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Dietary supplement

Magnolia Bark Ingredients & Drug Interactions

by Pure Health Naturally

Magnolia Bark label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Magnolia Bark against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Magnolia Bark is a dietary supplement by Pure Health Naturally with 1 active ingredient. Its ingredients are commonly taken for anxiety and stress, sleep problems, digestive upset.Based on those ingredients, 351 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Magnolia officinalis Bark Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Magnolia Bark by Pure Health Naturally

Ask about any prescription or over-the-counter medication and we check it for interactions with Magnolia Bark by Pure Health Naturally — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Magnolia Bark by Pure Health Naturally

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 20, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product is straightforward: one active ingredient, magnolia officinalis bark extract, in a vegetarian capsule. Magnolia bark has been studied for its active compounds honokiol and magnolol, which appear to have anti-inflammatory and sedative properties in lab and animal models.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Magnolia's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: rest and relaxation support.
  • We looked for evidence on: Anxiety, Stress, Sleep quality, Insomnia.
  • The closest evidence on file: Magnolia is rated "Insufficient Reliable Evidence To Rate" for Anxiety (Natural Medicines).
  • Also on file: Magnolia is rated "Insufficient Reliable Evidence To Rate" for Stress.

The evidence for magnolia bark is mixed. It's rated possibly effective for gingivitis (gum inflammation).

For allergic rhinitis (hay fever), anxiety, and dental plaque, there isn't enough reliable evidence in our data to rate whether it works.

The evidence, ingredient by ingredient Magnolia

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Orally, magnolia bark is generally well tolerated in short-term use for most adults, though human safety data is limited. During pregnancy, safety data advises against it — some sources raise concerns about effects on the uterus, so avoid use.

For breastfeeding, there isn't reliable safety data, so it's best avoided. In clinical trials, a small number of participants reported side effects including contact dermatitis (when applied topically), sexual dysfunction, shaking hands, numbness around the mouth, fatigue, and headache — though it's unclear whether these are tied to magnolia or other factors in the combination products tested.

Side effects, ingredient by ingredient Magnolia

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Magnolia.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 351 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start, check with your doctor or pharmacist if you take blood thinners or antiplatelet drugs (like warfarin, aspirin, or clopidogrel) — magnolia bark may increase bleeding risk. Also flag any CNS depressants, including sedatives, sleep aids, and anti-anxiety medications, since magnolia may add to drowsiness.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Magnolia bark may help with gum inflammation, but evidence for other uses is sparse. If you take blood thinners, antiplatelet drugs (like aspirin or clopidogrel), or CNS depressants, you'll want to clear this with your doctor or pharmacist first — the interaction risk is real.

Given the limited human safety data and pregnancy concerns, talk it over with your healthcare provider to see if it's right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 23, 2014.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Magnolia Bark, straight from the product label.

Brand Pure Health Naturally
Barcode (UPC) 812711013237
Net contents 30 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD May 23, 2014
DSLD ID 33387
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Magnolia Bark by Pure Health Naturally, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
30
UPC/BARCODE
812711013237
IngredientAmount% DV
Magnolia officinalis Bark Extract400 mg--

Other ingredients: Vegetarian Capsule

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Rest & Relaxation*

Due to the natural and pure ingredients in this product, taste, color and consistency may vary.

Pure Health's Magnolia Bark: - Supports Rest & Relaxation*

And Nothing Else!

Precautions

Keep out of reach of children.

Do not use if seal around cap is broken.

Formula

- 400 mg per Serving

400 mg Per Serving!

Formulation

- No Binders, Fillers or Excipients

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement take one or more times per day with a 10oz. glass of water or as directed by your healthcare provider.

FDA Disclaimer Statement

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Dietary Supplement

General

LBPH075-C

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Magnolia Bark by Pure Health Naturally label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Magnolia Bark label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Magnolia Bark by Pure Health Naturally

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Magnolia officinalis Bark Extract

Interacts with
351 drugs
400 mg per serving Form: Honokiol

Magnolia bark and flower buds have a long history in traditional Chinese and Japanese medicine, often for stress, sleep, and digestion. Modern human r...

Magnolia officinalis Bark Extract monograph & interactions

Other (inactive) ingredients: Vegetarian Capsule. These complete the product’s ingredient list but are not active constituents.

Interaction report

Magnolia Bark by Pure Health Naturally Drug Interactions

Want to check YOUR meds against Magnolia Bark?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
351Drugs
351 Moderate

Ingredients driving the most interactions

Magnolia officinalis Bark Extract 351

Individual Drug Interactions

The ingredients in Magnolia Bark interact with 351 drugs. Click any drug to see the details.

