Maximum Essential Omega-3 Natural Mint Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Maximum Essential Omega-3 Natural Mint against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Maximum Essential Omega-3 Natural Mint is a dietary supplement by ProCaps Laboratories with 7 active ingredients. Its ingredients are commonly taken for high triglycerides, heart health, joint pain and inflammation.Based on those ingredients, 1,260 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Peppermint Oil, Spearmint Oil, Fish Oil. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Maximum Essential Omega-3 Natural Mint by ProCaps Laboratories
Ask about any prescription or over-the-counter medication and we check it for interactions with Maximum Essential Omega-3 Natural Mint by ProCaps Laboratories — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Maximum Essential Omega-3 Natural Mint by ProCaps Laboratories
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains 7 ingredients, of which the active ones are the omega-3 fatty acids — eicosapentaenoic acid, docosahexaenoic acid, docosapentaenoic acid, and alpha-linolenic acid — plus fish oil as the source. The formula also includes peppermint oil and spearmint oil for flavor.
These omega-3s are the working ingredients; the rest are inactive components used to make the capsule.
Does it work?
Strong evidence
The fish oil in this product is effective for lowering high triglycerides (hypertriglyceridemia). It's possibly effective for cachexia (severe weight loss), heart failure, kidney damage from cyclosporine use, and nonalcoholic fatty liver disease.
Peppermint oil is likely effective for irritable bowel syndrome and possibly effective for indigestion, chemotherapy-related nausea, and colonic spasm. Spearmint oil doesn't have reliable evidence yet for the conditions tested — age-related cognitive decline, memory, gas, IBS, nausea after surgery, or osteoarthritis.
The omega-3 fatty acids themselves (the main actives here) don't have separate effectiveness ratings on file.
How safe is it?
Well-documented data
Fish oil is generally well tolerated at typical supplement doses. The most common side effects are abdominal pain, fishy aftertaste, heartburn, loose stools, and nausea.
Rare but serious effects include atrial fibrillation at doses of 3 grams or more daily and, in very high intakes (over 46 grams daily), increased stroke risk. Fish oil also carries antiplatelet effects at high doses — it may thin blood slightly.
One case of anaphylaxis was reported in someone with shellfish allergy. Peppermint and spearmint oils are generally well tolerated at culinary or tea amounts.
At high concentrations, peppermint oil can cause burning and irritation. Both oils can trigger allergic reactions in sensitive people.
For pregnancy and breastfeeding: Fish oil is likely safe in pregnancy when used under doctor guidance, though some evidence is conflicting. Omega-3s pass into breast milk, so discuss appropriate amounts with your healthcare provider.
Peppermint oil is likely safe in pregnancy and lactation. Spearmint oil has no pregnancy or lactation safety data on file — check with your provider.
Meds to double-check
Moderate interaction found
Blood pressure medications (antihypertensives), immunosuppressants like cyclosporine, tacrolimus, and sirolimus, and birth control pills warrant a Moderate-severity check. If you take a blood thinner (anticoagulant) like warfarin or an antiplatelet drug, flag that for your pharmacist — the interaction is Minor but worth verifying.
Also check any medications your liver metabolizes heavily, since peppermint oil theoretically could affect them. We could not verify the omega-3 fatty acids themselves for interactions, so their full interaction profile is unknown.
The bottom line
Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
This omega-3 product is well established for lowering high triglycerides and possibly helpful for heart failure and fatty liver disease. If you're on a blood thinner, blood pressure medication, birth control, or especially an immunosuppressant like cyclosporine or tacrolimus, you need to check your specific medications with the tool below or talk to your pharmacist before starting.
If you have a shellfish allergy, mention it.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 3 of 7 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2018.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Maximum Essential Omega-3 Natural Mint, straight from the product label.
| Brand | ProCaps Laboratories |
|---|---|
| Net contents | 360 Easy-To-Swallow Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Jul 25, 2018 |
| DSLD ID | 179250 |
| Product type | Botanical With Nutrients |
| Supplement form | Capsule |
| Dietary claims / uses | Nutrient, All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Maximum Essential Omega-3 Natural Mint by ProCaps Laboratories, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Calories | 12 Calorie(s) | -- |
| Calories from Fat | 12 Calorie(s) | -- |
| Eicosapentaenoic Acid | 350 mg | -- |
| Docosahexaenoic Acid | 450 mg | -- |
| Total Fat | 1.35 Gram(s) | 2% |
| Total Omega-3 Fatty Acids | 1000 mg | -- |
| Docosapentaenoic Acid | 50 mg | -- |
| Alpha-Linolenic Acid | 100 mg | -- |
| Cholesterol | 2 mg | 1% |
| Fish Oil | 1150 mg | -- |
| Peppermint Oil | 11 mg | -- |
| Spearmint Oil | 11 mg | -- |
Other ingredients: Soft-Gelatin Capsule
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Suggested Use Consume two capsules daily or as recommended by a health care professional.
General Statements
This product is most effective as part of a healthy diet and active lifestyle, along with one of Andrew Lessman's multi-vitamin-mineral formulas. For answers to questions about the use of this product, call 800.808.7311. Unsurpassed. Purity. Quality. Integrity. Effectiveness. Andrew Lessman Founder of ProCaps Labs
All-Solar manufacturing
Our Omega-3s exist in their most active, natural triglyceride form and not as inferior ethyl esters. Omega-3s are absolutely essential for our good health, yet they cannot be made by the body, so their benefits are only available from cold-water fish or a formula like Maximum Essential Omega-3. Research has shown that diets rich in Omega-3 oils are associated with superior heart, brain, circulatory and general health; yet sadly, the American diet delivers alarmingly low levels of these precious fatty acids.
