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Dietary supplement

Amplify A.T. Ingredients & Drug Interactions

by AdvoCare

Amplify A.T. label
See full label image
Softgel Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Amplify A.T. against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Amplify A.T. is a dietary supplement by AdvoCare with 2 active ingredients. Its ingredients are commonly taken for heart and cholesterol support, antioxidant support, liver health (fatty liver).Based on those ingredients, 758 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Astaxanthin, Mixed Tocotrienols. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Amplify A.T. by AdvoCare

Ask about any prescription or over-the-counter medication and we check it for interactions with Amplify A.T. by AdvoCare — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Amplify A.T. by AdvoCare

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Amplify A.T. contains 2 active ingredients. Mixed tocotrienols are a form of vitamin E believed to support cellular health, and astaxanthin is a red pigment from marine sources with antioxidant properties.

The softgel capsule is filled with extra virgin olive oil and also contains gelatin, glycerin, and purified water as inactive ingredients.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: Enhance nutrition with antioxidant and skin health support.
  • We looked for evidence on: Aging, Aging skin, Age-related macular degeneration (AMD), Dry eye, Exercise-induced muscle damage, Exercise-induced muscle soreness — and 4 related terms.
  • The closest evidence on file: Tocotrienols is rated "Possibly Ineffective" for Hypercholesterolemia (Natural Medicines).
  • Also on file: Astaxanthin is rated "Insufficient Reliable Evidence To Rate" for Age-related macular degeneration (AMD), Aging skin, Nonalcoholic fatty liver disease (NAFLD), Heart failure, and more.

The evidence for these ingredients is mixed and often thin. Mixed tocotrienols show possibly effective data for diabetes support, though possibly ineffective for cholesterol — and for alopecia areata and breast cancer, the evidence is too limited to rate.

Astaxanthin's effectiveness for age-related cognitive decline, macular degeneration, aging skin, Alzheimer disease, athletic performance, and carpal tunnel syndrome is similarly not yet established in the data we hold. Neither ingredient has strong evidence backing the claims often made about them.

The evidence, ingredient by ingredient Tocotrienols Astaxanthin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Both ingredients are generally well tolerated in studies, but long-term safety at supplement doses is not firmly established. Orally, no adverse effects were reported in clinical trials for tocotrienols.

Astaxanthin may cause mild stomach upset, loose stools, or red-colored stools in some people — a small number of trial participants reported abdominal pain or increased bowel movements at higher doses. During pregnancy, the safety data advise against tocotrienols and astaxanthin; there isn't enough information to know either way.

While breastfeeding, similar caution applies — talk with your doctor or pharmacist before using this product if you're pregnant or nursing.

Side effects, ingredient by ingredient Tocotrienols Astaxanthin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Astaxanthin, Tocotrienols.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 759 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check if you take blood thinners or antiplatelet drugs like warfarin or aspirin (Minor risk with tocotrienols). Also check any medications your liver breaks down via CYP3A4 or CYP2B6 enzymes — these include many statins, some antifungals, some antiretrovirals, and immunosuppressants (Moderate risk with astaxanthin).

Use the tool on this page to verify your medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Amplify A.T. may be worth considering if you're interested in antioxidant support and your doctor has ruled out interactions with your medications — especially blood thinners or drugs your liver processes through CYP3A4 and CYP2B6. Because the evidence for what it actually does is limited, and interactions are a real concern, check your exact medications here and talk with your pharmacist or doctor before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 24, 2018.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Amplify A.T., straight from the product label.

Brand AdvoCare
Barcode (UPC) W3031/00L0812
Net contents 30 Softgel(s)
Market status On market
Date entered into DSLD May 24, 2018
DSLD ID 177470
Product type Other Combinations
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Amplify A.T. by AdvoCare, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
Servings per container
30
UPC/BARCODE
W3031/00L0812
IngredientAmount% DV
Mixed Tocotrienols7.5 mg--
Astaxanthin4 mg--

Other ingredients: extra virgin Olive Oil, Gelatin, Glycerin, purified Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions for use: Take one softgel per day with a meal.

Precautions

Caution: If you are pregnant or nursing, check with your healthcare professional before using this product.

Keep out of reach of children.

Formula

Enhance your nutrition with Amplify A.T., a revolutionary formula that combines natural forms of astaxanthin and tocotrienols for advanced health and wellness.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Astaxathin and mixed Tocotrienols Dietary Supplement

General Statements

Well Amplify your nutrition Provides skin-enhancing nutrition

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Amplify A.T. by AdvoCare label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Amplify A.T. label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Amplify A.T. by AdvoCare

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Mixed Tocotrienols

Interacts with
122 drugs
7.5 mg per serving Form: Tocopherols

Tocotrienols are a less common form of vitamin E with strong antioxidant activity studied mostly for cholesterol, liver, and heart health. Early resea...

Mixed Tocotrienols monograph & interactions

Astaxanthin

Interacts with
671 drugs
4 mg per serving Form: Astaxanthin, Beta-Carotene, Canthaxanthin, Haematococcus pluvialis Algae extract, Lutein

Astaxanthin is a reddish carotenoid pigment with strong antioxidant activity in the lab, and it is widely promoted for skin, eye, heart, and exercise...

Astaxanthin monograph & interactions

Other (inactive) ingredients: Extra virgin Olive Oil, Gelatin, Glycerin, Purified Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Amplify A.T. by AdvoCare Drug Interactions

Want to check YOUR meds against Amplify A.T.?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
758Drugs
671 Moderate 87 Minor

Ingredients driving the most interactions

Astaxanthin 671
Mixed Tocotrienols 122

Individual Drug Interactions

The ingredients in Amplify A.T. interact with 758 drugs. Click any drug to see the details.

2 of the 2 ingredients in Amplify A.T. interact with drugs. Each result below shows which ingredient is responsible. Astaxanthin Mixed Tocotrienols

Each ingredient & the kinds of drugs it affects

For each ingredient in Amplify A.T. with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Astaxanthin2 drug types · 671 drugs

Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP2B6.
In vitro research shows that astaxanthin induces cytochrome CYP2B6 enzyme activity in human hepatocytes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
In vitro research shows that astaxanthin induces CYP3A4 enzyme activity in human hepatocytes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Astaxanthin full monograph & interactions

Mixed Tocotrienols1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Concomitant use of tocotrienols with anticoagulant or antiplatelet agents might increase the risk of bleeding. However, this has not been reported in humans.
Taking tocotrienols orally inhibits experimentally-induced platelet aggregation in humans. Theoretically tocotrienols might increase the risk of bleeding if taken with antiplatelet or anticoagulant drugs. However, tocotrienols 400-800 mg daily have been used with aspirin and/or clopidogrel for 1 year with no clear cumulative antiplatelet effects and no reports of bleeding.

Likelihood Unlikely Evidence B
Mixed Tocotrienols full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Amplify A.T., from the product label.

AdvoCare

Name
AdvoCare International L.P.
City
Plano
State
TX
ZipCode
75074
Phone Number
800-542-4800
Web Address
www.advocare.com
Pharmacist Counseling Corner

Amplify A.T. by AdvoCare: Common Questions

Does Amplify A.T. by AdvoCare interact with any medications?
Yes. Based on its ingredients, Amplify A.T. has a known interaction with 758 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Amplify A.T. contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is astaxanthin and what's it supposed to do?
Astaxanthin is a red pigment from marine sources with antioxidant properties. The evidence for what it actually does — whether for brain health, eye health, skin, or athletic performance — isn't yet established in the data we hold.
Can I take this if I'm pregnant or breastfeeding?
The safety data advise against both tocotrienols and astaxanthin during pregnancy and while breastfeeding. Talk with your doctor or pharmacist for personalized advice.
What side effects should I watch for?
Tocotrienols have caused no reported side effects in clinical trials when taken by mouth. Astaxanthin may cause mild stomach upset, loose stools, or red-colored stools — a small number of people reported abdominal pain or increased bowel movements at higher doses.
Will this help my cholesterol?
The evidence suggests tocotrienols are possibly ineffective for cholesterol. If cholesterol is your goal, talk with your doctor about proven approaches.
Is this safe long-term?
Both ingredients are generally well tolerated in studies, but long-term safety at supplement doses is not well established. Your pharmacist can discuss what's known and what gaps remain.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Amplify A.T. label
Go deeper

The Full Monographs Behind Amplify A.T.’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Tocotrienols

Interacts with 122 drugs

Tocotrienols are a less common form of vitamin E with strong antioxidant activity studied mostly for cholesterol, liver, and heart health. Early research is interesting but far from conclusi...

Read the full Tocotrienols monograph → Herb & supplement monograph

Astaxanthin

Interacts with 671 drugs

Astaxanthin is a reddish carotenoid pigment with strong antioxidant activity in the lab, and it is widely promoted for skin, eye, heart, and exercise benefits. Early human studies are promis...

Read the full Astaxanthin monograph →
Sources

Sources & How We Checked

Amplify A.T.'s label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 7 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Tocotrienols 4 references
  1. Mensink RP, van Houwelingen AC, Kromhout D, Hornstra G. A vitamin E concentrate rich in tocotrienols had no effect on serum lipids, lipoproteins, or platelet function in men with mildly elevated serum lipid concentrations. Am J Clin Nutr 1999;69:213-9. PubMed
  2. Baumann LS, Spencer JS. The effects of topical vitamin E on the cosmetic appearance of scars. Dermatol Surg 1999;25:311-5. PubMed
  3. Khoo TL, Halim AS, Zakaria Z, Mat Saad AZ, Wu LY, Lau HY. A prospective, randomised, double-blinded trial to study the efficacy of topical tocotrienol in the prevention of hypertrophic scars. J Plast Reconstr Aesthet Surg. 2011 Jun;64(6):e137-45. Epub 201 PubMed
  4. Slivka A, Rink C, Paoletto D, Sen CK. Platelet function in stroke/transient ischemic attack patients treated with tocotrienol. FASEB J. 2020;34(9):11838-11843. PubMed

See these in context on the Tocotrienols monograph →

Astaxanthin 3 references
  1. Kupcinskas L, Lafolie P, Lignell A, et al. Efficacy of the natural antioxidant astaxanthin in the treatment of functional dyspepsia in patients with or without Helicobacter pylori infection: A prospective, randomized, double blind, and placebo-controlled
  2. Kistler, A., Liechti, H., Pichard, L., Wolz, E., Oesterhelt, G., Hayes, A., and Maurel, P. Metabolism and CYP-inducer properties of astaxanthin in man and primary human hepatocytes. Arch.Toxicol. 2002;75(11-12):665-675. PubMed
  3. Choi HD, Youn YK, Shin WG. Positive effects of astaxanthin on lipid profiles and oxidative stress in overweight subjects. Plant Foods Hum Nutr. 2011;66:363-369. PubMed

See these in context on the Astaxanthin monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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