Magnesium Glycinate 665 mg Ingredients & Drug Interactions
by Meijer
What is this page for?
First and foremost: checking Magnesium Glycinate 665 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Magnesium Glycinate 665 mg is a dietary supplement by Meijer with 1 active ingredient. Its ingredients are commonly taken for preventing or treating magnesium deficiency, constipation, muscle cramps.Based on those ingredients, 295 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Magnesium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Magnesium Glycinate 665 mg by Meijer
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HelloPharmacist Scorecard of Magnesium Glycinate 665 mg by Meijer
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
This supplement contains 3 active ingredients, all forms of magnesium: magnesium oxide, magnesium bisglycinate chelate, and magnesium bisglycinate chelate buffered. Together they deliver magnesium, a mineral your body uses for muscle and nerve function, bone strength, and energy production.
The capsule also contains inactive ingredients — gelatin, rice powder, vegetable magnesium stearate, and silica — which help hold the supplement together and make it easier to swallow.
Does it work?
Moderate evidence
Magnesium in this form is shown to be effective for indigestion (dyspepsia), constipation, low magnesium levels (hypomagnesemia), and pre-eclampsia in pregnancy. The evidence supports its use for these specific purposes when taken at appropriate doses.
How safe is it?
Well-documented data
Magnesium is generally well tolerated in healthy adults at recommended doses. The most common side effects from oral magnesium are diarrhea, stomach irritation, nausea, and vomiting.
In pregnancy, magnesium is needed by your body, but supplements should only be used under your doctor's guidance. If you're breastfeeding, normal dietary amounts are fine, but check with your doctor before taking a supplement.
In rare cases, very high doses taken long-term may affect bone density, and there's a rare risk of a bezoar — an indigestible mass — forming in the stomach, though this occurred in a patient taking 1,500 mg daily with advanced cancer.
Meds to double-check
Major interaction found
Before taking this product, check with your doctor or pharmacist if you take levodopa/carbidopa (Sinemet) for Parkinson's disease — it's a Major interaction that can cut the drug's effectiveness. Also double-check if you use skeletal muscle relaxants, potassium-sparing diuretics, calcium channel blockers, stomach acid reducers, diabetes medications (sulfonylureas), quinolone antibiotics, or bisphosphonates — magnesium can alter how all of these work.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.
Magnesium glycinate works well for indigestion, constipation, and low magnesium levels, and the mineral itself is well tolerated by most people. But if you take levodopa/carbidopa for Parkinson's, skeletal muscle relaxants, diabetes medications, bone-health drugs, antibiotics, or blood-pressure medications, you'll want to review your specific prescriptions with your doctor or pharmacist before starting.
Talk it over with your own healthcare provider to make sure this supplement fits your situation.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2022.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Magnesium Glycinate 665 mg, straight from the product label.
| Brand | Meijer |
|---|---|
| Barcode (UPC) | 708820272194 |
| Net contents | 60 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Aug 23, 2022 |
| DSLD ID | 271900 |
| Product type | Mineral |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Magnesium Glycinate 665 mg by Meijer, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Magnesium | 120 mg | 29% |
| Magnesium Oxide | 0 NP | -- |
| Magnesium Bisglycinate Chelate | 0 NP | -- |
| Magnesium Bisglycinate Chelate buffered | 665 mg | -- |
Other ingredients: Gelatin Capsule, Rice powder, Vegetable Magnesium Stearate, Silica
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
Buffered
Bone health
Superior absorption
No yeast, wheat, soy, dairy, artificial colors, artificial flavors, preservatives, gluten, artificial sweetener, fish, lactose.
GF Gluten free
FDA Statement of Identity
Dietary Supplement
FDA Disclaimer Statement
This statements has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Brand IP Statement(s)
TRAACS is a registered trademark of Albion Laboratories, Inc.
Precautions
Caution: If you are pregnant, nursing a baby or considering becoming pregnant, ask a doctor before using this product. If you take a prescription medication or have any medical condition, consult a physician before using this product.
If any adverse reactions occur, immediately stop using this product and consult your doctor. If seal under cap is damaged or missing, do not use.
Keep out of reach of children.
Storage
Store at room temperature (59 degrees F - 86 degrees F) (15 degrees C - 30 degrees C).
General Statements
Our quality guarantee www.meijer.com/satisfaction
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Magnesium Glycinate 665 mg by Meijer label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Magnesium Glycinate 665 mg by Meijer
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container20 Amounts shown are per serving.
