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Dietary supplement

Magnolia Bark Ingredients & Drug Interactions

by Samsara Herbs

Magnolia Bark label
See full label image
Powder Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Magnolia Bark against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Magnolia Bark is a dietary supplement by Samsara Herbs with 1 active ingredient. Its ingredients are commonly taken for anxiety and stress, sleep problems, digestive upset.Based on those ingredients, 351 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Magnolia. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Magnolia Bark by Samsara Herbs

Ask about any prescription or over-the-counter medication and we check it for interactions with Magnolia Bark by Samsara Herbs — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Magnolia Bark by Samsara Herbs

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 20, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: magnolia bark powder. Magnolia has been used traditionally for centuries and contains active compounds called honokiol and magnolol, which research suggests may have calming and anti-inflammatory properties.

There are no inactive fillers listed for this product.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: support healthy digestion and respiration.
  • We looked for evidence on: gastrointestinal health, respiratory function.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

The data shows magnolia bark is possibly effective for gingivitis (gum inflammation). For other uses — anxiety, hay fever, and dental plaque — there isn't enough reliable evidence in our records to rate how well it works.

If you're considering it for one of those purposes, talk with your doctor about whether the current evidence is strong enough for your situation.

The evidence, ingredient by ingredient Magnolia

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Magnolia seems to be well tolerated when taken by mouth in the short term, though human safety data is limited. Topically, it can cause contact dermatitis in some people.

In clinical trials, a small number of participants reported side effects like sexual dysfunction, hand shaking, numbness around the mouth, fatigue, and headache, though it's unclear whether magnolia itself was responsible. Magnolia is not recommended in pregnancy because safety data suggests it may affect the uterus.

There isn't enough safety information for breastfeeding, so it's best avoided while nursing. Talk with your doctor or pharmacist if you're pregnant, planning pregnancy, or breastfeeding before taking this product.

Side effects, ingredient by ingredient Magnolia

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Magnolia.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 351 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before taking this product if you take blood thinners or antiplatelet drugs (like warfarin, aspirin, or clopidogrel) — magnolia may increase bleeding risk. Also double-check if you take any CNS depressants, such as benzodiazepines, sleep aids, or opioids, because magnolia could add to their drowsy effects.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Magnolia bark may be worth considering if you're dealing with gingivitis and want to explore herbal options — just know the evidence is modest. Because it can interact with blood thinners and sedating medications, check your prescriptions before starting.

If you're pregnant or breastfeeding, this one isn't recommended. Talk with your doctor or pharmacist about whether it's right for you and your medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 22, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Magnolia Bark, straight from the product label.

Brand Samsara Herbs
Barcode (UPC) X00107A7O7
Net contents 8 Ounce(s); 227 Gram(s)
Market status On market
Date entered into DSLD May 22, 2020
DSLD ID 220778
Product type Botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Magnolia Bark by Samsara Herbs, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.3 Gram(s)
Maximum serving Sizes:
0.3 Gram(s)
Servings per container
756
UPC/BARCODE
X00107A7O7
IngredientAmount% DV
Magnolia300 mg--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Magnolia Bark (60% Honokiol, 25% Magnolol extract)

Description Magnolia Bark has been used for over 2,000 years in Traditional Chinese Medicine to treat a wide range of hearth issues. Its active ingredients, Honokiol and Magnolol, are believed to support healthy digestion and respiration, regulate hormonal health and support normal stress levels.

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

GMP Good Manufacturing Practice USA Tested 3rd party USA tested

General Statements

About us At Samsara Herbs, we believe that all positive change in the world must first begin with positive change from within. We invite you to tap into your own infinite power through the use of our potent herbal extracts! We seek out only quality herbs from our trusted sources from around the world for use in our herbal extracts. Samsara Herbs, dedicated to empowering your life force!

Formulation

Standardized herbal extracts contain isolated herbal compounds, in guaranteed amounts. Often having the prevalent compound found in an herb, in a significantly higher concentration than found in nature.

Suggested/Recommended/Usage/Directions

Our water soluble herbal extracts are best mixed in juice or a smoothie, although mixing in water is perfectly fine if you can tolerate the taste.

Suggested Use: Take 1 Scoop 1-3 times per day or as recommended by your health care professional.

Storage

Storage Cool dry place, out of direct sunlight.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Precautions

Caution: If you have a medical condition, are pregnant or taking medications, consult your hearth care professional before using this product.

Keep out of reach of children.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Magnolia Bark by Samsara Herbs label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Magnolia Bark label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Magnolia Bark by Samsara Herbs

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size0.3 Gram(s) Dosage formPowder Servings per container756 Amounts shown are per serving.

Magnolia

Interacts with
351 drugs
300 mg per serving Form: Honokiol, Magnolol

Magnolia bark and flower buds have a long history in traditional Chinese and Japanese medicine, often for stress, sleep, and digestion. Modern human r...

Magnolia monograph & interactions
Interaction report

Magnolia Bark by Samsara Herbs Drug Interactions

Want to check YOUR meds against Magnolia Bark?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
351Drugs
351 Moderate

Ingredients driving the most interactions

Magnolia 351

Individual Drug Interactions

The ingredients in Magnolia Bark interact with 351 drugs. Click any drug to see the details.

1 of the 1 ingredient in Magnolia Bark interact with drugs. Each result below shows which ingredient is responsible. Magnolia

Each ingredient & the kinds of drugs it affects

For each ingredient in Magnolia Bark with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Magnolia2 drug types · 351 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, magnolia might have additive effects and increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
In vitro research shows that the chemicals magnolol and honokiol, isolated from magnolia bark, inhibit platelet aggregation that is experimentally induced by collagen and arachidonic acid. However, they do not inhibit platelet aggregation that is induced by adenosine diphosphate, platelet-activating factor, or thrombin. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, concomitant use of large doses of magnolia bark and CNS depressants might have additive effects.
In vitro and animal research shows that constituents extracted from magnolia bark, especially honokiol and magnolol, have sedative effects. These effects may be due to the inhibition of catecholamine release and modulation of gamma-aminobutyric acid-A (GABA-A) receptors.

Likelihood Possible Evidence D
Magnolia full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Magnolia Bark, from the product label.

Samsara Herbs

See all Samsara Herbs products
Name
Aspen Copacking
Street Address
810 North 2800 West
City
Lindon
State
Utah
ZipCode
84042
Pharmacist Counseling Corner

Magnolia Bark by Samsara Herbs: Common Questions

Does Magnolia Bark by Samsara Herbs interact with any medications?
Yes. Based on its ingredients, Magnolia Bark has a known interaction with 351 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Magnolia Bark contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take magnolia bark if I'm pregnant or breastfeeding?
No, magnolia is not recommended in pregnancy because safety data suggests it may affect the uterus. There isn't enough safety information for breastfeeding either, so it's best avoided while nursing. Talk with your doctor or pharmacist before taking it in either situation.
What does magnolia bark actually do?
The evidence shows magnolia is possibly effective for gingivitis (inflamed gums). For anxiety, hay fever, and dental plaque, we don't have enough reliable data yet to say whether it works.
Is this powder pure magnolia, or does it have fillers?
This product contains magnolia bark powder with no inactive fillers listed.
What side effects might I experience?
When taken by mouth, magnolia is generally well tolerated. If you apply it topically, contact dermatitis (skin irritation) can happen. In clinical trials, a small number of people reported sexual dysfunction, hand tremors, numbness around the mouth, fatigue, and headache, though it's unclear if magnolia caused these.
Will magnolia make me drowsy?
Lab research shows magnolia's active compounds have sedative effects. If you take sedating medications already — like sleep aids, benzodiazepines, or opioids — combining them could increase drowsiness. That's a Moderate interaction, so check with your doctor or pharmacist first.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Magnolia Bark is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Magnolia Bark label
Go deeper

The Full Monographs Behind Magnolia Bark’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Magnolia

Interacts with 351 drugs

Magnolia bark and flower buds have a long history in traditional Chinese and Japanese medicine, often for stress, sleep, and digestion. Modern human research is still limited, so we can't be...

Read the full Magnolia monograph →
Sources

Sources & How We Checked

Magnolia Bark's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 9 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Magnolia 9 references
  1. Kuribara H, Kishi E, Hattori N, et al. The anxiolytic effect of two oriental herbal drugs in Japan attributed to honokiol from magnolia bark. J Pharm Pharmacol 2000;52:1425-9. PubMed
  2. Tachikawa E, Takahashi M, Kashimoto T. Effects of extract and ingredients isolated from Magnolia obovata thunberg on catecholamine secretion from bovine adrenal chromaffin cells. Biochem Pharmacol 2000;60:433-40. PubMed
  3. Jung KY, Kim DS, Oh SR, et al. Magnone A and B, novel anti-PAF tetrahydrofuran lignans from the flower buds of Magnolia fargesii. J Nat Prod 1998;61:808-11.
  4. Garrison R, Chambliss WG. Effect of a proprietary Magnolia and Phellodendron extract on weight management: a pilot, double-blind, placebo-controlled clinical trial. Altern Ther Health Med 2006;12:50-4.
  5. Teng CM, Chen CC, Ko FN, et al. Two antiplatelet agents from Magnolia officinalis. Thromb Res 1988;50:757-65. PubMed
  6. Ghys K, De Palma A, Vandevenne A, Werbrouck J, Goossens A. Magnolia officinalis bark extract, a recently identified contact allergen in 'anti-ageing' cosmetics. Contact Dermatitis. 2015 Aug;73(2):130-2.
  7. Raison-Peyron N, Césaire A, Du-Thanh A, Dereure O. Allergic contact dermatitis caused by Magnolia officinalis bark extract in a facial anti-ageing cream. Contact Dermatitis. 2015 Jun;72(6):416-7.
  8. Nilausen TD, Johansen JD, Thyssen JP. Allergic contact dermatitis of the face caused by Magnolia officinalis bark extract. Contact Dermatitis. 2016;75(6):385-87.
  9. Amat-Samaranch V, López-Sánchez C, Tubau C, Puig L, Serra-Baldrich E. Vulvar allergic contact dermatitis caused by Magnolia officinalis bark extract. Contact Dermatitis 2022;87(1):96-97.

See these in context on the Magnolia monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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