Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Lutein 20 mg with Zeaxanthin Ingredients & Drug Interactions

by Herbal Secrets

Lutein 20 mg with Zeaxanthin label
See full label image
Softgel Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Lutein 20 mg with Zeaxanthin against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Lutein 20 mg with Zeaxanthin is a dietary supplement by Herbal Secrets with 2 active ingredients. Its ingredients are commonly taken for eye health, age-related macular degeneration, cataract prevention.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Zeaxanthin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Lutein 20 mg with Zeaxanthin by Herbal Secrets

Ask about any prescription or over-the-counter medication and we check it for interactions with Lutein 20 mg with Zeaxanthin by Herbal Secrets — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Lutein 20 mg with Zeaxanthin by Herbal Secrets

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 20, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This softgel contains two active ingredients: lutein 20 mg and zeaxanthin. Both are carotenoids—natural plant pigments found in leafy greens and other produce—that concentrate in the eye, particularly the macula (the part of the retina responsible for sharp central vision).

The product also contains inactive ingredients: beeswax, lecithin, and soybean oil, which help form and deliver the softgel capsule.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: eye health and macular protection.
  • We looked for evidence on: Age-related macular degeneration (AMD), Asthenopia (eye strain), Cataracts, Central serous retinopathy, Choroideremia, Diabetic retinopathy — and 4 related terms.
  • The strongest evidence on file: Lutein is rated "Possibly Effective" for Age-related macular degeneration (AMD) (Natural Medicines).
  • Also on file: Lutein is rated "Possibly Effective" for Cataracts.
  • Also on file: Zeaxanthin is rated "Possibly Effective" for Age-related macular degeneration (AMD).

Lutein is possibly effective for age-related macular degeneration (AMD) and cataracts, though the evidence isn't yet definitive. Zeaxanthin is also possibly effective for AMD.

For other conditions—retinitis pigmentosa, retinopathy of prematurity, bronchopulmonary dysplasia, and several others—the evidence does not support use, or there isn't enough reliable data to say either way. If you're interested in this supplement for a specific eye or brain condition, it's worth discussing with your eye doctor or pharmacist what the current evidence suggests for your situation.

The evidence, ingredient by ingredient Lutein Zeaxanthin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lutein at doses up to 20 mg daily is generally well tolerated, with no adverse effects reported at typical supplement levels. Zeaxanthin is also generally well tolerated at typical doses.

Both ingredients are rated Likely Safe in pregnancy and lactation. That said, most of the safety data comes from food sources; the long-term safety of higher concentrated supplement doses during pregnancy and breastfeeding hasn't been extensively studied.

If you're pregnant, nursing, or planning to become pregnant, talk with your doctor or pharmacist about whether this supplement is right for you.

Side effects, ingredient by ingredient Lutein Zeaxanthin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Zeaxanthin.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antidiabetes drugs (insulin, metformin, sulfonylureas, or others), double-check this product with your pharmacist or doctor first—zeaxanthin may theoretically increase the risk of low blood sugar. For the ingredients we checked, no other medication interactions are documented in our data.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This is a straightforward two-ingredient eye health supplement for anyone interested in lutein and zeaxanthin. The main caution is if you take antidiabetes medication—check your specific drugs before starting.

Both ingredients are generally well tolerated, though pregnancy and breastfeeding safety data on supplements (rather than food sources) is limited. Have a conversation with your doctor or pharmacist about whether it fits your health needs.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 27, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Lutein 20 mg with Zeaxanthin, straight from the product label.

Brand Herbal Secrets
Barcode (UPC) 810180027106
Net contents 240 Softgel(s)
Market status On market
Date entered into DSLD Jul 27, 2021
DSLD ID 251389
Product type Non-nutrient/non-botanical
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Lutein 20 mg with Zeaxanthin by Herbal Secrets, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
Servings per container
240
UPC/BARCODE
810180027106
IngredientAmount% DV
Lutein20 mg--
Zeaxanthin1 mg--

Other ingredients: Beeswax, Lecithin, Soybean Oil

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Herbal Secrets Lutein with Zeaxanthin is made from marigold petal extract. Lutein and Zeaxanthin are antioxidant carotenoids that occur naturally in the body. They play a key role in maintaining eye health. Lutein with Zeaxanthin is concentrated within the macula (a part of the retina that controls central vision). Lutein with Zeaxanthin may help protect the eyes from photons coming from light and from oxidative stress. Lutein with Zeaxanthin may also support heart health and overall well-being.

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, adults take one (1) softgel daily, preferably with a meal or as directed by a health care professional.

Precautions

Warning: If you are pregnant, nursing, taking any medication(s) or have any medical condition, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Keep out of reach of children.

Do not use if safety seal is damaged or missing.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formulation

100% natural

Supports visual function Promotes macular health Supports heart health & overall well-being

Contains no: Artificial color, flavor or sweetener, preservatives, sugar, starch, milk, lactose, gluten, wheat, yeast, fish or sodium.

Seals/Symbols

Made in the USA GMP - Good Manufacturing Practice - Quality Product

FDA Statement of Identity

Natural Dietary Supplement

Storage

Store in a cool, dry place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Lutein 20 mg with Zeaxanthin by Herbal Secrets label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Lutein 20 mg with Zeaxanthin label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Lutein 20 mg with Zeaxanthin by Herbal Secrets

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container240 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Lutein

No known
interactions
20 mg per serving Form: Marigold petal extract

Lutein is a plant-based antioxidant pigment that concentrates in the eye, and the best evidence suggests it (often combined with zeaxanthin) may help...

