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Dietary supplement

Lutein 20 mg Ingredients & Drug Interactions

by Sundown Naturalist

Lutein 20 mg label
See full label image
Softgel Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Lutein 20 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Lutein 20 mg is a dietary supplement by Sundown Naturalist with 1 active ingredient. Its ingredients are commonly taken for eye health, age-related macular degeneration, cataract prevention.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Lutein 20 mg by Sundown Naturalist

Ask about any prescription or over-the-counter medication and we check it for interactions with Lutein 20 mg by Sundown Naturalist — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Lutein 20 mg by Sundown Naturalist

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 20, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • “Lutein” is listed as a grouped ingredient — the label gives one combined amount (20 mg) without saying how much of each component you get.

This product contains one active ingredient: zeaxanthin, a carotenoid (plant pigment) closely related to lutein. Both work as antioxidants in the eye and elsewhere in the body.

The softgel capsule also holds safflower oil, gelatin, glycerin, and yellow beeswax as inactive ingredients to deliver and preserve the active compound.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: supports eye health.
  • We looked for evidence on: Age-related macular degeneration (AMD), Asthenopia (eye strain), Cataracts, Central serous retinopathy, Choroideremia, Diabetic retinopathy — and 4 related terms.
  • The strongest evidence on file: Zeaxanthin is rated "Possibly Effective" for Age-related macular degeneration (AMD) (Natural Medicines).
  • Also on file: Zeaxanthin is rated "Insufficient Reliable Evidence To Rate" for Cataracts, Asthenopia (eye strain), Macular telangiectasia type 2.

Zeaxanthin is possibly effective for age-related macular degeneration (AMD), a common eye condition that develops over time. For age-related cognitive decline, Alzheimer disease, asthma, breast cancer, and bronchopulmonary dysplasia, the evidence in our data is insufficient to say whether it works.

That doesn't mean it doesn't; it means the science isn't clear enough yet to rate it.

The evidence, ingredient by ingredient Lutein Zeaxanthin

How safe is it?

Some data gaps
Safety Information · database check
Some gaps

Safety data exists for these ingredients, but with some important gaps.

Why this rating?
  • We hold adverse-effect (side-effect) data for 0 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Zeaxanthin is generally well tolerated at typical supplement doses. For pregnancy, the available data suggests it's likely safe, though concentrated supplement safety during pregnancy hasn't been extensively studied — dietary amounts from food are fine, but check with your doctor or pharmacist before taking supplements.

The same caution applies to breastfeeding: food sources are safe, but there isn't enough data on concentrated supplements, so talk it over with your healthcare provider.

Side effects, ingredient by ingredient Lutein Zeaxanthin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Zeaxanthin.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your diabetes medications (like insulin, metformin, or sulfonylureas) with your doctor or pharmacist before starting this product — zeaxanthin may theoretically increase the risk of low blood sugar when combined with them.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and some safety-information gaps remain.

This product may help slow or prevent age-related macular degeneration, one of the leading causes of vision loss as we age. If you take any diabetes medication, check with your doctor or pharmacist first because of a potential low-blood-sugar interaction.

Pregnant or breastfeeding? Talk with your healthcare provider about whether the supplement form is right for you, since the data on concentrated supplements in these periods is limited.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 24, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Lutein 20 mg, straight from the product label.

Brand Sundown Naturalist
Barcode (UPC) 030768049010
Net contents 60 Softgel(s)
Market status On market
Date entered into DSLD Aug 24, 2016
DSLD ID 63385
Product type Non-nutrient/non-botanical
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Lutein 20 mg by Sundown Naturalist, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
UPC/BARCODE
030768049010
IngredientAmount% DV
Zeaxanthin800 mcg--
Lutein20 mg--

Other ingredients: Safflower Oil, Gelatin, Glycerin, yellow Beeswax

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Contains Zeaxanthin

Seals/Symbols

100% Quality assurance Laboratory tested

General Statements

Supports Eye Health

IMPORTANT FACTS YOU SHOULD KNOW Lutein plays a role in the maintenance of eye health and is the principal Carotenoid found in the central area of the retina called the macula.* Carotenoids are fat-soluble antioxidants found in fruits, vegetables, marigolds and other plants.

Quality Guaranteed Lab Tested Laboratory tested to meet strict quality control standards for potency, purity and disintegration. 100% Quality Guaranteed.

ACTUAL SIZE

FDA Statement of Identity

Dietary Supplement

Formulation

No yeast, wheat, gluten, milk or milk derivatives, lactose, sugar, preservatives, soy, artificial color, artificial flavor, sodium.

Suggested/Recommended/Usage/Directions

DIRECTIONS: FOR ADULTS, TAKE ONE (1) SOFTGEL DAILY, PREFERABLY WITH A MEAL.

Precautions

WARNING: If you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use.

Avoid this product if you are allergic to daisy-like flowers.

Discontinue use and consult your doctor if any adverse reactions occur.

KEEP OUT OF REACH OF CHILDREN.

TAMPER RESISTANT: DO NOT USE IF SEAL UNDER CAP IS BROKEN OR MISSING.

Storage

STORE AT ROOM TEMPERATURE AND AVOID EXCESSIVE HEAT.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General

Prod. No. 4901 00B B51815

Brand IP Statement(s)

2016

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Lutein 20 mg by Sundown Naturalist label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Lutein 20 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Lutein 20 mg by Sundown Naturalist

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Amounts shown are per serving.

