Interactions on record — worth a quick check against your medications. Based on 3 of 6 ingredients. Check your meds →
Dietary supplement

Mass 550 Ingredients & Drug Interactions

by FINAFLEX

Mass 550 label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Mass 550 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Mass 550 is a dietary supplement by FINAFLEX with 6 active ingredients. Its ingredients are commonly taken for bone health and osteoporosis, correcting vitamin d deficiency, immune system support.Based on those ingredients, 975 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Vitamin D3, Fenugreek. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Mass 550 by FINAFLEX

Ask about any prescription or over-the-counter medication and we check it for interactions with Mass 550 by FINAFLEX — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Mass 550 by FINAFLEX

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 20, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 6 active ingredients.
  • “Lean Mass Matrix” is a proprietary blend — the label gives one combined amount (120 mg) without saying how much of each component you get.
  • “Testosterone Matrix” is a proprietary blend — the label gives one combined amount (550 mg) without saying how much of each component you get.

Mass 550 contains 6 active ingredients. Vitamin D3 supports bone health and calcium absorption.

The Lean Mass Matrix and Testosterone Matrix are ingredient blends that contribute to the product's muscle-building profile. Fenugreek seed is included for its effects on sexual function and blood sugar.

D-Aspartic Acid, Naringin, and Letrosterone round out the formula. The capsules also contain inactive ingredients: maltodextrin, gelatin, silica, magnesium stearate, titanium dioxide, and FD&C Blue #1.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: lean muscle growth and strength gains.
  • We looked for evidence on: Athletic performance, Exercise-induced muscle damage, Muscle strength, Anabolism, Protein synthesis, Body composition.
  • The closest evidence on file: Fenugreek is rated "Insufficient Reliable Evidence To Rate" for Athletic performance (Natural Medicines).
  • Also on file: Fenugreek is rated "Insufficient Reliable Evidence To Rate" for Muscle strength.
  • Also on file: Vitamin D is rated "Insufficient Reliable Evidence To Rate" for Athletic performance, Muscle strength, Exercise-induced muscle damage.

Vitamin D3 is effective for treating rickets, osteomalacia (soft bones), renal bone disease, and familial hypophosphatemia—conditions involving calcium and bone metabolism. Fenugreek seed is possibly effective for sexual dysfunction and arousal, as well as diabetes management and menstrual pain.

Olive pomace oil, also in the product, has insufficient evidence to rate for osteoporosis, arthritis, and other conditions listed on file. The evidence supporting the other active ingredients is not established in our data.

The evidence, ingredient by ingredient Vitamin D Olive Fenugreek

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin D3 is generally well tolerated at recommended doses, but very high doses over time can cause toxicity with symptoms of high blood calcium. It is rated likely safe in pregnancy at recommended amounts, though use only under your doctor's guidance; it is likely safe during breastfeeding.

Fenugreek is rated likely unsafe in pregnancy because supplement amounts may affect the uterus; it is possibly safe during breastfeeding to support milk supply, but discuss this with your provider first. Fenugreek can cause abdominal pain, bloating, diarrhea, and nausea at supplement doses, and rarely severe allergic reactions including swelling, breathing difficulty, and shock.

Olive pomace oil as a food is very safe, but concentrated supplements are less studied and may cause headache or stomach discomfort.

Side effects, ingredient by ingredient Vitamin D Olive Fenugreek

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 3 matched ingredients can interact with medications — Fenugreek, Vitamin D.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; heart-rhythm medications.
  • For scale: 976 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Mass 550, double-check with your doctor or pharmacist if you use any of these medication types: thiazide diuretics (water pills), verapamil or diltiazem for heart rhythm, digoxin for heart rhythm, atorvastatin for cholesterol, blood thinners like warfarin or clopidogrel, diabetes medications, the seizure drug phenytoin, the beta blocker metoprolol, theophylline for asthma, or sildenafil for erectile dysfunction. These are the drug types where interactions have been documented with the ingredients we could check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Mass 550 is a multi-ingredient muscle and hormone formula with documented interactions involving vitamin D3 and fenugreek, affecting blood thinners, heart medications, diabetes drugs, and others. If you take any prescription medications—especially for your heart, blood clotting, blood sugar, or seizures—talk with your doctor or pharmacist before starting this product.

