Interactions on record — worth a quick check against your medications. Based on 3 of 4 ingredients. Check your meds →
Dietary supplement

Menopause Formula Ingredients & Drug Interactions

by GNC Women's

Menopause Formula label
See full label image
Other (e.g. Tea Bag) Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Menopause Formula against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Menopause Formula is a dietary supplement by GNC Women's with 4 active ingredients. Its ingredients are commonly taken for stress and anxiety, sleep problems, fatigue and low energy.Based on those ingredients, 1,430 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are KSM-66 Ashwagandha root extract, Libifem Fenugreek seed extract, Cuvitus Cucumber fruit extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Menopause Formula by GNC Women's

Ask about any prescription or over-the-counter medication and we check it for interactions with Menopause Formula by GNC Women's — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Menopause Formula by GNC Women's

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains four active ingredients. KSM-66 Ashwagandha root extract is included to support calm and sleep; fenugreek seed extract (Libifem) is meant to help with hormone-related concerns; cucumber fruit extract (Cuvitus) adds additional support; and triterpene glycosides round out the formula.

The supplement also contains several inactive ingredients—cellulose, oat bran, croscarmellose sodium, stearic acid, magnesium stearate, silica, triacetin, di-acetylated monoglycerides, oleic acid, and polyethylene glycol—which serve as binders, flow agents, and capsule materials.

Does it work?

Insufficient evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Insufficient

There isn't enough reliable clinical evidence to rate this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Manage menopause symptoms including hot flashes.
  • We looked for evidence on: Menopausal symptoms, Hot flashes, Night sweats, Menopause transition.
  • The closest evidence on file: Fenugreek is rated "Insufficient Reliable Evidence To Rate" for Menopausal symptoms (Natural Medicines).
  • Also on file: Ashwagandha is rated "Insufficient Reliable Evidence To Rate" for Menopausal symptoms.

Ashwagandha shows possibly effective evidence for insomnia, anxiety, stress, and generalized anxiety disorder (GAD). Fenugreek seed extract is possibly effective for sexual dysfunction, sexual arousal, and diabetes management.

For cucumber fruit extract, the evidence we hold is insufficient to rate its effectiveness for burns, diabetes, hyperlipidemia, high blood pressure, or osteoarthritis. No effectiveness data is on file for triterpene glycosides.

The evidence, ingredient by ingredient Ashwagandha Fenugreek Cucumber

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Ashwagandha is generally well tolerated in the short term in healthy adults, but long-term safety data are limited. The most common side effects are diarrhea, stomach upset, nausea, and vomiting, though these don't happen often at typical doses.

Serious side effects are rare but include liver damage and, in isolated cases, intracranial bleeding. Ashwagandha's safety data advise against use during pregnancy because it's traditionally thought to risk miscarriage, and there isn't enough safety information to recommend it while breastfeeding.

Fenugreek seed is generally well tolerated at food amounts, but supplement doses may cause abdominal pain, bloating, diarrhea, indigestion, gas, or nausea. Rare serious allergic reactions—including throat swelling, airway constriction, and shock—have occurred.

Supplement amounts may affect the uterus, so avoid medicinal use during pregnancy. Evidence for boosting milk supply is limited; discuss it with your provider first.

Cucumber is widely eaten as food and is generally well tolerated; concentrated extracts haven't been studied in pregnancy or breastfeeding, so personalized advice from your doctor or pharmacist is recommended if you're pregnant or nursing.

Side effects, ingredient by ingredient Ashwagandha Fenugreek Cucumber

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — Fenugreek, Ashwagandha, Cucumber.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 1,431 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your pharmacist if you take benzodiazepines, CNS depressants (sedatives, sleeping pills), blood pressure medications, diabetes medications, blood thinners (warfarin, clopidogrel), theophylline, metoprolol, phenytoin (Dilantin), sildenafil (Viagra), thyroid hormones, immunosuppressants, or drugs toxic to the liver. Ashwagandha may also interact with medications metabolized through CYP1A2 liver pathways.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with insufficient evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This formula is designed for women navigating menopause and may help with sleep and anxiety. However, if you take medications—especially for blood sugar, blood pressure, blood thinning, seizures, thyroid, asthma, or mood—you need to check them against this product before starting.

Talk to your pharmacist or doctor about your full medication list to make sure it's right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 25, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Menopause Formula, straight from the product label.

Brand GNC Women's
Net contents 60 Caplet(s)
Market status On market
Date entered into DSLD Jan 25, 2020
DSLD ID 211123
Product type Other Combinations
Supplement form Other (e.g. Tea Bag)
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult Female (18 - 50 Years), Menopause, Seniors/Mature (>50 Years) - Women ONLY, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Menopause Formula by GNC Women's, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Caplet(s)
Maximum serving Sizes:
2 Caplet(s)
Servings per container
30
IngredientAmount% DV
KSM-66 Ashwagandha root extract600 mg--
Triterpene Glycosides2 mg--
Libifem Fenugreek seed extract600 mg--
Cuvitus Cucumber fruit extract300 mg--

Other ingredients: Cellulose, Oat Bran, Croscarmellose Sodium, Stearic Acid, Magnesium Stearate, Silica, Triacetin, Di-Acetylated Monoglycerides, Oleic Acid, Polyethylene Glycol

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

Keep out of reach of children.

Contains: Milk.

Warning: Contains black cohosh

Consult your physician prior to using this product if you are pregnant, nursing, taking medication, or have a medical condition.

Discontinue use two weeks before surgery.

Brand IP Statement(s)

Cuvitus is a registered trademark of XSTO Solutions, LLC. KSM-66 is the registered trademark of Ixoreal Biomed Inc. Libifem is a registered trademark of Gencor

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General Statements

Our Quality Commitment to You Since 1935, our mission as the industry leader has been to provide you with the highest-quality nutritional supplements. We continue to stand behind this mission. If you're not 100% satisfied with your purchase, return the unused portion of the product with your receipt within 30 days and we'll either refund your money or find you a replacement product that is right for you.

Get the help you need to manage your menopause symptoms with GNC's Menopause Formula.

For additional support during menopause, consider adding EPA Omega-3 Fish Oil and Melatonin to your health regimen. New formula!

Conforms to USP <2091> for weight.

Formula

Support for discomfort Features Libifem fenugreek, which has been clinically shown to reduce the hot flashes and night sweats associated with menopause. Also contains black cohosh, traditionally used for menopause symptoms and a natural source of phytoestrogens. Support for sexual health Libifem fenugreek also provides clinically studied support for sexual health function. Support for stress Includes KSM-66 ashwagandha, which has been clinically shown to support a sense of calm and well-being and to impact a key marker of stress in the body.

FDA Statement of Identity

Dietary Supplement

Formulation

Clinically shown to support menopause symptoms Reduces hot flashes & night sweats Supports healthy sexual function Supports a sense of calm & well-being

No sugar, No Artificial Colors, No Artificial Flavors, No Preservatives, No Wheat, No Soy, Yeast free.

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take one caplet twice daily.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Menopause Formula by GNC Women's label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Menopause Formula label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Menopause Formula by GNC Women's

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Caplet(s) Dosage formOther (e.g. Tea Bag) Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

KSM-66 Ashwagandha root extract

Interacts with
1,372 drugs
600 mg per serving

Ashwagandha is an Ayurvedic herb most often taken to help with stress, anxiety, and sleep, and some small studies suggest it may help, though the evid...

KSM-66 Ashwagandha root extract monograph & interactions

Triterpene Glycosides

2 mg per serving

Libifem Fenugreek seed extract

Interacts with
389 drugs
600 mg per serving

Fenugreek is a common kitchen spice that is also taken as a supplement, mainly for blood sugar, cholesterol, and to support breast milk production. So...

Libifem Fenugreek seed extract monograph & interactions

Cuvitus Cucumber fruit extract

Interacts with
86 drugs
300 mg per serving

Cucumber is a common food vegetable that is mostly water and is generally safe to eat. As a supplement or skincare ingredient it is popular for hydrat...

Cuvitus Cucumber fruit extract monograph & interactions

Other (inactive) ingredients: Cellulose, Oat Bran, Croscarmellose Sodium, Stearic Acid, Magnesium Stearate, Silica, Triacetin, Di-Acetylated Monoglycerides, Oleic Acid, Polyethylene Glycol. These complete the product’s ingredient list but are not active constituents.

Interaction report

Menopause Formula by GNC Women's Drug Interactions

Want to check YOUR meds against Menopause Formula?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,430Drugs
1,008 Moderate 422 Minor

Ingredients driving the most interactions

KSM-66 Ashwagandha root extract 1,372
Libifem Fenugreek seed extract 389
Cuvitus Cucumber fruit extract 86

Individual Drug Interactions

The ingredients in Menopause Formula interact with 1,430 drugs. Click any drug to see the details.

3 of the 4 ingredients in Menopause Formula interact with drugs. Each result below shows which ingredient is responsible. KSM-66 Ashwagandha root extract Libifem Fenugreek seed extract Cuvitus Cucumber fruit extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Menopause Formula with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

KSM-66 Ashwagandha root extract10 drug types · 1,372 drugs

Antidiabetes Drugs

Theoretically, taking ashwagandha with antidiabetes drugs might increase the risk of hypoglycemia.
There is preliminary clinical evidence suggesting that ashwagandha might lower blood glucose levels. Theoretically, ashwagandha might have additive effects when used with antidiabetes drugs and increase the risk of hypoglycemia.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.
Animal research suggests that ashwagandha might lower systolic and diastolic blood pressure. Theoretically, ashwagandha might have additive effects when used with antihypertensive drugs and increase the risk of hypotension.

Likelihood Possible Evidence D
Benzodiazepines

Theoretically, taking ashwagandha might increase the sedative effects of benzodiazepines.
There is preliminary evidence that ashwagandha might have an additive effect with diazepam (Valium) and clonazepam (Klonopin). This may also occur with other benzodiazepines.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.
Ashwagandha seems to have sedative effects. Theoretically, this may potentiate the effects of barbiturates, other sedatives, and anxiolytics.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Ashwagandha has been linked to cases of acute hepatitis, liver failure, hepatic encephalopathy, autoimmune hepatitis, the need for liver transplantation, and death due to liver failure.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, taking ashwagandha might decrease the effects of immunosuppressants.
Ashwagandha has demonstrated immunostimulant effects in humans. Animal research has shown that ashwagandha can attenuate the immunosuppression caused by cyclophosphamide.

Likelihood Possible Evidence D
Thyroid Hormone

Ashwagandha might increase the effects and adverse effects of thyroid hormone.
Concomitant use of ashwagandha with thyroid hormones may cause additive therapeutic and adverse effects. Preliminary clinical research and animal studies suggest that ashwagandha boosts thyroid hormone synthesis and secretion. In one clinical study, ashwagandha increased triiodothyronine (T3) and thyroxine (T4) levels by 41.5% and 19.6%, respectively, and reduced serum TSH levels by 17.4% from baseline in adults with subclinical hypothyroidism.

Likelihood Probable Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that ashwagandha extract induces CYP1A2 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that ashwagandha extract induces CYP3A4 enzymes.

Likelihood Possible Evidence D
Serotonergic Drugs

Some animal studies have reported that ashwagandha can enhance serotonergic transmission by altering certain serotonin (5-HT) receptors. However, there is no evidence to suggest that ashwagandha increases the risk of serotonin-related effects, and there have been no published case reports of serotonin syndrome when combined with other serotonergic drugs. Nevertheless, due to the lack of extensive studies on the matter and the fact that ashwagandha appears to affect serotonergic pathways, it would be prudent to exercise caution when combining it with drugs that affect serotonin. [References: - Effects of Withania somnifera (Ashwaga ndha) on Stress and the Stress-Related Neuropsychiatric Disorders Anxiety, Depression, and Insomnia. Curr Neuropharmacol. 2021 Sep 14; 19: 1468–1495. - A Prospective, Randomized Double-Blind, Placebo-Controlled Study of Safety and Efficacy of a High-Concentration Full-Spectrum Extract of Ashwagandha Root in Reducing Stress and Anxiety in Adults. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573577/]

Likelihood Possible Evidence C
KSM-66 Ashwagandha root extract full monograph & interactions

Libifem Fenugreek seed extract9 drug types · 389 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Some of the constituents in fenugreek have antiplatelet effects in animal and in vitro research. However, common fenugreek products might not contain sufficient concentrations of these constituents for clinical effects. A clinical study in patients with coronary artery disease or diabetes shows that taking fenugreek seed powder 2.5 grams twice daily for 3 months does not affect platelet aggregation, fibrinolytic activity, or fibrinogen levels .

Likelihood Unlikely Evidence B
Antidiabetes Drugs

Theoretically, fenugreek seed might have additive hypoglycemic effects when used with antidiabetes drugs.
Clinical research shows that fenugreek seed can reduce fasting blood glucose and 2-hour postprandial glucose levels in adults with type 2 diabetes.

Likelihood Probable Evidence B
Clopidogrel (Plavix)

Theoretically, fenugreek seed might alter the clinical effects of clopidogrel by inhibiting its conversion to the active form.
Animal research shows that fenugreek seed 200 mg/kg daily for 14 days increases the maximum serum concentration of clopidogrel by 21%. It is unclear how this affects the pharmacokinetics of the active metabolite of clopidogrel; however, this study found that concomitant use of fenugreek seed and clopidogrel prolonged bleeding time by an additional 11%.

Likelihood Possible Evidence D
Metoprolol (Toprol)

Theoretically, fenugreek seed might have additive hypotensive effects when used with metoprolol.
Animal research shows that fenugreek seed 300 mg/kg daily for 2 weeks decreases systolic and diastolic blood pressure by 9% and 11%, respectively, when administered alone, and by 15% and 22%, respectively, when given with metoprolol 10 mg/kg.

Likelihood Probable Evidence B
Phenytoin (Dilantin)

Theoretically, fenugreek might decrease plasma levels of phenytoin.
Animal research shows that taking fenugreek seeds for 1 week decreases maximum concentrations and the area under the curve of a single dose of phenytoin by 44% and 72%, respectively. This seems to be related to increased clearance. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Sildenafil (Viagra)

Theoretically, concurrent use of sildenafil and fenugreek might reduce levels and therapeutic effects of sildenafil.
Animal research shows that taking fenugreek seeds for 1 week reduces maximum concentrations and the area under the curve of a single dose of sildenafil by 27% and 48%, respectively. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Theophylline

Theoretically, fenugreek may reduce the levels and clinical effects of theophylline.
Animal research shows that fenugreek 50 grams daily for 7 days reduces the maximum serum concentration (Cmax) of theophylline by 28% and the area under the plasma drug concentration-time curve (AUC) by 22%.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, fenugreek might have additive effects with warfarin and increase the international normalized ratio (INR).
Some fenugreek constituents have antiplatelet effects, although these might not be present in concentrations that are clinically significant. In one case report, a patient taking warfarin experienced an increased INR when starting to take fenugreek in combination with boldo.

Likelihood Possible Evidence D
Antihypertensive Drugs

Fenugreek may also have an additive effect on blood pressure-lowering medications. Studies on animals have shown that fenugreek seed can decrease both systolic and diastolic blood pressure by up to 22% when combined with metoprolol. Therefore, it is essential to monitor your blood pressure regularly if you are taking fenugreek and metoprolol together or any other antihypertensive drugs.

Likelihood Possible Evidence C
Libifem Fenugreek seed extract full monograph & interactions

Cuvitus Cucumber fruit extract1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, cucumber seed might have additive effects with antidiabetes drugs and may increase the risk of hypoglycemia.
Animal research shows that cucumber seed extract can decrease blood glucose levels. Monitor blood glucose levels closely.

Likelihood Possible Evidence D
Cuvitus Cucumber fruit extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Menopause Formula, from the product label.

GNC Women's

See all GNC Women's products
Name
General Nutrition Corporation
City
Pittsburgh
State
PA
ZipCode
15222
Phone Number
1-888-462-2548
Web Address
gnc.com
Pharmacist Counseling Corner

Menopause Formula by GNC Women's: Common Questions

Does Menopause Formula by GNC Women's interact with any medications?
Yes. Based on its ingredients, Menopause Formula has a known interaction with 1,430 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Menopause Formula contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
Ashwagandha's safety data advise against use during pregnancy because it's traditionally thought to risk miscarriage, and there isn't enough information to recommend it while breastfeeding. Fenugreek supplement amounts may affect the uterus, so medicinal use should be avoided in pregnancy; while often used to support milk supply, evidence is limited and you should discuss it with your doctor first. Cucumber extract safety in pregnancy and breastfeeding hasn't been studied. Talk to your doctor or pharmacist for personalized advice.
What are the most common side effects?
From ashwagandha, you might experience diarrhea, stomach upset, nausea, or vomiting, though these don't happen often at typical doses. Fenugreek seed commonly causes abdominal pain, bloating, diarrhea, indigestion, gas, or nausea. Cucumber extract is generally well tolerated based on the data we have.
Does ashwagandha in this formula really help with sleep?
Ashwagandha is possibly effective for insomnia based on the evidence, along with being possibly effective for anxiety, stress, and generalized anxiety disorder. That said, quality and long-term safety data are limited, so it's not a guarantee for everyone.
What's fenugreek in this for?
Fenugreek seed extract is included because it's possibly effective for sexual dysfunction and sexual arousal, and also for supporting healthy blood sugar in people with diabetes. It may also help with period pain (dysmenorrhea).
Why is there cucumber in a menopause formula?
Cucumber fruit extract is included as part of the supporting blend. However, we don't have strong evidence yet that it helps with the conditions it's typically used for—like diabetes, high cholesterol, high blood pressure, or osteoarthritis—so its specific role here isn't well established in our data.
Is this formula safe if I have liver problems?
Ashwagandha has been linked to rare cases of liver damage, including acute hepatitis and liver failure. If you have liver disease or take medications that can damage the liver, talk to your pharmacist or doctor before starting this product.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Menopause Formula label
Go deeper

The Full Monographs Behind Menopause Formula’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Ashwagandha

Interacts with 1,372 drugs

Ashwagandha is an Ayurvedic herb most often taken to help with stress, anxiety, and sleep, and some small studies suggest it may help, though the evidence is still limited. It is generally w...

