Sleep Sweetly Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Sleep Sweetly against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Sleep Sweetly is a dietary supplement by Pure Health Naturally with 3 active ingredients. Its ingredients are commonly taken for sleep quality and insomnia, relaxation, cognitive function.Based on those ingredients, 436 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are GABA, Cyracos(R) Lemon Balm (Melissa officinalis) Extract, L-Glycine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Sleep Sweetly by Pure Health Naturally
Ask about any prescription or over-the-counter medication and we check it for interactions with Sleep Sweetly by Pure Health Naturally — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Sleep Sweetly by Pure Health Naturally
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Sleep Sweetly contains three active ingredients. L-Glycine is an amino acid.
GABA (gamma-aminobutyric acid) is a neurotransmitter your brain uses naturally. Cyracos lemon balm extract is a standardized preparation from the melissa officinalis plant.
The capsule itself is vegetarian.
Does it work?
Moderate evidence
The evidence for these ingredients is limited. L-Glycine shows possibly effective evidence for schizophrenia, but the data supporting its use for sleep is not established in our records.
GABA's effectiveness for anxiety and other conditions is rated insufficient evidence — meaning the science hasn't yet shown it works for those purposes. Lemon balm extract shows possibly effective evidence for cold sores, stress, and depression.
None of these ratings directly address sleep quality, so the overall effectiveness of this product for sleep is not supported by the data we hold.
How safe is it?
Well-documented data
L-Glycine is generally well tolerated at typical doses, though long-term safety data are limited. Rarely, it may cause mild sedation, nausea, vomiting, or soft stools; these resolve quickly if you stop taking it.
GABA is often well tolerated short-term, but long-term safety isn't well studied — common side effects include drowsiness, nausea, muscle weakness, and throat irritation. Lemon balm extract is generally well tolerated for short-term use but long-term safety at high doses hasn't been studied.
It may cause dizziness and sedation, though studies show these don't occur more often than placebo. One rare case report linked a lemon-balm-containing product to heart rhythm changes, but other ingredients were involved so causality is unclear.
We have no pregnancy or breastfeeding safety data on file for any of these ingredients — talk with your doctor or pharmacist about whether it's appropriate for you.
Meds to double-check
Moderate interaction found
Before you take Sleep Sweetly, check with your pharmacist if you're on clozapine (Clozaril) — this is a Moderate-severity interaction. Also double-check if you take any blood pressure medications, thyroid hormones, or CNS depressants like sedatives, anti-anxiety drugs, or pain relievers.
Altogether, these interactions span 434 individual medications.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Sleep Sweetly combines ingredients with limited evidence for sleep support and several documented interactions with medications. If you take clozapine, blood pressure medications, thyroid hormones, or any sedating drugs, check with your pharmacist or doctor before starting this product.
Even if you're not on those medications, it's worth a quick conversation to make sure it's right for you.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 23, 2014.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Sleep Sweetly, straight from the product label.
| Brand | Pure Health Naturally |
|---|---|
| Barcode (UPC) | 812711013367 |
| Net contents | 30 Vegetarian Capsule(s) |
| Market status | On market |
| Date entered into DSLD | May 23, 2014 |
| DSLD ID | 33404 |
| Product type | Other Combinations |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Sleep Sweetly by Pure Health Naturally, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| L-Glycine | 350 mg | -- |
| GABA | 100 mg | -- |
| Cyracos(R) Lemon Balm (Melissa officinalis) Extract | 300 mg | -- |
Other ingredients: Vegetarian Capsule
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements
Pure Health's Sleep Sweetly: - Supports Rest & Relaxation* - Delivers Healthy Sleep Support*
Due to the natural and pure ingredients in this product, taste, color and consistency may vary.
Supports Rest & Relaxation
And Nothing Else!
Suggested/Recommended/Usage/Directions
Directions: Take 2 capsules 30 minutes before bed with a 10 oz. glass of water or as directed by your healthcare provider.
Precautions
Do not use if seal around cap is broken.
Keep out of reach of children.
Caution: Do not take if you are under 18, pregnant or trying to get pregnant or nursing.
Caution: Do not take if you are under 18, pregnant or trying to get pregnant or nursing.
Limit consumption to no more than 2 capsules daily.
FDA Disclaimer Statement
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Dietary Supplement
Formulation
- No Binders, Fillers or Excipients
Brand IP Statement(s)
Cyracos(R) is a registered trademark of Naturex, Inc.
Seals/Symbols
cyracos(R)
Formula
750 mg Per Serving!
