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Dietary supplement

MD's Ultimate Glucose Disposal Agent Ingredients & Drug Interactions

by True Nutrition

MD's Ultimate Glucose Disposal Agent label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking MD's Ultimate Glucose Disposal Agent against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

MD's Ultimate Glucose Disposal Agent is a dietary supplement by True Nutrition with 6 active ingredients. Its ingredients are commonly taken for hair growth and thinning hair, brittle nails, skin health.Based on those ingredients, 1,134 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Gymnema sylvestre Leaf Extract, Powder, Cinnamon bark extract, R-Alpha Lipoic Acid. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against MD's Ultimate Glucose Disposal Agent by True Nutrition

Ask about any prescription or over-the-counter medication and we check it for interactions with MD's Ultimate Glucose Disposal Agent by True Nutrition — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of MD's Ultimate Glucose Disposal Agent by True Nutrition

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 20, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 2 of its 6 active ingredients.
  • “UGDA Proprietary Blend” is a proprietary blend — the label gives one combined amount (805 mg) without saying how much of each component you get.

MD's Ultimate Glucose Disposal Agent contains 6 active ingredients: biotin, chromium, R-alpha lipoic acid, vanadyl sulfate, cinnamon bark extract, and gymnema sylvestre leaf extract. Biotin is a B vitamin; chromium and vanadyl sulfate are trace minerals; R-alpha lipoic acid is an antioxidant compound; cinnamon bark extract comes from the spice; and gymnema is a plant extract.

The product also contains inactive ingredients—magnesium stearate, rice flour, and the capsule itself—which serve as binders and fillers.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: blood sugar support with carbohydrate meals.
  • We looked for evidence on: Diabetes, Impaired glucose tolerance (prediabetes), Dyslipidemia, Metabolic syndrome, Diabetic neuropathy, Diabetic nephropathy — and 4 related terms.
  • The strongest evidence on file: Alpha-lipoic Acid is rated "Possibly Effective" for Diabetic neuropathy (Natural Medicines).
  • Also on file: Chromium is rated "Possibly Effective" for Diabetes.
  • Also on file: Alpha-lipoic Acid is rated "Possibly Ineffective" for Diabetes, Diabetic retinopathy.

For biotin, the evidence shows it's likely effective for biotin deficiency, but possibly ineffective for multiple sclerosis or seborrheic dermatitis. For chromium, it's likely effective for chromium deficiency and possibly effective for diabetes, though possibly ineffective for prediabetes.

R-alpha lipoic acid is possibly effective for diabetic nerve pain (neuropathy) and possibly effective for high cholesterol and weight management. Vanadyl sulfate is likely effective for vanadium deficiency, but evidence is insufficient to rate it for athletic performance, cancer, diabetes, or high cholesterol.

Cinnamon bark extract has insufficient evidence for amenorrhea, angina, cold, diabetes, diarrhea, or abnormal cholesterol levels. Gymnema sylvestre extract has insufficient evidence for diabetes, weight loss, prediabetes, or metabolic syndrome.

Because many of these ingredients lack solid evidence for the product's intended use, talk with your doctor or pharmacist about whether this supplement fits your goals.

The evidence, ingredient by ingredient Biotin Chromium Alpha-lipoic Acid Vanadium Cassia Cinnamon Gymnema

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 6 of the 6 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 6 of 6.
  • General safety write-ups exist for 6 of 6.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Biotin is generally well tolerated, even at high doses, though rarely mild diarrhea has been reported. Pregnancy and lactation are likely safe with biotin from food and prenatal vitamins, but check with your doctor before taking high-dose supplements.

Chromium is generally well tolerated at typical supplement doses, but gastrointestinal irritation, headaches, insomnia, and mood changes can occur; rare serious effects include kidney and liver damage. Pregnancy and lactation are likely safe with chromium.

R-alpha lipoic acid is generally well tolerated but can lower blood sugar; common side effects include headache, heartburn, nausea, and vomiting. It should be avoided during pregnancy and breastfeeding due to insufficient safety data.

Vanadyl sulfate is well tolerated below 1.8 mg daily, but higher doses may cause stomach upset, diarrhea, and nausea; long-term high doses risk kidney damage. Avoid during pregnancy and breastfeeding.

