interaction Summary
Theoretically, passion flower might decrease the effects of CYP3A4 substrates.
Read the full Passionflower Herb Extract, Fresh + Acetaminophen, Caffeine, Codeine, Salicylamide interactionElecampane Root ExtractCns Depressants Moderate
Interaction Summary
Theoretically, elecampane may cause additive sedative effects when taken with CNS depressants.
Read the full Elecampane Root Extract + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Lung Tonic Non-Alcohol — through 3 ingredients. Tap an ingredient for the detail:
Elecampane Root ExtractCns Depressants Moderate
Interaction Summary
Theoretically, elecampane may cause additive sedative effects when taken with CNS depressants.
Read the full Elecampane Root Extract + Acetaminophen, Caffeine, Dihydrocodeine interactionEchinacea Angustifolia Root ExtractCaffeine, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Echinacea can increase plasma levels of caffeine by inhibiting its metabolism.
Read the full Echinacea Angustifolia Root Extract + Acetaminophen, Caffeine, Dihydrocodeine interactionPassionflower Herb Extract, FreshCns Depressants, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.
Read the full Passionflower Herb Extract, Fresh + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Lung Tonic Non-Alcohol — through 2 ingredients. Tap an ingredient for the detail:
Echinacea Angustifolia Root ExtractCaffeine, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Echinacea can increase plasma levels of caffeine by inhibiting its metabolism.
Read the full Echinacea Angustifolia Root Extract + Acetaminophen, Caffeine, Isometheptene interactionPassionflower Herb Extract, FreshCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, passion flower might decrease the effects of CYP3A4 substrates.
Read the full Passionflower Herb Extract, Fresh + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Lung Tonic Non-Alcohol — through 3 ingredients. Tap an ingredient for the detail:
Echinacea Angustifolia Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Echinacea may induce hepatic CYP3A4 and inhibit intestinal CYP3A4.
Read the full Echinacea Angustifolia Root Extract + Acetaminophen, Caffeine, Pyrilamine interactionPleurisy Root ExtractDiuretic Drugs Moderate
Interaction Summary
Theoretically, concomitant use of potassium-depleting diuretics and pleurisy root can increase the risk of cardiac glycoside toxicity due to potassium depletion.
Read the full Pleurisy Root Extract + Acetaminophen, Caffeine, Pyrilamine interactionPassionflower Herb Extract, FreshCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, passion flower might decrease the effects of CYP3A4 substrates.
Read the full Passionflower Herb Extract, Fresh + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Lung Tonic Non-Alcohol — through 2 ingredients. Tap an ingredient for the detail:
Echinacea Angustifolia Root ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Echinacea might inhibit the metabolism of CYP1A2 and increase plasma levels of some drugs.
Read the full Echinacea Angustifolia Root Extract + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionPassionflower Herb Extract, FreshCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, passion flower might decrease the effects of CYP3A4 substrates.
Read the full Passionflower Herb Extract, Fresh + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Lung Tonic Non-Alcohol — through 3 ingredients. Tap an ingredient for the detail:
Passionflower Herb Extract, FreshCytochrome P450 3a4 (cyp3a4) Substrates, Cns Depressants Moderate
Interaction Summary
Theoretically, passion flower might decrease the effects of CYP3A4 substrates.
Read the full Passionflower Herb Extract, Fresh + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionElecampane Root ExtractCns Depressants Moderate
Interaction Summary
Theoretically, elecampane may cause additive sedative effects when taken with CNS depressants.
Read the full Elecampane Root Extract + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionEchinacea Angustifolia Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Echinacea may induce hepatic CYP3A4 and inhibit intestinal CYP3A4.
Read the full Echinacea Angustifolia Root Extract + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Lung Tonic Non-Alcohol — through 2 ingredients. Tap an ingredient for the detail:
Echinacea Angustifolia Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Echinacea may induce hepatic CYP3A4 and inhibit intestinal CYP3A4.
Read the full Echinacea Angustifolia Root Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionPassionflower Herb Extract, FreshCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, passion flower might decrease the effects of CYP3A4 substrates.
Read the full Passionflower Herb Extract, Fresh + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with Lung Tonic Non-Alcohol — through 2 ingredients. Tap an ingredient for the detail:
Echinacea Angustifolia Root ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Echinacea might inhibit the metabolism of CYP1A2 and increase plasma levels of some drugs.
