Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

MaitakeGold Mushroom Extract Ingredients & Drug Interactions

by Bluebonnet

MaitakeGold Mushroom Extract label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking MaitakeGold Mushroom Extract against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

MaitakeGold Mushroom Extract is a dietary supplement by Bluebonnet with 2 active ingredients. Its ingredients are commonly taken for immune support, blood sugar support in diabetes, high blood pressure.Based on those ingredients, 260 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Patented MaitakeGold 404 mushroom extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against MaitakeGold Mushroom Extract by Bluebonnet

Ask about any prescription or over-the-counter medication and we check it for interactions with MaitakeGold Mushroom Extract by Bluebonnet — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of MaitakeGold Mushroom Extract by Bluebonnet

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 20, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

MaitakeGold Mushroom Extract contains 2 active ingredients: a patented MaitakeGold 404 mushroom extract and maitake mushroom powder. Both deliver the bioactive compounds from the maitake mushroom—primarily polysaccharides—that are thought to support immune function and overall wellness.

The capsule also contains inactive ingredients (hypromellose, purified water, cellulose, and magnesium stearate) that serve as the capsule shell and flow agents.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Maitake Mushroom's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: support immune health.
  • We looked for evidence on: Allergic rhinitis (hay fever), Chemotherapy-induced leukopenia, Chronic fatigue syndrome (CFS), Coronavirus disease 2019 (COVID-19), HIV/AIDS, Immune function — and 1 related terms.
  • The closest evidence on file: Maitake Mushroom is rated "Insufficient Reliable Evidence To Rate" for Allergic rhinitis (hay fever) (Natural Medicines).
  • Also on file: Maitake Mushroom is rated "Insufficient Reliable Evidence To Rate" for Chronic fatigue syndrome (CFS), HIV/AIDS, Chemotherapy-induced leukopenia, Coronavirus disease 2019 (COVID-19).

The evidence for maitake mushroom's effectiveness on the conditions listed—hay fever (allergic rhinitis), chemotherapy-induced anemia, laryngeal cancer, chemotherapy-related diarrhea, and chronic fatigue syndrome—is insufficient. That means the data we hold does not establish reliable benefit for any of these uses.

If you're considering this product for a specific health goal, talk with your doctor or pharmacist about what the current evidence actually supports.

The evidence, ingredient by ingredient Maitake Mushroom

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Maitake mushroom is generally well tolerated when used as a food, but supplement safety hasn't been fully studied. The most common side effects reported in clinical trials were gastrointestinal—diarrhea, stomach pain (epigastric pain), and nausea—though these occurred in a small number of trial participants.

One participant developed a rash and itching after two doses, though it cleared on its own. During pregnancy and breastfeeding, there isn't enough safety data for concentrated maitake supplements, so the safety data advises against use.

If you're pregnant, nursing, or planning to become pregnant, talk with your doctor or pharmacist before taking this product.

Side effects, ingredient by ingredient Maitake Mushroom

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Maitake Mushroom.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 260 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start MaitakeGold, double-check with your doctor or pharmacist if you take any blood pressure medications (antihypertensives), diabetes drugs (antidiabetes medications), or warfarin (a blood thinner). These are Moderate-severity interactions where maitake mushroom may strengthen their effects or increase your risk of low blood pressure or low blood sugar.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

MaitakeGold is for anyone interested in maitake mushroom's potential immune support, but it's not the right choice if you take blood pressure medications, diabetes drugs, or warfarin—you'll need to check with your doctor or pharmacist first because the interactions are real. Pregnant and breastfeeding people should skip it until they've talked it over with their healthcare provider.

For everyone else, stomach upset is possible but usually mild.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 23, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about MaitakeGold Mushroom Extract, straight from the product label.

Brand Bluebonnet
Barcode (UPC) 743715012509
Net contents 30 Vegetable Capsule(s)
Market status On market
Date entered into DSLD Jan 23, 2023
DSLD ID 280171
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, No Allergies, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for MaitakeGold Mushroom Extract by Bluebonnet, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
30
UPC/BARCODE
743715012509
IngredientAmount% DV
Patented MaitakeGold 404 mushroom extract15 mg--
Maitake, Powder85 mg--

Other ingredients: Hypromellose, Water, Purified, Cellulose, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Bluebonnet’s MaitakeGold Mushroom Extract Vegetable Capsules are formulated with a combination of clinically-studied, patented MaitakeGold 404 extract with organic whole maitake mycelia grown on brown rice to support immune health.

Bluebonnet’s KOF-K Certification #K-0000700

K Parve (Kosher)

Formulation

Free of milk, egg, fish, crustacean shellfish, tree nuts, peanuts, wheat, soybeans and sesame. Also free of corn, gluten, barley, sodium and sugar.

Organic certification #C0030887-NOPCMP-3

Made with non GMO ingredients

Immune health

Vegan

Gluten free

Brand IP Statement(s)

MaitakeGold 404 is a trademark of Tradeworks Group, Inc. U.S. Patent number 5,854,404.

Seals/Symbols

MaitakeGold Certified Bioactivity ImmuneActive Certificate U.S. Patent 5,854,404

Made with non GMO ingredients K Parve (Kosher)

Precautions

Caution: For adults only.

Consult physician if pregnant/nursing, taking medication, or have a medical condition.

Keep out of reach of children.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take one capsule daily or as directed by a healthcare practitioner.

Storage

Store tightly closed in a cool, dry place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

MaitakeGold Mushroom Extract by Bluebonnet label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

MaitakeGold Mushroom Extract label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in MaitakeGold Mushroom Extract by Bluebonnet

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Patented MaitakeGold 404 mushroom extract

Interacts with
260 drugs
15 mg per serving

Maitake is an edible mushroom long used as food and in traditional Japanese medicine, and it is being studied for possible immune, blood sugar, and bl...

Patented MaitakeGold 404 mushroom extract monograph & interactions

Maitake, Powder

Interacts with
260 drugs
85 mg per serving

Maitake is an edible mushroom long used as food and in traditional Japanese medicine, and it is being studied for possible immune, blood sugar, and bl...

Maitake, Powder monograph & interactions

Other (inactive) ingredients: Hypromellose, Water, Purified, Cellulose, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

MaitakeGold Mushroom Extract by Bluebonnet Drug Interactions

Want to check YOUR meds against MaitakeGold Mushroom Extract?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
260Drugs
260 Moderate

Ingredients driving the most interactions

Patented MaitakeGold 404 mushroom extract 260

Individual Drug Interactions

The ingredients in MaitakeGold Mushroom Extract interact with 260 drugs. Click any drug to see the details.

1 of the 2 ingredients in MaitakeGold Mushroom Extract interact with drugs. Each result below shows which ingredient is responsible. Patented MaitakeGold 404 mushroom extract

Each ingredient & the kinds of drugs it affects

For each ingredient in MaitakeGold Mushroom Extract with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Patented MaitakeGold 404 mushroom extract3 drug types · 260 drugs

Antidiabetes Drugs

Theoretically, combining maitake mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that taking maitake mushroom polysaccharide (MMP) can lower blood glucose levels in patients with types 2 diabetes.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.
Animal research shows that maitake mushroom can lower blood pressure.

Likelihood Possible Evidence D
Warfarin (Coumadin)

There is limited evidence that maitake mushroom may increase the anticoagulant effects of warfarin.
In a case report, a patient previously stabilized on warfarin developed an elevated international normalized ratio (INR) of 5.1 after taking maitake mushroom (Grifron-Pro Maitake D-Fraction) 1 drop/kg daily in three divided doses for one week. The elevated INR resolved after holding warfarin for two days, then reducing the dose by 11%. It is thought that the beta-glucan constituent of maitake mushroom might cause warfarin dissociation from proteins, resulting in increased free warfarin levels and increased warfarin effects.

Likelihood Possible Evidence D
Patented MaitakeGold 404 mushroom extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for MaitakeGold Mushroom Extract, from the product label.

Bluebonnet

Name
Bluebonnet Nutrition Corporation
Street Address
12915 Dairy Ashford
City
Sugar Land
State
Texas
ZipCode
77478
Web Address
www.bluebonnetnutrition.com
Pharmacist Counseling Corner

MaitakeGold Mushroom Extract by Bluebonnet: Common Questions

Does MaitakeGold Mushroom Extract by Bluebonnet interact with any medications?
Yes. Based on its ingredients, MaitakeGold Mushroom Extract has a known interaction with 260 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
MaitakeGold Mushroom Extract contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on warfarin?
No—not without talking to your doctor first. Maitake mushroom may strengthen warfarin's blood-thinning effect, and one case report showed a patient's blood-thinning level rising dangerously after taking maitake for a week. You need your healthcare provider to review this combination.
What are the most common side effects?
Gastrointestinal effects—diarrhea, stomach pain, and nausea—are the main ones reported in clinical trials, though they occurred in a small number of participants. One person also reported a mild rash and itching that cleared on its own.
Is this safe during pregnancy or breastfeeding?
The safety data advises against use during pregnancy and breastfeeding because there isn't enough information. If you're pregnant, nursing, or planning to become pregnant, check with your doctor or pharmacist before taking it.
Does maitake mushroom actually work for hay fever or fatigue?
The evidence isn't established in the data we hold for hay fever, fatigue, or the other conditions listed on the label. If you're considering this product for a specific health goal, talk with your doctor or pharmacist about what research actually supports.
What's the difference between the extract and the powder in this capsule?
Both are maitake mushroom—one is a concentrated extract (MaitakeGold 404) and one is powder. They both deliver the same active compounds (polysaccharides) but in different forms.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if MaitakeGold Mushroom Extract is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

MaitakeGold Mushroom Extract label
Go deeper

The Full Monographs Behind MaitakeGold Mushroom Extract’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Maitake Mushroom

Interacts with 260 drugs

Maitake is an edible mushroom long used as food and in traditional Japanese medicine, and it is being studied for possible immune, blood sugar, and blood pressure effects. The human evidence...

Read the full Maitake Mushroom monograph →
Sources

Sources & How We Checked

MaitakeGold Mushroom Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 8 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Maitake Mushroom 8 references
  1. Kabir Y, Kimura S. Dietary mushrooms reduce blood pressure in spontaneously hypertensive rats (SHR). J Nutr Sci Vitaminol (Tokyo) 1989;35:91-4. PubMed
  2. Kabir Y, Yamaguchi M, Kimura S. Effect of shiitake (Lentinus edodes) and maitake (Grifola frondosa) mushrooms on blood pressure and plasma lipids of spontaneously hypertensive rats. J Nutr Sci Vitaminol (Tokyo) 1987;33:341-6. PubMed
  3. Konno S, Tortorelis DG, Fullerton SA, et al. A possible hypoglycaemic effect of maitake mushroom on Type 2 diabetic patients. Diabet Med 2001;18:1010. PubMed
  4. Chen JT, Tominaga K, Sato Y, et al. Maitake mushroom (Grifola frondosa) extract induces ovulation in patients with polycystic ovary syndrome: a possible monotherapy and a combination therapy after failure with first-line clomiphene citrate. J Altern Compl
  5. Hanselin MR, Vande Griend JP, Linnebur SA. INR elevation with maitake extract in combination with warfarin. Ann Pharmacother 2010;44:223-4. PubMed
  6. Talpur, N. A., Echard, B. W., Fan, A. Y., Jaffari, O., Bagchi, D., and Preuss, H. G. Antihypertensive and metabolic effects of whole Maitake mushroom powder and its fractions in two rat strains. Mol.Cell Biochem. 2002;237(1-2):129-136. PubMed
  7. Deng, G., Lin, H., Seidman, A., Fornier, M., D'Andrea, G., Wesa, K., Yeung, S., Cunningham-Rundles, S., Vickers, A. J., and Cassileth, B. A phase I/II trial of a polysaccharide extract from Grifola frondosa (Maitake mushroom) in breast cancer patients: i
  8. Wesa KM, Cunningham-Rundles S, Klimek VM, et al. Maitake mushroom extract in myelodysplastic syndromes (MDS): a phase II study. Cancer Immunol Immunother 2015;64(2):237-47. PubMed

See these in context on the Maitake Mushroom monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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