Cinnamon bark extract is generally safe in food amounts but supplement doses high in coumarin may harm the liver over time; avoid high-dose supplements during pregnancy and breastfeeding. Gymnema is generally well tolerated short-term but can lower blood sugar; a case of drug-induced hepatitis has been reported with concentrated tea.

Avoid during pregnancy and breastfeeding due to insufficient data.

Side effects, ingredient by ingredient Biotin Chromium Alpha-lipoic Acid Vanadium Cassia Cinnamon Gymnema

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 5 of the 6 matched ingredients can interact with medications — Vanadium, Alpha-lipoic Acid, Gymnema, Chromium, Cassia Cinnamon.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; cancer treatments; diabetes medications.
  • For scale: 1,135 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your doctor or pharmacist if you take antidiabetes drugs or insulin (Moderate risk of low blood sugar), anticoagulants or antiplatelet drugs like warfarin or clopidogrel (Moderate bleeding risk from R-alpha lipoic acid, vanadyl sulfate, and possibly gymnema), levothyroxine or other thyroid medication (Moderate risk of reduced absorption), or chemotherapy drugs—the antioxidants in this product may reduce their effectiveness. Also mention if you take any medication processed by your liver (gymnema can affect those levels) or drugs that can damage the liver (cinnamon may add to that risk).

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product is aimed at people interested in blood sugar management, but several of its ingredients—chromium, vanadyl sulfate, cinnamon, and gymnema—can lower blood sugar and may interact significantly with diabetes medications. If you take any blood sugar medication, blood thinner, thyroid medication, or liver-affecting drugs, or if you're on any prescription at all, check your specific medications with your doctor or pharmacist before starting.

The evidence for most ingredients in treating their intended purposes is limited or absent.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 6 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 21, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about MD's Ultimate Glucose Disposal Agent, straight from the product label.

Brand True Nutrition
Barcode (UPC) 850078007551
Net contents 180 Capsule(s)
Market status On market
Date entered into DSLD Jul 21, 2022
DSLD ID 268572
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for MD's Ultimate Glucose Disposal Agent by True Nutrition, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
90
UPC/BARCODE
850078007551
IngredientAmount% DV
Biotin100 mcg330%
Chromium24 mcg70%
R-Alpha Lipoic Acid0 NP--
Vanadyl Sulfate0 NP--
Cinnamon bark extract0 NP--
UGDA Proprietary Blend805 mg--
Gymnema sylvestre Leaf Extract, Powder0 NP--

Other ingredients: Magnesium Stearate, Rice Flour, Capsule

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

We're not a marketing company. We're a nutrition company. Since day one, we have focused on the quality of our products by only sourcing raw ingredients that are held to the most rigorous of standards. Because quality is so important to use, we 3rd party test all of our products to verify the value we offer to our customers. Other companies may be flashier, louder, and bigger... but our brand is built on the core values of results, legitimacy, and pure ingredients. Our reputation depends on it. Dante Trudel & Doug Smith, Co-Founders of True Nutrition

Certified Quality

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take 1 serving (2 capsules) with each starchy carb meal, up to 4 times a day.

Precautions

Warning: This product is not intended for use by those with a serious medical condition or pregnant or lactating women.

Consult your physician before use.

Keep out of reach of children.

Processed in a facility that handles milk, soy, egg, tree nuts, fish, crustaceans/shellfish, and wheat products.

Formulation

Quality 3rd party tested and verified content Value Supplements direct from manufacturer

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

Purity Third-Party Tested

Made in USA

FDA Disclaimer Statement

These label statements have not been approved by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

MD's Ultimate Glucose Disposal Agent by True Nutrition label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

MD's Ultimate Glucose Disposal Agent label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in MD's Ultimate Glucose Disposal Agent by True Nutrition

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Biotin

No known
interactions
100 mcg per serving

Biotin (vitamin B7) is a water-soluble vitamin your body needs to turn food into energy and to support healthy hair, skin, and nails. Most people get...

Biotin monograph & interactions

Chromium

Interacts with
178 drugs
24 mcg per serving Form: Chromium Picolinate

Chromium is an essential trace mineral involved in how the body handles sugar and fat. Some studies suggest it may modestly help blood sugar control i...