Read the full Echinacea Angustifolia Root Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionPassionflower Herb Extract, FreshCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, passion flower might decrease the effects of CYP3A4 substrates.
Read the full Passionflower Herb Extract, Fresh + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Lung Tonic Non-Alcohol with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Passionflower Herb Extract, Fresh
Cns Depressants
Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.
Research in animals and humans shows that passion flower has sedative effects which can be additive when used with sedative medications like lorazepam.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, passion flower might decrease the effects of CYP3A4 substrates.
In vitro research suggests that passion flower can induce CYP3A4 enzymes, albeit to a much lower degree than rifampin, a known CYP3A4 inducer.
Organic Anion-Transporting Polypeptide Substrates (Oatp)
Theoretically, passion flower might reduce the bioavailability of OATP2B1 and OATP1A2 substrates.
In vitro research shows that the passion flower constituents apigenin and vitexin inhibit OATP2B1 and OATP1A2. This inhibition may be dose-dependent. One specific high-flavonoid passion flower extract (Valverde) seems to inhibit OATP2B1 and OATP1A2, while another extract with a lower flavonoid concentration (Arkocaps) shows less potent inhibition. OATPs are responsible for the uptake of drugs and other compounds into the body; however, the specific activities of OATP2B1 and OATP1A2 are not well characterized.
Echinacea angustifolia Root Extract
Caffeine
Echinacea can increase plasma levels of caffeine by inhibiting its metabolism.
Echinacea seems to increase plasma concentrations of caffeine by around 30%. This is likely due to inhibition of cytochrome P450 1A2 (CYP1A2) by echinacea.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Echinacea might inhibit the metabolism of CYP1A2 and increase plasma levels of some drugs.
Echinacea appears to inhibit CYP1A2 enzymes in humans. Additionally, echinacea seems to increase plasma concentrations of caffeine, a CYP1A2 substrate, by around 30%. Theoretically, echinacea might increase levels of other drugs metabolized by CYP1A2.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Echinacea may induce hepatic CYP3A4 and inhibit intestinal CYP3A4. This may increase or decrease levels of drugs metabolized by CYP3A4.
Several clinical trials have shown that taking echinacea for up to one month does not significantly affect the metabolism of various CYP3A4 substrates, including midazolam, docetaxel, etravirine, lopinavir-ritonavir, and darunavir-ritonavir. However, other clinical research shows that echinacea may increase the clearance of midazolam, suggesting that echinacea might induce CYP3A4. The discrepancy is thought to be due to differing effects of echinacea on intestinal versus hepatic CYP3A4 enzymes. Echinacea appears to induce hepatic CYP3A4 but inhibit intestinal CYP3A4. In some cases, these effects might cancel each other out, but in others, drug levels may be increased or decreased depending on the level of effect at hepatic and intestinal sites. The effect of echinacea on CYP3A4 activity may differ depending on the CYP3A4 substrate.
Etoposide (Vepesid)
Echinacea may increase levels of etoposide.
In one report, concomitant use of etoposide and echinacea was associated with more severe thrombocytopenia than the use of etoposide alone, suggesting inhibition of etoposide metabolism. Etoposide is a cytochrome P450 3A4 (CYP3A4) substrate. Echinacea has variable effects on CYP3A4, but some studies have reported inhibition of the enzyme.
Immunosuppressants
Echinacea has immunostimulant activity which may interfere with immunosuppressant therapy.
Theoretically, echinacea may interfere with immunosuppressant therapy because of its immunostimulant activity.
Darunavir (Prezista)
Theoretically, echinacea may interfere with the metabolism of darunavir; however, a small clinical study found no effect.
Darunavir is metabolized by cytochrome P450 3A4 (CYP3A4) and is administered with the CYP3A4 inhibitor ritonavir to increase its plasma concentrations. Echinacea has variable effects on CYP3A4, but administration of an E. purpurea root extract (Arkocapsulas Echinacea, Arkopharma) 500 mg four times daily for 14 days did not affect darunavir/ritonavir pharmacokinetics in 15 HIV-infected patients.