General
LBPH089-A
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Sleep Sweetly by Pure Health Naturally label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Sleep Sweetly by Pure Health Naturally
These are the 3 active ingredients this product is made of. Select any to open its full monograph.
Serving size2 Capsule(s) Dosage formCapsule Servings per container15 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
L-Glycine
Interacts with1 drug
Glycine is a non-essential amino acid your body makes on its own and that also appears in protein-rich foods. It is most studied for improving sleep q...
L-Glycine monograph & interactionsGABA
Interacts with419 drugs
GABA is a calming chemical messenger (neurotransmitter) that your body makes on its own, and it is sold as a supplement for stress, anxiety, and sleep...
GABA monograph & interactionsCyracos(R) Lemon Balm (Melissa officinalis) Extract
Interacts with264 drugs
Lemon balm is a gentle, lemon-scented mint-family herb traditionally used to ease stress, support sleep, and calm digestion, and topically for cold so...
Cyracos(R) Lemon Balm (Melissa officinalis) Extract monograph & interactionsOther (inactive) ingredients: Vegetarian Capsule. These complete the product’s ingredient list but are not active constituents.
Sleep Sweetly by Pure Health Naturally Drug Interactions
HelloPharmacist Interaction Report
Sleep Sweetly by Pure Health Naturally contains three active ingredients, and together they interact with medications used to treat several conditions.
The most serious interaction involves L-Glycine and clozapine (Clozaril), an antipsychotic: a small clinical study showed that adding glycine to clozapine worsened schizophrenia symptoms, and the combination may reduce clozapine's effectiveness — this is a Moderate-severity interaction.
Read the full breakdown — every affected drug type, severity by severity
GABA may increase the blood-pressure-lowering effects of antihypertensive drugs (Moderate severity), which could lead to low blood pressure. Both GABA and lemon balm extract have Moderate-severity interactions with CNS depressants (sedatives, sleep aids, pain relievers, and anti-anxiety medications) — theoretically increasing drowsiness and sedation, though the clinical relevance of GABA's effect is unclear.
Lemon balm extract also interacts with thyroid hormone replacement therapy (Moderate severity), potentially interfering with how well the hormone works.
GABA may also cause minor additive sedation with CNS depressants, though the practical significance is uncertain. No interactions are documented for the lemon balm extract beyond those listed above.
Always check your exact medications with the tool on this page before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Sleep Sweetly?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Sleep Sweetly interact with 436 drugs. Click any drug to see the details.
3 of the 3 ingredients in Sleep Sweetly interact with drugs. Each result below shows which ingredient is responsible. GABA Cyracos(R) Lemon Balm (Melissa officinalis) Extract L-Glycine
AcebutololRhotral, Sectral
How Acebutolol interacts with Sleep Sweetly — through 1 ingredient. Tap an ingredient for the detail:
GabaAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking GABA with antihypertensive drugs might increase the risk of hypotension.
Read the full Gaba + Acebutolol interactionAcepromazineAtravet
How Acepromazine interacts with Sleep Sweetly — through 2 ingredients. Tap an ingredient for the detail:
Cyracos(r) Lemon Balm (melissa Officinalis) ExtractCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of lemon balm might have additive effects with CNS depressant drugs.
Read the full Cyracos(r) Lemon Balm (melissa Officinalis) Extract + Acepromazine interactionGabaCns Depressants Minor
Interaction Summary
Theoretically, GABA might have additive sedative effects when used in conjunction with CNS depressants.
Read the full Gaba + Acepromazine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Sleep Sweetly — through 2 ingredients. Tap an ingredient for the detail:
Cyracos(r) Lemon Balm (melissa Officinalis) ExtractCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of lemon balm might have additive effects with CNS depressant drugs.
Read the full Cyracos(r) Lemon Balm (melissa Officinalis) Extract + Acetaminophen, Butalbital, Caffeine, Codeine interactionGabaCns Depressants Minor
Interaction Summary
Theoretically, GABA might have additive sedative effects when used in conjunction with CNS depressants.
Read the full Gaba + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Sleep Sweetly — through 2 ingredients. Tap an ingredient for the detail:
Cyracos(r) Lemon Balm (melissa Officinalis) ExtractCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of lemon balm might have additive effects with CNS depressant drugs.
Read the full Cyracos(r) Lemon Balm (melissa Officinalis) Extract + Acetaminophen, Butalbital, Codeine interactionGabaCns Depressants Minor
Interaction Summary
Theoretically, GABA might have additive sedative effects when used in conjunction with CNS depressants.