In fact, the highest functioning areas of the brain and the most critical parts of the eye (macula and retina) contain and require ultra-high levels of DHA.
Brand IP Statement(s)
This product is only available from HSN 800.944.9999 www.HSN.com ProCaps Laboratories 800.800.1200 ProCapsLabs.com 2017 ProCaps Labs
General
605823-06U
Formula
Ultra-Concentrate of DHA and EPA
Fish oils without fish taste
Andrew Lessman's Maximum Essential Omega-3 is our ultra-pure, highest potency blend of Omega-3 oils uniquely delivered with absolutely no fishy aftertaste.
Our Maximum Essential Omega-3 is a uniquely concentrated source of both fish and flaxseed oils, delivering our highest levels of DHA (Docosahexaenoic Acid) and EPA (Eicosapentaenoic Acid), as well as DPA (Docosapentaenoic Acid). Typical Omega-3 formulas focus on EPA, which is less costly to provide, whereas our Omega-3s target vital DHA, which is essential for brain and eye function.
Formulation
Free of Mercury and Contaminants
Although fish oil supplements have long been praised for their countless health benefits, they are equally well-known for their aftertaste and potential contaminants; however, our Maximum Essential Omega-3 allows you to enjoy all the benefits of fish oil with no mercury, no contaminants, no stomach upset and no fishy aftertaste.
Contains no milk, soy, yeast, corn, wheat, gluten, sodium, salt, sugar, color, preservative or manufacturing additives. Contains no additives of any kind.
FDA Statement of Identity
Dietary Supplement
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Maximum Essential Omega-3 Natural Mint by ProCaps Laboratories label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Maximum Essential Omega-3 Natural Mint by ProCaps Laboratories
These are the 7 active ingredients this product is made of. Select any to open its full monograph.
Serving size2 Softgel(s) Dosage formCapsule Servings per container180 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Total Omega-3 Fatty Acids
- › Eicosapentaenoic Acid
- › Docosahexaenoic Acid
- › Docosapentaenoic Acid
Alpha-Linolenic Acid
Fish Oil
Interacts with327 drugs
Fish oil provides omega-3 fatty acids (EPA and DHA) that are best known for lowering high triglyceride levels. The evidence for other heart and health...
Fish Oil monograph & interactionsPeppermint Oil
Interacts with796 drugs
Peppermint is a popular herb with the best evidence supporting enteric-coated peppermint oil for easing IBS symptoms. It is generally well tolerated f...
Peppermint Oil monograph & interactionsSpearmint Oil
Interacts with579 drugs
Spearmint is a common culinary mint that is generally safe in food and tea amounts. Early research suggests possible benefits for digestion, mild horm...
Spearmint Oil monograph & interactionsOther (inactive) ingredients: Soft-Gelatin Capsule. These complete the product’s ingredient list but are not active constituents.
Maximum Essential Omega-3 Natural Mint by ProCaps Laboratories Drug Interactions
HelloPharmacist Interaction Report
Maximum Essential Omega-3 Natural Mint by ProCaps Laboratories contains fish oil, peppermint oil, and spearmint oil — three ingredients with documented drug interactions.
The most serious concern involves fish oil and several immunosuppressant medications (cyclosporine, tacrolimus, and sirolimus), all Moderate severity: fish oil may raise blood levels of these drugs, increasing the risk of side effects. Kidney transplant patients on these medications should check with their pharmacist before use.
Read the full breakdown — every affected drug type, severity by severity
Fish oil also interacts Moderately with blood pressure medications (antihypertensives) — it can lower blood pressure itself, so combining it with these drugs might lower your pressure too much. It may also interfere with how well birth control pills work at lowering triglycerides, and theoretically could reduce the absorption of the weight-loss drug orlistat if taken together.
Fish oil carries a Minor interaction with blood thinners (anticoagulants) like warfarin and with antiplatelet drugs: high doses might increase bleeding risk, though the evidence is conflicting.
Peppermint oil is documented to interact Moderately with several medications your liver breaks down, including CYP2C19, CYP2C9, and CYP3A4 substrates — in theory, it could raise their levels in your blood. It also carries a Moderate interaction with cyclosporine.
A Minor interaction exists with CYP1A2 substrates, though clinical evidence is limited. Spearmint oil has Moderate interactions with sedating medications (CNS depressants) and theoretically with drugs that can damage the liver (hepatotoxic drugs).
We couldn't check the omega-3 fatty acids themselves (eicosapentaenoic acid, docosahexaenoic acid, docosapentaenoic acid, and alpha-linolenic acid) — we hold no interaction data for them. Check your exact medications using the search tool on this page.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Maximum Essential Omega-3 Natural Mint?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Maximum Essential Omega-3 Natural Mint interact with 1,260 drugs. Click any drug to see the details.
3 of the 7 ingredients in Maximum Essential Omega-3 Natural Mint interact with drugs. Each result below shows which ingredient is responsible. Peppermint Oil Spearmint Oil Fish Oil
6-mercaptopurinePurinethol
How 6-mercaptopurine interacts with Maximum Essential Omega-3 Natural Mint — through 1 ingredient. Tap an ingredient for the detail:
Spearmint OilHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, high doses of spearmint might increase the risk of liver damage when taken with hepatotoxic drugs.
Read the full Spearmint Oil + 6-mercaptopurine interactionAdo-trastuzumab EmtansineKadcyla
How Ado-trastuzumab Emtansine interacts with Maximum Essential Omega-3 Natural Mint — through 1 ingredient. Tap an ingredient for the detail:
Peppermint OilCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Read the full Peppermint Oil + Ado-trastuzumab Emtansine interactionAbacavir Sulfate, Dolutegravir, LamivudineTriumeq
How Abacavir Sulfate, Dolutegravir, Lamivudine interacts with Maximum Essential Omega-3 Natural Mint — through 1 ingredient. Tap an ingredient for the detail:
Spearmint OilHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, high doses of spearmint might increase the risk of liver damage when taken with hepatotoxic drugs.
Read the full Spearmint Oil + Abacavir Sulfate, Dolutegravir, Lamivudine interactionAbacavir, LamivudineEpzicom
How Abacavir, Lamivudine interacts with Maximum Essential Omega-3 Natural Mint — through 1 ingredient. Tap an ingredient for the detail:
Spearmint OilHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, high doses of spearmint might increase the risk of liver damage when taken with hepatotoxic drugs.
Read the full Spearmint Oil + Abacavir, Lamivudine interactionAbemaciclibVerzenio
How Abemaciclib interacts with Maximum Essential Omega-3 Natural Mint — through 1 ingredient. Tap an ingredient for the detail:
Peppermint OilCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Read the full Peppermint Oil + Abemaciclib interactionAbiraterone
How Abiraterone interacts with Maximum Essential Omega-3 Natural Mint — through 2 ingredients. Tap an ingredient for the detail:
Spearmint OilHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, high doses of spearmint might increase the risk of liver damage when taken with hepatotoxic drugs.
Read the full Spearmint Oil + Abiraterone interactionPeppermint OilCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Read the full Peppermint Oil + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with Maximum Essential Omega-3 Natural Mint — through 2 ingredients. Tap an ingredient for the detail:
Spearmint OilHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, high doses of spearmint might increase the risk of liver damage when taken with hepatotoxic drugs.
Read the full Spearmint Oil + Abiraterone Acetate interactionPeppermint OilCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Read the full Peppermint Oil + Abiraterone Acetate interactionAbrocitinibCibinqo
How Abrocitinib interacts with Maximum Essential Omega-3 Natural Mint — through 2 ingredients. Tap an ingredient for the detail:
Peppermint OilCytochrome P450 2c19 (cyp2c19) Substrates, Cytochrome P450 2c9 (cyp2c9) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP2C19 substrates.
Read the full Peppermint Oil + Abrocitinib interactionFish OilAnticoagulant/antiplatelet Drugs Minor
Interaction Summary
Fish oil may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Fish Oil + Abrocitinib interactionAcalabrutinibCalquence
How Acalabrutinib interacts with Maximum Essential Omega-3 Natural Mint — through 1 ingredient. Tap an ingredient for the detail:
Peppermint OilCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Read the full Peppermint Oil + Acalabrutinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Maximum Essential Omega-3 Natural Mint — through 1 ingredient. Tap an ingredient for the detail:
Spearmint OilHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, high doses of spearmint might increase the risk of liver damage when taken with hepatotoxic drugs.
Read the full Spearmint Oil + Acarbose interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Maximum Essential Omega-3 Natural Mint — through 2 ingredients. Tap an ingredient for the detail:
Spearmint OilHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, high doses of spearmint might increase the risk of liver damage when taken with hepatotoxic drugs.
Read the full Spearmint Oil + Acebutolol interactionFish OilAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking fish oil with antihypertensive drugs might increase the risk of hypotension.
Read the full Fish Oil + Acebutolol interactionAcepromazineAtravet
How Acepromazine interacts with Maximum Essential Omega-3 Natural Mint — through 1 ingredient. Tap an ingredient for the detail:
Spearmint OilCns Depressants Moderate
Interaction Summary
Theoretically, spearmint might alter the sedative effects of CNS depressants.
Read the full Spearmint Oil + Acepromazine interactionAcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength
How Acetaminophen interacts with Maximum Essential Omega-3 Natural Mint — through 2 ingredients. Tap an ingredient for the detail:
Spearmint OilHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, high doses of spearmint might increase the risk of liver damage when taken with hepatotoxic drugs.
Read the full Spearmint Oil + Acetaminophen interactionPeppermint OilCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, peppermint might increase the levels of CYP1A2 substrates.
Read the full Peppermint Oil + Acetaminophen interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Maximum Essential Omega-3 Natural Mint — through 3 ingredients. Tap an ingredient for the detail:
Spearmint OilHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, high doses of spearmint might increase the risk of liver damage when taken with hepatotoxic drugs.
Read the full Spearmint Oil + Acetaminophen, Aspirin interactionPeppermint OilCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, peppermint might increase the levels of CYP1A2 substrates.
Read the full Peppermint Oil + Acetaminophen, Aspirin interactionFish OilAnticoagulant/antiplatelet Drugs Minor
Interaction Summary
Fish oil may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Fish Oil + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Maximum Essential Omega-3 Natural Mint — through 3 ingredients. Tap an ingredient for the detail:
Spearmint OilHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, high doses of spearmint might increase the risk of liver damage when taken with hepatotoxic drugs.
Read the full Spearmint Oil + Acetaminophen, Aspirin, Caffeine interactionPeppermint OilCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP1A2 substrates.
Read the full Peppermint Oil + Acetaminophen, Aspirin, Caffeine interactionFish OilAnticoagulant/antiplatelet Drugs Minor
Interaction Summary
Fish oil may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Fish Oil + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with Maximum Essential Omega-3 Natural Mint — through 2 ingredients. Tap an ingredient for the detail:
Spearmint OilHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, high doses of spearmint might increase the risk of liver damage when taken with hepatotoxic drugs.
Read the full Spearmint Oil + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionPeppermint OilCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, peppermint might increase the levels of CYP1A2 substrates.
Read the full Peppermint Oil + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more
How Acetaminophen, Butalbital interacts with Maximum Essential Omega-3 Natural Mint — through 2 ingredients. Tap an ingredient for the detail:
Spearmint OilHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, high doses of spearmint might increase the risk of liver damage when taken with hepatotoxic drugs.
Read the full Spearmint Oil + Acetaminophen, Butalbital interactionPeppermint OilCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, peppermint might increase the levels of CYP1A2 substrates.
Read the full Peppermint Oil + Acetaminophen, Butalbital interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Maximum Essential Omega-3 Natural Mint — through 2 ingredients. Tap an ingredient for the detail:
Spearmint OilHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, high doses of spearmint might increase the risk of liver damage when taken with hepatotoxic drugs.
Read the full Spearmint Oil + Acetaminophen, Butalbital, Caffeine interactionPeppermint OilCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Read the full Peppermint Oil + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Maximum Essential Omega-3 Natural Mint — through 2 ingredients. Tap an ingredient for the detail:
Peppermint OilCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP1A2 substrates.
Read the full Peppermint Oil + Acetaminophen, Butalbital, Caffeine, Codeine interactionSpearmint OilHepatotoxic Drugs, Cns Depressants Moderate
Interaction Summary
Theoretically, high doses of spearmint might increase the risk of liver damage when taken with hepatotoxic drugs.
Read the full Spearmint Oil + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Maximum Essential Omega-3 Natural Mint — through 2 ingredients. Tap an ingredient for the detail:
Spearmint OilHepatotoxic Drugs, Cns Depressants Moderate
Interaction Summary
Theoretically, high doses of spearmint might increase the risk of liver damage when taken with hepatotoxic drugs.
Read the full Spearmint Oil + Acetaminophen, Butalbital, Codeine interactionPeppermint OilCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, peppermint might increase the levels of CYP1A2 substrates.
Read the full Peppermint Oil + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Maximum Essential Omega-3 Natural Mint — through 2 ingredients. Tap an ingredient for the detail:
Spearmint OilCns Depressants, Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, spearmint might alter the sedative effects of CNS depressants.
Read the full Spearmint Oil + Acetaminophen, Butalbital, Codeine Phosphate interactionPeppermint OilCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, peppermint might increase the levels of CYP1A2 substrates.
Read the full Peppermint Oil + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Maximum Essential Omega-3 Natural Mint — through 2 ingredients. Tap an ingredient for the detail:
Peppermint OilCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP1A2 substrates.
Read the full Peppermint Oil + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionSpearmint OilCns Depressants, Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, spearmint might alter the sedative effects of CNS depressants.
Read the full Spearmint Oil + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Maximum Essential Omega-3 Natural Mint — through 2 ingredients. Tap an ingredient for the detail:
Peppermint OilCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Read the full Peppermint Oil + Acetaminophen, Caffeine, Codeine interactionSpearmint OilHepatotoxic Drugs, Cns Depressants Moderate
Interaction Summary
Theoretically, high doses of spearmint might increase the risk of liver damage when taken with hepatotoxic drugs.
Read the full Spearmint Oil + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Maximum Essential Omega-3 Natural Mint — through 2 ingredients. Tap an ingredient for the detail:
Spearmint OilCns Depressants, Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, spearmint might alter the sedative effects of CNS depressants.
Read the full Spearmint Oil + Acetaminophen, Caffeine, Codeine, Salicylamide interactionPeppermint OilCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Read the full Peppermint Oil + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Maximum Essential Omega-3 Natural Mint — through 2 ingredients. Tap an ingredient for the detail:
Peppermint OilCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP1A2 substrates.
Read the full Peppermint Oil + Acetaminophen, Caffeine, Dihydrocodeine interactionSpearmint OilCns Depressants, Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, spearmint might alter the sedative effects of CNS depressants.
Read the full Spearmint Oil + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Maximum Essential Omega-3 Natural Mint — through 2 ingredients. Tap an ingredient for the detail:
Spearmint OilHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, high doses of spearmint might increase the risk of liver damage when taken with hepatotoxic drugs.
Read the full Spearmint Oil + Acetaminophen, Caffeine, Isometheptene interactionPeppermint OilCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP1A2 substrates.
Read the full Peppermint Oil + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Maximum Essential Omega-3 Natural Mint — through 2 ingredients. Tap an ingredient for the detail:
Peppermint OilCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Read the full Peppermint Oil + Acetaminophen, Caffeine, Pyrilamine interactionSpearmint OilHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, high doses of spearmint might increase the risk of liver damage when taken with hepatotoxic drugs.
Read the full Spearmint Oil + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Maximum Essential Omega-3 Natural Mint — through 2 ingredients. Tap an ingredient for the detail:
Peppermint OilCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP1A2 substrates.
Read the full Peppermint Oil + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionSpearmint OilHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, high doses of spearmint might increase the risk of liver damage when taken with hepatotoxic drugs.
Read the full Spearmint Oil + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Maximum Essential Omega-3 Natural Mint — through 2 ingredients. Tap an ingredient for the detail:
Peppermint OilCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP1A2 substrates.
Read the full Peppermint Oil + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionSpearmint OilCns Depressants, Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, spearmint might alter the sedative effects of CNS depressants.
Read the full Spearmint Oil + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Maximum Essential Omega-3 Natural Mint — through 2 ingredients. Tap an ingredient for the detail:
Peppermint OilCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Read the full Peppermint Oil + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionSpearmint OilHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, high doses of spearmint might increase the risk of liver damage when taken with hepatotoxic drugs.
Read the full Spearmint Oil + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Maximum Essential Omega-3 Natural Mint with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Peppermint Oil
Cyclosporine (Neoral, Sandimmune)
Theoretically, peppermint oil might increase the levels and adverse effects of cyclosporine.
In animal research, peppermint oil inhibits cyclosporine metabolism and increases cyclosporine levels. Inhibition of cytochrome P450 3A4 (CYP3A4) may be partially responsible for this interaction. An interaction between peppermint oil and cyclosporine has not been reported in humans.
Cytochrome P450 2C19 (Cyp2C19) Substrates
Theoretically, peppermint might increase the levels of CYP2C19 substrates.
In vitro research shows that peppermint oil inhibits CYP2C19. So far, this interaction has not been reported in humans.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, peppermint might increase the levels of CYP2C9 substrates.
In vitro research shows that peppermint oil inhibits CYP2C9. So far, this interaction has not been reported in humans.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Clinical research in healthy volunteers shows that a single dose of peppermint oil 600 mg inhibits CYP3A4 enzymes and increases the AUC of felodipine, a CYP3A4 substrate. However, in vitro research suggests that peppermint oil only inhibits CYP3A4 at very high concentrations.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, peppermint might increase the levels of CYP1A2 substrates.
In vitro and animal research shows that peppermint oil and peppermint leaf inhibit CYP1A2. However, in clinical research, peppermint tea did not significantly affect the metabolism of caffeine, a CYP1A2 substrate. It is possible that the 6-day duration of treatment may have been too short to identify a difference.
Spearmint Oil
Cns Depressants
Theoretically, spearmint might alter the sedative effects of CNS depressants.
Animal research suggests that (-)-carvone, a major constituent of spearmint, has sedative effects. However, in humans, chewing spearmint-flavored gum induced arousal effects.
Hepatotoxic Drugs
Theoretically, high doses of spearmint might increase the risk of liver damage when taken with hepatotoxic drugs.
Animal research suggests that drinking spearmint tea for 30 days can increase markers of liver damage, including aspartate aminotransferase (AST) and alanine aminotransferase (ALT), and cause liver degeneration and necrosis, in a dose-dependent manner. This effect has not been reported in humans.
Fish Oil
Antihypertensive Drugs
Theoretically, taking fish oil with antihypertensive drugs might increase the risk of hypotension.
Clinical evidence indicates that fish oils can modestly lower blood pressure and might have additive effects in patients treated with antihypertensives.
Contraceptive Drugs
Theoretically, taking fish oil with contraceptive drugs might decrease the triglyceride-lowering effects of fish oil.
There is some evidence that contraceptive drugs might interfere with the triglyceride lowering effects of fish oils.
Cyclosporine (Neoral, Sandimmune)
Taking fish oil with cyclosporine might increase levels and adverse effects of cyclosporine.
In kidney transplant recipients on a general immunosuppressive regimen, taking omega-3 fatty acids daily seems to increase peak blood levels of cyclosporine when compared with placebo. This increase was as much as 20% after one month. However, the area under the curve was not significantly affected.
Orlistat (Xenical, Alli)
Theoretically, taking fish oil with orlistat might decrease the absorption of fish oil fatty acids.
Orlistat binds lipase in the gastrointestinal tract and reduces fat absorption. Theoretically, taking fish oil with orlistat might decrease absorption of fish oil fatty acids. To avoid this potential interaction, recommend separating administration of orlistat and fish oil by at least 2 hours.
Sirolimus (Rapamune)
Taking fish oil with sirolimus might increase levels and adverse effects of sirolimus.
Pharmacokinetic research shows that omega-3 fatty acids increase exposure to sirolimus in kidney transplant patients on a calcineurin inhibitor-free immunosuppressive regimen. A 25% dose reduction in sirolimus was required to keep patients within the expected trough-concentration window. Researchers hypothesize that this may be due to inhibition of cytochrome P450 3A4 (CYP3A4) by fish oil, although this has not been confirmed in clinical research.
Tacrolimus (Prograf)
Taking fish oil with tacrolimus might increase levels and adverse effects of tacrolimus.
In a small group of patients, taking fish oil 2.6 grams (Omacor) daily for 4 weeks increased the 8-hour area under the curve of tacrolimus by 25% when compared with baseline. Peak levels were increased by approximately 22%. Researchers hypothesize that this may be due either to an increase in bioavailability or to inhibition of cytochrome P450 3A4 (CYP3A4) by fish oil, although this has not been confirmed in clinical research.
Anticoagulant/Antiplatelet Drugs
Fish oil may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs. However, evidence is conflicting.
While fish oil may not be a potent inhibitor of platelet function, high doses of fish oil might have antiplatelet effects. Theoretically, concomitant use of fish oil with anticoagulant or antiplatelet drugs may increase the risk of bleeding. However, the most rigorous research shows that short-term doses of fish oil 10 grams daily or long-term doses of 1.5 grams daily for up to 52 weeks does not increase the risk of bleeding or affect coagulation parameters in chronically ill and vulnerable patients. Other controlled research shows that fish oil does not affect platelet function or increase the risk of bleeding. Some research even suggests that perioperative fish oil use decreases bleeding risk. Some research suggests fish oil does not have additive antiplatelet effects when combined with aspirin, but other clinical evidence suggests that adding fish oil to low-dose aspirin treatment increases antiplatelet effects in patients who are aspirin-resistant. Also, some clinical research seems to show that fish oil has additive antiplatelet effects when used with aspirin and clopidogrel compared to aspirin and clopidogrel alone.
Platinum Agents
Theoretically, taking fish oil with platinum agents can cause resistance to platinum agents, potentially decreasing their effectiveness.
Platinum-induced fatty acids (PIFAs) are fatty acids secreted from human and mouse stem cells when exposed to platinum-based chemotherapy. Animal research suggests that PIFAs cause resistance to chemotherapy by stimulating lysophospholipid production in the spleen, which interferes with the DNA damage caused by certain chemotherapy drugs. One PIFA, known as 16:4(n-3), has been found in both raw fish and some commercially available fish oil products. Mackerel and herring have high PIFA concentrations, while salmon and tuna have low PIFA concentrations. Levels of PIFA in commercial fish oil products ranged from 0.2- 5.7 microMol. Animal research shows that PIFA-containing fish oil products cause resistance to cisplatin, fluorouracil, irinotecan, and oxaliplatin. It is unclear if all commercially available fish oil products contain PIFAs. Additionally, it is argued that levels of PIFA found in some fish oil products are too low to be of clinical concern. Furthermore, a lack of chemotherapy resistance in countries with high fish intake, such as Greenland, Japan, and Norway, suggest that this interaction may not be clinically significant.
Warfarin (Coumadin)
Fish oil may have antiplatelet effects and might increase the risk of bleeding if used with warfarin.
Fish oil has antiplatelet effects at high doses. Case reports show elevated INR in patients taking warfarin and fish oil 1-2 grams daily. However, some clinical research shows that taking fish oil 3-6 grams daily does not significantly increase INR in patients taking warfarin.
Brand information
Manufacturer and brand details for Maximum Essential Omega-3 Natural Mint, from the product label.
ProCaps Laboratories
See all ProCaps Laboratories products- Name
- ProCaps Labs
- City
- Henderson
- State
- NV
- ZipCode
- 89011
- Phone Number
- 800-800-1200
- Web Address
- ProCapsLabs.com
Maximum Essential Omega-3 Natural Mint by ProCaps Laboratories: Common Questions
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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The Full Monographs Behind Maximum Essential Omega-3 Natural Mint’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Fish Oil
Interacts with 327 drugsFish oil provides omega-3 fatty acids (EPA and DHA) that are best known for lowering high triglyceride levels. The evidence for other heart and health benefits is mixed, and it is generally...
Read the full Fish Oil monograph → Herb & supplement monographPeppermint
Interacts with 796 drugsPeppermint is a popular herb with the best evidence supporting enteric-coated peppermint oil for easing IBS symptoms. It is generally well tolerated for most adults, but it can cause heartbu...
Read the full Peppermint monograph → Herb & supplement monographSpearmint
Interacts with 579 drugsSpearmint is a common culinary mint that is generally safe in food and tea amounts. Early research suggests possible benefits for digestion, mild hormone-related issues (such as excess facia...
Read the full Spearmint monograph →Sources & How We Checked
Maximum Essential Omega-3 Natural Mint's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 218 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Fish Oil 157 references
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- Bulstra-Ramakers MT, Huisjes HJ, Visser GH. The effects of 3g eicosapentaenoic acid daily on recurrence of intrauterine growth retardation and pregnancy induced hypertension. Br J Obstet Gynaecol 1995;102:123-6. PubMed
- Sacks FM, Hebert P, Appel LJ, et al. Short report: the effect of fish oil on blood pressure and high-density lipoprotein-cholesterol levels in phase I of the trials of hypertension prevention. J Hypertens 1994;12:209-13.
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- Hawthorne AB, Daneshmend TK, Hawkey CJ, et al. Treatment of ulcerative colitis with fish oil supplementation: a prospective 12 month randomised controlled trial. Gut 1992;33:922-8. PubMed
- D'Almeida A, Carter JP, Anatol A, Prost C. Effects of a combination of evening primrose oil (gamma linolenic acid) and fish oil (eicosapentaenoic + docahexaenoic acid) versus magnesium, and versus placebo in preventing pre-eclampsia. Women Health 1992;19 PubMed
- FDA. Center for Food Safety and Applied Nutrition. Letter regarding dietary supplement health claim for omega-3 fatty acids and coronary heart disease. Available at: http://www.fda.gov/ohrms/dockets/dockets/95s0316/95s-0316-Rpt0272-38-Appendix-D-Reference
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- Anon. Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Gruppo Italiano per lo Studio della Soprawivenza nell'Infarto miocardico. Lancet 1999;354:447-55. DOI
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- Kelley DS, Rudolph IL. Effect of individual fatty acids of omega-6 and omega-3 type on human immune status and role of eicosanoids. Nutrition 2000;16:143-5.
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- Connor WE. n-3 Fatty acids from fish and fish oil: panacea or nostrum? Am J Clin Nutr 2001;74;415-6. PubMed
- Maresta A, Balduccelli M, Varani E, et al. Prevention of postcoronary angioplasty restenosis by omega-3 fatty acids: main results of the Esapent for Prevention of Restenosis Italian Study (ESPRIT). Am Heart J 143:E5. PubMed
- Deutch B, Jorgensen EB, Hansen JC. n-3 PUFA from fish or seal oil reduce atherogenic risk indicators in Danish women. Nutr Res 2000;20:1065-77. DOI
- Higgins S, McCarthy SN, Corridan BM, et al. Measurement of free cholesterol, cholesteryl esters and cholesteryl linoleate hydroperoxide in copper-oxidised low density lipoprotein in healthy volunteers supplemented with a low dose of n-3 polyunsaturated f
- Calder PC. N-3 polyunsaturated fatty acids, inflammation and immunity: pouring oil on troubled waters or another fishy tale? Nutr Res 2001;21:309-41. DOI
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- Higdon JV, Du SH, Lee YS, et al. Supplementation of postmenopausal women with fish oil does not increase overall oxidation of LDL ex vivo compared to dietary oils rich in oleate and linoleate. J Lipid Res 2001;42:407-18. DOI
- Olsen SF, Sorensen JD, Secher NJ, et al. Randomised controlled trial of effect of fish-oil supplementation on pregnancy duration. Lancet 1992;339:1003-7. PubMed
- Ito Y, Suzuki K, Imai H, et al. Effects of polyunsaturated fatty acids on atrophic gastritis in a Japanese population. Cancer Lett 2001;163:171-8. PubMed
- Bender NK, Kraynak MA, Chiquette E, et al. Effects of marine fish oils on the anticoagulation status of patients receiving chronic warfarin therapy. J Thromb Thrombolysis 1998;5:257-61.. PubMed
- Suzukawa M, Abbey M, Howe PR, Nestel PJ. Effects of fish oil fatty acids on low density lipoprotein size, oxidizability, and uptake by macrophages. J Lipid Res 1995;36:473-84.. DOI
- Su KP, Huang SY, Chiu CC, Shen WW. Omega-3 fatty acids in major depressive disorder. A preliminary double-blind, placebo-controlled trial. Eur Neuropsychopharmacol 2003;13:267-71..
- Wang C, Chung M, Lichtenstein A, et al. Effects of omega-3 fatty acids on cardiovascular disease. Evid Rep Technol Assess (Summ) 2004 Mar;(94):1-8.
- US Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Seafood. Mercury levels in seafood species. Available at: http://www.cfsan.fda.gov/~frf/sea-mehg.html.
- US Environmental Protection Agency. Fish Advisories web page. Available at: http://www.epa.gov/waterscience/fish.
- Dunstan JA, Roper J, Mitoulas L, et al. The effect of supplementation with fish oil during pregnancy on breast milk immunoglobulin A, soluble CD14, cytokine levels and fatty acid composition. Clin Exp Allergy 2004;34:1237-42. PubMed
- Lauritzen L, Jorgensen MH, Mikkelsen TB, et al. Maternal fish oil supplementation in lactation: effect on visual acuity and n-3 fatty acid content of infant erythrocytes. Lipids 2004;39:195-206. PubMed
- Dunstan JA, Mori TA, Barden A et al. Fish oil supplementation in pregnancy modifies neonatal allergen-specific immune responses and clinical outcomes in infants at high risk of atopy: a randomized, controlled trial. J Allergy Clin Immunol 2003;112:1178-84 PubMed
- Olsen SF, Secher NJ, Tabor A, et al. Randomised clinical trials of fish oil supplementation in high risk pregnancies. Fish Oil Trials In Pregnancy (FOTIP) Team. BJOG 2000;107:382-95. PubMed
- Stern AH. A review of the studies of the cardiovascular health effects of methylmercury with consideration of their suitability for risk assessment. Environ Res 2005;98:133-42. PubMed
- Harris WS. Fish oil supplementation: evidence for health benefits. Cleve Clin J Med 2004;71:208-10, 212, 215-8 passim. PubMed
- Raitt MH, Connor WE, Morris C, et al. Fish oil supplementation and risk of ventricular tachycardia and ventricular fibrillation in patients with implantable defibrillators: a randomized controlled trial. JAMA 2005;293:2884-91. DOI
- Svaneborg N, Kristensen SD, Hansen LM, et al. The acute and short-time effect of supplementation with the combination of n-3 fatty acids and acetylsalicylic acid on platelet function and plasma lipids. Thromb Res 2002;105:311-6. PubMed
- Lauritzen L, Hoppe C, Straarup EM, Michaelsen KF. Maternal fish oil supplementation in lactation and growth during the first 2.5 years of life. Pediatr Res 2005;58:235-42. PubMed
- Dunstan JA, Mori TA, Barden A, et al. Effects of n-3 polyunsaturated fatty acid supplementation in pregnancy on maternal and fetal erythrocyte fatty acid composition. Eur J Clin Nutr 2004;58:429-37. PubMed
- Dunstan JA, Simmer K, Dixon G, Prescott SL. Cognitive assessment at 2 1/2 years following fish oil supplementation in pregnancy: a randomized controlled trial. Arch Dis Child Fetal Neonatal Ed 2008;93(1):F45-50.
- McKenney JM, Sica D. Prescription omega-3 fatty acids for the treatment of hypertriglyceridemia. Am J Health-Syst Pharm 2007;64:595-605. PubMed
- Malinowski JM, Metka K. Elevation of low-density lipoprotein cholesterol concentration with over-the-counter fish oil supplementation. Ann Pharmacother 2007;41:1296-300. PubMed
- Gissi-HF Investigators; Tavazzi L, Maggioni AP, Marchioli R, et al. Effect of n-3 polyunsaturated fatty acids in patients with chronic heart failure (the GISSI-HF trial): a randomised, double-blind, placebo-controlled trial. Lancet 2008;372:1223-30. PubMed
- Lucas M, Asselin G, Merette C, et al. Effects of ethyl-eicosapentaenoic acid omega-3 fatty acid supplementation on hot flashes and quality of life among middle-aged women: a double-blind, placebo-controlled, randomized clinical trial. Menopause 2009;16:3 PubMed
- Holland S, Silberstein SD, Freitag F, et al. Evidence-based guideline update: NSAIDs and other complementary treatments for episodic migraine prevention in adults: Report of the Quality Standards Subcommittee of the American Academy of Neurology and the A
- Kwak SM, Myung SK, Lee YJ, Seo HG. Efficacy of omega-3 fatty acid supplements (eicosapentaenoic acid and docosahexaenoic acid) in the secondary prevention of cardiovascular disease: a meta-analysis of randomized, double-blind, placebo-controlled trials. A PubMed
- Armaganijan L, Lopes RD, Healey JS, et al. Do omega-3 fatty acids prevent atrial fibrillation after open heart surgery? A meta-analysis of randomized controlled trials. Clinics (Sao Paulo) 2011;66:1923-8.
- Jalili M, Dehpour AR. Extremely prolonged INR associated with warfarin in combination with both trazodone and omega-3 fatty acids. Arch Med Res. 2007 Nov;38(8):901-4. PubMed
- von Houwelingen R, Nordøy A, van der Beek E, et al. Effect of a moderate fish intake on blood pressure, bleeding time, hematology, and clinical chemistry in healthy males. Am J Clin Nutr. 1987 Sep;46(3):424-36. PubMed
- Goodnight SH Jr, Harris WS, Connor WE. The effects of dietary omega 3 fatty acids on platelet composition and function in man: a prospective, controlled study. Blood. 1981 Nov;58(5):880-5. DOI
- Gajos G1, Rostoff P, Undas A, et al. Effects of polyunsaturated omega-3 fatty acids on responsiveness to dual antiplatelet therapy in patients undergoing percutaneous coronary intervention: the OMEGA-PCI (OMEGA-3 fatty acids after pci to modify responsive
- Lev EI, Solodky A, Harel N, et al. Treatment of aspirin-resistant patients with omega-3 fatty acids versus aspirin dose escalation. J Am Coll Cardiol. 2010 Jan 12;55(2):114-21. DOI
- Sanders, T. A., Gleason, K., Griffin, B., and Miller, G. J. Influence of an algal triacylglycerol containing docosahexaenoic acid (22 : 6n-3) and docosapentaenoic acid (22 : 5n-6) on cardiovascular risk factors in healthy men and women. Br J Nutr 2006;95
- Persson, C., Glimelius, B., Ronnelid, J., and Nygren, P. Impact of fish oil and melatonin on cachexia in patients with advanced gastrointestinal cancer: a randomized pilot study. Nutrition 2005;21(2):170-178. PubMed
- Cobiac, L., Nestel, P. J., Wing, L. M., and Howe, P. R. A low-sodium diet supplemented with fish oil lowers blood pressure in the elderly. J Hypertens. 1992;10(1):87-92. PubMed
- Maclean, C. H., Mojica, W. A., Morton, S. C., Pencharz, J., Hasenfeld, Garland R., Tu, W., Newberry, S. J., Jungvig, L. K., Grossman, J., Khanna, P., Rhodes, S., and Shekelle, P. Effects of omega-3 fatty acids on lipids and glycemic control in type II di
- Schachter, H. M., Kourad, K., Merali, Z., Lumb, A., Tran, K., and Miguelez, M. Effects of omega-3 fatty acids on mental health. Evid.Rep.Technol.Assess.(Summ.) 2005;(116):1-11.
- Reisman, J., Schachter, H. M., Dales, R. E., Tran, K., Kourad, K., Barnes, D., Sampson, M., Morrison, A., Gaboury, I., and Blackman, J. Treating asthma with omega-3 fatty acids: where is the evidence? A systematic review. BMC.Complement Altern Med 2006;6 PubMed
- Caniato, R. N., Alvarenga, M. E., and Garcia-Alcaraz, M. A. Effect of omega-3 fatty acids on the lipid profile of patients taking clozapine. Aust N Z J Psychiatry 2006;40(8):691-697. DOI
- Amminger, G. P., Berger, G. E., Schafer, M. R., Klier, C., Friedrich, M. H., and Feucht, M. Omega-3 fatty acids supplementation in children with autism: a double-blind randomized, placebo-controlled pilot study. Biol.Psychiatry 2-15-2007;61(4):551-553. PubMed
- Bowden, R. G., Wilson, R. L., Gentile, M., Ounpraseuth, S., Moore, P., and Leutholtz, B. C. Effects of omega-3 fatty acid supplementation on vascular access thrombosis in polytetrafluorethylene grafts. J Ren Nutr 2007;17(2):126-131. PubMed
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