Magnesium
Interacts with295 drugs
Magnesium is an essential mineral your body needs for muscles, nerves, blood pressure, and many other functions, and supplements are useful for preven...
Magnesium monograph & interactionsOther (inactive) ingredients: Gelatin Capsule, Rice powder, Vegetable Magnesium Stearate, Silica. These complete the product’s ingredient list but are not active constituents.
Magnesium Glycinate 665 mg by Meijer Drug Interactions
HelloPharmacist Interaction Report
Meijer's Magnesium Glycinate 665 mg interacts with several medication types through its magnesium oxide and magnesium bisglycinate chelate content.
The most serious interaction is with levodopa/carbidopa (Sinemet), a medication for Parkinson's disease — magnesium can cut the drug's effectiveness by reducing how much of it your body absorbs, with research showing a 35% drop in levodopa levels and an 81% drop in carbidopa levels.
Read the full breakdown — every affected drug type, severity by severity
Magnesium also has Moderate interactions with skeletal muscle relaxants (it can strengthen their effects and speed up how quickly they work), potassium-sparing diuretics (which may raise your magnesium levels), calcium channel blockers used for blood pressure and heart conditions (additive blood-pressure-lowering effects are possible), and stomach acid reducers like H2 blockers and proton pump inhibitors (which may require a higher magnesium dose for a laxative effect).
Additionally, magnesium decreases how well your body absorbs quinolone antibiotics and bisphosphonates (bone-health drugs) — you'd need to space magnesium and these medications several hours apart. It also increases absorption of sulfonylureas (diabetes medications), raising the risk of low blood sugar (hypoglycemia).
Altogether, these interactions span 295 individual medications. Use the medication checker on this page to look up your exact prescriptions before starting this supplement.
Check your own medications below · Editorial policy · How we use AI
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Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Magnesium Glycinate 665 mg interact with 295 drugs. Click any drug to see the details.
1 of the 1 ingredient in Magnesium Glycinate 665 mg interact with drugs. Each result below shows which ingredient is responsible. Magnesium
Benserazide, LevodopaMadopar, Prolopa
How Benserazide, Levodopa interacts with Magnesium Glycinate 665 mg — through 1 ingredient. Tap an ingredient for the detail:
Magnesium Bisglycinate Chelate BufferedLevodopa/carbidopa (sinemet) Major
Interaction Summary
Magnesium can reduce the bioavailability of levodopa/carbidopa.
Read the full Magnesium Bisglycinate Chelate Buffered + Benserazide, Levodopa interactionCarbidopaLodosyn
How Carbidopa interacts with Magnesium Glycinate 665 mg — through 1 ingredient. Tap an ingredient for the detail:
Magnesium Bisglycinate Chelate BufferedLevodopa/carbidopa (sinemet) Major
Interaction Summary
Magnesium can reduce the bioavailability of levodopa/carbidopa.
Read the full Magnesium Bisglycinate Chelate Buffered + Carbidopa interactionCarbidopa, LevodopaDhivy, Rytary, Sinemet, Sinemet CR
How Carbidopa, Levodopa interacts with Magnesium Glycinate 665 mg — through 1 ingredient. Tap an ingredient for the detail:
Magnesium Bisglycinate Chelate BufferedLevodopa/carbidopa (sinemet) Major
Interaction Summary
Magnesium can reduce the bioavailability of levodopa/carbidopa.
Read the full Magnesium Bisglycinate Chelate Buffered + Carbidopa, Levodopa interactionCarbidopa, Levodopa, EntacaponeStalevo
How Carbidopa, Levodopa, Entacapone interacts with Magnesium Glycinate 665 mg — through 1 ingredient. Tap an ingredient for the detail:
Magnesium Bisglycinate Chelate BufferedLevodopa/carbidopa (sinemet) Major
Interaction Summary
Magnesium can reduce the bioavailability of levodopa/carbidopa.
Read the full Magnesium Bisglycinate Chelate Buffered + Carbidopa, Levodopa, Entacapone interactionLevodopaInbrija, Larodopa
How Levodopa interacts with Magnesium Glycinate 665 mg — through 1 ingredient. Tap an ingredient for the detail:
Magnesium Bisglycinate Chelate BufferedLevodopa/carbidopa (sinemet) Major
Interaction Summary
Magnesium can reduce the bioavailability of levodopa/carbidopa.