Lutein monograph & interactions

Zeaxanthin

Interacts with
86 drugs
1 mg per serving Form: Marigold petal extract

Zeaxanthin is a carotenoid pigment that, along with lutein, concentrates in the macula of the eye and may help support long-term eye health. The stron...

Zeaxanthin monograph & interactions

Other (inactive) ingredients: Beeswax, Lecithin, Soybean Oil. These complete the product’s ingredient list but are not active constituents.

Interaction report

Lutein 20 mg with Zeaxanthin by Herbal Secrets Drug Interactions

Want to check YOUR meds against Lutein 20 mg with Zeaxanthin?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

Zeaxanthin 86

Individual Drug Interactions

The ingredients in Lutein 20 mg with Zeaxanthin interact with 86 drugs. Click any drug to see the details.

1 of the 2 ingredients in Lutein 20 mg with Zeaxanthin interact with drugs. Each result below shows which ingredient is responsible. Zeaxanthin

Each ingredient & the kinds of drugs it affects

For each ingredient in Lutein 20 mg with Zeaxanthin with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Zeaxanthin1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking zeaxanthin with antidiabetes drugs might increase the risk of hypoglycemia.
In an animal diabetic model, zeaxanthin has hypoglycemic effects. However, population research has found that increasing intake of dietary zeaxanthin plus lutein does not decrease the risk of developing type 2 diabetes.

Likelihood Possible Evidence D
Zeaxanthin full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Lutein 20 mg with Zeaxanthin, from the product label.

Herbal Secrets

See all Herbal Secrets products
Name
Herbal Secrets
Street Address
629 Grove Street
City
Jersey City
State
NJ
ZipCode
07310
Web Address
amazingnutrition.com
Pharmacist Counseling Corner

Lutein 20 mg with Zeaxanthin by Herbal Secrets: Common Questions

Does Lutein 20 mg with Zeaxanthin by Herbal Secrets interact with any medications?
Yes. Based on its ingredients, Lutein 20 mg with Zeaxanthin has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Lutein 20 mg with Zeaxanthin contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to take while pregnant or breastfeeding?
Both lutein and zeaxanthin are rated Likely Safe in pregnancy and lactation. However, most safety information comes from eating these nutrients in food, not from concentrated supplements at higher doses. The science on supplement safety during pregnancy and breastfeeding isn't as complete as we'd like, so talk with your doctor or pharmacist for personalized advice.
Can I take this for cataracts?
Lutein is possibly effective for cataracts based on current evidence, but that doesn't mean it will prevent or reverse them in every person. If you have cataracts, discuss this supplement with your eye doctor—they can tell you whether adding it makes sense for your situation.
I take diabetes medication. Can I use this?
There's a documented interaction to be aware of: zeaxanthin may theoretically increase the risk of low blood sugar when combined with antidiabetes drugs. Before starting this supplement, check with your doctor or pharmacist about your specific medications and whether it's safe for you.
Does this contain soy?
Yes, the softgel capsule contains soybean oil as an inactive ingredient. If you have a soy allergy, you'll want to skip this product or confirm with your pharmacist that you can tolerate it.
What's the difference between lutein and zeaxanthin?
Both are carotenoids that protect the eye, particularly the macula. Zeaxanthin is thought to filter harmful blue light, while lutein acts as an antioxidant. They work together in the retina and are often found together in supplements and foods.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Lutein 20 mg with Zeaxanthin is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Lutein 20 mg with Zeaxanthin label
Go deeper

The Full Monographs Behind Lutein 20 mg with Zeaxanthin’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lutein

Lutein is a plant-based antioxidant pigment that concentrates in the eye, and the best evidence suggests it (often combined with zeaxanthin) may help slow progression of age-related macular...

Read the full Lutein monograph → Herb & supplement monograph

Zeaxanthin

Interacts with 86 drugs

Zeaxanthin is a carotenoid pigment that, along with lutein, concentrates in the macula of the eye and may help support long-term eye health. The strongest evidence relates to slowing progres...

Read the full Zeaxanthin monograph →
Sources

Sources & How We Checked

Lutein 20 mg with Zeaxanthin's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lutein 2 references
  1. Brown L, Rimm EB, Seddon JM, et al. A prospective study of carotenoid intake and risk of cataract extraction in US men. Am J Clin Nutr 1999;70:517-24. PubMed
  2. Chasan-Taber L, Willett WC, Seddon JM, et al. A prospective study of carotenoid and vitamin A intakes and risk of cataract extraction in US women. Am J Clin Nutr 1999;70:509-16. PubMed

See these in context on the Lutein monograph →

Zeaxanthin 4 references
  1. Montonen J, Knekt P, Jarvinen R, Reunanen A. Dietary antioxidant intake and risk of type 2 diabetes. Diabetes Care 2004;27:362-6. PubMed
  2. Leermakers ET, Darweesh SK, Baena CP, et al. The effects of lutein on cardiometabolic health across the life course: a systematic review and meta-analysis. Am J Clin Nutr 2016;103(2):481-94. PubMed
  3. Kou L, Du M, Zhang C, Dai Z, Li X, Zhang B. The Hypoglycemic, Hypolipidemic, and Anti-Diabetic Nephritic Activities of Zeaxanthin in Diet-Streptozotocin-Induced Diabetic Sprague Dawley Rats. Appl Biochem Biotechnol 2017;182(3):944-955. PubMed
  4. Xu X, Zhao X, Berde Y, Low YL, Kuchan MJ. Milk and Plasma Lutein and Zeaxanthin Concentrations in Chinese Breast-Feeding Mother-Infant Dyads With Healthy Maternal Fruit and Vegetable Intake. J Am Coll Nutr 2019;38(2):179-184. PubMed

See these in context on the Zeaxanthin monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team