Read the full Gaba + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Sleep Sweetly — through 2 ingredients. Tap an ingredient for the detail:
Cyracos(r) Lemon Balm (melissa Officinalis) ExtractCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of lemon balm might have additive effects with CNS depressant drugs.
Read the full Cyracos(r) Lemon Balm (melissa Officinalis) Extract + Acetaminophen, Butalbital, Codeine Phosphate interactionGabaCns Depressants Minor
Interaction Summary
Theoretically, GABA might have additive sedative effects when used in conjunction with CNS depressants.
Read the full Gaba + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Sleep Sweetly — through 2 ingredients. Tap an ingredient for the detail:
Cyracos(r) Lemon Balm (melissa Officinalis) ExtractCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of lemon balm might have additive effects with CNS depressant drugs.
Read the full Cyracos(r) Lemon Balm (melissa Officinalis) Extract + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionGabaCns Depressants Minor
Interaction Summary
Theoretically, GABA might have additive sedative effects when used in conjunction with CNS depressants.
Read the full Gaba + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Sleep Sweetly — through 2 ingredients. Tap an ingredient for the detail:
Cyracos(r) Lemon Balm (melissa Officinalis) ExtractCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of lemon balm might have additive effects with CNS depressant drugs.
Read the full Cyracos(r) Lemon Balm (melissa Officinalis) Extract + Acetaminophen, Caffeine, Codeine interactionGabaCns Depressants Minor
Interaction Summary
Theoretically, GABA might have additive sedative effects when used in conjunction with CNS depressants.
Read the full Gaba + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Sleep Sweetly — through 2 ingredients. Tap an ingredient for the detail:
Cyracos(r) Lemon Balm (melissa Officinalis) ExtractCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of lemon balm might have additive effects with CNS depressant drugs.
Read the full Cyracos(r) Lemon Balm (melissa Officinalis) Extract + Acetaminophen, Caffeine, Codeine, Salicylamide interactionGabaCns Depressants Minor
Interaction Summary
Theoretically, GABA might have additive sedative effects when used in conjunction with CNS depressants.
Read the full Gaba + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Sleep Sweetly — through 2 ingredients. Tap an ingredient for the detail:
Cyracos(r) Lemon Balm (melissa Officinalis) ExtractCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of lemon balm might have additive effects with CNS depressant drugs.
Read the full Cyracos(r) Lemon Balm (melissa Officinalis) Extract + Acetaminophen, Caffeine, Dihydrocodeine interactionGabaCns Depressants Minor
Interaction Summary
Theoretically, GABA might have additive sedative effects when used in conjunction with CNS depressants.
Read the full Gaba + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Sleep Sweetly — through 2 ingredients. Tap an ingredient for the detail:
Cyracos(r) Lemon Balm (melissa Officinalis) ExtractCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of lemon balm might have additive effects with CNS depressant drugs.
Read the full Cyracos(r) Lemon Balm (melissa Officinalis) Extract + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionGabaCns Depressants Minor
Interaction Summary
Theoretically, GABA might have additive sedative effects when used in conjunction with CNS depressants.
Read the full Gaba + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, OpiumHista-Derfule
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interacts with Sleep Sweetly — through 2 ingredients. Tap an ingredient for the detail:
Cyracos(r) Lemon Balm (melissa Officinalis) ExtractCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of lemon balm might have additive effects with CNS depressant drugs.
Read the full Cyracos(r) Lemon Balm (melissa Officinalis) Extract + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interactionGabaCns Depressants Minor
Interaction Summary
Theoretically, GABA might have additive sedative effects when used in conjunction with CNS depressants.
Read the full Gaba + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interactionAcetaminophen, Chlorzoxazone, CodeineAcetazone Forte C8, Parafon Forte C8
How Acetaminophen, Chlorzoxazone, Codeine interacts with Sleep Sweetly — through 2 ingredients. Tap an ingredient for the detail:
Cyracos(r) Lemon Balm (melissa Officinalis) ExtractCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of lemon balm might have additive effects with CNS depressant drugs.
Read the full Cyracos(r) Lemon Balm (melissa Officinalis) Extract + Acetaminophen, Chlorzoxazone, Codeine interactionGabaCns Depressants Minor
Interaction Summary
Theoretically, GABA might have additive sedative effects when used in conjunction with CNS depressants.