1 of the 1 ingredient in Magnolia Bark interact with drugs. Each result below shows which ingredient is responsible. Magnolia officinalis Bark Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Magnolia Bark with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Magnolia officinalis Bark Extract2 drug types · 351 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, magnolia might have additive effects and increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
In vitro research shows that the chemicals magnolol and honokiol, isolated from magnolia bark, inhibit platelet aggregation that is experimentally induced by collagen and arachidonic acid. However, they do not inhibit platelet aggregation that is induced by adenosine diphosphate, platelet-activating factor, or thrombin. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, concomitant use of large doses of magnolia bark and CNS depressants might have additive effects.
In vitro and animal research shows that constituents extracted from magnolia bark, especially honokiol and magnolol, have sedative effects. These effects may be due to the inhibition of catecholamine release and modulation of gamma-aminobutyric acid-A (GABA-A) receptors.

Likelihood Possible Evidence D
Magnolia officinalis Bark Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Magnolia Bark, from the product label.

Pure Health Naturally

See all Pure Health Naturally products
Name
Pure Health
Street Address
3753 Howard Hughes Parkway Suite 200, #428
City
Las Vegas
State
NV
ZipCode
89169
Phone Number
(888) 323-9355
Pharmacist Counseling Corner

Magnolia Bark by Pure Health Naturally: Common Questions

Does Magnolia Bark by Pure Health Naturally interact with any medications?
Yes. Based on its ingredients, Magnolia Bark has a known interaction with 351 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Magnolia Bark contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while pregnant?
No — the safety data advises against it during pregnancy. Some sources raise concerns about magnolia's effects on the uterus, so it's best avoided. Talk with your doctor about whether it's appropriate for you.
Is it safe to breastfeed while taking magnolia bark?
There isn't reliable safety data during breastfeeding, so it's best avoided. Check with your doctor or pharmacist for personalized advice.
What side effects might I see?
When taken by mouth, it's generally well tolerated. In trials, a small number of people reported sexual dysfunction, shaking hands, numbness, fatigue, and headache, though it's unclear if magnolia was the cause. If applied topically, contact dermatitis is possible.
Does magnolia bark actually work for gum inflammation?
It's rated possibly effective for gingivitis. For hay fever, anxiety, and plaque buildup, there isn't enough reliable evidence in our data to say whether it works.
What's in this product besides magnolia?
Just magnolia officinalis bark extract and the vegetarian capsule itself — no other active ingredients.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Magnolia Bark is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Magnolia Bark label
Go deeper

The Full Monographs Behind Magnolia Bark’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Magnolia

Interacts with 351 drugs

Magnolia bark and flower buds have a long history in traditional Chinese and Japanese medicine, often for stress, sleep, and digestion. Modern human research is still limited, so we can't be...

Read the full Magnolia monograph →
Sources

Sources & How We Checked

Magnolia Bark's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 9 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Magnolia 9 references
  1. Kuribara H, Kishi E, Hattori N, et al. The anxiolytic effect of two oriental herbal drugs in Japan attributed to honokiol from magnolia bark. J Pharm Pharmacol 2000;52:1425-9. PubMed
  2. Tachikawa E, Takahashi M, Kashimoto T. Effects of extract and ingredients isolated from Magnolia obovata thunberg on catecholamine secretion from bovine adrenal chromaffin cells. Biochem Pharmacol 2000;60:433-40. PubMed
  3. Jung KY, Kim DS, Oh SR, et al. Magnone A and B, novel anti-PAF tetrahydrofuran lignans from the flower buds of Magnolia fargesii. J Nat Prod 1998;61:808-11.
  4. Garrison R, Chambliss WG. Effect of a proprietary Magnolia and Phellodendron extract on weight management: a pilot, double-blind, placebo-controlled clinical trial. Altern Ther Health Med 2006;12:50-4.
  5. Teng CM, Chen CC, Ko FN, et al. Two antiplatelet agents from Magnolia officinalis. Thromb Res 1988;50:757-65. PubMed
  6. Ghys K, De Palma A, Vandevenne A, Werbrouck J, Goossens A. Magnolia officinalis bark extract, a recently identified contact allergen in 'anti-ageing' cosmetics. Contact Dermatitis. 2015 Aug;73(2):130-2.
  7. Raison-Peyron N, Césaire A, Du-Thanh A, Dereure O. Allergic contact dermatitis caused by Magnolia officinalis bark extract in a facial anti-ageing cream. Contact Dermatitis. 2015 Jun;72(6):416-7.
  8. Nilausen TD, Johansen JD, Thyssen JP. Allergic contact dermatitis of the face caused by Magnolia officinalis bark extract. Contact Dermatitis. 2016;75(6):385-87.
  9. Amat-Samaranch V, López-Sánchez C, Tubau C, Puig L, Serra-Baldrich E. Vulvar allergic contact dermatitis caused by Magnolia officinalis bark extract. Contact Dermatitis 2022;87(1):96-97.

See these in context on the Magnolia monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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