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Dietary supplement

Sleep Sweetly Ingredients & Drug Interactions

by Pure Health Naturally

Capsule Category: Other Combinations
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Sleep Sweetly is a dietary supplement by Pure Health Naturally with 3 active ingredients. Its ingredients are commonly taken for sleep quality and insomnia, relaxation, cognitive function.Based on those ingredients, 436 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are GABA, Cyracos(R) Lemon Balm (Melissa officinalis) Extract, L-Glycine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Sleep Sweetly by Pure Health Naturally

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Sleep Sweetly contains three active ingredients. L-Glycine is an amino acid.

GABA (gamma-aminobutyric acid) is a neurotransmitter your brain uses naturally. Cyracos lemon balm extract is a standardized preparation from the melissa officinalis plant.

The capsule itself is vegetarian.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Supports rest and relaxation for healthy sleep.
  • We looked for evidence on: Insomnia, Anxiety, Stress, Psychological well-being, Sleep quality, Restlessness — and 1 related terms.
  • The strongest evidence on file: Lemon Balm is rated "Possibly Effective" for Stress (Natural Medicines).
  • Also on file: Lemon Balm is rated "Insufficient Reliable Evidence To Rate" for Anxiety, Insomnia.
  • Also on file: Gamma-aminobutyric Acid (gaba) is rated "Insufficient Reliable Evidence To Rate" for Anxiety, Insomnia, Post-traumatic stress disorder (PTSD), Psychological well-being.

The evidence for these ingredients is limited. L-Glycine shows possibly effective evidence for schizophrenia, but the data supporting its use for sleep is not established in our records.

GABA's effectiveness for anxiety and other conditions is rated insufficient evidence — meaning the science hasn't yet shown it works for those purposes. Lemon balm extract shows possibly effective evidence for cold sores, stress, and depression.

None of these ratings directly address sleep quality, so the overall effectiveness of this product for sleep is not supported by the data we hold.

The evidence, ingredient by ingredient Glycine Gamma-aminobutyric Acid (gaba) Lemon Balm

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-Glycine is generally well tolerated at typical doses, though long-term safety data are limited. Rarely, it may cause mild sedation, nausea, vomiting, or soft stools; these resolve quickly if you stop taking it.

GABA is often well tolerated short-term, but long-term safety isn't well studied — common side effects include drowsiness, nausea, muscle weakness, and throat irritation. Lemon balm extract is generally well tolerated for short-term use but long-term safety at high doses hasn't been studied.

It may cause dizziness and sedation, though studies show these don't occur more often than placebo. One rare case report linked a lemon-balm-containing product to heart rhythm changes, but other ingredients were involved so causality is unclear.

We have no pregnancy or breastfeeding safety data on file for any of these ingredients — talk with your doctor or pharmacist about whether it's appropriate for you.

Side effects, ingredient by ingredient Glycine Gamma-aminobutyric Acid (gaba) Lemon Balm

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — Lemon Balm, Gamma-aminobutyric Acid (gaba), Glycine.
  • The most serious interaction on file is rated Moderate.
  • For scale: 436 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take Sleep Sweetly, check with your pharmacist if you're on clozapine (Clozaril) — this is a Moderate-severity interaction. Also double-check if you take any blood pressure medications, thyroid hormones, or CNS depressants like sedatives, anti-anxiety drugs, or pain relievers.

Altogether, these interactions span 434 individual medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Sleep Sweetly combines ingredients with limited evidence for sleep support and several documented interactions with medications. If you take clozapine, blood pressure medications, thyroid hormones, or any sedating drugs, check with your pharmacist or doctor before starting this product.

Even if you're not on those medications, it's worth a quick conversation to make sure it's right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 23, 2014.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Sleep Sweetly, straight from the product label.

Brand Pure Health Naturally
Barcode (UPC) 812711013367
Net contents 30 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD May 23, 2014
DSLD ID 33404
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Sleep Sweetly by Pure Health Naturally, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
15
UPC/BARCODE
812711013367
IngredientAmount% DV
L-Glycine350 mg--
GABA100 mg--
Cyracos(R) Lemon Balm (Melissa officinalis) Extract300 mg--

Other ingredients: Vegetarian Capsule

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Pure Health's Sleep Sweetly: - Supports Rest & Relaxation* - Delivers Healthy Sleep Support*

Due to the natural and pure ingredients in this product, taste, color and consistency may vary.

Supports Rest & Relaxation

And Nothing Else!

Suggested/Recommended/Usage/Directions

Directions: Take 2 capsules 30 minutes before bed with a 10 oz. glass of water or as directed by your healthcare provider.

