Cordychi Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Cordychi against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Cordychi is a dietary supplement by Host Defense Mushrooms with 2 active ingredients. Its ingredients are commonly taken for fatigue and low energy, athletic performance and stamina, respiratory and lung support.Based on those ingredients, 502 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Reishi, Cordyceps. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Cordychi by Host Defense Mushrooms
Ask about any prescription or over-the-counter medication and we check it for interactions with Cordychi by Host Defense Mushrooms — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Cordychi by Host Defense Mushrooms
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Cordychi contains 2 active ingredients: cordyceps and reishi mushroom. Both are whole-mushroom extracts designed to support overall wellness.
The capsule itself is made from pullulan, an inactive ingredient.
Does it work?
Not established
The evidence for what cordyceps and reishi actually do is mixed and often limited. For cordyceps, athletic performance has been rated possibly ineffective — it doesn't seem to help much there.
Sexual function, heart rhythm problems, asthma, and lung conditions don't have enough reliable evidence to rate either way. For reishi, high cholesterol (hyperlipidemia) rates as possibly ineffective, and altitude sickness, Alzheimer's disease, and athletic performance don't have enough solid evidence to know if it works.
How safe is it?
Well-documented data
Both cordyceps and reishi are generally well tolerated in the short term, though cordyceps data is limited and product quality varies widely. The most common side effects from cordyceps are belly discomfort, constipation, and diarrhea — these can sometimes be reduced by taking it after a meal.
Reishi may cause dizziness, dry mouth, itching, nausea, rash, or stomach upset; respiratory allergies to reishi spores, sore throat, and runny nose have also been reported. There's one older case report of liver inflammation (hepatitis) possibly linked to a cordyceps product, though it's unclear whether cordyceps itself or a contaminant caused it.
During pregnancy and breastfeeding, there isn't enough safety data for either ingredient, so they're best avoided.
Meds to double-check
Moderate interaction found
Check your medications if you take blood thinners or antiplatelet drugs (like warfarin or aspirin), blood pressure medications, diabetes medications, or immunosuppressants — cordyceps and reishi both have moderate interactions with these. Also mention any testosterone therapy or supplements.
No interactions are documented for the other effects listed, but checking your exact medications with the tool on this page is the safest step.
The bottom line
Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.
Cordychi may appeal to you if you're interested in mushroom-based supplements, but the evidence that it actually works for most conditions isn't strong. If you take blood thinners, blood pressure medications, diabetes drugs, or immunosuppressants, talk to your pharmacist or doctor before starting this — the interactions are real enough that you'll want personalized advice.
Avoid it if you're pregnant or breastfeeding.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2024.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Cordychi, straight from the product label.
| Brand | Host Defense Mushrooms |
|---|---|
| Barcode (UPC) | 633422037431 |
| Net contents | 120 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Jul 25, 2024 |
| DSLD ID | 312389 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Organic, Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Cordychi by Host Defense Mushrooms, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Calories | 5 Calorie(s) | -- |
| Total Carbohydrates | 1 Gram(s) | 1% |
| Cordyceps | 500 mg | -- |
| Reishi | 500 mg | -- |
Other ingredients: Pullulan
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
Supports stress & fatigue reduction CordyChi is a synergistic blend of equal parts Cordyceps and Reishi that supports both sustained energy to keep you going and stress reduction to help you relax.
Gluten free & vegan Non GMO
Gluten free & vegan
Certified Organic by the WSDA
Suggested/Recommended/Usage/Directions
Directions: As a dietary supplement, take 2 capsules once per day. Can be taken with food or on an empty stomach or as recommended by your healthcare professional.
Precautions
Caution: If you have a medical condition, are taking medications, or are pregnant or breastfeeding, consult your healthcare professional before using this product.
Keep out of reach of children.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Formula
CordyChi made with organic mushroom mycelium Cordyceps Reishi
Seals/Symbols
Certified Organic Washington State Department of Agriculture Organic Program
FDA Statement of Identity
Dietary Supplement
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Cordychi by Host Defense Mushrooms label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Cordychi by Host Defense Mushrooms
These are the 2 active ingredients this product is made of. Select any to open its full monograph.
