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Dietary supplement

Mangosteen Ingredients & Drug Interactions

by Emerald Labs

Mangosteen label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Mangosteen against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Mangosteen is a dietary supplement by Emerald Labs with 1 active ingredient. Its ingredients are commonly taken for antioxidant support, anti-inflammatory support, immune support.Based on those ingredients, 125 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Mangosteen Blend. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Mangosteen by Emerald Labs

Ask about any prescription or over-the-counter medication and we check it for interactions with Mangosteen by Emerald Labs — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Mangosteen by Emerald Labs

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 20, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 2 active ingredients.
  • “Mangosteen Blend” is a proprietary blend — the label gives one combined amount (1,200 mg) without saying how much of each component you get.

This product contains 2 active ingredients: mangosteen pericarp extract and mangosteen powder. Both are forms of the mangosteen fruit, a tropical plant whose rind (pericarp) and whole powder are used in traditional and supplement medicine.

The product also contains a vegetable capsule as an inactive ingredient.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Mangosteen's overall clinical evidence instead.

Moderate

Some clinical evidence supports Mangosteen for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Periodontitis — rated "Possibly Effective" (Natural Medicines).

The evidence for mangosteen is mixed. It's possibly effective for periodontitis (gum disease), based on available research.

For androgenic alopecia (male or female pattern hair loss), Alzheimer disease, and atopic dermatitis (eczema), there isn't enough reliable evidence in our data to rate whether it works. If you're considering this for one of those conditions, talk with your doctor about what the research actually supports for your situation.

The evidence, ingredient by ingredient Mangosteen

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Mangosteen is generally well tolerated as a food, but the long-term safety of concentrated supplements hasn't been thoroughly studied. People taking mangosteen extract up to 560 mg daily in studies have reported tiredness, headache, dizziness, constipation, nausea, and cough — though it's unclear whether mangosteen caused these or they happened by chance.

Pregnancy and breastfeeding: there isn't enough safety information to recommend mangosteen supplements during pregnancy or while breastfeeding. If you're pregnant, planning to become pregnant, or breastfeeding, talk with your doctor or pharmacist before taking this product.

Side effects, ingredient by ingredient Mangosteen

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Mangosteen.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 125 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take blood thinners or antiplatelet drugs (warfarin, aspirin, clopidogrel, and others), mangosteen may increase your bleeding risk — check with your doctor or pharmacist before adding this product. If you take donepezil (Aricept) for Alzheimer disease, let your healthcare provider know, as mangosteen might raise its levels in your brain.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

Mangosteen may help with gum disease, but the evidence for other uses is unclear. If you take blood thinners or donepezil, check with your doctor or pharmacist before starting this — the interaction risk is real.

It's generally well tolerated, though some people report digestive or mild neurological side effects. This isn't the kind of supplement to take without looking at your own medication list first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Mangosteen, straight from the product label.

Brand Emerald Labs
Barcode (UPC) 743650001439
Net contents 60 Vegetable Cap(s)
Market status On market
Date entered into DSLD Feb 22, 2024
DSLD ID 302619
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Mangosteen by Emerald Labs, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
UPC/BARCODE
743650001439
IngredientAmount% DV
Mangosteen pericarp extract0 NP--
Mangosteen Blend1200 mg--
Mangosteen, Powder0 NP--

Other ingredients: Vegetable capsule

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

The bitter outer shell of the tropical Mangosteen fruit (pericarp) is thought to be a superior source of lactones, flavonoids, and the antioxidant phytonutrients known as xanthones.

Pericarp extract 10:1

General Statements

Emerald Labs is family owned and operated since our beginnings in 1996.

Doctor-formulated

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Brand IP Statement(s)

Copyright 2021 Emerald Labs, Inc.

Emerald Labs The additive-free company

FDA Statement of Identity

Dietary Supplement

Formulation

Clinical potency

Made with Non-GMO ingredients NO magnesium stearate Gluten-free

Vegan formula

This product is free of: corn, milk, salt, yeast, soy, added sugar, wheat, artificial flavors and preservatives.

We are committed to providing your family with additive-free formulas and superior nutrient forms in therapeutic amounts.

Suggested/Recommended/Usage/Directions

Suggested Use: Adults, take two (2) capsules daily or as directed by your Health Care Practitioner.

Precautions

Keep Out of Reach of Children.

Do not use if safety seal on cap or printed inner seal is missing or broken.

Consult a physician if pregnant, lactating, currently on prescription medication or diagnosed with a medical condition.

Product is manufactured in a facility that processes milk, egg, soy, tree nuts, fish and shellfish.

Storage

Store in a Cool, Dry Place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Mangosteen by Emerald Labs label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Mangosteen label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Mangosteen by Emerald Labs

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Mangosteen Blend

Interacts with
125 drugs
1200 mg per serving

Mangosteen is a tropical fruit whose rind is rich in plant compounds called xanthones that act as antioxidants. While it is popular in juices and supp...

Mangosteen Blend monograph & interactions

Other (inactive) ingredients: Vegetable capsule. These complete the product’s ingredient list but are not active constituents.

Interaction report

Mangosteen by Emerald Labs Drug Interactions

Want to check YOUR meds against Mangosteen?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
125Drugs
122 Moderate 3 Minor

Ingredients driving the most interactions

Mangosteen Blend 125

Individual Drug Interactions

The ingredients in Mangosteen interact with 125 drugs. Click any drug to see the details.

1 of the 1 ingredient in Mangosteen interact with drugs. Each result below shows which ingredient is responsible. Mangosteen Blend

Each ingredient & the kinds of drugs it affects

For each ingredient in Mangosteen with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Mangosteen Blend2 drug types · 125 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, concomitant use of mangosteen with anticoagulant or antiplatelet drugs may increase the risk of bleeding.
In vitro and animal research shows that gamma-mangostin, a constituent of mangosteen, is a potent and competitive antagonist of the serotonin 2A (5-HT2A) receptor. Antagonism of the 5-HT2A receptor is believed to reduce platelet aggregation.

Likelihood Possible Evidence D
Donepezil (Aricept)

Theoretically, concomitant use of mangosteen with donepezil might increase the effects of donepezil.
Animal research shows that concomitant use of an aqueous extract of mangosteen pericarp with donepezil increases brain concentrations of donepezil at 4 hours by 64% without associated effects on systemic exposure.

Likelihood Possible Evidence D
Mangosteen Blend full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Mangosteen, from the product label.

Emerald Labs

See all Emerald Labs products
Name
Emerald Labs
Street Address
20600 Belshaw Ave.
City
Carson
State
CA
ZipCode
90746
Phone Number
800-436-4366
Web Address
www.emeraldlabs.com
Pharmacist Counseling Corner

Mangosteen by Emerald Labs: Common Questions

Does Mangosteen by Emerald Labs interact with any medications?
Yes. Based on its ingredients, Mangosteen has a known interaction with 125 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Mangosteen contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while pregnant or breastfeeding?
The data we have doesn't show it's safe in those situations. There isn't enough information either way. Talk with your doctor or pharmacist before taking it if you're pregnant, trying to become pregnant, or breastfeeding — they can give you personalized advice.
What side effects might I see?
Some people taking mangosteen extract reported tiredness, headache, dizziness, constipation, nausea, vomiting, and cough. It's not certain mangosteen caused these, but they've been reported in people taking up to 560 mg daily. Most people don't report problems.
Does it actually work for gum disease?
Possibly. The evidence suggests mangosteen may help with periodontitis (gum disease), though more research would strengthen that claim. For other uses like hair loss or eczema, there isn't enough reliable evidence yet.
What exactly is in this product?
It contains two forms of mangosteen — the pericarp extract (the rind) and mangosteen powder — both made from the tropical mangosteen fruit. It's wrapped in a vegetable capsule.
Is it safe to use long-term?
Mangosteen is generally recognized as safe as a food, but the long-term safety of concentrated supplements like this one hasn't been well studied. If you're thinking of taking it regularly, talk with your pharmacist about what we know.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Mangosteen label
Go deeper

The Full Monographs Behind Mangosteen’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Mangosteen

Interacts with 125 drugs

Mangosteen is a tropical fruit whose rind is rich in plant compounds called xanthones that act as antioxidants. While it is popular in juices and supplements for inflammation, immune support...

Read the full Mangosteen monograph →
Sources

Sources & How We Checked

Mangosteen's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Mangosteen 6 references
  1. Chairungsrilerd N, Furukawa K, Ohta T, et al. Histaminergic and serotonergic receptor blocking substances from the medicinal plant Garcinia mangostana. Planta Med 1996;62:471-2.
  2. Wong LP, Klemmer PJ. Severe lactic acidosis associated with juice of the mangosteen fruit Garcinia mangostana. Am J Kidney Dis 2008;51:829-33. PubMed
  3. Furukawa, K., Chairungsrilerd, N., Ohta, T., Nozoe, S., and Ohizumi, Y. [Novel types of receptor antagonists from the medicinal plant Garcinia mangostana]. Nippon Yakurigaku Zasshi 1997;110 Suppl 1:153P-158P. PubMed
  4. Chairungsrilerd, N., Furukawa, K., Tadano, T., Kisara, K., and Ohizumi, Y. Effect of gamma-mangostin through the inhibition of 5-hydroxy-tryptamine2A receptors in 5-fluoro-alpha-methyltryptamine-induced head-twitch responses of mice. Br J Pharmacol. 1998
  5. Suthammarak W, Numpraphrut P, Charoensakdi R, et al. Antioxidant-enhancing property of the polar fraction of mangosteen pericarp extract and evaluation of its safety in humans. Oxid Med Cell Longev 2016;2016:1293036. PubMed
  6. Bae M, Han SY, Kim ES, et al. Effect of Water Extract of Mangosteen Pericarp on Donepezil Pharmacokinetics in Mice. Molecules 2021;26(17):5246. PubMed

See these in context on the Mangosteen monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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