Chromium monograph & interactions

UGDA Proprietary Blend

805 mg per serving

Other (inactive) ingredients: Magnesium Stearate, Rice Flour, Capsule. These complete the product’s ingredient list but are not active constituents.

Interaction report

MD's Ultimate Glucose Disposal Agent by True Nutrition Drug Interactions

Want to check YOUR meds against MD's Ultimate Glucose Disposal Agent?

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 Go to the checker
1,134Drugs
717 Moderate 417 Minor

Ingredients driving the most interactions

Gymnema sylvestre Leaf Extract, Powder 851
Cinnamon bark extract 442
R-Alpha Lipoic Acid 263
Vanadyl Sulfate 208
Chromium 178

Individual Drug Interactions

The ingredients in MD's Ultimate Glucose Disposal Agent interact with 1,134 drugs. Click any drug to see the details.

5 of the 6 ingredients in MD's Ultimate Glucose Disposal Agent interact with drugs. Each result below shows which ingredient is responsible. Gymnema sylvestre Leaf Extract, Powder Cinnamon bark extract R-Alpha Lipoic Acid Vanadyl Sulfate Chromium

Each ingredient & the kinds of drugs it affects

For each ingredient in MD's Ultimate Glucose Disposal Agent with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Gymnema sylvestre Leaf Extract, Powder6 drug types · 851 drugs

Antidiabetes Drugs

Theoretically, taking gymnema with antidiabetes drugs might increase the risk of hypoglycemia.
Gymnema reduces blood glucose levels in some human and animal research. In human studies, it has been shown to enhance the blood glucose lowering effects of hypoglycemic drugs. However, other research in adults with prediabetes or metabolic syndrome suggests that gymnema does not reduce fasting levels of blood glucose. Until more is known, monitor blood glucose levels closely.

Likelihood Probable Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, gymnema might increase levels of drugs metabolized by CYP1A2.
Animal and in vitro research shows that gymnema can inhibit the CYP1A2 enzyme. In one animal study, oral administration of gymnema for 7 days increased the plasma concentrations of phenacetin, a CYP1A2 substrate, by about 1.4-fold and reduced the clearance of phenacetin by about 29%.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, gymnema might increase or decrease levels of drugs metabolized by CYP2C9.
Animal research shows that gymnema can induce the CYP2C9 enzyme. In one animal study, gymnema caused a 2.4-fold increase in the clearance of tolbutamide, a CYP2C9 substrate, in rats. In vitro research also shows that gymnema can inhibit CYP2C9.

Likelihood Possible Evidence D
Phenacetin

Theoretically, taking gymnema with phenacetin might increase the levels of phenacetin.
Animal research shows that gymnema, administered orally for 7 days, decreases the clearance of phenacetin in a dose-dependent manner by about 21% to 29% and increases plasma levels about 1.3- to 1.4-fold when compared to control.

Likelihood Possible Evidence D
Tolbutamide (Orinase)

Theoretically, taking gymnema with tolbutamide might the decrease levels of tolbutamide.
Animal research shows that gymnema, administered orally for 7 days, increases the clearance of tolbutamide by 2.4-fold when compared to control.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, gymnema might increase levels of drugs metabolized by CYP3A4.
One in vitro study using rat liver microsomes shows that gymnema can modestly inhibit the CYP3A4 enzyme. However, other in vitro research using human liver microsomes shows that gymnema does not affect CYP3A4 activity. Animal research also shows that gymnema does not alter the function of CYP3A4. In one study in rats, oral administration of gymnema for 7 days did not alter the clearance of amlodipine, a CYP3A4 substrate.

Likelihood Unlikely Evidence D
Gymnema sylvestre Leaf Extract, Powder full monograph & interactions

Cinnamon bark extract2 drug types · 442 drugs

Antidiabetes Drugs

Theoretically, cassia cinnamon may have additive effects with antidiabetes drugs.
Cassia cinnamon may lower blood glucose levels, and have additive effects in patients treated with antidiabetic agents. Dose adjustments to diabetes medications might be necessary.

Likelihood Possible Evidence B
Hepatotoxic Drugs

Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
There is some concern that ingesting large amounts of cassia cinnamon for an extended duration might cause hepatotoxicity in some people. Cassia cinnamon contains coumarin, which can cause hepatotoxicity in animal models. In humans, very high doses of coumarin from 50-7000 mg/day can result in hepatotoxicity that resolves when coumarin use is discontinued. Lower amounts might also cause liver problems in sensitive people, such as those with liver disease or those taking potentially hepatotoxic agents.

Likelihood Possible Evidence D
Cinnamon bark extract full monograph & interactions

R-Alpha Lipoic Acid5 drug types · 263 drugs

Alkylating Agents

Theoretically, the antioxidant effects of alpha-lipoic acid might alter the effectiveness of alkylating agents.
The use of antioxidants like alpha-lipoic acid during chemotherapy is controversial. There are concerns that antioxidants could reduce the activity of chemotherapy drugs that generate free radicals. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as alpha-lipoic acid have on chemotherapy. Advise patients to consult their oncologist before using alpha-lipoic acid.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, alpha-lipoic acid may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro, alpha-lipoic acid inhibits platelet aggregation.

Likelihood Possible Evidence D
Antitumor Antibiotics

Theoretically, the antioxidant effects of alpha-lipoic acid might alter the effectiveness of antitumor antibiotics.
The use of antioxidants like alpha-lipoic acid during chemotherapy is controversial. There are concerns that antioxidants could reduce the activity of antitumor antibiotic drugs, which work by generating free radicals. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as alpha-lipoic acid have on chemotherapy involving antitumor antibiotics. Advise patients to consult their oncologist before using alpha-lipoic acid.

Likelihood Possible Evidence D
Thyroid Hormone

Theoretically, alpha-lipoic acid might decrease the effects of thyroid hormone drugs.
Animal research suggests that co-administration of thyroxine with alpha-lipoic acid reduces conversion into the active T3 form.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking alpha-lipoic acid with antidiabetes drugs might increase the risk of hypoglycemia.
Although some small clinical studies have suggested that alpha-lipoic acid can lower blood glucose levels, larger clinical studies in patients with diabetes have shown no clinically meaningful effect. Additionally, co-administration of single doses of alpha-lipoic acid and glyburide or acarbose did not cause detectable drug interactions in healthy volunteers.

Likelihood Unlikely Evidence B
R-Alpha Lipoic Acid full monograph & interactions

Vanadyl Sulfate2 drug types · 208 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, vanadium might increase the risk of bleeding when taken with anticoagulant/antiplatelet drugs.
In vitro research shows that the sodium orthovanadate form of vanadium prolongs clotting time, likely through inhibition of thrombin and factor Xa.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, vanadium might increase the risk of hypoglycemia when taken with antidiabetes drugs.
A few very small clinical studies in patients with type 2 diabetes show that the vanadyl sulfate form of vanadium increases insulin sensitivity and might lower blood glucose levels.

Likelihood Probable Evidence B
Vanadyl Sulfate full monograph & interactions

Chromium5 drug types · 178 drugs

Antidiabetes Drugs

Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Some research shows that taking chromium might lower blood glucose levels, especially in patients with poorly controlled type 2 diabetes.

Likelihood Possible Evidence A
Insulin

Theoretically, concomitant use of chromium and insulin might increase the risk of hypoglycemia.
In clinical research, chromium has been shown to increase insulin sensitivity,

Likelihood Possible Evidence B
Levothyroxine (Synthroid, Others)

Chromium might bind levothyroxine in the intestinal tract and decrease levothyroxine absorption.
Clinical research in healthy volunteers shows that taking chromium picolinate 1000 mcg with levothyroxine 1 mg decreases serum levels of levothyroxine by 17% when compared to taking levothyroxine alone. Advise patients to take levothyroxine at least 30 minutes before or 3-4 hours after taking chromium.

Likelihood Probable Evidence B
Aspirin

Theoretically, aspirin might increase chromium absorption.
Animal research suggests that aspirin may increase chromium absorption and chromium levels in the blood.

Likelihood Possible Evidence D
Nonsteroidal Anti-Inflammatory Drugs (Nsaids)

NSAIDs might increase chromium levels in the body.
Drugs that are prostaglandin inhibitors, such as NSAIDs, seem to increase chromium absorption and retention.

Likelihood Possible Evidence D
Chromium full monograph & interactions
The maker

Brand information

Manufacturer and brand details for MD's Ultimate Glucose Disposal Agent, from the product label.

True Nutrition

See all True Nutrition products
Name
Truenutrition.com
Street Address
1211 Liberty Way
City
Vista
State
CA
ZipCode
92081
Pharmacist Counseling Corner

MD's Ultimate Glucose Disposal Agent by True Nutrition: Common Questions

Does MD's Ultimate Glucose Disposal Agent by True Nutrition interact with any medications?
Yes. Based on its ingredients, MD's Ultimate Glucose Disposal Agent has a known interaction with 1,134 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
MD's Ultimate Glucose Disposal Agent contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I have type 2 diabetes and take metformin?
No — do not start this without talking to your doctor first. Chromium, vanadyl sulfate, cinnamon, and gymnema can all lower blood sugar and may work together with your diabetes medication to drop it too far, raising your risk of low blood sugar (hypoglycemia). Your doctor may need to adjust your metformin dose or monitor you more closely. This is a conversation to have with your own doctor or pharmacist, not something to decide on your own.
What does gymnema actually do?
Gymnema is a plant extract that some research suggests may lower blood glucose levels and possibly enhance the effects of diabetes medications. However, the evidence isn't strong enough to say it reliably works for any condition, according to the data we hold. It's generally well tolerated short-term, but quality varies between products and it can lower blood sugar.
Is biotin safe during pregnancy?
Yes — biotin from food and prenatal vitamins is likely safe during pregnancy and breastfeeding. That said, before taking any high-dose biotin supplement, check with your doctor, since the data we have is most solid for normal dietary amounts.
Can this interact with my blood thinner (warfarin)?
Possibly. R-alpha lipoic acid and vanadyl sulfate both carry a Moderate risk of increasing bleeding if combined with anticoagulants. You need to talk with your doctor or pharmacist before adding this product — they may advise against it or want to monitor you more closely.
I take levothyroxine for my thyroid. Is this product okay?
Not without checking first. Chromium in this product can bind levothyroxine in your gut and reduce how much of it your body absorbs — research shows a potential 17% drop in absorption. Talk to your doctor or pharmacist; they may suggest taking them several hours apart or advise against this product altogether.
What are the inactive ingredients?
The capsule contains magnesium stearate and rice flour as binders and fillers. If you have allergies or sensitivities to any of those, check the label or ask the manufacturer for more details.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

MD's Ultimate Glucose Disposal Agent label
Go deeper

The Full Monographs Behind MD's Ultimate Glucose Disposal Agent’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Biotin

Biotin (vitamin B7) is a water-soluble vitamin your body needs to turn food into energy and to support healthy hair, skin, and nails. Most people get plenty from a normal diet, and true defi...

Read the full Biotin monograph → Herb & supplement monograph

Chromium

Interacts with 178 drugs

Chromium is an essential trace mineral involved in how the body handles sugar and fat. Some studies suggest it may modestly help blood sugar control in certain people with type 2 diabetes, b...

Read the full Chromium monograph → Herb & supplement monograph

Alpha-lipoic Acid

Interacts with 263 drugs

Alpha-lipoic acid (ALA) is an antioxidant made naturally by the body and found in small amounts in foods. It is most studied for diabetic nerve pain, where some evidence suggests it may help...

Read the full Alpha-lipoic Acid monograph → Herb & supplement monograph

Vanadium

Interacts with 208 drugs

Vanadium is a trace mineral found in tiny amounts in food, and people get plenty from a normal diet. Supplement claims for diabetes, weight, and athletic performance are not well proven, and...

Read the full Vanadium monograph → Herb & supplement monograph

Cassia Cinnamon

Interacts with 442 drugs

Cassia cinnamon is the common, inexpensive cinnamon used in cooking, and it is also taken as a supplement, most often for blood sugar support. The evidence for its health benefits is mixed a...

Read the full Cassia Cinnamon monograph → Herb & supplement monograph

Gymnema

Interacts with 851 drugs

Gymnema is an Ayurvedic herb best known for possibly helping lower blood sugar and reducing the taste of sweetness on the tongue. Some early human studies are encouraging for blood sugar sup...

Read the full Gymnema monograph →
Sources

Sources & How We Checked

MD's Ultimate Glucose Disposal Agent's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 152 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Biotin 4 references
  1. Debourdeau PM, Djezzar S, Estival JL, et al. Life-threatening eosinophilic pleuropericardial effusion related to vitamins B5 and H. Ann Pharmacother 2001;35:424-6. DOI
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. Mock DM, Quirk JG, Mock NI. Marginal biotin deficiency during normal pregnancy. Am J Clin Nutr 2002;75:295-9. PubMed
  4. Sedel F, Papeix C, Bellanger A, Touitou V, Lebrun-Frenay C, Galanaud D, et al. High doses of biotin in chronic progressive multiple sclerosis: a pilot study.Mult Scler Relat Disord. 2015;4(2):159-69. doi: 10.1016/j.msard.2015.01.005. PubMed

See these in context on the Biotin monograph →

Chromium 53 references
  1. Cerulli J, Grabe DW, Gauthier I, et al. Chromium picolinate toxicity. Ann Pharmacother 1998;32:428-31. PubMed
  2. Urberg M, Zemel MB. Evidence for synergism between chromium and nicotinic acid in the control of glucose tolerance in elderly humans. Metabolism 1987;36:896-9. PubMed
  3. Mohamedshah FY, Moser-Veillon PB, Yamini S, et al. Distribution of a stable isotope of chromium (53Cr) in serum, urine, and breast milk in lactating women. Am J Clin Nutr 1998;67:1250-5. PubMed
  4. Wasser WG, Feldman NS, D'Agati VD. Chronic renal failure after ingestion of over-the-counter chromium picolinate. [letter]. Ann Intern Med 1997;126:410. PubMed
  5. Mertz W. Interaction of chromium with insulin: a progress report. Nutr Rev 1998;56:174-7. PubMed
  6. Anderson RA. Chromium, glucose intolerance and diabetes. J Am Coll Nutr 1998;17:548-55. PubMed
  7. McLeod MN, Gaynes BN, Golden RN. Chromium potentiation of antidepressant pharmacotherapy for dysthymic disorder in 5 patients. J Clin Psych 1999;60:237-40. PubMed
  8. Fowler JF Jr. Systemic contact dermatitis caused by oral chromium picolinate. Cutis 2000;65:116. DOI
  9. Trent LK, Thieding-Cancel D. Effects of chromium picolinate on body composition. J Sports Med Phys Fitness 1995;35:273-80.
  10. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
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Alpha-lipoic Acid 48 references
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Cassia Cinnamon 20 references
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Gymnema 12 references
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  7. Zuniga LY, Gonzalez-Ortiz M, Martinez-Abundis E. Effect of gymnema sylvestre administration on metabolic syndrome, insulin sensitivity, and insulin secretion. J Med Food. 2017 Aug;20(8):750-54.
  8. Rammohan B, Samit K, Chinmoy D, et al. Human cytochrome P450 enzyme modulation by gymnema sylvestre: a predictive safety evaluation by LC-MS/MS. Pharmacogn Mag. 2016 Jul;12(Suppl 4):S389-S394.
  9. Vaghela M, Sahu N, Kharkar P, Pandita N. In vivo pharmacokinetic interaction by ethanolic extract of gymnema sylvestre with CYP2C9 (tolbutamide), CYP3A4 (amlodipine) and CYP1A2 (phenacetin) in rats. Chem Biol Interact. 2017 Dec 25;278:141-151. PubMed
  10. Vaghela M, Iyer K, Pandita N. In vitro inhibitory effect of gymnema sylvestre extracts and total gymnemic acids fraction on select cytochrome P450 activities in rat liver microsomes. Eur J Drug Metab Pharmacokinet. 2017 Oct 10. PubMed
  11. Gaytán Martínez LA, Sánchez-Ruiz LA, Zuñiga LY, González-Ortiz M, Martínez-Abundis E. Effect of Gymnema sylvestre administration on glycemic control, insulin secretion, and insulin sensitivity in patients with impaired glucose tolerance. J Med Food. 2021;
  12. Philips CA, Theruvath AH, Ravindran R. Toxic hepatitis-associated aplastic anaemia after dual homeopathic remedies and Gymnema sylvestre use. BMJ Case Rep 2022;15(3):e247867. PubMed

See these in context on the Gymnema monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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