Read the full Gaba + Acetaminophen, Chlorzoxazone, Codeine interactionAcetaminophen, CodeineTylenol No.3, Tylenol w/ Codeine
How Acetaminophen, Codeine interacts with Sleep Sweetly — through 2 ingredients. Tap an ingredient for the detail:
Cyracos(r) Lemon Balm (melissa Officinalis) ExtractCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of lemon balm might have additive effects with CNS depressant drugs.
Read the full Cyracos(r) Lemon Balm (melissa Officinalis) Extract + Acetaminophen, Codeine interactionGabaCns Depressants Minor
Interaction Summary
Theoretically, GABA might have additive sedative effects when used in conjunction with CNS depressants.
Read the full Gaba + Acetaminophen, Codeine interactionAcetaminophen, Codeine, DoxylamineMersyndol
How Acetaminophen, Codeine, Doxylamine interacts with Sleep Sweetly — through 2 ingredients. Tap an ingredient for the detail:
Cyracos(r) Lemon Balm (melissa Officinalis) ExtractCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of lemon balm might have additive effects with CNS depressant drugs.
Read the full Cyracos(r) Lemon Balm (melissa Officinalis) Extract + Acetaminophen, Codeine, Doxylamine interactionGabaCns Depressants Minor
Interaction Summary
Theoretically, GABA might have additive sedative effects when used in conjunction with CNS depressants.
Read the full Gaba + Acetaminophen, Codeine, Doxylamine interactionAcetaminophen, Codeine, MethocarbamolAcetaminophen, Codeine, Methocarbamol, Robaxacet 8
How Acetaminophen, Codeine, Methocarbamol interacts with Sleep Sweetly — through 2 ingredients. Tap an ingredient for the detail:
Cyracos(r) Lemon Balm (melissa Officinalis) ExtractCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of lemon balm might have additive effects with CNS depressant drugs.
Read the full Cyracos(r) Lemon Balm (melissa Officinalis) Extract + Acetaminophen, Codeine, Methocarbamol interactionGabaCns Depressants Minor
Interaction Summary
Theoretically, GABA might have additive sedative effects when used in conjunction with CNS depressants.
Read the full Gaba + Acetaminophen, Codeine, Methocarbamol interactionAcetaminophen, Dichloralantipyrine, IsomethepteneAmidrine, Midchlor, Migquin, Migratine
How Acetaminophen, Dichloralantipyrine, Isometheptene interacts with Sleep Sweetly — through 2 ingredients. Tap an ingredient for the detail:
Cyracos(r) Lemon Balm (melissa Officinalis) ExtractCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of lemon balm might have additive effects with CNS depressant drugs.
Read the full Cyracos(r) Lemon Balm (melissa Officinalis) Extract + Acetaminophen, Dichloralantipyrine, Isometheptene interactionGabaCns Depressants Minor
Interaction Summary
Theoretically, GABA might have additive sedative effects when used in conjunction with CNS depressants.
Read the full Gaba + Acetaminophen, Dichloralantipyrine, Isometheptene interactionAcetaminophen, Dichloralphenazone, IsomethepteneMidrin
How Acetaminophen, Dichloralphenazone, Isometheptene interacts with Sleep Sweetly — through 2 ingredients. Tap an ingredient for the detail:
Cyracos(r) Lemon Balm (melissa Officinalis) ExtractCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of lemon balm might have additive effects with CNS depressant drugs.
Read the full Cyracos(r) Lemon Balm (melissa Officinalis) Extract + Acetaminophen, Dichloralphenazone, Isometheptene interactionGabaCns Depressants Minor
Interaction Summary
Theoretically, GABA might have additive sedative effects when used in conjunction with CNS depressants.
Read the full Gaba + Acetaminophen, Dichloralphenazone, Isometheptene interactionAcetaminophen, Dichlorophenazone, IsometheptaneIsocom
How Acetaminophen, Dichlorophenazone, Isometheptane interacts with Sleep Sweetly — through 2 ingredients. Tap an ingredient for the detail:
Cyracos(r) Lemon Balm (melissa Officinalis) ExtractCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of lemon balm might have additive effects with CNS depressant drugs.
Read the full Cyracos(r) Lemon Balm (melissa Officinalis) Extract + Acetaminophen, Dichlorophenazone, Isometheptane interactionGabaCns Depressants Minor
Interaction Summary
Theoretically, GABA might have additive sedative effects when used in conjunction with CNS depressants.
Read the full Gaba + Acetaminophen, Dichlorophenazone, Isometheptane interactionAcetaminophen, DiphenhydramineTylenol PM, Tylenol PM Ex Strength
How Acetaminophen, Diphenhydramine interacts with Sleep Sweetly — through 2 ingredients. Tap an ingredient for the detail:
Cyracos(r) Lemon Balm (melissa Officinalis) ExtractCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of lemon balm might have additive effects with CNS depressant drugs.
Read the full Cyracos(r) Lemon Balm (melissa Officinalis) Extract + Acetaminophen, Diphenhydramine interactionGabaCns Depressants Minor
Interaction Summary
Theoretically, GABA might have additive sedative effects when used in conjunction with CNS depressants.
Read the full Gaba + Acetaminophen, Diphenhydramine interactionAcetaminophen, Diphenhydramine, PseudoephedrineChildren's Tylenol Allergy, Cold Control, Contac Night Allergy Relief
How Acetaminophen, Diphenhydramine, Pseudoephedrine interacts with Sleep Sweetly — through 2 ingredients. Tap an ingredient for the detail:
Cyracos(r) Lemon Balm (melissa Officinalis) ExtractCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of lemon balm might have additive effects with CNS depressant drugs.
Read the full Cyracos(r) Lemon Balm (melissa Officinalis) Extract + Acetaminophen, Diphenhydramine, Pseudoephedrine interactionGabaCns Depressants Minor
Interaction Summary
Theoretically, GABA might have additive sedative effects when used in conjunction with CNS depressants.
Read the full Gaba + Acetaminophen, Diphenhydramine, Pseudoephedrine interactionAcetaminophen, HydrocodoneAnexsia, Anodynos DHC, Azdone, Co-Gesic, Doucet, Lorcet +9 more
How Acetaminophen, Hydrocodone interacts with Sleep Sweetly — through 2 ingredients. Tap an ingredient for the detail:
Cyracos(r) Lemon Balm (melissa Officinalis) ExtractCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of lemon balm might have additive effects with CNS depressant drugs.
Read the full Cyracos(r) Lemon Balm (melissa Officinalis) Extract + Acetaminophen, Hydrocodone interactionGabaCns Depressants Minor
Interaction Summary
Theoretically, GABA might have additive sedative effects when used in conjunction with CNS depressants.
Read the full Gaba + Acetaminophen, Hydrocodone interactionAcetaminophen, MeperidineDemerol APAP
How Acetaminophen, Meperidine interacts with Sleep Sweetly — through 2 ingredients. Tap an ingredient for the detail:
Cyracos(r) Lemon Balm (melissa Officinalis) ExtractCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of lemon balm might have additive effects with CNS depressant drugs.
Read the full Cyracos(r) Lemon Balm (melissa Officinalis) Extract + Acetaminophen, Meperidine interactionGabaCns Depressants Minor
Interaction Summary
Theoretically, GABA might have additive sedative effects when used in conjunction with CNS depressants.
Read the full Gaba + Acetaminophen, Meperidine interactionAcetaminophen, OxycodonePercocet, Roxicet, Tylox, Xartemis XR
How Acetaminophen, Oxycodone interacts with Sleep Sweetly — through 2 ingredients. Tap an ingredient for the detail:
Cyracos(r) Lemon Balm (melissa Officinalis) ExtractCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of lemon balm might have additive effects with CNS depressant drugs.
Read the full Cyracos(r) Lemon Balm (melissa Officinalis) Extract + Acetaminophen, Oxycodone interactionGabaCns Depressants Minor
Interaction Summary
Theoretically, GABA might have additive sedative effects when used in conjunction with CNS depressants.
Read the full Gaba + Acetaminophen, Oxycodone interactionAcetaminophen, PentazocineTalacen
How Acetaminophen, Pentazocine interacts with Sleep Sweetly — through 2 ingredients. Tap an ingredient for the detail:
Cyracos(r) Lemon Balm (melissa Officinalis) ExtractCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of lemon balm might have additive effects with CNS depressant drugs.
Read the full Cyracos(r) Lemon Balm (melissa Officinalis) Extract + Acetaminophen, Pentazocine interactionGabaCns Depressants Minor
Interaction Summary
Theoretically, GABA might have additive sedative effects when used in conjunction with CNS depressants.
Read the full Gaba + Acetaminophen, Pentazocine interactionAcetaminophen, PropoxypheneDarvocet-N 100, Darvocet-N 50, E-Lor, Wygesic
How Acetaminophen, Propoxyphene interacts with Sleep Sweetly — through 2 ingredients. Tap an ingredient for the detail:
Cyracos(r) Lemon Balm (melissa Officinalis) ExtractCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of lemon balm might have additive effects with CNS depressant drugs.