Read the full Magnesium Bisglycinate Chelate Buffered + Levodopa interactionLevodopa, CarbidopaDuodopa
How Levodopa, Carbidopa interacts with Magnesium Glycinate 665 mg — through 1 ingredient. Tap an ingredient for the detail:
Magnesium Bisglycinate Chelate BufferedLevodopa/carbidopa (sinemet) Major
Interaction Summary
Magnesium can reduce the bioavailability of levodopa/carbidopa.
Read the full Magnesium Bisglycinate Chelate Buffered + Levodopa, Carbidopa interactionAcetaminophen, ChlorzoxazoneAcetazone Forte, Extra Strength Tylenol Aches & Strains, Parafon Forte
How Acetaminophen, Chlorzoxazone interacts with Magnesium Glycinate 665 mg — through 1 ingredient. Tap an ingredient for the detail:
Magnesium Bisglycinate Chelate BufferedSkeletal Muscle Relaxants Moderate
Interaction Summary
Parenteral magnesium alters the pharmacokinetics of skeletal muscle relaxants, increasing their effects and accelerating the onset of effect.
Read the full Magnesium Bisglycinate Chelate Buffered + Acetaminophen, Chlorzoxazone interactionAcetaminophen, Chlorzoxazone, CodeineAcetazone Forte C8, Parafon Forte C8
How Acetaminophen, Chlorzoxazone, Codeine interacts with Magnesium Glycinate 665 mg — through 1 ingredient. Tap an ingredient for the detail:
Magnesium Bisglycinate Chelate BufferedSkeletal Muscle Relaxants Moderate
Interaction Summary
Parenteral magnesium alters the pharmacokinetics of skeletal muscle relaxants, increasing their effects and accelerating the onset of effect.
Read the full Magnesium Bisglycinate Chelate Buffered + Acetaminophen, Chlorzoxazone, Codeine interactionAcetaminophen, Codeine, MethocarbamolAcetaminophen, Codeine, Methocarbamol, Robaxacet 8
How Acetaminophen, Codeine, Methocarbamol interacts with Magnesium Glycinate 665 mg — through 1 ingredient. Tap an ingredient for the detail:
Magnesium Bisglycinate Chelate BufferedSkeletal Muscle Relaxants Moderate
Interaction Summary
Parenteral magnesium alters the pharmacokinetics of skeletal muscle relaxants, increasing their effects and accelerating the onset of effect.
Read the full Magnesium Bisglycinate Chelate Buffered + Acetaminophen, Codeine, Methocarbamol interactionAcetaminophen, MethocarbamolRobaxacet
How Acetaminophen, Methocarbamol interacts with Magnesium Glycinate 665 mg — through 1 ingredient. Tap an ingredient for the detail:
Magnesium Bisglycinate Chelate BufferedSkeletal Muscle Relaxants Moderate
Interaction Summary
Parenteral magnesium alters the pharmacokinetics of skeletal muscle relaxants, increasing their effects and accelerating the onset of effect.
Read the full Magnesium Bisglycinate Chelate Buffered + Acetaminophen, Methocarbamol interactionAcetaminophen, OrphenadrineOrfenagesic
How Acetaminophen, Orphenadrine interacts with Magnesium Glycinate 665 mg — through 1 ingredient. Tap an ingredient for the detail:
Magnesium Bisglycinate Chelate BufferedSkeletal Muscle Relaxants Moderate
Interaction Summary
Parenteral magnesium alters the pharmacokinetics of skeletal muscle relaxants, increasing their effects and accelerating the onset of effect.
Read the full Magnesium Bisglycinate Chelate Buffered + Acetaminophen, Orphenadrine interactionAcetohexamideDymelor
How Acetohexamide interacts with Magnesium Glycinate 665 mg — through 1 ingredient. Tap an ingredient for the detail:
Magnesium Bisglycinate Chelate BufferedSulfonylureas Moderate
Interaction Summary
Magnesium increases the systemic absorption of sulfonylureas, increasing their effects and side effects.
Read the full Magnesium Bisglycinate Chelate Buffered + Acetohexamide interactionAlcuroniumAlcuronium
How Alcuronium interacts with Magnesium Glycinate 665 mg — through 1 ingredient. Tap an ingredient for the detail:
Magnesium Bisglycinate Chelate BufferedSkeletal Muscle Relaxants Moderate
Interaction Summary
Parenteral magnesium alters the pharmacokinetics of skeletal muscle relaxants, increasing their effects and accelerating the onset of effect.