Lutein

No known
interactions
20 mg per serving

Lutein is a plant-based antioxidant pigment that concentrates in the eye, and the best evidence suggests it (often combined with zeaxanthin) may help...

Lutein monograph & interactions

Other (inactive) ingredients: Safflower Oil, Gelatin, Glycerin, Yellow Beeswax. These complete the product’s ingredient list but are not active constituents.

Interaction report

Lutein 20 mg by Sundown Naturalist Drug Interactions

Want to check YOUR meds against Lutein 20 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

Individual Drug Interactions

The ingredients in Lutein 20 mg interact with 86 drugs. Click any drug to see the details.

0 of the 1 ingredient in Lutein 20 mg interact with drugs. Each result below shows which ingredient is responsible.

Each ingredient & the kinds of drugs it affects

For each ingredient in Lutein 20 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

The maker

Brand information

Manufacturer and brand details for Lutein 20 mg, from the product label.

Sundown Naturalist

See all Sundown Naturalist products
Name
Rexall Sundown, Inc.
City
Boca Raton
State
FL
ZipCode
33487
Phone Number
1-888-848-2435
Pharmacist Counseling Corner

Lutein 20 mg by Sundown Naturalist: Common Questions

Does Lutein 20 mg by Sundown Naturalist interact with any medications?
Yes. Based on its ingredients, Lutein 20 mg has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Lutein 20 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is zeaxanthin, and why is it in a lutein product?
Zeaxanthin is a plant pigment (carotenoid) that works alongside lutein in the eye and body as an antioxidant. Both are naturally found together in foods like leafy greens, so supplement makers often combine them or include zeaxanthin in lutein products because they work similarly.
Will this help my vision or prevent macular degeneration?
Zeaxanthin is possibly effective for age-related macular degeneration (AMD). That's a solid lead, but it's not a guarantee — the evidence supports its use but isn't ironclad. Talk with your eye doctor about whether it fits your eye health plan.
Is zeaxanthin safe if I'm pregnant or breastfeeding?
The data says zeaxanthin itself is likely safe in pregnancy. However, concentrated supplement safety during pregnancy and breastfeeding hasn't been well studied — eating zeaxanthin in food is fine, but before taking the supplement form, check with your doctor or pharmacist for personalized advice.
Can I take this if I have diabetes?
Zeaxanthin may theoretically raise the risk of low blood sugar when combined with diabetes medications. This doesn't mean you can't take it, but you'll need to clear it with your doctor or pharmacist first so they can watch your blood sugar and adjust your medication if needed.
What are the side effects?
Zeaxanthin is generally well tolerated at typical doses, and no adverse effects are listed in our data. That doesn't mean none exist, but most people don't report problems with it.
Does this product have fillers or other inactive ingredients?
Yes — the softgel contains safflower oil, gelatin, glycerin, and yellow beeswax as inactive ingredients to hold and preserve the zeaxanthin.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Lutein 20 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Lutein 20 mg label
Go deeper

The Full Monographs Behind Lutein 20 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lutein

Lutein is a plant-based antioxidant pigment that concentrates in the eye, and the best evidence suggests it (often combined with zeaxanthin) may help slow progression of age-related macular...

Read the full Lutein monograph → Herb & supplement monograph

Zeaxanthin

Interacts with 86 drugs

Zeaxanthin is a carotenoid pigment that, along with lutein, concentrates in the macula of the eye and may help support long-term eye health. The strongest evidence relates to slowing progres...

Read the full Zeaxanthin monograph →
Sources

Sources & How We Checked

Lutein 20 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Zeaxanthin 4 references
  1. Montonen J, Knekt P, Jarvinen R, Reunanen A. Dietary antioxidant intake and risk of type 2 diabetes. Diabetes Care 2004;27:362-6. PubMed
  2. Leermakers ET, Darweesh SK, Baena CP, et al. The effects of lutein on cardiometabolic health across the life course: a systematic review and meta-analysis. Am J Clin Nutr 2016;103(2):481-94. PubMed
  3. Kou L, Du M, Zhang C, Dai Z, Li X, Zhang B. The Hypoglycemic, Hypolipidemic, and Anti-Diabetic Nephritic Activities of Zeaxanthin in Diet-Streptozotocin-Induced Diabetic Sprague Dawley Rats. Appl Biochem Biotechnol 2017;182(3):944-955. PubMed
  4. Xu X, Zhao X, Berde Y, Low YL, Kuchan MJ. Milk and Plasma Lutein and Zeaxanthin Concentrations in Chinese Breast-Feeding Mother-Infant Dyads With Healthy Maternal Fruit and Vegetable Intake. J Am Coll Nutr 2019;38(2):179-184. PubMed

See these in context on the Zeaxanthin monograph →

Lutein 2 references
  1. Brown L, Rimm EB, Seddon JM, et al. A prospective study of carotenoid intake and risk of cataract extraction in US men. Am J Clin Nutr 1999;70:517-24. PubMed
  2. Chasan-Taber L, Willett WC, Seddon JM, et al. A prospective study of carotenoid and vitamin A intakes and risk of cataract extraction in US women. Am J Clin Nutr 1999;70:509-16. PubMed

See these in context on the Lutein monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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