Dayquil Severe
Echinacea is reported to have varying effects on a number of Cytochrome P450 metabolizing enzymes in the liver, including CYP1A2 and CYP3A4, which play a role in acetaminophen and dextromethorphan metabolism (both contained in DayQuil Severe), respectively. Studies have reported both enzyme inhibition and induction, making it difficult to predict clinically significant drug interactions with reliability. Specific drug interaction studies reporting definitive results are rare, and potential drug interactions involving echinacea should likely be taken on a case-by-case basis. Based on what we know about how acetaminophen and dextromethorphan are metabolized, the risk of a clinically significant interaction between echinacea and DayQuil Severe is low.
Docetaxel (Taxotere)
Theoretically, echinacea may interfere with the metabolism of docetaxel; however, a small clinical study found no effect.
Docetaxel is metabolized by cytochrome P450 3A4 (CYP3A4). Echinacea has variable effects on CYP3A4, but taking E. purpurea whole plant extract (Echinaforce, A. Vogel Biopharma AG) 20 drops three times daily for 2 weeks did not alter the pharmacokinetics of docetaxel in one clinical study.
Etravirine (Intelence)
Theoretically, echinacea may interfere with the metabolism of etravirine; however, a small clinical study found no effect.
Etravirine is metabolized by cytochrome P450 3A4 (CYP3A4). Echinacea has variable effects on CYP3A4, but taking E. purpurea root extract (Arkocapsulas Echinacea, Arkopharma) 500 mg three times daily for 14 days did not alter the pharmacokinetics of etravirine in HIV-infected patients.
Lopinavir/Ritonavir (Kaletra)
Theoretically, echinacea may interfere with the metabolism of lopinavir; however, a small clinical study found no effect.
Lopinavir is metabolized by cytochrome P450 3A4 (CYP3A4) and is administered with the CYP3A4 inhibitor ritonavir to increase its plasma concentrations. Echinacea has variable effects on CYP3A4, but taking E. purpurea (Echinamide, Natural Factors Nutritional Products, Inc.) 500 mg three times daily for 14 days did not alter the pharmacokinetics of lopinavir/ritonavir in healthy volunteers.
Midazolam (Versed)
Theoretically, echinacea may increase the metabolism of intravenous midazolam.
Echinacea induces hepatic CYP3A4 and might decrease plasma levels of midazolam by about 20%, reducing the effectiveness of intravenous midazolam. Echinacea also appears to inhibit intestinal CYP3A4, which could theoretically increase the bioavailability of oral midazolam. This may cancel out the decrease in availability caused by induction of hepatic CYP3A4, such that overall plasma levels after oral administration of midazolam are not affected by echinacea.
Warfarin (Coumadin)
Echinacea seems to increase the clearance of warfarin, although the effect may not be clinically significant.
Preliminary clinical research in healthy male volunteers suggests that taking echinacea increases the clearance of the active S-isomer of warfarin after a single dose of warfarin, but there was not a clinically significant effect on the INR.
Horehound herb extract
Antidiabetes Drugs
Evidence from animal research suggests that white horehound might lower blood glucose. However, preliminary clinical research suggests that white horehound only slightly lowers blood glucose when taken in combination with antidiabetic agents, suggesting that the effect may not be clinically significant. Until more is known, use with caution. Theoretically, white horehound may have additive effects when used by patients taking antidiabetic drugs. The dose of diabetes medications might need to be adjusted. Some antidiabetes drugs include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, metformin (Glucophage), pioglitazone (Actos), rosiglitazone (Avandia), and others.
Antihypertensive Drugs
Evidence from animal research suggests that taking white horehound extract lowers blood pressure. Theoretically, taking white horehound with antihypertensive drugs might enhance therapeutic effects and increase the risk of hypotension. Some antihypertensive drugs include captopril (Capoten), enalapril (Vasotec), losartan (Cozaar), valsartan (Diovan), diltiazem (Cardizem), Amlodipine (Norvasc), hydrochlorothiazide (HydroDiuril), furosemide (Lasix), and many others.
Elecampane Root Extract
Cns Depressants
Theoretically, elecampane may cause additive sedative effects when taken with CNS depressants.
Elecampane might have sedative effects.
Mullein Leaf Extract, Fresh
Anticoagulant/Antiplatelet Drugs
Lab tests on extracts from different parts of common and dense-flowered mullein plants show that they do have some blood-thinning effects, as they increase the time it takes for blood to clot. This is likely due to at least one of the known constituents of muellein, triterpenoid saponins. However, the effects appear to be mild and results have been inconsistent. Extracts from different plant parts have been show to have varying anticoagulant strengths, with water-based ones being more potent than alcohol-based extracts.