Read the full Magnesium Bisglycinate Chelate Buffered + Alcuronium interactionAlendronateBinosto, Fosamax
How Alendronate interacts with Magnesium Glycinate 665 mg — through 1 ingredient. Tap an ingredient for the detail:
Magnesium Bisglycinate Chelate BufferedBisphosphonates Moderate
Interaction Summary
Magnesium can decrease absorption of bisphosphonates.
Read the full Magnesium Bisglycinate Chelate Buffered + Alendronate interactionAlendronate Sodium
How Alendronate Sodium interacts with Magnesium Glycinate 665 mg — through 1 ingredient. Tap an ingredient for the detail:
Magnesium Bisglycinate Chelate BufferedBisphosphonates Moderate
Interaction Summary
Magnesium can decrease absorption of bisphosphonates.
Read the full Magnesium Bisglycinate Chelate Buffered + Alendronate Sodium interactionAlendronate Sodium, CholecalciferolFosamax Plus D
How Alendronate Sodium, Cholecalciferol interacts with Magnesium Glycinate 665 mg — through 1 ingredient. Tap an ingredient for the detail:
Magnesium Bisglycinate Chelate BufferedBisphosphonates Moderate
Interaction Summary
Magnesium can decrease absorption of bisphosphonates.
Read the full Magnesium Bisglycinate Chelate Buffered + Alendronate Sodium, Cholecalciferol interactionAlginic Acid, Aluminum HydroxideRafton
How Alginic Acid, Aluminum Hydroxide interacts with Magnesium Glycinate 665 mg — through 1 ingredient. Tap an ingredient for the detail:
Magnesium Bisglycinate Chelate BufferedAntacids Moderate
Interaction Summary
Use of acid reducers may reduce the laxative effect of magnesium oxide.
Read the full Magnesium Bisglycinate Chelate Buffered + Alginic Acid, Aluminum Hydroxide interactionAluminum HydroxideAlu-Cap, Amphojel, Gaviscon
How Aluminum Hydroxide interacts with Magnesium Glycinate 665 mg — through 1 ingredient. Tap an ingredient for the detail:
Magnesium Bisglycinate Chelate BufferedAntacids Moderate
Interaction Summary
Use of acid reducers may reduce the laxative effect of magnesium oxide.
Read the full Magnesium Bisglycinate Chelate Buffered + Aluminum Hydroxide interactionAluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #2
How Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interacts with Magnesium Glycinate 665 mg — through 1 ingredient. Tap an ingredient for the detail:
Magnesium Bisglycinate Chelate BufferedAnticoagulant/antiplatelet Drugs, Antacids Moderate
Interaction Summary
Theoretically, magnesium may have antiplatelet effects, but the evidence is conflicting.
Read the full Magnesium Bisglycinate Chelate Buffered + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionAluminum Hydroxide, Aspirin, Magnesium HydroxideAscriptin
How Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interacts with Magnesium Glycinate 665 mg — through 1 ingredient. Tap an ingredient for the detail:
Magnesium Bisglycinate Chelate BufferedAnticoagulant/antiplatelet Drugs, Antacids Moderate
Interaction Summary
Theoretically, magnesium may have antiplatelet effects, but the evidence is conflicting.
Read the full Magnesium Bisglycinate Chelate Buffered + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionAluminum Hydroxide, Magnesium Hydroxide (otc Drug)Maalox, Mucogel
How Aluminum Hydroxide, Magnesium Hydroxide (otc Drug) interacts with Magnesium Glycinate 665 mg — through 1 ingredient. Tap an ingredient for the detail:
Magnesium Bisglycinate Chelate BufferedAntacids Moderate
Interaction Summary
Use of acid reducers may reduce the laxative effect of magnesium oxide.
Read the full Magnesium Bisglycinate Chelate Buffered + Aluminum Hydroxide, Magnesium Hydroxide (otc Drug) interactionAluminum Hydroxide, Magnesium Hydroxide, Simethicone (otc Drug)Mylanta
How Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (otc Drug) interacts with Magnesium Glycinate 665 mg — through 1 ingredient. Tap an ingredient for the detail:
Magnesium Bisglycinate Chelate BufferedAntacids Moderate
Interaction Summary
Use of acid reducers may reduce the laxative effect of magnesium oxide.