Read the full Cyracos(r) Lemon Balm (melissa Officinalis) Extract + Acetaminophen, Propoxyphene interactionGabaCns Depressants Minor
Interaction Summary
Theoretically, GABA might have additive sedative effects when used in conjunction with CNS depressants.
Read the full Gaba + Acetaminophen, Propoxyphene interactionAcetazolamideAk-Zol, Diamox
How Acetazolamide interacts with Sleep Sweetly — through 2 ingredients. Tap an ingredient for the detail:
GabaCns Depressants, Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, GABA might have additive sedative effects when used in conjunction with CNS depressants.
Read the full Gaba + Acetazolamide interactionCyracos(r) Lemon Balm (melissa Officinalis) ExtractCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of lemon balm might have additive effects with CNS depressant drugs.
Read the full Cyracos(r) Lemon Balm (melissa Officinalis) Extract + Acetazolamide interactionAlfentanilAlfenta
How Alfentanil interacts with Sleep Sweetly — through 2 ingredients. Tap an ingredient for the detail:
Cyracos(r) Lemon Balm (melissa Officinalis) ExtractCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of lemon balm might have additive effects with CNS depressant drugs.
Read the full Cyracos(r) Lemon Balm (melissa Officinalis) Extract + Alfentanil interactionGabaCns Depressants Minor
Interaction Summary
Theoretically, GABA might have additive sedative effects when used in conjunction with CNS depressants.
Read the full Gaba + Alfentanil interactionAliskirenTekturna
How Aliskiren interacts with Sleep Sweetly — through 1 ingredient. Tap an ingredient for the detail:
GabaAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking GABA with antihypertensive drugs might increase the risk of hypotension.
Read the full Gaba + Aliskiren interactionAlprazolamNiravam, Xanax
How Alprazolam interacts with Sleep Sweetly — through 2 ingredients. Tap an ingredient for the detail:
Cyracos(r) Lemon Balm (melissa Officinalis) ExtractCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of lemon balm might have additive effects with CNS depressant drugs.
Read the full Cyracos(r) Lemon Balm (melissa Officinalis) Extract + Alprazolam interactionGabaCns Depressants Minor
Interaction Summary
Theoretically, GABA might have additive sedative effects when used in conjunction with CNS depressants.
Read the full Gaba + Alprazolam interactionAluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #2
How Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interacts with Sleep Sweetly — through 2 ingredients. Tap an ingredient for the detail:
Cyracos(r) Lemon Balm (melissa Officinalis) ExtractCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of lemon balm might have additive effects with CNS depressant drugs.
Read the full Cyracos(r) Lemon Balm (melissa Officinalis) Extract + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionGabaCns Depressants Minor
Interaction Summary
Theoretically, GABA might have additive sedative effects when used in conjunction with CNS depressants.
Read the full Gaba + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Sleep Sweetly with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
GABA
Antihypertensive Drugs
Theoretically, taking GABA with antihypertensive drugs might increase the risk of hypotension.
Some clinical research shows that GABA can decrease blood pressure in patients with hypertension.
Cns Depressants
Theoretically, GABA might have additive sedative effects when used in conjunction with CNS depressants. However, it is unclear if this concern is clinically relevant.
Endogenous GABA has well-established relaxant effects and GABA(A) receptors have an established physiological role in sleep. However, the effects of GABA supplements are unclear, as it is unknown whether exogenous GABA crosses the blood-brain barrier. Although there have been limited reports of drowsiness or tiredness with GABA supplements, these effects have not been widely reported in clinical studies. Additionally, intravenous GABA 0.1-1 mg/kg has been shown to induce anxiety in a dose-dependent manner.
Cyracos(R) Lemon Balm (Melissa officinalis) Extract
Cns Depressants
Theoretically, concomitant use of lemon balm might have additive effects with CNS depressant drugs.
Lemon balm seems to have CNS depressant activity in animals and in humans.
Thyroid Hormone
Theoretically, lemon balm might interfere with thyroid hormone replacement therapy.
In vitro, constituents of lemon balm extract bind to thyroid stimulating hormone (TSH), preventing TSH receptor-binding and leading to the inhibition of TSH-stimulated adenylate cyclase activity. In animals, lemon balm extract has been shown to decrease levels of circulating TSH and inhibit thyroid secretion.
L-Glycine
Clozapine (Clozaril)
Theoretically, glycine might decrease the effectiveness of clozapine.
One small clinical study in patients with schizophrenia shows that adding glycine to clozapine therapy worsens symptoms of schizophrenia when compared with clozapine alone. The mechanism of this interaction is unclear.
Brand information
Manufacturer and brand details for Sleep Sweetly, from the product label.
Pure Health Naturally
See all Pure Health Naturally products- Name
- Pure Health
- Street Address
- 3753 Howard Hughes Parkway Suite 200, #428
- City
- Las Vegas
- State
- NV
- ZipCode
- 89169
- Phone Number
- (888) 323-9355
Sleep Sweetly by Pure Health Naturally: Common Questions
Does Sleep Sweetly by Pure Health Naturally interact with any medications?
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Where does this information come from?
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Can I take this if I'm on thyroid medication?
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Is it okay to take this with my blood pressure medication?
What's lemon balm extract doing in a sleep product?
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Sleep Sweetly’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Glycine
Interacts with 1 drugGlycine is a non-essential amino acid your body makes on its own and that also appears in protein-rich foods. It is most studied for improving sleep quality, where early research is promisin...
Read the full Glycine monograph → Herb & supplement monographGamma-aminobutyric Acid (gaba)
Interacts with 419 drugsGABA is a calming chemical messenger (neurotransmitter) that your body makes on its own, and it is sold as a supplement for stress, anxiety, and sleep. The science behind oral GABA supplemen...
Read the full Gamma-aminobutyric Acid (gaba) monograph → Herb & supplement monographLemon Balm
Interacts with 264 drugsLemon balm is a gentle, lemon-scented mint-family herb traditionally used to ease stress, support sleep, and calm digestion, and topically for cold sores. Early studies are promising but gen...
Read the full Lemon Balm monograph →Sources & How We Checked
Sleep Sweetly's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 29 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Glycine 5 references
- Heresco-Levy U, Javitt DC, Ermilov M, et al. Efficacy of high-dose glycine in the treatment of enduring negative symptoms of schizophrenia. Arch Gen Psychiatry 1999;56:29-36.. PubMed
- Potkin SG, Jin Y, Bunney BG, Costa J, Gulasekaram B. Effect of clozapine and adjunctive high-dose glycine in treatment-resistant schizophrenia. Am J Psychiatry 1999;156:145-7.. PubMed
- Gusev EI, Skvortsova VI, Dambinova SA, et al. Neuroprotective effects of glycine for therapy of acute ischaemic stroke. Cerebrovasc Dis 2000;10:49-60. PubMed
- Inagawa K, Kawai N, Ono K, Sukegawa E, Tsubuku S, Takahashi M. Assessment of acute adverse effects of glycine ingestion at a high dose in human volunteers. Seikatsu Eisei. 2006; 50:27-32.
- Woods SW, Walsh BC, Hawkins KA, Miller TJ, Saksa JR, D'Souza DC, Pearlson GD, Javitt DC, McGlashan TH, Krystal JH. Glycine treatment of the risk syndrome for psychosis: report of two pilot studies. Eur Neuropsychopharmacol. 2013 Aug;23(8):931-40. PubMed
Gamma-aminobutyric Acid (gaba) 12 references
- Cavagnini F, Invitti C, Pinto M, et al. Effect of acute and repeated administration of gamma aminobutyric acid (GABA) on growth hormone and prolactin secretion in man. Acta Endocrinol (Copenh) 1980;93:149-54.
- Nurnberger JI Jr, Berrettini WH, Simmons-Alling S, et al. Intravenous GABA administration is anxiogenic in man. Psychiatry Res 1986;19:113-7. PubMed
- Gershman RN, Vasilenko MA, Iliushina GG, et al. [Gammalon in the rehabilitation in infantile cerebral palsy]. Pediatr.Akus.Ginekol. 1977;(6):26-7.
- Loeb C, Benassi E, Bo, GP, et al. Preliminary evaluation of the effect of GABA and phosphatidylserine in epileptic patients. Epilepsy Res. 1987;1:209-12 . PubMed
- Inoue K, Shirai T, Ochiai H, et al. Blood-pressure-lowering effect of a novel fermented milk containing gamma-aminobutyric acid (GABA) in mild hypertensives. Eur J Clin Nutr 2003;57:490-95.
- ELLIOTT, K. A. and JASPER, H. H. Gammaaminobutyric acid. Physiol Rev. 1959;39(2):383-406.
- Winsky-Sommerer, R. Role of GABAA receptors in the physiology and pharmacology of sleep. Eur.J.Neurosci. 2009;29(9):1779-1794.