Precautions

Do not use if seal around cap is broken.

Keep out of reach of children.

Caution: Do not take if you are under 18, pregnant or trying to get pregnant or nursing.

Caution: Do not take if you are under 18, pregnant or trying to get pregnant or nursing.

Limit consumption to no more than 2 capsules daily.

FDA Disclaimer Statement

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Dietary Supplement

Formulation

- No Binders, Fillers or Excipients

Brand IP Statement(s)

Cyracos(R) is a registered trademark of Naturex, Inc.

Seals/Symbols

cyracos(R)

Formula

750 mg Per Serving!

General

LBPH089-A

See for yourself

Sleep Sweetly by Pure Health Naturally label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Sleep Sweetly by Pure Health Naturally

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container15 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

L-Glycine

Interacts with
1 drug
350 mg per serving

Glycine is a non-essential amino acid your body makes on its own and that also appears in protein-rich foods. It is most studied for improving sleep q...

L-Glycine monograph & interactions

GABA

Interacts with
419 drugs
100 mg per serving

GABA is a calming chemical messenger (neurotransmitter) that your body makes on its own, and it is sold as a supplement for stress, anxiety, and sleep...

GABA monograph & interactions
300 mg per serving

Lemon balm is a gentle, lemon-scented mint-family herb traditionally used to ease stress, support sleep, and calm digestion, and topically for cold so...

Cyracos(R) Lemon Balm (Melissa officinalis) Extract monograph & interactions

Other (inactive) ingredients: Vegetarian Capsule. These complete the product’s ingredient list but are not active constituents.

Interaction report

Sleep Sweetly by Pure Health Naturally Drug Interactions

Want to check YOUR meds against Sleep Sweetly?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
436Drugs
436 Moderate

Ingredients driving the most interactions

GABA 419

Each ingredient & the kinds of drugs it affects

For each ingredient in Sleep Sweetly with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

GABA2 drug types · 419 drugs

Antihypertensive Drugs

Theoretically, taking GABA with antihypertensive drugs might increase the risk of hypotension.
Some clinical research shows that GABA can decrease blood pressure in patients with hypertension.

Likelihood Possible Evidence B
Cns Depressants

Theoretically, GABA might have additive sedative effects when used in conjunction with CNS depressants. However, it is unclear if this concern is clinically relevant.
Endogenous GABA has well-established relaxant effects and GABA(A) receptors have an established physiological role in sleep. However, the effects of GABA supplements are unclear, as it is unknown whether exogenous GABA crosses the blood-brain barrier. Although there have been limited reports of drowsiness or tiredness with GABA supplements, these effects have not been widely reported in clinical studies. Additionally, intravenous GABA 0.1-1 mg/kg has been shown to induce anxiety in a dose-dependent manner.

Likelihood Unlikely Evidence D

Cyracos(R) Lemon Balm (Melissa officinalis) Extract2 drug types · 264 drugs

Cns Depressants

Theoretically, concomitant use of lemon balm might have additive effects with CNS depressant drugs.
Lemon balm seems to have CNS depressant activity in animals and in humans.

Likelihood Possible Evidence B
Thyroid Hormone

Theoretically, lemon balm might interfere with thyroid hormone replacement therapy.
In vitro, constituents of lemon balm extract bind to thyroid stimulating hormone (TSH), preventing TSH receptor-binding and leading to the inhibition of TSH-stimulated adenylate cyclase activity. In animals, lemon balm extract has been shown to decrease levels of circulating TSH and inhibit thyroid secretion.

Likelihood Possible Evidence D

L-Glycine1 drug type · 1 drug

Clozapine (Clozaril)

Theoretically, glycine might decrease the effectiveness of clozapine.
One small clinical study in patients with schizophrenia shows that adding glycine to clozapine therapy worsens symptoms of schizophrenia when compared with clozapine alone. The mechanism of this interaction is unclear.

Likelihood Probable Evidence B
The maker

Brand information

Manufacturer and brand details for Sleep Sweetly, from the product label.

Pure Health Naturally

See all Pure Health Naturally products
Name
Pure Health
Street Address
3753 Howard Hughes Parkway Suite 200, #428
City
Las Vegas
State
NV
ZipCode
89169
Phone Number
(888) 323-9355
Pharmacist Counseling Corner

Sleep Sweetly by Pure Health Naturally: Common Questions

Does Sleep Sweetly by Pure Health Naturally interact with any medications?
Yes. Based on its ingredients, Sleep Sweetly has a known interaction with 436 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Sleep Sweetly contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is GABA in this product the same as the GABA my brain makes?
GABA is the same neurotransmitter your brain produces naturally. However, the effects of GABA supplements are less clear than the effects of endogenous GABA — whether oral GABA actually reaches your brain and works the way your natural GABA does isn't fully established.
Can I take this if I'm on thyroid medication?
The lemon balm extract in this product may interfere with thyroid hormone replacement therapy. Talk with your pharmacist or doctor before adding this product if you take thyroid hormones — they can help you decide if it's safe for you specifically.
What side effects might I notice?
The most common are drowsiness, nausea, and gastrointestinal upset. Rarely, you might experience mild sedation, dizziness, muscle weakness, headache, or memory effects — if these occur and bother you, stop taking it and they should resolve quickly.
Is it okay to take this with my blood pressure medication?
No — not without checking first. GABA in this product may increase the blood-pressure-lowering effect of your medication, which could cause your blood pressure to drop too low. Talk with your pharmacist or doctor before you start.
What's lemon balm extract doing in a sleep product?
Lemon balm appears to have calming and sleep-supporting properties — it's been shown to have CNS depressant activity in both animals and humans. The extract in this product is a standardized form called Cyracos.
Is this safe during pregnancy or while breastfeeding?
We don't have enough safety data on file for any of these ingredients in pregnancy or breastfeeding. Talk with your doctor or pharmacist before using this product if you're pregnant, planning to become pregnant, or breastfeeding — they can give you personalized advice.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Sleep Sweetly is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Sleep Sweetly label
Sources

Sources & How We Checked

Sleep Sweetly's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 29 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glycine 5 references
  1. Heresco-Levy U, Javitt DC, Ermilov M, et al. Efficacy of high-dose glycine in the treatment of enduring negative symptoms of schizophrenia. Arch Gen Psychiatry 1999;56:29-36.. PubMed
  2. Potkin SG, Jin Y, Bunney BG, Costa J, Gulasekaram B. Effect of clozapine and adjunctive high-dose glycine in treatment-resistant schizophrenia. Am J Psychiatry 1999;156:145-7.. PubMed
  3. Gusev EI, Skvortsova VI, Dambinova SA, et al. Neuroprotective effects of glycine for therapy of acute ischaemic stroke. Cerebrovasc Dis 2000;10:49-60. PubMed
  4. Inagawa K, Kawai N, Ono K, Sukegawa E, Tsubuku S, Takahashi M. Assessment of acute adverse effects of glycine ingestion at a high dose in human volunteers. Seikatsu Eisei. 2006; 50:27-32.
  5. Woods SW, Walsh BC, Hawkins KA, Miller TJ, Saksa JR, D'Souza DC, Pearlson GD, Javitt DC, McGlashan TH, Krystal JH. Glycine treatment of the risk syndrome for psychosis: report of two pilot studies. Eur Neuropsychopharmacol. 2013 Aug;23(8):931-40. PubMed

See these in context on the Glycine monograph →

Gamma-aminobutyric Acid (gaba) 12 references
  1. Cavagnini F, Invitti C, Pinto M, et al. Effect of acute and repeated administration of gamma aminobutyric acid (GABA) on growth hormone and prolactin secretion in man. Acta Endocrinol (Copenh) 1980;93:149-54.
  2. Nurnberger JI Jr, Berrettini WH, Simmons-Alling S, et al. Intravenous GABA administration is anxiogenic in man. Psychiatry Res 1986;19:113-7. PubMed
  3. Gershman RN, Vasilenko MA, Iliushina GG, et al. [Gammalon in the rehabilitation in infantile cerebral palsy]. Pediatr.Akus.Ginekol. 1977;(6):26-7.
  4. Loeb C, Benassi E, Bo, GP, et al. Preliminary evaluation of the effect of GABA and phosphatidylserine in epileptic patients. Epilepsy Res. 1987;1:209-12 . PubMed
  5. Inoue K, Shirai T, Ochiai H, et al. Blood-pressure-lowering effect of a novel fermented milk containing gamma-aminobutyric acid (GABA) in mild hypertensives. Eur J Clin Nutr 2003;57:490-95.
  6. ELLIOTT, K. A. and JASPER, H. H. Gammaaminobutyric acid. Physiol Rev. 1959;39(2):383-406.
  7. Winsky-Sommerer, R. Role of GABAA receptors in the physiology and pharmacology of sleep. Eur.J.Neurosci. 2009;29(9):1779-1794.
  8. Meldrum, B. S. GABAergic mechanisms in the pathogenesis and treatment of epilepsy. Br.J.Clin.Pharmacol. 1989;27 Suppl 1:3S-11S. PubMed
  9. Loeb, C., Marinari, U. M., Benassi, E., Besio, G., Cottalasso, D., Cupello, A., Maffini, M., Mainardi, P., Pronzato, M. A., and Scotto, P. A. Phosphatidylserine increases in vivo the synaptosomal uptake of exogenous GABA in rats. Exp.Neurol. 1988;99(2):4 PubMed
  10. Melis, G. B., Paoletti, A. M., Mais, V., and Fioretti, P. Interference of dopamine infusion on gamma-amino butyric acid (GABA)-stimulated prolactin increase. J.Endocrinol.Invest 1980;3(4):445-448.
  11. Boonstra E, de Kleijn R, Colzato LS, Alkemade A, Forstmann BU, Nieuwenhuis S. Neurotransmitters as food supplements: the effects of GABA on brain and behavior. Front Psychol. 2015 Oct 6;6:1520. doi: 10.3389/fpsyg.2015.01520. eCollection 2015. PubMed
  12. de Bie TH, Witkamp RF, Balvers MG, Jongsma MA. Effects of ?-aminobutyric acid supplementation on glucose control in adults with prediabetes: A double-blind, randomized, placebo-controlled trial. Am J Clin Nutr 2023;118(3):708-719. PubMed

See these in context on the Gamma-aminobutyric Acid (gaba) monograph →

Lemon Balm 12 references
  1. Wolbling RH, Leonhardt K. Local therapy of herpes simplex with dried extract from Melissa officinalis. Phytomedicine 1994;1:25-31.
  2. Akhondzadeh S, Noroozian M, Mohammadi M, et al. Melissa officinalis extract in the treatment of patients with mild to moderate Alzheimer's disease: a double blind, randomised, placebo controlled trial. J Neurol Neurosurg Psychiatry 2003;74:863-6. PubMed
  3. Kennedy DO, Scholey AB, Tildesley NT, et al. Modulation of mood and cognitive performance following acute administration of Melissa officinalis (lemon balm). Pharmacol Biochem Behav 2002;72:953-64. PubMed
  4. Albrecht M, Berger W, Laux P, Schmidt U, et al. Psychopharmaka und Verkehrssicherheit. Der Einfluß von Euvegal® - Dragees forte auf die Fahrtüchtigkeit und Kombinationswirkungen mit Alkohol Z Allg Med 1995;71:1215-25.
  5. Herberg, KW. Nebenwirkungen pflanzlicher Beruhigungsmittel/ Leistung und Befinden nach Einnahme einer Baldrian-Hopfen-Kombination. Z.Allg Med 1996;72:234-240.
  6. Soulimani R, Fleurentin J, Mortier F, et al. Neurotropic action of the hydroalcoholic extract of Melissa officinalis in the mouse. Planta Med. 1991 Apr;57:105-9.
  7. Sourgens H, Winterhoff H, Gumbinger HG, et al. Antihormonal effects of plant extracts. TSH- and prolactin-suppressing properties of Lithospermum officinale and other plants. Planta Med. 1982 Jun;45:78-86. DOI
  8. Auf'mkolk M, Ingbar JC, Amir SM, et al. Inhibition by certain plant extracts of the binding and adenylate cyclase stimulatory effect of bovine thyrotropin in human thyroid membranes. Endocrinology. 1984 Aug;115:527-34. PubMed
  9. Santini F, Vitti P, Ceccarini G, et al. In vitro assay of thyroid disruptors affecting TSH-stimulated adenylate cyclase activity. J Endocrinol Invest. 2003 Oct;26:950-5. PubMed
  10. Alijaniha F, et al. Heart palpitation relief with Melissa officinalis leaf extract: double blind, randomized, placebo controlled trial of efficacy and safety. J Ethnopharmacol. 2015;164:378-384. doi: 10.1016/j.jep.2015.02.007. Epub 2015 Feb 11. PubMed
  11. Araj-Khodaei M, Noorbala AA, Yarani R, et al. A double-blind, randomized pilot study for comparison of Melissa officinalis L. and Lavandula angustifolia Mill. with Fluoxetine for the treatment of depression. BMC Complement Med Ther. 2020;20(1):207. PubMed
  12. Kucuk U, Pham M, Raza Raja MH, Saad Shaukat MH, Clark R. Transient complete atrioventricular block associated with herbal supplement use. S D Med 2023;76(7):311-313.

See these in context on the Lemon Balm monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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