Read the full Magnesium Bisglycinate Chelate Buffered + Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (otc Drug) interactionAluminum, Magnesium (otc Drug)Almagel
How Aluminum, Magnesium (otc Drug) interacts with Magnesium Glycinate 665 mg — through 1 ingredient. Tap an ingredient for the detail:
Magnesium Bisglycinate Chelate BufferedAntacids Moderate
Interaction Summary
Use of acid reducers may reduce the laxative effect of magnesium oxide.
Read the full Magnesium Bisglycinate Chelate Buffered + Aluminum, Magnesium (otc Drug) interactionAmikacinAmikin, Arikayce
How Amikacin interacts with Magnesium Glycinate 665 mg — through 1 ingredient. Tap an ingredient for the detail:
Magnesium Bisglycinate Chelate BufferedAminoglycoside Antibiotics Moderate
Interaction Summary
Concomitant use of aminoglycoside antibiotics and magnesium can increase the risk for neuromuscular weakness.
Read the full Magnesium Bisglycinate Chelate Buffered + Amikacin interactionAmilorideAmilamont, Midamor
How Amiloride interacts with Magnesium Glycinate 665 mg — through 1 ingredient. Tap an ingredient for the detail:
Magnesium Bisglycinate Chelate BufferedPotassium-sparing Diuretics Moderate
Interaction Summary
Potassium-sparing diuretics decrease excretion of magnesium, possibly increasing magnesium levels.
Read the full Magnesium Bisglycinate Chelate Buffered + Amiloride interactionAmiloride, HydrochlorothiazideAmil-Co, Amilzide, Moduret 25, Moduretic
How Amiloride, Hydrochlorothiazide interacts with Magnesium Glycinate 665 mg — through 1 ingredient. Tap an ingredient for the detail:
Magnesium Bisglycinate Chelate BufferedPotassium-sparing Diuretics Moderate
Interaction Summary
Potassium-sparing diuretics decrease excretion of magnesium, possibly increasing magnesium levels.
Read the full Magnesium Bisglycinate Chelate Buffered + Amiloride, Hydrochlorothiazide interactionAmlodipineNorliqva
How Amlodipine interacts with Magnesium Glycinate 665 mg — through 1 ingredient. Tap an ingredient for the detail:
Magnesium Bisglycinate Chelate BufferedCalcium Channel Blockers Moderate
Interaction Summary
Magnesium can have additive effects with calcium channel blockers, although evidence is conflicting.
Read the full Magnesium Bisglycinate Chelate Buffered + Amlodipine interactionAmlodipine BenzoateKaterzia
How Amlodipine Benzoate interacts with Magnesium Glycinate 665 mg — through 1 ingredient. Tap an ingredient for the detail:
Magnesium Bisglycinate Chelate BufferedCalcium Channel Blockers Moderate
Interaction Summary
Magnesium can have additive effects with calcium channel blockers, although evidence is conflicting.
Read the full Magnesium Bisglycinate Chelate Buffered + Amlodipine Benzoate interactionAmlodipine BesilateIstin
How Amlodipine Besilate interacts with Magnesium Glycinate 665 mg — through 1 ingredient. Tap an ingredient for the detail:
Magnesium Bisglycinate Chelate BufferedCalcium Channel Blockers Moderate
Interaction Summary
Magnesium can have additive effects with calcium channel blockers, although evidence is conflicting.
Read the full Magnesium Bisglycinate Chelate Buffered + Amlodipine Besilate interactionAmlodipine BesylateNorvasc
How Amlodipine Besylate interacts with Magnesium Glycinate 665 mg — through 1 ingredient. Tap an ingredient for the detail:
Magnesium Bisglycinate Chelate BufferedCalcium Channel Blockers Moderate
Interaction Summary
Magnesium can have additive effects with calcium channel blockers, although evidence is conflicting.
Read the full Magnesium Bisglycinate Chelate Buffered + Amlodipine Besylate interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Magnesium Glycinate 665 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Magnesium
Levodopa/Carbidopa (Sinemet)
Magnesium can reduce the bioavailability of levodopa/carbidopa.