Pleurisy Root Extract
Digoxin (Lanoxin)
Pleurisy root contains digitalis-like cardenolide glycosides. Taking pleurisy root in combination with digoxin could increase the risk of adverse effects and toxicity.
Diuretic Drugs
Theoretically, concomitant use of potassium-depleting diuretics and pleurisy root can increase the risk of cardiac glycoside toxicity due to potassium depletion. Some diuretics that can deplete potassium include chlorothiazide (Diuril), chlorthalidone (Thalitone), furosemide (Lasix), hydrochlorothiazide (HCTZ, Hydrodiuril, Microzide), and others.
Estrogens
Theoretically, excessive amounts of pleurisy root might interfere with hormone drug therapy.
Yerba Santa leaf extract
Lithium
Yerba santa is thought to have diuretic properties. Theoretically, due to these potential diuretic effects, yerba santa might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.
Lobelia Extract, Fresh
Lithium
Lobelia is thought to have diuretic properties. Theoretically, due to these potential diuretic effects, lobelia might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.
Brand information
Manufacturer and brand details for Lung Tonic Non-Alcohol, from the product label.
Herbs, Etc.
See all Herbs, Etc. products- Name
- Herbs, Etc., Inc.
- Street Address
- 1340 Rufina Circle
- City
- Sante Fe
- State
- NM
- ZipCode
- 87507
- Web Address
- www.herbsetc.com
Lung Tonic Non-Alcohol by Herbs, Etc.: Common Questions
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Lung Tonic Non-Alcohol’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
White Horehound
Interacts with 258 drugsWhite horehound is a traditional bitter herb used mainly for coughs, sore throats, and mild digestive complaints, and it is a common flavoring in old-fashioned cough drops. Solid human evide...
Read the full White Horehound monograph → Herb & supplement monographOsha
Osha is a root from a wild mountain plant native to the western United States and Mexico, traditionally used by Native American and Hispanic communities for coughs, colds, and sore throats....
Read the full Osha monograph → Herb & supplement monographMullein
Interacts with 122 drugsMullein is a traditional herbal remedy most often used as a tea or syrup to soothe coughs, sore throats, and respiratory irritation. High-quality human studies are lacking, so its benefits a...
Read the full Mullein monograph → Herb & supplement monographElecampane
Interacts with 248 drugsElecampane is a traditional herb used mainly for coughs and other respiratory complaints, and as a bitter for digestion. Modern human evidence is very limited, so it should be seen as a folk...
Read the full Elecampane monograph → Herb & supplement monographYerba Santa
Interacts with 1 drugYerba Santa is an aromatic shrub from the western United States and Mexico that has long been used in folk medicine for coughs, congestion, and other respiratory complaints. Modern scientifi...
Read the full Yerba Santa monograph → Herb & supplement monographEchinacea
Interacts with 816 drugsEchinacea is a popular herb taken to help prevent or shorten the common cold, but study results are mixed and the overall benefit appears small at best. It is generally well tolerated for sh...
Read the full Echinacea monograph → Herb & supplement monographPassion Flower
Interacts with 836 drugsPassion flower is a traditional calming herb that many people use for anxiety and sleep. Early studies hint it may help with mild anxiety and restlessness, but the evidence is limited and mo...
Read the full Passion Flower monograph → Herb & supplement monographPleurisy Root
Interacts with 117 drugsPleurisy root is the dried root of Asclepias tuberosa (butterfly weed), a plant used in traditional North American and herbal medicine mainly for respiratory complaints. There is very little...
Read the full Pleurisy Root monograph → Herb & supplement monographLobelia
Interacts with 1 drugLobelia is a traditional herb once used for breathing problems and to help people quit smoking, but reliable evidence supporting these uses is lacking. It can be toxic in higher amounts, cau...
Read the full Lobelia monograph →Sources & How We Checked
Lung Tonic Non-Alcohol's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 100 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
White Horehound 8 references
- Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
- Roman, Ramos R., Alarcon-Aguilar, F., Lara-Lemus, A., and Flores-Saenz, J. L. Hypoglycemic effect of plants used in Mexico as antidiabetics. Arch.Med.Res 1992;23:59-64.
- Novaes AP, Rossi C, Poffo C, et al. Preliminary evaluation of the hypoglycemic effect of some Brazilian medicinal plants. Therapie. 2001;56(4):427-30.
- El Bardai, S., Lyoussi, B., Wibo, M., and Morel, N. Pharmacological evidence of hypotensive activity of Marrubium vulgare and Foeniculum vulgare in spontaneously hypertensive rat. Clin Exp Hypertens. 2001;23(4):329-343.
- El Bardai, S., Lyoussi, B., Wibo, M., and Morel, N. Comparative study of the antihypertensive activity of Marrubium vulgare and of the dihydropyridine calcium antagonist amlodipine in spontaneously hypertensive rat. Clin Exp Hypertens. 2004;26(6):465-474 PubMed
- Herrera-Arellano, A., Aguilar-Santamaria, L., Garcia-Hernandez, B., Nicasio-Torres, P., and Tortoriello, J. Clinical trial of Cecropia obtusifolia and Marrubium vulgare leaf extracts on blood glucose and serum lipids in type 2 diabetics. Phytomedicine 200 PubMed
Osha 2 references
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
Mullein 2 references
- Castro AI, Carmona JB, Gonzales FG, Nestar OB. Occupational airborne dermatitis from gordolobo (Verbascum densiflorum). Contact Dermatitis 2006;55(5):301.
- Flores Echaiz C, Al Ali A, Cao AQ, Sasseville D. Simultaneous contact dermatitis caused by Asteraceae and Verbascum thapsus. Contact Dermatitis 2017;76(5):316-8.
Elecampane 5 references
- Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Lamminpaa A, Estlander T, Jolanki R, Kanerva L. Occupational allergic contact dermatitis caused by decorative plants. Contact Dermatitis 1996;34:330-5. PubMed
- Pazzaglia, M., Venturo, N., Borda, G., and Tosti, A. Contact dermatitis due to a massage liniment containing Inula helenium extract. Contact Dermatitis 1995;33(4):267.
- Aalto-Korte, K., Alanko, K., Kuuliala, O., and Jolanki, R. Late reactions in patch tests: a 4-year review from a clinic of occupational dermatology. Contact Dermatitis 2007;56(2):81-86. PubMed
Echinacea 51 references
- Mullins RJ. Echinacea-associated anaphylaxis. Med J Aust 1998;168:170-1. PubMed
- Mullins RJ. Allergic reactions to Echinacea. J Allergy Clin Immunol 2000;104:S340-341 (Abstract 1003).
- Chavez ML, Chavez PI. Echinacea. Hosp Pharm 1998;33:180-8.
- Grimm W, Muller HH. A randomized controlled trial of the effect of fluid extract of Echinacea purpurea on the incidence and severity of colds and respiratory infections. Am J Med 1999;106:138-43. PubMed
- Taylor JA, Weber W, Standish L, et al. Efficacy and safety of echinacea in treating upper respiratory tract infections in children: a randomized controlled trial. JAMA 2003;290:2824-30.. PubMed
- Luettig B, Steinmuller C, Gifford GE, et al. Macrophage activation by the polysaccharide arabinogalactan isolated from plant cell cultures of Echinacea purpurea. J Natl Cancer Inst 1989;81:669-75. PubMed
- Stimpel M, Proksch A, Wagner H, et al. Macrophage activation and induction of macrophage cytotoxicity by purified polysaccharide fractions from the plant Echinacea purpurea. Infect Immun 1984;46:845-9. PubMed
- Budzinski JW, Foster BC, Vandenhoek S, Arnason JT. An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tinctures. Phytomedicine 2000;7:273-82. PubMed
- Gallo M, Sarkar M, Au W, et al. Pregnancy outcome following gestational exposure to echinacea: A prospective controlled study. Arch Intern Med 2000;160:3141-3. PubMed
- Soon SL, Crawford RI. Recurrent erythema nodosum associated with echinacea herbal therapy. J Am Acad Dermatol 2001;44:298-9. PubMed
- Mullins RJ, Heddle R. Adverse reactions associated with echinacea: the Australian experience. Ann Allergy Asthma Immunol 2002;88:42-51. PubMed
- Logan JL, Ahmed J. Critical hypokalemic renal tubular acidosis due to Sjogren's syndrome: association with the purported immune stimulant echinacea. Clin Rheumatol 2003;22:158-9.