- Meldrum, B. S. GABAergic mechanisms in the pathogenesis and treatment of epilepsy. Br.J.Clin.Pharmacol. 1989;27 Suppl 1:3S-11S. PubMed
- Loeb, C., Marinari, U. M., Benassi, E., Besio, G., Cottalasso, D., Cupello, A., Maffini, M., Mainardi, P., Pronzato, M. A., and Scotto, P. A. Phosphatidylserine increases in vivo the synaptosomal uptake of exogenous GABA in rats. Exp.Neurol. 1988;99(2):4 PubMed
- Melis, G. B., Paoletti, A. M., Mais, V., and Fioretti, P. Interference of dopamine infusion on gamma-amino butyric acid (GABA)-stimulated prolactin increase. J.Endocrinol.Invest 1980;3(4):445-448.
- Boonstra E, de Kleijn R, Colzato LS, Alkemade A, Forstmann BU, Nieuwenhuis S. Neurotransmitters as food supplements: the effects of GABA on brain and behavior. Front Psychol. 2015 Oct 6;6:1520. doi: 10.3389/fpsyg.2015.01520. eCollection 2015. PubMed
- de Bie TH, Witkamp RF, Balvers MG, Jongsma MA. Effects of ?-aminobutyric acid supplementation on glucose control in adults with prediabetes: A double-blind, randomized, placebo-controlled trial. Am J Clin Nutr 2023;118(3):708-719. PubMed
See these in context on the Gamma-aminobutyric Acid (gaba) monograph →
Lemon Balm 12 references
- Wolbling RH, Leonhardt K. Local therapy of herpes simplex with dried extract from Melissa officinalis. Phytomedicine 1994;1:25-31.
- Akhondzadeh S, Noroozian M, Mohammadi M, et al. Melissa officinalis extract in the treatment of patients with mild to moderate Alzheimer's disease: a double blind, randomised, placebo controlled trial. J Neurol Neurosurg Psychiatry 2003;74:863-6. PubMed
- Kennedy DO, Scholey AB, Tildesley NT, et al. Modulation of mood and cognitive performance following acute administration of Melissa officinalis (lemon balm). Pharmacol Biochem Behav 2002;72:953-64. PubMed
- Albrecht M, Berger W, Laux P, Schmidt U, et al. Psychopharmaka und Verkehrssicherheit. Der Einfluß von Euvegal® - Dragees forte auf die Fahrtüchtigkeit und Kombinationswirkungen mit Alkohol Z Allg Med 1995;71:1215-25.
- Herberg, KW. Nebenwirkungen pflanzlicher Beruhigungsmittel/ Leistung und Befinden nach Einnahme einer Baldrian-Hopfen-Kombination. Z.Allg Med 1996;72:234-240.
- Soulimani R, Fleurentin J, Mortier F, et al. Neurotropic action of the hydroalcoholic extract of Melissa officinalis in the mouse. Planta Med. 1991 Apr;57:105-9.
- Sourgens H, Winterhoff H, Gumbinger HG, et al. Antihormonal effects of plant extracts. TSH- and prolactin-suppressing properties of Lithospermum officinale and other plants. Planta Med. 1982 Jun;45:78-86. DOI
- Auf'mkolk M, Ingbar JC, Amir SM, et al. Inhibition by certain plant extracts of the binding and adenylate cyclase stimulatory effect of bovine thyrotropin in human thyroid membranes. Endocrinology. 1984 Aug;115:527-34. PubMed
- Santini F, Vitti P, Ceccarini G, et al. In vitro assay of thyroid disruptors affecting TSH-stimulated adenylate cyclase activity. J Endocrinol Invest. 2003 Oct;26:950-5. PubMed
- Alijaniha F, et al. Heart palpitation relief with Melissa officinalis leaf extract: double blind, randomized, placebo controlled trial of efficacy and safety. J Ethnopharmacol. 2015;164:378-384. doi: 10.1016/j.jep.2015.02.007. Epub 2015 Feb 11. PubMed
- Araj-Khodaei M, Noorbala AA, Yarani R, et al. A double-blind, randomized pilot study for comparison of Melissa officinalis L. and Lavandula angustifolia Mill. with Fluoxetine for the treatment of depression. BMC Complement Med Ther. 2020;20(1):207. PubMed
- Kucuk U, Pham M, Raza Raja MH, Saad Shaukat MH, Clark R. Transient complete atrioventricular block associated with herbal supplement use. S D Med 2023;76(7):311-313.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC