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Dietary supplement

Mesima Ingredients & Drug Interactions

by Host Defense Mushrooms

Mesima label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Mesima against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Mesima is a dietary supplement by Host Defense Mushrooms with 1 active ingredient. Its ingredients are commonly taken for immune system support, antioxidant support, general wellness.Based on those ingredients, 308 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Mesima. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Mesima by Host Defense Mushrooms

Ask about any prescription or over-the-counter medication and we check it for interactions with Mesima by Host Defense Mushrooms — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Mesima by Host Defense Mushrooms

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: mesima (also called black hoof mushroom), a medicinal fungus traditionally used in Asian medicine. The capsule itself is made of pullulan, an inactive ingredient that forms the shell.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: immune system support.
  • We looked for evidence on: immune function, infection resistance, immune response.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

The data we hold shows insufficient reliable evidence to rate mesima for COVID-19. We have no effectiveness information on file for other uses.

The evidence, ingredient by ingredient Black Hoof Mushroom

How safe is it?

Some data gaps
Safety Information · database check
Some gaps

Safety data exists for these ingredients, but with some important gaps.

Why this rating?
  • We hold adverse-effect (side-effect) data for 0 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Black hoof mushroom is used in traditional medicine, but human safety data are limited. The safety data advises against use during pregnancy and while breastfeeding — there isn't enough information to know it's safe in either situation, so it's best to skip it if you're pregnant or nursing.

Side effects, ingredient by ingredient Black Hoof Mushroom

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Black Hoof Mushroom.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: immunosuppressants / transplant drugs.
  • For scale: 308 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check if you take any CYP1A2 substrates (certain caffeine-containing drugs and some antidepressants and antibiotics) or CYP2E1 substrates (acetaminophen, disulfiram, and others), as the mushroom may raise their levels. Also flag any immunosuppressant medications, since black hoof mushroom may interfere with their intended effect.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and some safety-information gaps remain.

Mesima is a traditional medicinal mushroom, but it's not well studied in people. If you take medications broken down by liver enzymes (CYP1A2 or CYP2E1) or immunosuppressants, check your exact drugs with the tool below before starting.

Pregnant and breastfeeding people should avoid it. Talk to your pharmacist about whether this fits your situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 20, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Mesima, straight from the product label.

Brand Host Defense Mushrooms
Barcode (UPC) 633422032924
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Jun 20, 2024
DSLD ID 312247
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Organic, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Mesima by Host Defense Mushrooms, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
UPC/BARCODE
633422032924
IngredientAmount% DV
Calories5 Calorie(s)--
Total Carbohydrates1 Gram(s)1%
Mesima1 Gram(s)--

Other ingredients: Pullulan

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

The Mesima mushroom is found throughout the tropical and subtropical regions of the world. This mushroom is increasingly drawing the attention of researchers for its immune system supporting properties.

Made with organic mushroom mycelium

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take 2 capsules once per day. Can be taken with food or on an empty stomach or as recommended by your healthcare professional.

Precautions

Caution: If you have a medical condition, are taking medications, or are pregnant or breastfeeding, consult a healthcare professional before using this product.

Keep out of reach of children.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formulation

Non-GMO Gluten free & vegan

Certified Organic by the Washington State Department of Agriculture.

Promotes reduction of free radicals

Gluten free & vegan

Seals/Symbols

Certified Organic Washington State Department of Agriculture

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Mesima by Host Defense Mushrooms label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Mesima label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Mesima by Host Defense Mushrooms

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Mesima

Interacts with
308 drugs
1 Gram(s) per serving

Black Hoof Mushroom (Phellinus linteus) is a medicinal mushroom long used in East Asian traditional medicine, mainly for immune support. Most of the s...

Mesima monograph & interactions

Other (inactive) ingredients: Pullulan. These complete the product’s ingredient list but are not active constituents.

Interaction report

Mesima by Host Defense Mushrooms Drug Interactions

Want to check YOUR meds against Mesima?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
308Drugs
308 Moderate

Ingredients driving the most interactions

Mesima 308

Individual Drug Interactions

The ingredients in Mesima interact with 308 drugs. Click any drug to see the details.