Serving size2 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Cordyceps
Interacts with249 drugs
Cordyceps is a fungus used in traditional Chinese medicine for energy, exercise performance, and lung and immune support. Human research is limited an...
Cordyceps monograph & interactionsReishi
Interacts with375 drugs
Reishi is a traditional Asian mushroom widely used to support the immune system and overall wellness. Human evidence for most of its claimed benefits...
Reishi monograph & interactionsOther (inactive) ingredients: Pullulan. These complete the product’s ingredient list but are not active constituents.
Cordychi by Host Defense Mushrooms Drug Interactions
HelloPharmacist Interaction Report
Host Defense Mushrooms Cordychi contains cordyceps and reishi, two mushroom extracts with documented interactions affecting a substantial number of medications.
The most serious interaction is cordyceps with blood thinners (anticoagulants) and antiplatelet drugs — cordyceps may theoretically increase bleeding risk, though this hasn't been seen in human studies yet. Animal research suggests cordyceps inhibits platelet function, so if you take any blood-thinning medication, this is worth checking.
Read the full breakdown — every affected drug type, severity by severity
Reishi also interacts with blood thinners at higher doses (3 grams daily or above), but the lower doses don't seem to affect them. Reishi can theoretically lower blood pressure further when combined with blood pressure medications, and it may have additive effects with diabetes drugs, though clinical evidence for that last interaction is mixed.
Cordyceps theoretically might interfere with immunosuppressant drugs like cyclosporine. Cordyceps also has a minor theoretical interaction with testosterone supplements or hormone therapy.
Altogether, these interactions span 495 individual medications. Use the medication checker on this page to look up your exact prescriptions before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Cordychi?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Cordychi interact with 502 drugs. Click any drug to see the details.
2 of the 2 ingredients in Cordychi interact with drugs. Each result below shows which ingredient is responsible. Reishi Cordyceps
6-mercaptopurinePurinethol
How 6-mercaptopurine interacts with Cordychi — through 1 ingredient. Tap an ingredient for the detail:
CordycepsImmunosuppressants Moderate
Interaction Summary
Theoretically, concurrent use of cordyceps might interfere with immunosuppressive therapy.
Read the full Cordyceps + 6-mercaptopurine interactionAbciximabReoPro
How Abciximab interacts with Cordychi — through 2 ingredients. Tap an ingredient for the detail:
CordycepsAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Cordyceps + Abciximab interactionReishiAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
Read the full Reishi + Abciximab interactionAbrocitinibCibinqo
How Abrocitinib interacts with Cordychi — through 2 ingredients. Tap an ingredient for the detail:
ReishiAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
Read the full Reishi + Abrocitinib interactionCordycepsAnticoagulant/antiplatelet Drugs, Immunosuppressants Moderate
Interaction Summary
Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Cordyceps + Abrocitinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Cordychi — through 1 ingredient. Tap an ingredient for the detail:
ReishiAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, reishi mushroom might have additive effects with antidiabetes drugs.
Read the full Reishi + Acarbose interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Cordychi — through 1 ingredient. Tap an ingredient for the detail:
ReishiAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.
Read the full Reishi + Acebutolol interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Cordychi — through 2 ingredients. Tap an ingredient for the detail:
ReishiAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
Read the full Reishi + Acenocoumarol interactionCordycepsAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Cordyceps + Acenocoumarol interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Cordychi — through 2 ingredients. Tap an ingredient for the detail:
CordycepsAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Cordyceps + Acetaminophen, Aspirin interactionReishiAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
Read the full Reishi + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Cordychi — through 2 ingredients. Tap an ingredient for the detail:
ReishiAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
Read the full Reishi + Acetaminophen, Aspirin, Caffeine interactionCordycepsAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Cordyceps + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, IbuprofenCombogesic
How Acetaminophen, Ibuprofen interacts with Cordychi — through 2 ingredients. Tap an ingredient for the detail:
CordycepsAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Cordyceps + Acetaminophen, Ibuprofen interactionReishiAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
Read the full Reishi + Acetaminophen, Ibuprofen interactionAcetazolamideAk-Zol, Diamox
How Acetazolamide interacts with Cordychi — through 1 ingredient. Tap an ingredient for the detail:
ReishiAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.
Read the full Reishi + Acetazolamide interactionAcetohexamideDymelor
How Acetohexamide interacts with Cordychi — through 1 ingredient. Tap an ingredient for the detail:
ReishiAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, reishi mushroom might have additive effects with antidiabetes drugs.
Read the full Reishi + Acetohexamide interactionAcetylsalicylic AcidEntrophen
How Acetylsalicylic Acid interacts with Cordychi — through 2 ingredients. Tap an ingredient for the detail:
ReishiAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
Read the full Reishi + Acetylsalicylic Acid interactionCordycepsAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Cordyceps + Acetylsalicylic Acid interactionAdalimumabHumira
How Adalimumab interacts with Cordychi — through 1 ingredient. Tap an ingredient for the detail:
CordycepsImmunosuppressants Moderate
Interaction Summary
Theoretically, concurrent use of cordyceps might interfere with immunosuppressive therapy.
Read the full Cordyceps + Adalimumab interactionAdalimumab-adazHyrimoz
How Adalimumab-adaz interacts with Cordychi — through 1 ingredient. Tap an ingredient for the detail:
CordycepsImmunosuppressants Moderate
Interaction Summary
Theoretically, concurrent use of cordyceps might interfere with immunosuppressive therapy.
Read the full Cordyceps + Adalimumab-adaz interactionAdalimumab-adbmCyltezo
How Adalimumab-adbm interacts with Cordychi — through 1 ingredient. Tap an ingredient for the detail:
CordycepsImmunosuppressants Moderate
Interaction Summary
Theoretically, concurrent use of cordyceps might interfere with immunosuppressive therapy.
Read the full Cordyceps + Adalimumab-adbm interactionAdalimumab-afzbAbrilada
How Adalimumab-afzb interacts with Cordychi — through 1 ingredient. Tap an ingredient for the detail:
CordycepsImmunosuppressants Moderate
Interaction Summary
Theoretically, concurrent use of cordyceps might interfere with immunosuppressive therapy.
Read the full Cordyceps + Adalimumab-afzb interactionAdalimumab-attoAmjevita
How Adalimumab-atto interacts with Cordychi — through 1 ingredient. Tap an ingredient for the detail:
CordycepsImmunosuppressants Moderate
Interaction Summary
Theoretically, concurrent use of cordyceps might interfere with immunosuppressive therapy.
Read the full Cordyceps + Adalimumab-atto interactionAdalimumab-bwwdHadlima
How Adalimumab-bwwd interacts with Cordychi — through 1 ingredient. Tap an ingredient for the detail:
CordycepsImmunosuppressants Moderate
Interaction Summary
Theoretically, concurrent use of cordyceps might interfere with immunosuppressive therapy.
Read the full Cordyceps + Adalimumab-bwwd interactionAdalimumab-fkjpHulio
How Adalimumab-fkjp interacts with Cordychi — through 1 ingredient. Tap an ingredient for the detail:
CordycepsImmunosuppressants Moderate
Interaction Summary
Theoretically, concurrent use of cordyceps might interfere with immunosuppressive therapy.
Read the full Cordyceps + Adalimumab-fkjp interactionAlbiglutideTanzeum
How Albiglutide interacts with Cordychi — through 1 ingredient. Tap an ingredient for the detail:
ReishiAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, reishi mushroom might have additive effects with antidiabetes drugs.
Read the full Reishi + Albiglutide interactionAlefaceptAmevive
How Alefacept interacts with Cordychi — through 1 ingredient. Tap an ingredient for the detail:
CordycepsImmunosuppressants Moderate
Interaction Summary
Theoretically, concurrent use of cordyceps might interfere with immunosuppressive therapy.
Read the full Cordyceps + Alefacept interactionAlemtuzumabCampath
How Alemtuzumab interacts with Cordychi — through 1 ingredient. Tap an ingredient for the detail:
CordycepsImmunosuppressants Moderate
Interaction Summary
Theoretically, concurrent use of cordyceps might interfere with immunosuppressive therapy.
Read the full Cordyceps + Alemtuzumab interactionAliskirenTekturna
How Aliskiren interacts with Cordychi — through 1 ingredient. Tap an ingredient for the detail:
ReishiAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.
Read the full Reishi + Aliskiren interactionAlogliptinNesina
How Alogliptin interacts with Cordychi — through 1 ingredient. Tap an ingredient for the detail:
ReishiAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, reishi mushroom might have additive effects with antidiabetes drugs.
Read the full Reishi + Alogliptin interactionAlogliptin, MetforminKazano
How Alogliptin, Metformin interacts with Cordychi — through 1 ingredient. Tap an ingredient for the detail:
ReishiAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, reishi mushroom might have additive effects with antidiabetes drugs.
Read the full Reishi + Alogliptin, Metformin interactionAlogliptin, PioglitazoneOseni
How Alogliptin, Pioglitazone interacts with Cordychi — through 1 ingredient. Tap an ingredient for the detail:
ReishiAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, reishi mushroom might have additive effects with antidiabetes drugs.
Read the full Reishi + Alogliptin, Pioglitazone interactionAlteplase, TpaActilyse, Activase
How Alteplase, Tpa interacts with Cordychi — through 2 ingredients. Tap an ingredient for the detail:
ReishiAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
Read the full Reishi + Alteplase, Tpa interactionCordycepsAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Cordyceps + Alteplase, Tpa interactionAluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #2
How Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interacts with Cordychi — through 2 ingredients. Tap an ingredient for the detail:
CordycepsAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Cordyceps + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionReishiAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
Read the full Reishi + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionAluminum Hydroxide, Aspirin, Magnesium HydroxideAscriptin
How Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interacts with Cordychi — through 2 ingredients. Tap an ingredient for the detail:
CordycepsAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Cordyceps + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionReishiAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
Read the full Reishi + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionAmbrisentanLetairis, Volibris
How Ambrisentan interacts with Cordychi — through 1 ingredient. Tap an ingredient for the detail:
ReishiAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.
Read the full Reishi + Ambrisentan interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Cordychi with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Reishi
Anticoagulant/Antiplatelet Drugs
Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
A dose of 1.5 grams daily of reishi mushroom does not seem to decrease platelet aggregation, but a higher dose of 3 grams daily does.
Antidiabetes Drugs
Theoretically, reishi mushroom might have additive effects with antidiabetes drugs.
Animal research suggests that reishi mushroom decreases blood sugar. However, in patients with type 2 diabetes, taking reishi mushroom does not reduce fasting glucose levels, and its effects on glycated hemoglobin are inconsistent.
Antihypertensive Drugs
Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.
Reishi mushroom has shown hypotensive activity in animal research. Clinical evidence suggests that reishi mushroom reduces blood pressure in some, but not all, patients with hypertension.
Cordyceps
Anticoagulant/Antiplatelet Drugs
Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
In vitro and animal research suggests that cordyceps extract inhibits platelet aggregation and function. However, this interaction has not been reported in humans.
Immunosuppressants
Theoretically, concurrent use of cordyceps might interfere with immunosuppressive therapy.
Animal and in vitro research suggests that cordyceps stimulates the immune system. However, limited clinical research suggests that taking cordyceps may lower the necessary therapeutic dose of the immunosuppressant cyclosporine, which suggests that cordyceps may have an immunosuppressive effect.
Testosterone
Theoretically, concurrent use of cordyceps and testosterone might have additive effects.
Animal research suggests that cordyceps can increase testosterone levels. The clinical significance of this finding is unclear.
Brand information
Manufacturer and brand details for Cordychi, from the product label.
Host Defense Mushrooms
See all Host Defense Mushrooms products- Name
- Fungi Perfecti, LLC
- Street Address
- PO Box 7634
- City
- Olympia
- State
- WA
- ZipCode
- 98507
- Phone Number
- 877-504-6926
- Web Address
- Hostdefense.com
Cordychi by Host Defense Mushrooms: Common Questions
Does Cordychi by Host Defense Mushrooms interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take this if I'm on a blood thinner like warfarin or aspirin?
What's the most common side effect I might see?
Does cordyceps really improve athletic performance?
Is it safe to take during pregnancy?
Can I take this with my blood pressure medication?
