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Dietary supplement

Lutein 40 mg plus Zeaxanthin Ingredients & Drug Interactions

by Nature's Truth

Lutein 40 mg plus Zeaxanthin label
See full label image
Softgel Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Lutein 40 mg plus Zeaxanthin against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Lutein 40 mg plus Zeaxanthin is a dietary supplement by Nature's Truth with 2 active ingredients. Its ingredients are commonly taken for eye health, age-related macular degeneration, cataract prevention.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Zeaxanthin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Lutein 40 mg plus Zeaxanthin by Nature's Truth

Ask about any prescription or over-the-counter medication and we check it for interactions with Lutein 40 mg plus Zeaxanthin by Nature's Truth — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Lutein 40 mg plus Zeaxanthin by Nature's Truth

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains two active carotenoids (plant pigments) that concentrate in your eye: lutein and zeaxanthin. These are the same compounds you'd get from leafy greens and other foods, though in a more concentrated supplement form.

The softgel capsule also contains several inactive ingredients—gelatin, sunflower oil, glycerin, beeswax, calcium carbonate, and iron oxide—to deliver and stabilize the active compounds.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: eye health and macular support.
  • We looked for evidence on: Age-related macular degeneration (AMD), Asthenopia (eye strain), Cataracts, Central serous retinopathy, Choroideremia, Diabetic retinopathy — and 4 related terms.
  • The strongest evidence on file: Lutein is rated "Possibly Effective" for Age-related macular degeneration (AMD) (Natural Medicines).
  • Also on file: Lutein is rated "Possibly Effective" for Cataracts.
  • Also on file: Zeaxanthin is rated "Possibly Effective" for Age-related macular degeneration (AMD).

Lutein is possibly effective for age-related macular degeneration (AMD) and cataracts. Zeaxanthin is also possibly effective for AMD.

For other conditions listed in the data—retinitis pigmentosa, retinopathy of prematurity, bronchopulmonary dysplasia, and various others—the evidence either points to likely ineffective or is too weak to rate. If you're considering this for eye health, talk with your eye doctor about whether it makes sense for your situation.

The evidence, ingredient by ingredient Lutein Zeaxanthin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Both lutein and zeaxanthin are generally well tolerated at typical supplement doses. Lutein has been studied at doses up to 20 mg daily without adverse effects reported.

The safety notes flag that while these compounds are naturally present in food and breast milk, the safety of higher concentrated supplement doses hasn't been extensively studied, so talk with your doctor or pharmacist before taking it if you're pregnant or breastfeeding. Both ingredients carry a pregnancy/lactation rating of likely safe, though caution with supplements is advised.

Side effects, ingredient by ingredient Lutein Zeaxanthin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Zeaxanthin.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Antidiabetes drugs are the one medication type with a documented interaction. Zeaxanthin may theoretically increase the risk of low blood sugar if you're on diabetes medication.

Check your exact prescriptions with the tool on this page before starting.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

If you're looking to support eye health and have AMD or are concerned about cataracts, this combination is possibly effective—and the evidence supports it more than it does for other conditions. If you take antidiabetes medications, check with your pharmacist first.

Pregnant or breastfeeding? Talk with your doctor before starting, since long-term safety data on these concentrated doses is limited.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Lutein 40 mg plus Zeaxanthin, straight from the product label.

Brand Nature's Truth
Barcode (UPC) 840093109149
Net contents 30 Quick Release Softgel(s)
Market status On market
Date entered into DSLD Sep 25, 2025
DSLD ID 339758
Product type Non-nutrient/non-botanical
Supplement form Softgel Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Lutein 40 mg plus Zeaxanthin by Nature's Truth, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Quick Release Softgel(s)
Maximum serving Sizes:
1 Quick Release Softgel(s)
Servings per container
30
UPC/BARCODE
840093109149
IngredientAmount% DV
Lutein40 mg--
Zeaxanthin2 mg--

Other ingredients: Gelatin, Sunflower Oil, Glycerin, yellow Beeswax, Calcium Carbonate, Red Iron Oxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: For adults, take one (1) quick release softgel daily, preferably with a meal.

Precautions

Warning: If you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use.

Avoid this product if you are allergic to daisy-like flowers.

If any adverse reactions occur, immediately stop using this product and consult your doctor. If seal under cap is damaged or missing, do not use.

Keep out of reach of children.

Storage

Store in a cool, dry place.

Formulation

No gluten, wheat, yeast, milk, lactose, soy, artificial flavor, artificial sweetener, preservatives. Non-GMO

Gluten free Non GMO

Synergistic formula

Brand IP Statement(s)

Copyright 2023 Nature's Truth LLC

Seals/Symbols

Our Non-GMO Pledge Visit our website

100% Quality Satisfaction Guarantee

General Statements

Vitamins

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Lutein 40 mg plus Zeaxanthin by Nature's Truth label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Lutein 40 mg plus Zeaxanthin label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Lutein 40 mg plus Zeaxanthin by Nature's Truth

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Quick Release Softgel(s) Dosage formSoftgel Capsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Lutein

No known
interactions
40 mg per serving Form: Marigold Petal Extract

Lutein is a plant-based antioxidant pigment that concentrates in the eye, and the best evidence suggests it (often combined with zeaxanthin) may help...

Lutein monograph & interactions

Zeaxanthin

Interacts with
86 drugs
2 mg per serving Form: Marigold Petal Extract

Zeaxanthin is a carotenoid pigment that, along with lutein, concentrates in the macula of the eye and may help support long-term eye health. The stron...

Zeaxanthin monograph & interactions

Other (inactive) ingredients: Gelatin, Sunflower Oil, Glycerin, Yellow Beeswax, Calcium Carbonate, Red Iron Oxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Lutein 40 mg plus Zeaxanthin by Nature's Truth Drug Interactions

Want to check YOUR meds against Lutein 40 mg plus Zeaxanthin?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

Zeaxanthin 86

Individual Drug Interactions

The ingredients in Lutein 40 mg plus Zeaxanthin interact with 86 drugs. Click any drug to see the details.

1 of the 2 ingredients in Lutein 40 mg plus Zeaxanthin interact with drugs. Each result below shows which ingredient is responsible. Zeaxanthin

Each ingredient & the kinds of drugs it affects

For each ingredient in Lutein 40 mg plus Zeaxanthin with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Zeaxanthin1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking zeaxanthin with antidiabetes drugs might increase the risk of hypoglycemia.
In an animal diabetic model, zeaxanthin has hypoglycemic effects. However, population research has found that increasing intake of dietary zeaxanthin plus lutein does not decrease the risk of developing type 2 diabetes.

Likelihood Possible Evidence D
Zeaxanthin full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Lutein 40 mg plus Zeaxanthin, from the product label.

Nature's Truth

See all Nature's Truth products
Name
Nature's Truth LLC
City
Bohemia
State
NY
ZipCode
11716
Phone Number
1-844-544-1030
Web Address
NaturesTruth.com
Pharmacist Counseling Corner

Lutein 40 mg plus Zeaxanthin by Nature's Truth: Common Questions

Does Lutein 40 mg plus Zeaxanthin by Nature's Truth interact with any medications?
Yes. Based on its ingredients, Lutein 40 mg plus Zeaxanthin has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Lutein 40 mg plus Zeaxanthin contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to take if I'm pregnant or breastfeeding?
Both lutein and zeaxanthin carry a pregnancy/lactation rating of likely safe. However, the safety data on concentrated supplements (rather than food sources) hasn't been fully studied, so talk with your doctor or pharmacist to decide what's right for you individually.
What are lutein and zeaxanthin, and why are they in one supplement?
They're plant pigments (carotenoids) that naturally concentrate in your eyes and help protect the macula—the part of your retina that lets you see fine detail. They work together in the eye, which is why they're often paired in supplements for eye health.
Does this product work for cataracts?
Lutein is possibly effective for cataracts based on current evidence, and zeaxanthin is possibly effective for age-related macular degeneration. If you have cataracts, talk with your eye doctor about whether this supplement makes sense as part of your care plan.
Can I take this if I'm on diabetes medication?
Zeaxanthin may theoretically increase the risk of low blood sugar if you take antidiabetes drugs. Check with your pharmacist before starting, especially if you're on insulin or other blood-sugar-lowering medications.
What are the side effects?
Lutein at typical supplement doses is generally well tolerated with no adverse effects reported in studies up to 20 mg daily. Zeaxanthin is also generally well tolerated at typical amounts, with no adverse effects documented in our data.
Does this product have a lot of fillers?
The inactive ingredients are gelatin (the capsule material), sunflower oil, glycerin, beeswax, calcium carbonate, and iron oxide. These are standard excipients that help deliver and stabilize the lutein and zeaxanthin.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Lutein 40 mg plus Zeaxanthin is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Lutein 40 mg plus Zeaxanthin label
Go deeper

The Full Monographs Behind Lutein 40 mg plus Zeaxanthin’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lutein

Lutein is a plant-based antioxidant pigment that concentrates in the eye, and the best evidence suggests it (often combined with zeaxanthin) may help slow progression of age-related macular...

Read the full Lutein monograph → Herb & supplement monograph

Zeaxanthin

Interacts with 86 drugs

Zeaxanthin is a carotenoid pigment that, along with lutein, concentrates in the macula of the eye and may help support long-term eye health. The strongest evidence relates to slowing progres...

Read the full Zeaxanthin monograph →
Sources

Sources & How We Checked

Lutein 40 mg plus Zeaxanthin's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lutein 2 references
  1. Brown L, Rimm EB, Seddon JM, et al. A prospective study of carotenoid intake and risk of cataract extraction in US men. Am J Clin Nutr 1999;70:517-24. PubMed
  2. Chasan-Taber L, Willett WC, Seddon JM, et al. A prospective study of carotenoid and vitamin A intakes and risk of cataract extraction in US women. Am J Clin Nutr 1999;70:509-16. PubMed

See these in context on the Lutein monograph →

Zeaxanthin 4 references
  1. Montonen J, Knekt P, Jarvinen R, Reunanen A. Dietary antioxidant intake and risk of type 2 diabetes. Diabetes Care 2004;27:362-6. PubMed
  2. Leermakers ET, Darweesh SK, Baena CP, et al. The effects of lutein on cardiometabolic health across the life course: a systematic review and meta-analysis. Am J Clin Nutr 2016;103(2):481-94. PubMed
  3. Kou L, Du M, Zhang C, Dai Z, Li X, Zhang B. The Hypoglycemic, Hypolipidemic, and Anti-Diabetic Nephritic Activities of Zeaxanthin in Diet-Streptozotocin-Induced Diabetic Sprague Dawley Rats. Appl Biochem Biotechnol 2017;182(3):944-955. PubMed
  4. Xu X, Zhao X, Berde Y, Low YL, Kuchan MJ. Milk and Plasma Lutein and Zeaxanthin Concentrations in Chinese Breast-Feeding Mother-Infant Dyads With Healthy Maternal Fruit and Vegetable Intake. J Am Coll Nutr 2019;38(2):179-184. PubMed

See these in context on the Zeaxanthin monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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