Clinical research in healthy volunteers shows that taking magnesium oxide 1000 mg with levodopa 100 mg/carbidopa 10 mg reduces the area under the curve (AUC) of levodopa by 35% and of carbidopa by 81%. In vitro and animal research shows that magnesium produces an alkaline environment in the digestive tract, which might lead to degradation and reduced bioavailability of levodopa/carbidopa.
Aminoglycoside Antibiotics
Concomitant use of aminoglycoside antibiotics and magnesium can increase the risk for neuromuscular weakness.
Both aminoglycosides and magnesium reduce presynaptic acetylcholine release, which can lead to neuromuscular blockade and possible paralysis. This is most likely to occur with high doses of magnesium given intravenously.
Antacids
Use of acid reducers may reduce the laxative effect of magnesium oxide.
A retrospective analysis shows that, in the presence of H2 receptor antagonists (H2RAs) or proton pump inhibitors (PPIs), a higher dose of magnesium oxide is needed for a laxative effect. This may also occur with antacids. Under acidic conditions, magnesium oxide is converted to magnesium chloride and then to magnesium bicarbonate, which has an osmotic laxative effect. By reducing acidity, antacids may reduce the conversion of magnesium oxide to the active bicarbonate salt.
Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)
Magnesium might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide should be taken at least 2 hours before or 6 hours after magnesium containing products.
Bisphosphonates
Magnesium can decrease absorption of bisphosphonates.
Cations, including magnesium, can decrease bisphosphonate absorption. Advise patients to separate doses of magnesium and these drugs by at least 2 hours.
Calcium Channel Blockers
Magnesium can have additive effects with calcium channel blockers, although evidence is conflicting.
Magnesium inhibits calcium entry into smooth muscle cells and may therefore have additive effects with calcium channel blockers. Severe hypotension and neuromuscular blockades may occur when nifedipine is used with intravenous magnesium, although some contradictory evidence suggests that concurrent use of magnesium with nifedipine does not increase the risk of neuromuscular weakness. High doses of magnesium could theoretically have additive effects with other calcium channel blockers.
Digoxin
Magnesium salts may reduce absorption of digoxin.
Clinical evidence suggests that treatment with oral magnesium hydroxide or magnesium trisilicate reduces absorption of digoxin from the intestines. This may reduce the blood levels of digoxin and decrease its therapeutic effects.
Potassium-Sparing Diuretics
Potassium-sparing diuretics decrease excretion of magnesium, possibly increasing magnesium levels.
Potassium-sparing diuretics also have magnesium-sparing properties, which can counteract the magnesium losses associated with loop and thiazide diuretics. Theoretically, increased magnesium levels could result from concomitant use of potassium-sparing diuretics and magnesium supplements.
Quinolone Antibiotics
Magnesium decreases absorption of quinolones.
Magnesium can form insoluble complexes with quinolones and decrease their absorption. Advise patients to take these drugs at least 2 hours before, or 4 to 6 hours after, magnesium supplements.
Skeletal Muscle Relaxants
Parenteral magnesium alters the pharmacokinetics of skeletal muscle relaxants, increasing their effects and accelerating the onset of effect.
Parenteral magnesium shortens the time to onset of skeletal muscle relaxants by about 1 minute and prolongs the duration of action by about 2 minutes. Magnesium potentiates the effects of skeletal muscle relaxants by decreasing calcium-mediated release of acetylcholine from presynaptic nerve terminals, reducing postsynaptic sensitivity to acetylcholine, and having a direct effect on the membrane potential of myocytes. Magnesium also has vasodilatory actions and increases cardiac output, allowing a greater amount of muscle relaxant to reach the motor end plate. A clinical study found that low-dose rocuronium (0.45 mg/kg), when given after administration of magnesium 30 mg/kg over 10 minutes, has an accelerated onset of effect, which matches the onset of effect seen with a full-dose rocuronium regimen (0.6 mg/kg). In another clinical study, onset times for rocuronium doses of 0.3, 0.6, and 1.2 mg/kg were 86, 76, and 50 seconds, respectively, when given alone, but were reduced to 66, 44, and 38 seconds, respectively, when the doses were given after a 15-minute infusion of magnesium sulfate 60 mg/kg. Giving intraoperative intravenous magnesium sulfate, 50 mg/kg loading dose followed by 15 mg/kg/hour, reduces the onset time of rocuronium, enhances its clinical effects, reduces the dose of intraoperative opiates, and prolongs the spontaneous recovery time. It does not affect the activity of subsequently administered neostigmine.