1 of the 1 ingredient in Mesima interact with drugs. Each result below shows which ingredient is responsible. Mesima

Each ingredient & the kinds of drugs it affects

For each ingredient in Mesima with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Mesima3 drug types · 308 drugs

Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, black hoof mushroom might increase the levels and clinical effects of CYP1A2 substrates.
In vitro, polysaccharides from black hoof mushroom grown in culture inhibit CYP1A2. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2E1 (Cyp2E1) Substrates

Theoretically, black hoof mushroom might increase the levels and clinical effects of CYP2E1 substrates.
In vitro, polysaccharides from black hoof mushroom grown in culture inhibit CYP2E1. This effect has not been reported in humans.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, black hoof mushroom might reduce the effects of immunosuppressant medications.
In animal research, polysaccharides from black hoof mushroom and black hoof mushroom extract stimulate immune responses.

Likelihood Possible Evidence D
Mesima full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Mesima, from the product label.

Host Defense Mushrooms

See all Host Defense Mushrooms products
Name
Fungi Perfecti, LLC
Street Address
PO Box 7634
City
Olympia
State
WA
ZipCode
98507
Phone Number
877-504-6926
Web Address
Hostdefense.com
Pharmacist Counseling Corner

Mesima by Host Defense Mushrooms: Common Questions

Does Mesima by Host Defense Mushrooms interact with any medications?
Yes. Based on its ingredients, Mesima has a known interaction with 308 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Mesima contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is mesima safe to take while I'm pregnant or breastfeeding?
No. The safety data advises against it during pregnancy, and there's no reliable safety information for breastfeeding, so avoid it in both situations. Talk with your doctor or pharmacist if you're thinking about it.
Does mesima actually work for COVID-19?
The evidence we have is insufficient to say whether it works for COVID-19. If you're interested in it for another reason, we don't have effectiveness data on file for other uses either.
What is black hoof mushroom?
Black hoof mushroom — the active ingredient in this product — is a medicinal fungus that's been used in traditional medicine, especially in Asia. It's rich in compounds called polysaccharides that may affect how your immune system and liver enzymes work.
Does this product have any fillers?
The capsule is made of pullulan, which is an inactive ingredient that forms the shell. There are no other fillers listed.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Mesima is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Mesima label
Go deeper

The Full Monographs Behind Mesima’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Black Hoof Mushroom

Interacts with 308 drugs

Black Hoof Mushroom (Phellinus linteus) is a medicinal mushroom long used in East Asian traditional medicine, mainly for immune support. Most of the supporting evidence comes from laboratory...

Read the full Black Hoof Mushroom monograph →
Sources

Sources & How We Checked

Mesima's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Black Hoof Mushroom 6 references
  1. Song, K. S., Cho, S. M., Lee, J. H., Kim, H. M., Han, S. B., Ko, K. S., and Yoo, I. D. B-lymphocyte-stimulating polysaccharide from mushroom Phellinus linteus. Chem Pharm Bull (Tokyo) 1995;43(12):2105-2108. PubMed
  2. Matsuba, S., Matsuno, H., Sakuma, M., and Komatsu, Y. Phellinus linteus Extract Augments the Immune Response in Mitomycin C-Induced Immunodeficient Mice. Evid Based Complement Alternat Med 2008;5(1):85-90.
  3. Kim, G. Y., Roh, S. I., Park, S. K., Ahn, S. C., Oh, Y. H., Lee, J. D., and Park, Y. M. Alleviation of experimental septic shock in mice by acidic polysaccharide isolated from the medicinal mushroom Phellinus linteus. Biol Pharm Bull 2003;26(10):1418-1423 PubMed
  4. Shon, Y. H. and Nam, K. S. Inhibition of cytochrome P450 isozymes in rat liver microsomes by polysaccharides derived from Phellinus linteus. Biotechnol Lett 2003;25(2):167-172. PubMed
  5. Oh, G. S., Lee, M. S., Pae, H. O., Kwon, J., Lee, S. S., Jeong, J. G., Shin, M. K., Kwon, T. O., and Chung, H. T. Effects of oral administration of Phellinus linteus on the production of Th1- and Th2-type cytokines in mice. Immunopharmacol Immunotoxicol 2
  6. Kim, G. Y., Lee, J. Y., Lee, J. O., Ryu, C. H., Choi, B. T., Jeong, Y. K., Lee, K. W., Jeong, S. C., and Choi, Y. H. Partial characterization and immunostimulatory effect of a novel polysaccharide-protein complex extracted from Phellinus linteus. Biosci B

See these in context on the Black Hoof Mushroom monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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