Read the full Ashwagandha monograph → Herb & supplement monograph

Fenugreek

Interacts with 389 drugs

Fenugreek is a common kitchen spice that is also taken as a supplement, mainly for blood sugar, cholesterol, and to support breast milk production. Some early research is encouraging for blo...

Read the full Fenugreek monograph → Herb & supplement monograph

Cucumber

Interacts with 86 drugs

Cucumber is a common food vegetable that is mostly water and is generally safe to eat. As a supplement or skincare ingredient it is popular for hydration and soothing the skin, but solid hum...

Read the full Cucumber monograph →
Sources

Sources & How We Checked

Menopause Formula's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 66 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Ashwagandha 32 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Upton R, ed. Ashwagandha Root (Withania somnifera): Analytical, quality control, and therapuetic monograph. Santa Cruz, CA: American Herbal Pharmacopoeia 2000:1-25.
  3. Davis L, Kuttan G. Effect of Withania somnifera on cyclophosphamide-induced urotoxicity. Cancer Lett 2000;148:9-17. PubMed
  4. Davis L, Kuttan G. Suppressive effect of cyclophosphamide-induced toxicity by Withania somnifera extract in mice. J Ethnopharmacol 1998;62:209-14. PubMed
  5. Mishra LC, Singh BB, Dagenais S. Scientific basis for the therapeutic use of Withania somnifera (ashwagandha): a review. Altern Med Rev 2000;5:334-46. DOI
  6. Andallu B, Radhika B. Hypoglycemic, diuretic and hypocholesterolemic effect of winter cherry (Withania somnifera, Dunal) root. Indian J Exp Biol 2000;38:607-9.
  7. Kulkarni RR, Patki PS, Jog VP, et al. Treatment of osteoarthritis with a herbomineral formulation: a double-blind, placebo-controlled, cross-over study. J Ethnopharmacol 1991;33:91-5. PubMed
  8. Ahumada F, Aspee F, Wikman G, Hancke J. Withania somnifera exract. Its effects on arterial blood pressure in anaesthetized dogs. Phytother Res 1991;5:111-14.
  9. Panda S, Kar A. Withania somnifera and Bauhinia purpurea in the regulation of circulating thyroid hormone concentrations in female mice. J Ethnopharmacol 1999;67:233-39. PubMed
  10. Panda S, Kar A. Changes in thyroid hormone concentrations after administration of ashwagandha root extract to adult male mice. J Pharm Pharmacol 1998;50:1065-68. PubMed
  11. Sehgal, V. N., Verma, P., and Bhattacharya, S. N. Fixed-drug eruption caused by ashwagandha (Withania somnifera): a widely used Ayurvedic drug. Skinmed. 2012;10(1):48-49.
  12. Agnihotri AP, Sontakke SD, Thawani VR, Saoji A, Goswami VS. Effects of Withania somnifera in patients of schizophrenia: a randomized, double blind, placebo controlled pilot trial study. Indian J Pharmacol. 2013;45(4):417-8. PubMed
  13. Biswal BM, Sulaiman SA, Ismail HC, Zakaria H, Musa KI. Effect of Withania somnifera (Ashwagandha) on the development of chemotherapy-induced fatigue and quality of life in breast cancer patients. Integr Cancer Ther. 2013;12(4):312-22.
  14. Sharma AK, Basu I, Singh S. Efficacy and safety of Ashwagandha root extract in subclinical hypothyroid patients: a double-blind, randomized placebo-controlled trial. J Altern Complement Med. 2018 Mar;24(3):243-248. PubMed
  15. Durg S, Bavage S, Shivaram SB. Withania somnifera (Indian ginseng) in diabetes mellitus: A systematic review and meta-analysis of scientific evidence from experimental research to clinical application. Phytother Res. 2020;34(5):1041-1059.
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Cucumber 4 references
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See these in context on the Cucumber monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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