Sulfonylureas
Magnesium increases the systemic absorption of sulfonylureas, increasing their effects and side effects.
Clinical research shows that administration of magnesium hydroxide with glyburide increases glyburide absorption, increases maximal insulin response by 35-fold, and increases the risk of hypoglycemia, when compared with glyburide alone. A similar interaction occurs between magnesium hydroxide and glipizide. The mechanism of this effect appears to be related to the elevation of gastrointestinal pH by magnesium-based antacids, increasing solubility and enhancing absorption of sulfonylureas.
Tetracycline Antibiotics
Magnesium decreases absorption of tetracyclines.
Magnesium can form insoluble complexes with tetracyclines in the gut and decrease their absorption and antibacterial activity. Advise patients to take these drugs 1 hour before or 2 hours after magnesium supplements.
Anticoagulant/Antiplatelet Drugs
Theoretically, magnesium may have antiplatelet effects, but the evidence is conflicting.
In vitro evidence shows that magnesium sulfate inhibits platelet aggregation, even at low concentrations. Some preliminary clinical evidence shows that infusion of magnesium sulfate increases bleeding time by 48% and reduces platelet activity. However, other clinical research shows that magnesium does not affect platelet aggregation, although inhibition of platelet-dependent thrombosis can occur.
Gabapentin (Neurontin)
Gabapentin absorption can be decreased by magnesium.
Clinical research shows that giving magnesium oxide orally along with gabapentin decreases the maximum plasma concentration of gabapentin by 33%, time to maximum concentration by 36%, and area under the curve by 43%. Advise patients to take gabapentin at least 2 hours before, or 4 to 6 hours after, magnesium supplements.
Sevelamer (Renagel, Renvela)
Sevelamer may increase serum magnesium levels.
In patients on hemodialysis, sevelamer use was associated with a 0.28 mg/dL increase in serum magnesium. The mechanism of this interaction remains unclear.
Brand information
Manufacturer and brand details for Magnesium Glycinate 665 mg, from the product label.
Meijer
See all Meijer products- Name
- Meijer Distribution, Inc.
- City
- Grand Rapids
- State
- MI
- ZipCode
- 49544
- Phone Number
- 1-844-338-0108
- Web Address
- www.meijer.com
Magnesium Glycinate 665 mg by Meijer: Common Questions
Does Magnesium Glycinate 665 mg by Meijer interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is this safe to take if I'm pregnant?
Can I take this while breastfeeding?
What are the most common side effects?
Will this help my constipation?
What is magnesium bisglycinate, and is it different from magnesium oxide?
Can I take this with my stomach acid reducer?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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The Full Monographs Behind Magnesium Glycinate 665 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Magnesium Glycinate 665 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 82 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Magnesium 82 references
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- Henyan, N. N., Gillespie, E. L., White, C. M., Kluger, J., and Coleman, C. I. Impact of intravenous magnesium on post-cardiothoracic surgery atrial fibrillation and length of hospital stay: a meta-analysis. Ann.Thorac.Surg. 2005;80(6):2402-2406. PubMed
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- Ji D. Oral magnesium sulfate causes perforation during bowel preparation for fiberoptic colonoscopy in patients with colorectal cancer. J Emerg Med 2012;43(4):716-7. PubMed
- Yagi T, Naito T, Mino Y, Umemura K, Kawakami J. Impact of concomitant antacid administration on gabapentin plasma exposure and oral bioavailability in healthy adult subjects. Drug Metab Pharmacokinet 2012;27(2):248-54. PubMed
- Yamasaki M, Funakoshi S, Matsuda S, Imazu T, Takeda Y, Murakami T, Maeda Y. Interaction of magnesium oxide with gastric acid secretion inhibitors in clinical pharmacotherapy. Eur J Clin Pharmacol 2014;70(8):921-4. PubMed
- Choi ES, Jeong WJ, Ahn SH, Oh AY, Jeon YT, Do SH. Magnesium sulfate accelerates the onset of low-dose rocuronium in patients undergoing laryngeal microsurgery. J Clin Anesth. 2017 Feb;36:102-106. PubMed
- Ikee R, Toyoyama T, Endo T, Tsunoda M, Hashimoto N. Impact of sevelamer hydrochloride on serum magnesium concentrations in hemodialysis patients. Magnes Res. 2016 Apr 1;29(4):184-90. PubMed
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC