Magnolia Flower Teapills Ingredients & Drug Interactions
by Plum Flower
What is this page for?
First and foremost: checking Magnolia Flower Teapills against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Magnolia Flower Teapills is a dietary supplement by Plum Flower with 9 active ingredients. Its ingredients are commonly taken for sore throat and cough, heartburn and stomach upset, mouth ulcers and digestive complaints.Based on those ingredients, 1,388 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Glycyrrhiza uralensis Root Extract, Cimicifuga heracleifolia Rhizome Extract, Magnolia biondii Flower Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Magnolia Flower Teapills by Plum Flower
Ask about any prescription or over-the-counter medication and we check it for interactions with Magnolia Flower Teapills by Plum Flower — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Magnolia Flower Teapills by Plum Flower
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
Magnolia Flower Teapills contains 9 ingredients, including a proprietary extract blend. The active ingredients are licorice root extract, magnolia flower extract, black cohosh rhizome extract, and angelica, lovage, saposhnikovia, and notopterygium extracts.
The product also contains inactive ingredients (dextrin, magnesium silicate, activated carbon, and china wax) used as fillers and binders.
Does it work?
Moderate evidence
Licorice root extract is possibly effective for atopic dermatitis (eczema) and canker sores, though evidence is limited. Magnolia flower is possibly effective for gingivitis.
Black cohosh is possibly effective for menopausal symptoms. The other ingredients and most other uses listed — like asthma, anxiety, allergic rhinitis, and dental plaque — lack sufficient reliable evidence in the data we hold to establish whether they work.
How safe is it?
Well-documented data
Licorice root is generally well tolerated in small food amounts, but at higher doses or with long-term use, the compound glycyrrhizin can cause serious problems. The most common side effects from licorice are headache, nausea, and vomiting; contact dermatitis can occur with topical use.
Avoid licorice in pregnancy because glycyrrhizin has been linked to harmful effects, and there isn't enough safety data for breastfeeding — talk with your doctor. Magnolia flower extract is well tolerated orally, though human safety data is limited.
It should be avoided in pregnancy and breastfeeding due to insufficient data and concerns about effects on the uterus. Black cohosh is generally well tolerated short-term at typical doses, but rare liver concerns warrant medical guidance.
Common side effects include breast tenderness, dizziness, headache, gastrointestinal upset, and tiredness. Avoid in pregnancy and breastfeeding — safety has not been established.
Meds to double-check
Moderate interaction found
Before you start, double-check with a pharmacist if you take heart medications like digoxin; blood thinners or antiplatelet drugs like warfarin or aspirin; water pills (loop diuretics); drugs processed by your liver (including statins, sedatives, and many cancer treatments); antidepressants or other mood medications; or estrogen therapy. No interactions are documented for several of the herbal extracts in this blend, but we hold no safety data for them either.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.
If you have no prescription medications or are taking only those unrelated to heart function, blood thinning, liver health, or mood, this product may be worth discussing with your pharmacist. Anyone on digoxin, blood thinners like warfarin, loop diuretics, statins, antidepressants, cancer drugs, or sedatives should check their exact medications against the interaction tool before starting.
Pregnant or breastfeeding women should not use this product.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 4 of 9 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 24, 2024.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Magnolia Flower Teapills, straight from the product label.
| Brand | Plum Flower |
|---|---|
| Barcode (UPC) | 739934833155 |
| Net contents | 200 Pill(s) |
| Market status | On market |
| Date entered into DSLD | Oct 24, 2024 |
| DSLD ID | 310579 |
| Product type | Botanical |
| Supplement form | Tablet Or Pill |
| Dietary claims / uses | All Other |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Magnolia Flower Teapills by Plum Flower, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Proprietary Extract Blend | 1360 mg | -- |
| Glycyrrhiza uralensis Root Extract | 0 NP | -- |
| Angelica dahurica Root Extract | 0 NP | -- |
| Ligusticum chuanxiong Rhizome Extract | 0 NP | -- |
| Saposhnikovia divaricata Root Extract | 0 NP | -- |
| Magnolia biondii Flower Extract | 0 NP | -- |
| Cimicifuga heracleifolia Rhizome Extract | 0 NP | -- |
| Ligusticum sinense Rhizome, Root Extract | 0 NP | -- |
| Akebia trifoliata Stem Extract | 0 NP | -- |
| Notopterygium incisum Rhizome, Root Extract | 0 NP | -- |
Other ingredients: Dextrin, Magnesium Silicate, Hydrated, Carbon, Activated, China Wax
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity
Herbal Supplement
Suggested/Recommended/Usage/Directions
Take 8 pills 3 times daily or as directed by your health care practitioner
Precautions
Caution during pregnancy
Keep out of reach of children
Formulation
US owned & operated since 1969. Made in China in partnership with the award-winning Lanzhou Foci Pharmaceutical Co. Ltd. Plum Flower Quality Guarantee Scientifically authenticated herbs Produced at a Good Manufacturing Practices (GMP) certified factory
No pharmaceuticals or dyes Unsulfured preservative-free herbs when available Microbial and heavy metal tested
Formula
Xin Yi Wan
General Statements
Foci Pharmaceutical 1929
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Magnolia Flower Teapills by Plum Flower label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Magnolia Flower Teapills by Plum Flower
These are the 9 active ingredients this product is made of. Select any to open its full monograph.
Serving size8 Pill(s) Dosage formTablet Or Pill Servings per container25 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Proprietary Extract Blend
- › Glycyrrhiza uralensis Root Extract
- › Angelica dahurica Root Extract
- › Ligusticum chuanxiong Rhizome Extract
- › Saposhnikovia divaricata Root Extract
- › Magnolia biondii Flower Extract
- › Cimicifuga heracleifolia Rhizome Extract
- › Ligusticum sinense Rhizome, Root Extract
- › Akebia trifoliata Stem Extract
- › Notopterygium incisum Rhizome, Root Extract
Other (inactive) ingredients: Dextrin, Magnesium Silicate, Hydrated, Carbon, Activated, China Wax. These complete the product’s ingredient list but are not active constituents.
Magnolia Flower Teapills by Plum Flower Drug Interactions
HelloPharmacist Interaction Report
Magnolia Flower Teapills by Plum Flower contains several ingredients with documented interactions.
The most serious concern is licorice root extract, which has Moderate-severity interactions with a heart medication (digoxin). Licorice can theoretically increase the risk of heart toxicity when combined with digoxin, especially if misused or taken in high doses over time.
Read the full breakdown — every affected drug type, severity by severity
Licorice also interacts with blood thinners like warfarin — it may actually reduce how well warfarin works by speeding up how your body clears it, which could lower your protection against clots. It similarly affects drugs broken down by your liver's CYP2B6, CYP2C19, and other enzyme systems (Moderate severity).
Additionally, licorice has Moderate interactions with loop diuretics (water pills), midazolam (a sedative), and certain cancer drugs like cisplatin and paclitaxel.
Magnolia flower extract carries Moderate interactions with blood thinners and antiplatelet drugs — it may increase bleeding risk. It also has Moderate interactions with CNS depressants (sleeping pills, sedatives, alcohol), which could add up to too much drowsiness.
Black cohosh rhizome extract has Moderate interactions with several drug types: liver-toxic medications, liver-statin drugs like atorvastatin, estrogen therapy, serotonin-boosting antidepressants (with rare risk of serotonin syndrome), cancer drugs, and a Minor interaction with certain transporter substrates. We could not check Angelica dahurica, Ligusticum chuanxiong, Saposhnikovia divaricata, Ligusticum sinense, Akebia trifoliata, or Notopterygium incisum for interactions.
Altogether, these interactions span 1,367 individual medications. Check your exact prescriptions with the tool on this page before starting.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Magnolia Flower Teapills?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Magnolia Flower Teapills interact with 1,388 drugs. Click any drug to see the details.
4 of the 9 ingredients in Magnolia Flower Teapills interact with drugs. Each result below shows which ingredient is responsible. Glycyrrhiza uralensis Root Extract Cimicifuga heracleifolia Rhizome Extract Magnolia biondii Flower Extract Angelica dahurica Root Extract
6-mercaptopurinePurinethol
How 6-mercaptopurine interacts with Magnolia Flower Teapills — through 1 ingredient. Tap an ingredient for the detail:
Cimicifuga Heracleifolia Rhizome ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking black cohosh with hepatotoxic drugs may increase the risk of liver damage.
Read the full Cimicifuga Heracleifolia Rhizome Extract + 6-mercaptopurine interactionAdo-trastuzumab EmtansineKadcyla
How Ado-trastuzumab Emtansine interacts with Magnolia Flower Teapills — through 1 ingredient. Tap an ingredient for the detail:
Glycyrrhiza Uralensis Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, licorice might increase or decrease levels of drugs metabolized by CYP3A4.
Read the full Glycyrrhiza Uralensis Root Extract + Ado-trastuzumab Emtansine interactionAbacavir Sulfate, Dolutegravir, LamivudineTriumeq
How Abacavir Sulfate, Dolutegravir, Lamivudine interacts with Magnolia Flower Teapills — through 1 ingredient. Tap an ingredient for the detail:
Cimicifuga Heracleifolia Rhizome ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking black cohosh with hepatotoxic drugs may increase the risk of liver damage.
Read the full Cimicifuga Heracleifolia Rhizome Extract + Abacavir Sulfate, Dolutegravir, Lamivudine interactionAbacavir, LamivudineEpzicom
How Abacavir, Lamivudine interacts with Magnolia Flower Teapills — through 1 ingredient. Tap an ingredient for the detail:
Cimicifuga Heracleifolia Rhizome ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking black cohosh with hepatotoxic drugs may increase the risk of liver damage.
Read the full Cimicifuga Heracleifolia Rhizome Extract + Abacavir, Lamivudine interactionAbciximabReoPro
How Abciximab interacts with Magnolia Flower Teapills — through 1 ingredient. Tap an ingredient for the detail:
Magnolia Biondii Flower ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, magnolia might have additive effects and increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Magnolia Biondii Flower Extract + Abciximab interactionAbemaciclibVerzenio
How Abemaciclib interacts with Magnolia Flower Teapills — through 1 ingredient. Tap an ingredient for the detail:
Glycyrrhiza Uralensis Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, licorice might increase or decrease levels of drugs metabolized by CYP3A4.
Read the full Glycyrrhiza Uralensis Root Extract + Abemaciclib interactionAbiraterone
How Abiraterone interacts with Magnolia Flower Teapills — through 2 ingredients. Tap an ingredient for the detail:
Glycyrrhiza Uralensis Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, licorice might increase or decrease levels of drugs metabolized by CYP3A4.
Read the full Glycyrrhiza Uralensis Root Extract + Abiraterone interactionCimicifuga Heracleifolia Rhizome ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking black cohosh with hepatotoxic drugs may increase the risk of liver damage.
Read the full Cimicifuga Heracleifolia Rhizome Extract + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with Magnolia Flower Teapills — through 2 ingredients. Tap an ingredient for the detail:
Cimicifuga Heracleifolia Rhizome ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking black cohosh with hepatotoxic drugs may increase the risk of liver damage.
Read the full Cimicifuga Heracleifolia Rhizome Extract + Abiraterone Acetate interactionGlycyrrhiza Uralensis Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, licorice might increase or decrease levels of drugs metabolized by CYP3A4.
Read the full Glycyrrhiza Uralensis Root Extract + Abiraterone Acetate interactionAbrocitinibCibinqo
How Abrocitinib interacts with Magnolia Flower Teapills — through 2 ingredients. Tap an ingredient for the detail:
Magnolia Biondii Flower ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, magnolia might have additive effects and increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Magnolia Biondii Flower Extract + Abrocitinib interactionGlycyrrhiza Uralensis Root ExtractCytochrome P450 2c19 (cyp2c19) Substrates, Cytochrome P450 2c9 (cyp2c9) Substrates Moderate
Interaction Summary
Theoretically, licorice might increase levels of drugs metabolized by CYP2C19.
Read the full Glycyrrhiza Uralensis Root Extract + Abrocitinib interactionAcalabrutinibCalquence
How Acalabrutinib interacts with Magnolia Flower Teapills — through 1 ingredient. Tap an ingredient for the detail:
Glycyrrhiza Uralensis Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates, P-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, licorice might increase or decrease levels of drugs metabolized by CYP3A4.
Read the full Glycyrrhiza Uralensis Root Extract + Acalabrutinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Magnolia Flower Teapills — through 1 ingredient. Tap an ingredient for the detail:
Cimicifuga Heracleifolia Rhizome ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking black cohosh with hepatotoxic drugs may increase the risk of liver damage.
Read the full Cimicifuga Heracleifolia Rhizome Extract + Acarbose interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Magnolia Flower Teapills — through 2 ingredients. Tap an ingredient for the detail:
Cimicifuga Heracleifolia Rhizome ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking black cohosh with hepatotoxic drugs may increase the risk of liver damage.
Read the full Cimicifuga Heracleifolia Rhizome Extract + Acebutolol interactionGlycyrrhiza Uralensis Root ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, licorice might reduce the effects of antihypertensive drugs.
Read the full Glycyrrhiza Uralensis Root Extract + Acebutolol interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Magnolia Flower Teapills — through 1 ingredient. Tap an ingredient for the detail:
Magnolia Biondii Flower ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, magnolia might have additive effects and increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Magnolia Biondii Flower Extract + Acenocoumarol interactionAcepromazineAtravet
How Acepromazine interacts with Magnolia Flower Teapills — through 1 ingredient. Tap an ingredient for the detail:
Magnolia Biondii Flower ExtractCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of large doses of magnolia bark and CNS depressants might have additive effects.
Read the full Magnolia Biondii Flower Extract + Acepromazine interactionAcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength
How Acetaminophen interacts with Magnolia Flower Teapills — through 3 ingredients. Tap an ingredient for the detail:
Angelica Dahurica Root ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
In vitro research shows that ashitaba extract inhibits cytochrome P450 (CYP) 1A2.
Read the full Angelica Dahurica Root Extract + Acetaminophen interactionCimicifuga Heracleifolia Rhizome ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking black cohosh with hepatotoxic drugs may increase the risk of liver damage.
Read the full Cimicifuga Heracleifolia Rhizome Extract + Acetaminophen interactionGlycyrrhiza Uralensis Root ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, licorice might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Glycyrrhiza Uralensis Root Extract + Acetaminophen interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Magnolia Flower Teapills — through 4 ingredients. Tap an ingredient for the detail:
Cimicifuga Heracleifolia Rhizome ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking black cohosh with hepatotoxic drugs may increase the risk of liver damage.
Read the full Cimicifuga Heracleifolia Rhizome Extract + Acetaminophen, Aspirin interactionMagnolia Biondii Flower ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, magnolia might have additive effects and increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Magnolia Biondii Flower Extract + Acetaminophen, Aspirin interactionAngelica Dahurica Root ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
In vitro research shows that ashitaba extract inhibits cytochrome P450 (CYP) 1A2.
Read the full Angelica Dahurica Root Extract + Acetaminophen, Aspirin interactionGlycyrrhiza Uralensis Root ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, licorice might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Glycyrrhiza Uralensis Root Extract + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Magnolia Flower Teapills — through 4 ingredients. Tap an ingredient for the detail:
Angelica Dahurica Root ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
In vitro research shows that ashitaba extract inhibits cytochrome P450 (CYP) 1A2.
Read the full Angelica Dahurica Root Extract + Acetaminophen, Aspirin, Caffeine interactionCimicifuga Heracleifolia Rhizome ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking black cohosh with hepatotoxic drugs may increase the risk of liver damage.
Read the full Cimicifuga Heracleifolia Rhizome Extract + Acetaminophen, Aspirin, Caffeine interactionGlycyrrhiza Uralensis Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, licorice might increase or decrease levels of drugs metabolized by CYP3A4.
Read the full Glycyrrhiza Uralensis Root Extract + Acetaminophen, Aspirin, Caffeine interactionMagnolia Biondii Flower ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, magnolia might have additive effects and increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Magnolia Biondii Flower Extract + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with Magnolia Flower Teapills — through 3 ingredients. Tap an ingredient for the detail:
Cimicifuga Heracleifolia Rhizome ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking black cohosh with hepatotoxic drugs may increase the risk of liver damage.
Read the full Cimicifuga Heracleifolia Rhizome Extract + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAngelica Dahurica Root ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
In vitro research shows that ashitaba extract inhibits cytochrome P450 (CYP) 1A2.
Read the full Angelica Dahurica Root Extract + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionGlycyrrhiza Uralensis Root ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, licorice might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Glycyrrhiza Uralensis Root Extract + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more
How Acetaminophen, Butalbital interacts with Magnolia Flower Teapills — through 3 ingredients. Tap an ingredient for the detail:
Angelica Dahurica Root ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
In vitro research shows that ashitaba extract inhibits cytochrome P450 (CYP) 1A2.
Read the full Angelica Dahurica Root Extract + Acetaminophen, Butalbital interactionCimicifuga Heracleifolia Rhizome ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking black cohosh with hepatotoxic drugs may increase the risk of liver damage.
Read the full Cimicifuga Heracleifolia Rhizome Extract + Acetaminophen, Butalbital interactionGlycyrrhiza Uralensis Root ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, licorice might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Glycyrrhiza Uralensis Root Extract + Acetaminophen, Butalbital interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Magnolia Flower Teapills — through 3 ingredients. Tap an ingredient for the detail:
Glycyrrhiza Uralensis Root ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, licorice might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Glycyrrhiza Uralensis Root Extract + Acetaminophen, Butalbital, Caffeine interactionCimicifuga Heracleifolia Rhizome ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking black cohosh with hepatotoxic drugs may increase the risk of liver damage.
Read the full Cimicifuga Heracleifolia Rhizome Extract + Acetaminophen, Butalbital, Caffeine interactionAngelica Dahurica Root ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
In vitro research shows that ashitaba extract inhibits cytochrome P450 (CYP) 1A2.
Read the full Angelica Dahurica Root Extract + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Magnolia Flower Teapills — through 4 ingredients. Tap an ingredient for the detail:
Glycyrrhiza Uralensis Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, licorice might increase or decrease levels of drugs metabolized by CYP3A4.
Read the full Glycyrrhiza Uralensis Root Extract + Acetaminophen, Butalbital, Caffeine, Codeine interactionCimicifuga Heracleifolia Rhizome ExtractHepatotoxic Drugs, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, taking black cohosh with hepatotoxic drugs may increase the risk of liver damage.
Read the full Cimicifuga Heracleifolia Rhizome Extract + Acetaminophen, Butalbital, Caffeine, Codeine interactionAngelica Dahurica Root ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
In vitro research shows that ashitaba extract inhibits cytochrome P450 (CYP) 1A2.
Read the full Angelica Dahurica Root Extract + Acetaminophen, Butalbital, Caffeine, Codeine interactionMagnolia Biondii Flower ExtractCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of large doses of magnolia bark and CNS depressants might have additive effects.
Read the full Magnolia Biondii Flower Extract + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Magnolia Flower Teapills — through 4 ingredients. Tap an ingredient for the detail:
Cimicifuga Heracleifolia Rhizome ExtractCytochrome P450 2d6 (cyp2d6) Substrates, Hepatotoxic Drugs Moderate
Interaction Summary
Some research suggests that black cohosh might inhibit CYP2D6, but there is conflicting evidence.
Read the full Cimicifuga Heracleifolia Rhizome Extract + Acetaminophen, Butalbital, Codeine interactionMagnolia Biondii Flower ExtractCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of large doses of magnolia bark and CNS depressants might have additive effects.
Read the full Magnolia Biondii Flower Extract + Acetaminophen, Butalbital, Codeine interactionAngelica Dahurica Root ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
In vitro research shows that ashitaba extract inhibits cytochrome P450 (CYP) 1A2.
Read the full Angelica Dahurica Root Extract + Acetaminophen, Butalbital, Codeine interactionGlycyrrhiza Uralensis Root ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, licorice might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Glycyrrhiza Uralensis Root Extract + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Magnolia Flower Teapills — through 4 ingredients. Tap an ingredient for the detail:
Angelica Dahurica Root ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
In vitro research shows that ashitaba extract inhibits cytochrome P450 (CYP) 1A2.
Read the full Angelica Dahurica Root Extract + Acetaminophen, Butalbital, Codeine Phosphate interactionCimicifuga Heracleifolia Rhizome ExtractCytochrome P450 2d6 (cyp2d6) Substrates, Hepatotoxic Drugs Moderate
Interaction Summary
Some research suggests that black cohosh might inhibit CYP2D6, but there is conflicting evidence.
Read the full Cimicifuga Heracleifolia Rhizome Extract + Acetaminophen, Butalbital, Codeine Phosphate interactionMagnolia Biondii Flower ExtractCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of large doses of magnolia bark and CNS depressants might have additive effects.
Read the full Magnolia Biondii Flower Extract + Acetaminophen, Butalbital, Codeine Phosphate interactionGlycyrrhiza Uralensis Root ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, licorice might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Glycyrrhiza Uralensis Root Extract + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Magnolia Flower Teapills — through 4 ingredients. Tap an ingredient for the detail:
Magnolia Biondii Flower ExtractCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of large doses of magnolia bark and CNS depressants might have additive effects.
Read the full Magnolia Biondii Flower Extract + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAngelica Dahurica Root ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
In vitro research shows that ashitaba extract inhibits cytochrome P450 (CYP) 1A2.
Read the full Angelica Dahurica Root Extract + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionGlycyrrhiza Uralensis Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, licorice might increase or decrease levels of drugs metabolized by CYP3A4.
Read the full Glycyrrhiza Uralensis Root Extract + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionCimicifuga Heracleifolia Rhizome ExtractHepatotoxic Drugs, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, taking black cohosh with hepatotoxic drugs may increase the risk of liver damage.
Read the full Cimicifuga Heracleifolia Rhizome Extract + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Magnolia Flower Teapills — through 4 ingredients. Tap an ingredient for the detail:
Cimicifuga Heracleifolia Rhizome ExtractCytochrome P450 2d6 (cyp2d6) Substrates, Hepatotoxic Drugs Moderate
Interaction Summary
Some research suggests that black cohosh might inhibit CYP2D6, but there is conflicting evidence.
Read the full Cimicifuga Heracleifolia Rhizome Extract + Acetaminophen, Caffeine, Codeine interactionAngelica Dahurica Root ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
In vitro research shows that ashitaba extract inhibits cytochrome P450 (CYP) 1A2.
Read the full Angelica Dahurica Root Extract + Acetaminophen, Caffeine, Codeine interactionMagnolia Biondii Flower ExtractCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of large doses of magnolia bark and CNS depressants might have additive effects.
Read the full Magnolia Biondii Flower Extract + Acetaminophen, Caffeine, Codeine interactionGlycyrrhiza Uralensis Root ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, licorice might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Glycyrrhiza Uralensis Root Extract + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Magnolia Flower Teapills — through 4 ingredients. Tap an ingredient for the detail:
Cimicifuga Heracleifolia Rhizome ExtractHepatotoxic Drugs, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, taking black cohosh with hepatotoxic drugs may increase the risk of liver damage.
Read the full Cimicifuga Heracleifolia Rhizome Extract + Acetaminophen, Caffeine, Codeine, Salicylamide interactionGlycyrrhiza Uralensis Root ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, licorice might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Glycyrrhiza Uralensis Root Extract + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAngelica Dahurica Root ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
In vitro research shows that ashitaba extract inhibits cytochrome P450 (CYP) 1A2.
Read the full Angelica Dahurica Root Extract + Acetaminophen, Caffeine, Codeine, Salicylamide interactionMagnolia Biondii Flower ExtractCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of large doses of magnolia bark and CNS depressants might have additive effects.
Read the full Magnolia Biondii Flower Extract + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Magnolia Flower Teapills — through 4 ingredients. Tap an ingredient for the detail:
Magnolia Biondii Flower ExtractCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of large doses of magnolia bark and CNS depressants might have additive effects.
Read the full Magnolia Biondii Flower Extract + Acetaminophen, Caffeine, Dihydrocodeine interactionAngelica Dahurica Root ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
In vitro research shows that ashitaba extract inhibits cytochrome P450 (CYP) 1A2.
Read the full Angelica Dahurica Root Extract + Acetaminophen, Caffeine, Dihydrocodeine interactionCimicifuga Heracleifolia Rhizome ExtractHepatotoxic Drugs, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, taking black cohosh with hepatotoxic drugs may increase the risk of liver damage.
Read the full Cimicifuga Heracleifolia Rhizome Extract + Acetaminophen, Caffeine, Dihydrocodeine interactionGlycyrrhiza Uralensis Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, licorice might increase or decrease levels of drugs metabolized by CYP3A4.
Read the full Glycyrrhiza Uralensis Root Extract + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Magnolia Flower Teapills — through 3 ingredients. Tap an ingredient for the detail:
Glycyrrhiza Uralensis Root ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, licorice might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Glycyrrhiza Uralensis Root Extract + Acetaminophen, Caffeine, Isometheptene interactionAngelica Dahurica Root ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
In vitro research shows that ashitaba extract inhibits cytochrome P450 (CYP) 1A2.
Read the full Angelica Dahurica Root Extract + Acetaminophen, Caffeine, Isometheptene interactionCimicifuga Heracleifolia Rhizome ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking black cohosh with hepatotoxic drugs may increase the risk of liver damage.
Read the full Cimicifuga Heracleifolia Rhizome Extract + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Magnolia Flower Teapills — through 3 ingredients. Tap an ingredient for the detail:
Glycyrrhiza Uralensis Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Diuretic Drugs +1 Moderate
Interaction Summary
Theoretically, licorice might increase or decrease levels of drugs metabolized by CYP3A4.
Read the full Glycyrrhiza Uralensis Root Extract + Acetaminophen, Caffeine, Pyrilamine interactionCimicifuga Heracleifolia Rhizome ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking black cohosh with hepatotoxic drugs may increase the risk of liver damage.
Read the full Cimicifuga Heracleifolia Rhizome Extract + Acetaminophen, Caffeine, Pyrilamine interactionAngelica Dahurica Root ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
In vitro research shows that ashitaba extract inhibits cytochrome P450 (CYP) 1A2.
Read the full Angelica Dahurica Root Extract + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Magnolia Flower Teapills — through 3 ingredients. Tap an ingredient for the detail:
Glycyrrhiza Uralensis Root ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, licorice might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Glycyrrhiza Uralensis Root Extract + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionCimicifuga Heracleifolia Rhizome ExtractHepatotoxic Drugs, Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Theoretically, taking black cohosh with hepatotoxic drugs may increase the risk of liver damage.
Read the full Cimicifuga Heracleifolia Rhizome Extract + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAngelica Dahurica Root ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
In vitro research shows that ashitaba extract inhibits cytochrome P450 (CYP) 1A2.
Read the full Angelica Dahurica Root Extract + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Magnolia Flower Teapills with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Glycyrrhiza uralensis Root Extract
Antihypertensive Drugs
Theoretically, licorice might reduce the effects of antihypertensive drugs.
In human research, licorice increases blood pressure in a dose-dependent manner.
Cisplatin (Platinol-Aq)
Theoretically, licorice might reduce the effects of cisplatin.
In animal research, licorice diminished the therapeutic efficacy of cisplatin.
Corticosteroids
Theoretically, concomitant use of licorice and corticosteroids might increase the side effects of corticosteroids.
Case reports suggest that concomitant use of licorice and oral corticosteroids, such as hydrocortisone, can potentiate the duration of activity and increase blood levels of corticosteroids. Additionally, in one case report, a patient with neurogenic orthostatic hypertension stabilized on fludrocortisone 0.1 mg twice daily developed pseudohyperaldosteronism after recent consumption of large amounts of black licorice.
Cytochrome P450 2B6 (Cyp2B6) Substrates
Theoretically, licorice might increase levels of drugs metabolized by CYP2B6.
In vitro research shows that licorice extract and glabridin, a licorice constituent, inhibit CYP2B6 isoenzymes. Licorice extract from the species G. uralensis seems to inhibit CYP2B6 isoenzymes to a greater degree than G. glabra extract in vitro. Theoretically, these species of licorice might increase levels of drugs metabolized by CYP2B6; however, these interactions have not yet been reported in humans.
Cytochrome P450 2C19 (Cyp2C19) Substrates
Theoretically, licorice might increase levels of drugs metabolized by CYP2C19.
In vitro, licorice extracts from the species G. glabra and G. uralensis inhibit CYP2C19 isoenzymes in vitro. Theoretically, these species of licorice might increase levels of drugs metabolized by CYP2C19; however, this interaction has not yet been reported in humans.
Cytochrome P450 2C8 (Cyp2C8) Substrates
Theoretically, licorice might increase levels of drugs metabolized by CYP2C8.
In vitro, licorice extract from the species G. glabra and G. uralensis inhibits CYP2C8 isoenzymes. Theoretically, these species of licorice might increase levels of drugs metabolized by CYP2C8; however, this interaction has not yet been reported in humans.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, licorice might increase or decrease levels of drugs metabolized by CYP2C9.
There is conflicting evidence about the effect of licorice on CYP2C9 enzyme activity. In vitro research shows that extracts from the licorice species G. glabra and G. uralensis moderately inhibit CYP2C9 isoenzymes. However, evidence from an animal model shows that licorice extract from the species G. uralensis can induce hepatic CYP2C9 activity. Until more is known, licorice should be used cautiously in people taking CYP2C9 substrates.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, licorice might increase or decrease levels of drugs metabolized by CYP3A4.
Pharmacokinetic research shows that the licorice constituent glycyrrhizin, taken in a dosage of 150 mg orally twice daily for 14 days, modestly decreases the area under the concentration-time curve of midazolam by about 20%. Midazolam is a substrate of CYP3A4, suggesting that glycyrrhizin modestly induces CYP3A4 activity. Animal research also shows that licorice extract from the species G. uralensis induces CYP3A4 activity. However, licorice extract from G. glabra species appear to inhibit CYP3A4-induced metabolism of testosterone in vitro. It is thought that the G. glabra inhibits CYP3A4 due to its constituent glabridin, which is a moderate CYP3A4 inhibitor in vitro and not present in other licorice species. Until more is known, licorice should be used cautiously in people taking CYP3A4 substrates.
Digoxin (Lanoxin)
Theoretically, concomitant use of licorice with digoxin might increase the risk of cardiac toxicity.
Overuse or misuse of licorice with cardiac glycoside therapy might increase the risk of cardiac toxicity due to potassium loss.
Diuretic Drugs
Theoretically, concomitant use of licorice with diuretic drugs might increase the risk of hypokalemia.
Overuse of licorice might compound diuretic-induced potassium loss. In one case report, a 72-year-old male with a past medical history of hypertension, type 2 diabetes, hyperlipidemia, arrhythmia, stroke, and hepatic dysfunction was hospitalized with severe hypokalemia and uncontrolled hypertension due to pseudohyperaldosteronism. This was thought to be provoked by concomitant daily consumption of a product containing 225 mg of glycyrrhizin, a constituent of licorice, and hydrochlorothiazide 12.5 mg for 1 month.
Estrogens
Theoretically, licorice might increase or decrease the effects of estrogen therapy.
Theoretically, licorice might interfere with estrogen therapy due to estrogenic and anti-estrogenic effects.
Loop Diuretics
Theoretically, loop diuretics might increase the mineralocorticoid effects of licorice.
Theoretically, loop diuretics might enhance the mineralocorticoid effects of licorice by inhibiting the enzyme that converts cortisol to cortisone; however, bumetanide (Bumex) does not appear to have this effect.
Midazolam (Versed)
Theoretically, licorice might decrease levels of midazolam.
In humans, the licorice constituent glycyrrhizin appears to moderately induce the metabolism of midazolam. This is likely due to induction of cytochrome P450 3A4 by licorice. Until more is known, licorice should be used cautiously in people taking midazolam.
P-Glycoprotein Substrates
Theoretically, licorice might decrease the absorption of P-glycoprotein substrates.
In vitro research shows that licorice can increase P-glycoprotein activity.
Paclitaxel (Abraxane, Onxol)
Theoretically, licorice might decrease plasma levels and clinical effects of paclitaxel.
Multiple doses of licorice taken concomitantly with paclitaxel might reduce the effectiveness of paclitaxel. Animal research shows that licorice 3 grams/kg given orally for 14 days before intravenous administration of paclitaxel decreases the exposure to paclitaxel and increases its clearance. Theoretically, this occurs because licorice induces cytochrome P450 3A4 enzymes, which metabolize paclitaxel. Notably, a single dose of licorice did not affect exposure or clearance of paclitaxel.
Warfarin (Coumadin)
Theoretically, licorice might decrease plasma levels and clinical effects of warfarin.
Licorice seems to increase metabolism and decrease levels of warfarin in animal models. This is likely due to induction of cytochrome P450 2C9 (CYP2C9) metabolism by licorice. Advise patients taking warfarin to avoid taking licorice.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, licorice might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that licorice induces CYP1A2 enzymes.
Methotrexate (Trexall, Others)
Theoretically, licorice might increase levels of methotrexate.
Animal research suggests that intravenous administration of glycyrrhizin, a licorice constituent, and high-dose methotrexate may delay methotrexate excretion and increase systemic exposure, leading to transient elevations in liver enzymes and total bilirubin. This interaction has not yet been reported in humans.
Cimicifuga heracleifolia Rhizome Extract
Atorvastatin (Lipitor)
Taking black cohosh with atorvastatin might increase the risk for elevated liver function tests.
In one case report, a patient taking atorvastatin (Lipitor) developed significantly elevated liver function enzymes after starting black cohosh 100 mg four times daily. Liver enzymes returned to normal when black cohosh was discontinued. It is unclear whether the elevated liver enzymes were due to black cohosh itself or an interaction between atorvastatin and black cohosh.
Cisplatin (Platinol-Aq)
Theoretically, black cohosh may reduce the clinical effects of cisplatin.
Animal research suggests that black cohosh might decrease the cytotoxic effect of cisplatin on breast cancer cells.
Cytochrome P450 2D6 (Cyp2D6) Substrates
Some research suggests that black cohosh might inhibit CYP2D6, but there is conflicting evidence.
Some clinical research suggests that black cohosh might modestly inhibit CYP2D6 and increase levels of drugs metabolized by this enzyme. However, contradictory clinical research shows a specific black cohosh product (Remifemin, Enzymatic Therapy) 40 mg twice daily does not significantly inhibit metabolism of a CYP2D6 substrate in healthy study volunteers. Until more is known, use black cohosh cautiously in patients taking drugs metabolized by CYP2D6.
Estrogens
Theoretically, black cohosh may alter the effects of estrogen therapy.
Some research suggests that black cohosh has estrogenic effects. This may enhance or inhibit the effects of estrogen therapy.
Hepatotoxic Drugs
Theoretically, taking black cohosh with hepatotoxic drugs may increase the risk of liver damage.
There is concern that black cohosh might be linked to cases of liver failure and autoimmune hepatitis.
Serotonergic Drugs
Combining serotonergic drugs with black cohosh might cause additive serotonergic effects.
Black cohosh might increase the risk of serotonin syndrome when combined with other serotonergic drugs. Black cohosh acts as an agonist at several serotonin receptor subtypes and might interact with other serotonergic medications. In one case, a 55-year-old female who had been on stable treatment with sertraline 50 mg and duloxetine 60 mg daily developed serotonin syndrome after taking black cohosh extract 40 mg daily for 3 days.
Organic Anion-Transporting Polypeptide Substrates (Oatp)
Black cohosh may inhibit one form of OATP, OATP2B1, which could reduce the bioavailability and clinical effects of OATP2B1 substrates.
In vitro research shows that black cohosh modestly inhibits OATP2B1. OATPs are expressed in the small intestine and liver and are responsible for the uptake of drugs and other compounds into the body. Inhibition of OATP may reduce the bioavailability of oral drugs that are substrates of OATP.
Magnolia biondii Flower Extract
Anticoagulant/Antiplatelet Drugs
Theoretically, magnolia might have additive effects and increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
In vitro research shows that the chemicals magnolol and honokiol, isolated from magnolia bark, inhibit platelet aggregation that is experimentally induced by collagen and arachidonic acid. However, they do not inhibit platelet aggregation that is induced by adenosine diphosphate, platelet-activating factor, or thrombin. This interaction has not been reported in humans.
Cns Depressants
Theoretically, concomitant use of large doses of magnolia bark and CNS depressants might have additive effects.
In vitro and animal research shows that constituents extracted from magnolia bark, especially honokiol and magnolol, have sedative effects. These effects may be due to the inhibition of catecholamine release and modulation of gamma-aminobutyric acid-A (GABA-A) receptors.
Angelica dahurica Root Extract
Cytochrome P450 1A2 (Cyp1A2) Substrates
In vitro research shows that ashitaba extract inhibits cytochrome P450 (CYP) 1A2. Theoretically, concomitant use of ashitaba with CYP1A2 substrates might decrease the clearance of these substrates and increase the risk for adverse effects. However, this interaction has yet to be reported in humans. Until more is known, use with caution.
Brand information
Manufacturer and brand details for Magnolia Flower Teapills, from the product label.
Plum Flower
- Name
- Mayway Herbs
- City
- Oakland
- State
- CA
- Web Address
- plumflowerherbs.com
Magnolia Flower Teapills by Plum Flower: Common Questions
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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The Full Monographs Behind Magnolia Flower Teapills’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Licorice
Interacts with 1,040 drugsLicorice root is a traditional remedy used for sore throats, coughs, and digestive complaints, but solid human evidence is limited for most uses. Regular licorice contains glycyrrhizin, whic...
Read the full Licorice monograph → Herb & supplement monographAshitaba
Interacts with 186 drugsAshitaba is a leafy plant from Japan that is eaten as a vegetable and taken as a supplement for general health, antioxidant, and heart benefits. Most of the supporting research comes from la...
Read the full Ashitaba monograph → Herb & supplement monographMagnolia
Interacts with 351 drugsMagnolia bark and flower buds have a long history in traditional Chinese and Japanese medicine, often for stress, sleep, and digestion. Modern human research is still limited, so we can't be...
Read the full Magnolia monograph → Herb & supplement monographBlack Cohosh
Interacts with 652 drugsBlack cohosh is a North American plant most often used to ease menopause symptoms like hot flashes, but the research is mixed and far from settled. It is generally well tolerated for short-t...
Read the full Black Cohosh monograph →Sources & How We Checked
Magnolia Flower Teapills's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 171 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Licorice 92 references
- Farese RV Jr, Biglieri EG, Shackleton CH, et al. Licorice-induced hypermineralocorticoidism. N Engl J Med 1991;325:1223-7. PubMed
- Sigurjonsdottir HA, Ragnarsson J, Franzson L, Sigurdsson G. Is blood pressure commonly raised by moderate consumption of liquorice? J Hum Hypertens 1995;9:345-8.
- Armanini D, Lewicka S, Pratesi C, et al. Further studies on the mechanism of the mineralocorticoid action of licorice in humans. J Endocrinol Invest 1996;19:624-9. PubMed
- Zhang YD, Lorenzo B, Reidenberg MM. Inhibition of 11 beta hydroxysteroid dehydrogenase obtained from guinea pig kidney by furosemide, naringenin and some other compounds. J Steroid Biochem Mol Biol 1994;49:81-5.
- Strandberg TE, Jarvenpaa AL, Vanhanen H, McKeigue PM. Birth outcome in relation to licorice consumption during pregnancy. Am J Epidemiol 2001;153:1085-8. PubMed
- Sigurjonsdottir HA, Franzson L, Manhem K, et al. Liquorice-induced rise in blood pressure: a linear dose-response relationship. J Hum Hypertens 2001;15:549-52. PubMed
- Amato P, Christophe S, Mellon PL. Estrogenic activity of herbs commonly used as remedies for menopausal symptoms. Menopause 2002;9:145-50. PubMed
- Kent UM, Aviram M, Rosenblat M, Hollenberg PF. The licorice root derived isoflavan glabridin inhibits the activities of human cytochrome P450S 3A4, 2B6, and 2C9. Drug Metab Dispos 2002;30:709-15.. PubMed
- Yoshida S, Takayama Y. Licorice-induced hypokalemia as a treatable cause of dropped head syndrome. Clin Neurol Neurosurg 2003;105:286-7.. PubMed
- Strandberg TE, Andersson S, Jarvenpaa AL, et al. Preterm birth and licorice consumption during pregnancy. Am J Epidemiol 2002;156:803-5.. PubMed
- Hussain RM. The sweet cake that reaches parts other cakes can't! Postgrad Med J 2003;79:115-6.. PubMed
- Morris DJ, Davis E, Latif SA. Licorice, tobacco chewing, and hypertension. N Engl J Med 1990;322:849-50. PubMed
- Quinkler M, Stewart PM. Hypertension and the cortisol-cortisone shuttle. J Clin Endocrinol Metab 2003;88:2384-92. PubMed
- Westman EC, Guthrie GP. Licorice, tobacco chewing, and hypertension. N Engl J Med 1990;322:850. PubMed
- Mu Y, Zhang J, Zhang S, et al. Traditional Chinese medicines Wu Wei Zi (Schisandra chinensis Baill) and Gan Cao (Glycyrrhiza uralensis Fisch) activate pregnane X receptor and increase warfarin clearance in rats. J Pharmacol Exp Ther 2006;316:1369-77. PubMed
- Yasue H, Itoh T, Mizuno Y, Harada E. Severe hypokalemia, rhabdomyolysis, muscle paralysis, and respiratory impairment in a hypertensive patient taking herbal medicines containing licorice. Intern Med 2007;46:575-8. PubMed
- Brayley J, Jones J. Life-threatening hypokalemia associated with excessive licorice ingestion (letter). Am J Psychiatry 1994;151:617-8. PubMed
- de Klerk GJ, Nieuwenhuis G, Beutler JJ. Hypokalaemia and hypertension associated with use of liquorice flavoured chewing gum. BMJ 1997;314:731-2.
- Dellow EL, Unwin RJ, Honour JW. Pontefract cakes can be bad for you: refractory hypertension and liquorice excess. Nephol Dial Transplant 1999;14:218-20. PubMed
- Elinav E, Chajek-Shaul T. Licorice consumption causing severe hypokalemic paralysis. Mayo Clin Proc 2003;78:767-8. PubMed
- Eriksson JW, Carlberg B, Hillom V. Life-threatening ventricular tachycardia due to liquorice-induced hypokalemia. J Intern Med 1999;245:307-10.
- Janse A, van Iersel M, Hoefnagels WH, Olde Rikker MG. The old lady who liked liquorice: hypertension due to chronic intoxication in a memory-impaired patient. Neth J Med 2005;63:149-50.
- Lin SH, Yang SS, Chau T, Halperin ML. An unusual cause of hypokalemic paralysis: chronic licorice ingestion. Am J Med Sci 2003;325:153-6. PubMed
- van den Bosch AE, van der Klooster JM, Zuidgeest DM, et al. Severe hypokalemic paralysis and rhabdomyolysis due to ingestion of liquorice. Neth J Med 2005;63:146-8.
- van Uum SH. Liquorice and hypertension. Neth J Med 2005;63:119-20.
- Russo S, Mastropasqua M, Mosetti MA, et al. Low doses of liquorice can induce hypertension encephalopathy. Am J Nephrol 2000;20:145-8. PubMed
- Stormer FC, Reistad R, Alexander J. Glycyrrhizic acid in liquorice - evaluation of health hazard. Food Chem Toxicol 1993;31:303-12. PubMed
- Sontia B, Mooney J, Gaudet L, Touyz RM. Pseudohyperaldosteronism, liquorice, and hypertension. J Clin Hypertens (Greenwich) 2008;10:153-7. PubMed
- Francini-Pesenti F, Puato M, Piccoli A, Brocadello F. Liquorice-induced hypokalaemia and water retention in the absence of hypertension. Phytother Res 2008;22:563-5. PubMed
- Lapi F, Gallo E, Bernasconi S, et al. Myopathies associated with red yeast rice and liquorice: spontaneous reports from the Italian Surveillance System of Natural Health Products. Br J Clin Pharmacol 2008;66:572-4. PubMed
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