- Schulten B, Bulitta M, Ballering-Bruhl B, et al. Efficacy of Echinacea purpurea in patients with a common cold. A placebo-controlled, randomised, double-blind clinical trial. Arzneimittelforschung 2001;51:563-8.. PubMed
- Yale SH, Glurich I. Analysis of the inhibitory potential of Ginkgo biloba, Echinacea purpurea, and Serenoa repens on the metabolic activity of cytochrome P450 3A4, 2D6, and 2C9. J Altern Complement Med 2005;11:433-9.
- Yale SH, Liu K. Echinacea purpurea therapy for the treatment of the common cold: a randomized, double-blind, placebo-controlled clinical trial. Arch Intern Med 2004;164:1237-41. PubMed
- Gorski JC, Huang S, Zaheer NA, et al. The effect of echinacea (Echinacea purpurea root) on cytochrome P450 activity in vivo.Clin Pharmacol Ther 2003;73 (Abstract PDII-A-8):P94. PubMed
- Lee AN, Werth VP. Activation of autoimmunity following use of immunostimulatory herbal supplements. Arch Dermatol 2004;140:723-7. PubMed
- Goel V, Lovlin R, Barton R, et al. Efficacy of a standardized echinacea preparation (Echinilin) for the treatment of the common cold: a randomized, double-blind, placebo-controlled trial. J Clin Pharm Ther 2004;29:75-83.
- Barrett B. Medicinal properties of Echinacea: a critical review. Phytomedicine 2003;10:66-86. PubMed
- Huntley AL, Thompson Coon J, Ernst E. The safety of herbal medicinal products derived from Echinacea species: a systematic review. Drug Saf 2005;28:387-400. PubMed
- Turner RB, Bauer R, Woelkart K, et al. An evaluation of Echinacea angustifolia in experimental rhinovirus infections. N Engl J Med 2005;353:341-8.
- Gurley BJ, Gardner SF, Hubbard MA, et al. In vivo assessment of botanical supplementation on human cytochrome P450 phenotypes: Citrus aurantium, Echinacea purpurea, milk thistle, and saw palmetto. Clin Pharmacol Ther 2004;76:428-40. .
- Perri D, Dugoua JJ, Mills E, Koren G. Safety and efficacy of echinacea (Echinacea augustafolia, e. purpurea and e. pallida) during pregnancy and lactation. Can J Clin Pharmacol 2006;13:e262-7.
- Kocaman O, Hulagu S, Senturk O. Echinacea-induced severe acute hepatitis with features of cholestatic autoimmune hepatitis. Eur J Intern Med 2008;19:148. PubMed
- Barrett B, Brown R, Rakel D. et al. Echinacea for treating the common cold: a randomized trial. Ann Intern Med 2010;153:769-77. PubMed
- Press Release: Echinacea herbal products should not be used in children under 12 years old. Medicines and Healthcare Products Regulatory Agency (UK). August 20, 2012. Available at: www.mhra.gov.uk/NewsCentre/Pressreleases/CON180627. (Accessed 21 October
- Barrett B, Brown R, Rakel D, Rabago D, et al. Placebo effects and the common cold: a randomized controlled trial. Ann.Fam.Med 2011;9:312-22. PubMed
- Haller J, Freund, TF, Pelczer, KG, et al. The anxiolytic potential and psychotropic side effects of an echinacea preparation in laboratory animals and healthy volunteers. Phytother.Res. 2013;27:54-61.
- Grbic J, Wexler I, Celenti R, et al. A phase II trial of a transmucosal herbal patch for the treatment of gingivitis. J Am Dent.Assoc. 2011;142:1168-75. PubMed
- Schapowal A, Berger D, Klein P, et al. Echinacea/sage or chlorhexidine/lidocaine for treating acute sore throats: a randomized double-blind trial. Eur.J Med Res 9-1-2009;14:406-12. PubMed
- Bossaer JB and Odle BL. Probable etoposide interaction with Echinacea. J.Diet.Suppl 2012;9:90-5.
- Abdul MI, Jiang X, Williams KM, et al. Pharmacokinetic and pharmacodynamic interactions of echinacea and policosanol with warfarin in healthy subjects. Br J Clin.Pharmacol. 2010;69:508-15. PubMed
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