Will this help with my high cholesterol?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Cordychi is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Cordychi’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Cordyceps
Interacts with 249 drugsCordyceps is a fungus used in traditional Chinese medicine for energy, exercise performance, and lung and immune support. Human research is limited and mostly low quality, so its benefits ar...
Read the full Cordyceps monograph → Herb & supplement monographReishi Mushroom
Interacts with 375 drugsReishi is a traditional Asian mushroom widely used to support the immune system and overall wellness. Human evidence for most of its claimed benefits is limited or low-quality, so it should...
Read the full Reishi Mushroom monograph →Sources & How We Checked
Cordychi's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 31 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Cordyceps 14 references
- Zhu JS, Halpern GM, Jones K. The scientific rediscovery of an ancient Chinese herbal medicine: Cordyceps sinensis: part I. J Altern Complement Med 1998;4:289-303.
- Zhu JS, Halpern GM, Jones K. The scientific rediscovery of a precious ancient Chinese herbal regimen: Cordyceps sinensis: part II. J Altern Complement Med 1998;4:429-57.
- Chen YJ, Shiao MS, Lee SS, Wang SY. Effect of Cordyceps sinensis on the proliferation and differentiation of human leukemic U937 cells. Life Sci 1997;60:2349-59. PubMed
- Zhao Y. [Inhibitory effects of alcoholic extract of Cordyceps sinensis on abdominal aortic thrombus formation in rabbits]. Chung Hua I Hsueh Tsa Chih (Taipei) 1991;71:612-5, 42.
- Chen GZ, Chen GL, Sun T, et al. Effects of Cordyceps sinensis on murine T lymphocyte subsets. Chin Med J (English) 1991;104:4-8.
- Zhu XY, Yu HY. [Immunosuppressive effect of cultured Cordyceps sinensis on cellular immune response]. Chung Hsi I Chieh Ho Tsa Chih 1990;10:485-7, 454.
- Hsu, C. C., Huang, Y. L., Tsai, S. J., Sheu, C. C., and Huang, B. M. In vivo and in vitro stimulatory effects of Cordyceps sinensis on testosterone production in mouse Leydig cells. Life Sci 9-5-2003;73(16):2127-2136. PubMed
- Ikumoto, T., Sasaki, S., Namba, H., Toyama, R., Moritoki, H., and Mouri, T. [Physiologically active compounds in the extracts from tochukaso and cultured mycelia of Cordyceps and Isaria]. Yakugaku Zasshi 1991;111(9):504-509. PubMed
- Wu, T. N., Yang, K. C., Wang, C. M., Lai, J. S., Ko, K. N., Chang, P. Y., and Liou, S. H. Lead poisoning caused by contaminated Cordyceps, a Chinese herbal medicine: two case reports. Sci.Total Environ. 4-5-1996;182(1-3):193-195. PubMed
- Hong T, Zhang M, Fan J. Cordyceps sinensis (a traditional Chinese medicine) for kidney transplant recipients (Review). Cochrane Database Syst Rev. 2015;(10):CD009698. doi: 10.1002/14651858.CD009698.pub2.
- Zhang HW, Lin ZX, Tung YS, Kwan TH, Mok CK, Leung C, Chan LS. Cordyceps sinensis (a traditional Chinese medicine) for treating chronic kidney disease (Review). Cochrane Database Syst Rev. 2014;(12):CD008353. doi: 10.1002/14651858.CD008353.pub2. PubMed
- Bee Yean O, Zoriah A. Efficacy of Cordyceps sinensis as an adjunctive treatment in hemodialysis patients: a systematic review and Meta-analysis. J Tradit Chin Med. 2019;39(1):1-14.
- Thurian D, Montani M, Stickel F. Drug-induced, mixed-type hepatitis following ingestion of Cordyceps sinensis. Int J Clin Pharmacol Ther 2022;60(2):115-120. PubMed
- Yu X, Mao Y, Shergis JL, et al. Effectiveness and safety of oral Cordyceps sinensis on stable COPD of GOLD stages 2-3: Systematic review and meta-analysis. Evid Based Complement Alternat Med. 2019;2019:4903671.
Reishi Mushroom 17 references
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
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