Pregnant women should avoid it (fenugreek is likely unsafe in pregnancy). Check your specific medications with the interaction tool on this page.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 25, 2018.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Mass 550, straight from the product label.

Brand FINAFLEX
Barcode (UPC) 689466670226
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Jun 25, 2018
DSLD ID 178078
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Mass 550 by FINAFLEX, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
UPC/BARCODE
689466670226
IngredientAmount% DV
D-Aspartic Acid0 NP--
Vitamin D31600 IU400%
Naringin0 NP--
Lean Mass Matrix120 mg--
Letrosterone0 NP--
Olive pomace Oil0 NP--
Testosterone Matrix550 mg--
Fenugreek0 NP--

Other ingredients: Maltodextrin, Gelatin, Silica, Magnesium Stearate, Titanium Dioxide, FD&C Blue #1

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Xtreme Anabolic Matrix

Sport performance Ultimate bodybuilding product Promote lean muscle gains Increase protein synthesis Reduce estrogen levels Boost testosterone 30 servings

Brand IP Statement(s)

Mass 550 is the most pivotal advancement in lean muscle acquisition ever introduced.

Redefine yourself.

Formula

Mass 550 contains two of the most innovative and exotic bodybuilding ingredients available today. The novel combination of Letrosterone and Maslinic acid creates an anabolic environment that promotes lean muscle growth, increased protein synthesis, and a reduction in overall estrogen in the body.

Built with Letrosterone

Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement take 2 capsules 1-2 times daily with food. Take Mass 500 every day, including non-training days. Increase protein intake during cycle of Mass 550 to maximize lean muscle and strength gains. For extreme results use 2-3 bottles of Mass 550 consecutively over a 40-90 day period. Do not use Mass 550 for more than 90 days consecutively.

Precautions

Do not use Mass 550 for more than 90 days consecutively.

Warning: Keep out of reach of children.

Do no use if pregnant or nursing.

Consult your doctor prior to use if you have or are at risk for prostate disease, heart disease, or any other general medical condition.

Consult your doctor prior to use if you are taking any other prescription medications. All persons are advised to consult with their doctor or other medical authority before use of this or any other other dietary supplement. Warning: Discuss possible interactions and contradictions of this dietary supplement with other medicines currently prescribed by your doctor.

Discontinue use 2 weeks prior to surgery. Do not combine this product with alcohol. Do not use if your health status is unknown. Caution: Athletes or other persons who are subject to testing for performance enhancing drugs may test positive when using dietary supplements. All persons are advised to contact their drug testing organization prior to use of this or any other dietary supplement.

May not be suitable for persons under the age of 18 years old.

FDA Statement of Identity

Dietary Supplement - 60 capsules

Dietary Supplement

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Mass 550 by FINAFLEX label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Mass 550 label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Mass 550 by FINAFLEX

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitamin D3

Interacts with
715 drugs
1600 IU per serving

Vitamin D is a fat-soluble vitamin that helps your body absorb calcium and is important for healthy bones, muscles, and immune function. Many people,...

Vitamin D3 monograph & interactions

Lean Mass Matrix

120 mg per serving

Testosterone Matrix

550 mg per serving

Other (inactive) ingredients: Maltodextrin, Gelatin, Silica, Magnesium Stearate, Titanium Dioxide, FD&C Blue #1. These complete the product’s ingredient list but are not active constituents.

Interaction report

Mass 550 by FINAFLEX Drug Interactions

Want to check YOUR meds against Mass 550?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
975Drugs
299 Moderate 676 Minor

Ingredients driving the most interactions

Vitamin D3 715
Fenugreek 389

Individual Drug Interactions

The ingredients in Mass 550 interact with 975 drugs. Click any drug to see the details.

2 of the 6 ingredients in Mass 550 interact with drugs. Each result below shows which ingredient is responsible. Vitamin D3 Fenugreek

Each ingredient & the kinds of drugs it affects

For each ingredient in Mass 550 with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin D38 drug types · 715 drugs

Aluminum

Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
The protein that transports calcium across the intestinal wall can also bind and transport aluminum. This protein is stimulated by vitamin D, which may therefore increase aluminum absorption. This mechanism may contribute to increased aluminum levels and toxicity in people with renal failure, when they take vitamin D and aluminum-containing phosphate binders chronically.

Likelihood Probable Evidence B
Atorvastatin (Lipitor)

Vitamin D might reduce absorption of atorvastatin.
A small, low-quality clinical study shows that taking vitamin D reduces levels of atorvastatin and its active metabolites by up to 55%. However, while atorvastatin levels decreased, total cholesterol, low-density lipoprotein (LDL) cholesterol, and high-density lipoprotein (HDL) cholesterol levels did not substantially change. Atorvastatin is metabolized in the gut by CYP3A4 enzymes, and researchers theorized that vitamin D might induce CYP3A4, causing reduced levels of atorvastatin. However, this proposed mechanism was not specifically studied.

Likelihood Probable Evidence B
Calcipotriene (Dovonex)

Taking calcipotriene with vitamin D increases the risk for hypercalcemia.
Calcipotriene is a vitamin D analog used topically for psoriasis. It can be absorbed in sufficient amounts to cause systemic effects, including hypercalcemia. Theoretically, combining calcipotriene with vitamin D supplements might increase the risk of hypercalcemia.

Likelihood Probable Evidence D
Digoxin (Lanoxin)

Theoretically, hypercalcemia induced by high-dose vitamin D can increase the risk of arrhythmia from digoxin.
High doses of vitamin D can cause hypercalcemia. Hypercalcemia increases the risk of fatal cardiac arrhythmias with digoxin. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and digoxin concurrently.

Likelihood Possible Evidence D
Diltiazem (Cardizem, Others)

Theoretically, hypercalcemia induced by high-dose vitamin D can reduce the therapeutic effects of diltiazem for arrhythmia.
High doses of vitamin D can cause hypercalcemia. Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically this could also occur with diltiazem. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and diltiazem concurrently.

Likelihood Probable Evidence B
Thiazide Diuretics

Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Thiazide diuretics decrease urinary calcium excretion, which could lead to hypercalcemia if vitamin D supplements are taken concurrently. This has been reported in people being treated with vitamin D for hypoparathyroidism, and also in elderly people with normal parathyroid function who were taking a thiazide, vitamin D, and calcium-containing antacids daily.

Likelihood Probable Evidence D
Verapamil (Calan, Others)

Hypercalcemia induced by high-dose vitamin D can reduce the therapeutic effects of verapamil for arrhythmia.
Hypercalcemia due to high doses of vitamin D can reduce the effectiveness of verapamil in atrial fibrillation. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and verapamil concurrently.

Likelihood Probable Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
There is some concern that vitamin D might induce CYP3A4. In vitro research suggests that vitamin D induces CYP3A4 transcription. Additionally, observational research has found that increased UV light exposure and serum vitamin D levels are associated with decreased serum levels of CYP3A4 substrates such as tacrolimus and sirolimus, while no association between UV light exposure or vitamin D levels and levels of mycophenolic acid, a non-CYP3A4 substrate, was found. A small, low-quality clinical study shows that taking vitamin D reduces levels of the CYP3A4 substrate atorvastatin and its active metabolites by up to 55%; however, the clinical effects of atorvastatin were not reduced. While researchers theorized that vitamin D might induce CYP3A4, this proposed mechanism was not specifically studied.

Likelihood Possible Evidence D
Vitamin D3 full monograph & interactions

Fenugreek9 drug types · 389 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Some of the constituents in fenugreek have antiplatelet effects in animal and in vitro research. However, common fenugreek products might not contain sufficient concentrations of these constituents for clinical effects. A clinical study in patients with coronary artery disease or diabetes shows that taking fenugreek seed powder 2.5 grams twice daily for 3 months does not affect platelet aggregation, fibrinolytic activity, or fibrinogen levels .

Likelihood Unlikely Evidence B
Antidiabetes Drugs

Theoretically, fenugreek seed might have additive hypoglycemic effects when used with antidiabetes drugs.
Clinical research shows that fenugreek seed can reduce fasting blood glucose and 2-hour postprandial glucose levels in adults with type 2 diabetes.

Likelihood Probable Evidence B
Clopidogrel (Plavix)

Theoretically, fenugreek seed might alter the clinical effects of clopidogrel by inhibiting its conversion to the active form.
Animal research shows that fenugreek seed 200 mg/kg daily for 14 days increases the maximum serum concentration of clopidogrel by 21%. It is unclear how this affects the pharmacokinetics of the active metabolite of clopidogrel; however, this study found that concomitant use of fenugreek seed and clopidogrel prolonged bleeding time by an additional 11%.

Likelihood Possible Evidence D
Metoprolol (Toprol)

Theoretically, fenugreek seed might have additive hypotensive effects when used with metoprolol.
Animal research shows that fenugreek seed 300 mg/kg daily for 2 weeks decreases systolic and diastolic blood pressure by 9% and 11%, respectively, when administered alone, and by 15% and 22%, respectively, when given with metoprolol 10 mg/kg.

Likelihood Probable Evidence B
Phenytoin (Dilantin)

Theoretically, fenugreek might decrease plasma levels of phenytoin.
Animal research shows that taking fenugreek seeds for 1 week decreases maximum concentrations and the area under the curve of a single dose of phenytoin by 44% and 72%, respectively. This seems to be related to increased clearance. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Sildenafil (Viagra)

Theoretically, concurrent use of sildenafil and fenugreek might reduce levels and therapeutic effects of sildenafil.
Animal research shows that taking fenugreek seeds for 1 week reduces maximum concentrations and the area under the curve of a single dose of sildenafil by 27% and 48%, respectively. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Theophylline

Theoretically, fenugreek may reduce the levels and clinical effects of theophylline.
Animal research shows that fenugreek 50 grams daily for 7 days reduces the maximum serum concentration (Cmax) of theophylline by 28% and the area under the plasma drug concentration-time curve (AUC) by 22%.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, fenugreek might have additive effects with warfarin and increase the international normalized ratio (INR).
Some fenugreek constituents have antiplatelet effects, although these might not be present in concentrations that are clinically significant. In one case report, a patient taking warfarin experienced an increased INR when starting to take fenugreek in combination with boldo.

Likelihood Possible Evidence D
Antihypertensive Drugs

Fenugreek may also have an additive effect on blood pressure-lowering medications. Studies on animals have shown that fenugreek seed can decrease both systolic and diastolic blood pressure by up to 22% when combined with metoprolol. Therefore, it is essential to monitor your blood pressure regularly if you are taking fenugreek and metoprolol together or any other antihypertensive drugs.

Likelihood Possible Evidence C
Fenugreek full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Mass 550, from the product label.

FINAFLEX

See all FINAFLEX products
Name
FinaFlex
Street Address
1190 Tidwell Road, Ste 304
City
Alpharetta
State
GA
ZipCode
30004
Web Address
www.FinaFlex.com
Pharmacist Counseling Corner

Mass 550 by FINAFLEX: Common Questions

Does Mass 550 by FINAFLEX interact with any medications?
Yes. Based on its ingredients, Mass 550 has a known interaction with 975 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Mass 550 contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is Mass 550 safe to take if I'm pregnant or breastfeeding?
Pregnancy: Fenugreek in this product is rated likely unsafe because supplement amounts may affect the uterus, so you should avoid it. Vitamin D3 is rated likely safe at recommended doses, but only use it under your doctor's guidance. Breastfeeding: Fenugreek is possibly safe and is often used to support milk supply, but talk with your provider first about whether it's right for you; vitamin D3 is likely safe. Either way, discuss this product with your doctor or pharmacist before taking it while pregnant or nursing.
What side effects might I experience from Mass 550?
Fenugreek can cause abdominal pain, bloating, diarrhea, upset stomach, gas, and nausea at supplement doses. Rarely, it may trigger severe allergic reactions including swelling of the face or throat, difficulty breathing, and shock. Vitamin D3 is well tolerated at normal doses but can cause toxicity at very high doses over time. Olive pomace oil may cause headache or stomach discomfort. If you notice any of these effects, stop and talk to your doctor or pharmacist.
Does fenugreek really work for sexual function?
Fenugreek seed is rated possibly effective for sexual dysfunction and sexual arousal based on the evidence we hold. Results vary, and it's not guaranteed to work for everyone.
What is vitamin D3 in this product meant to do?
Vitamin D3 supports bone health and calcium absorption. In this muscle-building formula, it helps your body utilize calcium for bone strength. It's effective for treating rickets, soft bones, kidney-related bone disease, and familial hypophosphatemia, but those are medical conditions—your doctor would prescribe it for those purposes.
Can I take Mass 550 if I'm on blood thinners?
No—not without checking first with your doctor or pharmacist. Both vitamin D3 and fenugreek have documented interactions with blood thinners like warfarin and clopidogrel, and the effects could be serious. Bring a list of your medications to your pharmacist and ask them to check this product against your specific drugs before you start it.
What ingredients in Mass 550 couldn't be checked for interactions?
We couldn't check D-Aspartic Acid, Naringin, and Letrosterone against our medication database because we don't hold interaction data for them. That doesn't mean they're safe with all medications—it just means we have no documented information. Talk with your pharmacist about your full medication list.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Mass 550 label
Go deeper

The Full Monographs Behind Mass 550’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin D

Interacts with 715 drugs

Vitamin D is a fat-soluble vitamin that helps your body absorb calcium and is important for healthy bones, muscles, and immune function. Many people, especially those with low sun exposure,...

Read the full Vitamin D monograph → Herb & supplement monograph

Olive

Olive comes from the same tree that gives us olives and olive oil, and its leaf and fruit contain antioxidant compounds like oleuropein and hydroxytyrosol. Olive oil as part of a Mediterrane...

Read the full Olive monograph → Herb & supplement monograph

Fenugreek

Interacts with 389 drugs

Fenugreek is a common kitchen spice that is also taken as a supplement, mainly for blood sugar, cholesterol, and to support breast milk production. Some early research is encouraging for blo...

Read the full Fenugreek monograph →
Sources

Sources & How We Checked

Mass 550's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 58 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin D 26 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Tatro DS, ed. Drug Interactions Facts. Facts and Comparisons Inc., St. Louis, MO. 1999.
  3. Koutkia P, Chen TC, Holick MF. Vitamin D intoxication associated with an over-the-counter supplement. N Engl J Med 2001;345:66-7. PubMed
  4. Bar-Or D, Yoel G. Calcium and calciferol antagonize effect of verapamil in atrial fibrillation. Br Med J 1981;282:1585-6.
  5. Demontis R, Leflon A, Fournier A, et al. 1 alpha(OH) vitamin D3 increases plasma aluminum in hemodialyzed patients taking AI(OH)3. Clin Nephrol 1986;26:146-9.
  6. Crowe M, Wollner L, Griffiths RA. Hypercalcemia following vitamin D and thiazide therapy in the elderly. Practitioner 1984;228:312-3.
  7. Parfitt AM. Thiazide-induced hypercalcemia in vitamin D-treated hypoparathyroidism. Ann Intern Med 1972;77:557-63. PubMed
  8. Thiazide diuretics and the risk of osteoporosis. Pharmacist's Letter/Prescriber's Letter 2003;19(11):191105.
  9. Moon J. The role of vitamin D in toxic metal absorption. J Am Coll Nutr 1994;13:559-64.
  10. Demontis R, Reissi D, Noel C, et al. Indirect clinical evidence that 1alphaOH vitamin D<SUB>3</SUB> increases the intestinal absorption of aluminum. Clin Nephrol 1989;31:123-7.
  11. Adler AJ, Berlyne GM. Duodenal aluminum absorption in the rat: effect of vitamin D. Am J Physiol 1985;249:G209-13. PubMed
  12. Schwartz JB. Effects of vitamin D supplementation in atorvastatin-treated patients: A new drug interaction with an unexpected consequence. Clin Pharmacol Ther 2009;85:198-203. PubMed
  13. Dietary reference intakes for calcium and vitamin D. Institute of Medicine, November 30, 2010. Available at: http://www.iom.edu/~/media/Files/Report%20Files/2010/Dietary-Reference-Intakes-for-Calcium-and-Vitamin-D/Vitamin%20D%20and%20Calcium%202010%20Repo
  14. Cox KA, Dunn MA. Aluminum toxicity alters the regulation of calbindin-D28k protein and mRNA expression in chick intestine. J Nutr 2001;131:2007-13. PubMed
  15. Escribano, J., Balaguer, A., Pagone, F., Feliu, A., and Roque, I. Figuls. Pharmacological interventions for preventing complications in idiopathic hypercalciuria. Cochrane.Database.Syst.Rev. 2009;(1):CD004754. PubMed
  16. Carlton, S., Clopton, D., and Cappuzzo, K. A. Vitamin D deficiency: appropriate replenishment therapies and the effects of vitamin D toxicity. Consult Pharm 2010;25(3):171-177. PubMed
  17. Wang, H., Xia, N., Yang, Y., and Peng, D. Q. Influence of vitamin D supplementation on plasma lipid profiles: a meta-analysis of randomized controlled trials. Lipids Health Dis. 2012;11:42. PubMed
  18. Turner AN, Carr Reese P, Fields KS, Anderson J, Ervin M, Davis JA, Fichorova RN, Roberts MW, Klebanoff MA, Jackson RD. A blinded, randomized controlled trial of high-dose vitamin D supplementation to reduce recurrence of bacterial vaginosis. Am J Obstet G PubMed
  19. Weiner M, Epstein FH. Signs and symptoms of electrolyte disorders. Yale J Biol Med. 1970;43(2):76-109.
  20. Lappe J, Watson P, Travers-Gustafson D, Recker R, Garland C, Gorham E, Baggerly K, McDonnell SL. Effect of Vitamin D and Calcium Supplementation on Cancer Incidence in Older Women: A Randomized Clinical Trial. JAMA. 2017 Mar 28;317(12):1234-1243. PubMed
  21. Roth DE, Leung M, Mesfin E, Qamar H, Watterworth J, Papp E. Vitamin D supplementation during pregnancy: state of the evidence from a systematic review of randomised trials. BMJ. 2017;359:j5237. PubMed
  22. Murai IH, Fernandes AL, Sales LP, et al. Effect of a single high dose of vitamin D3 on hospital length of stay in patients with moderate to severe COVID-19: A randomized clinical trial. JAMA. 2021.
  23. Wang Z, Schuetz EG, Xu Y, Thummel KE. Interplay between vitamin D and the drug metabolizing enzyme CYP3A4. J Steroid Biochem Mol Biol 2013;136:54-8. PubMed
  24. Doyle D, Browne U, Brickley A, Murphy D. Vitamin D-induced hypercalcaemia and acute kidney injury in sarcoidosis. BMJ Case Rep 2023;16(1):e250580. PubMed
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See these in context on the Olive monograph →

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See these in context on the Fenugreek monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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