Major interaction on record — check this product against your medications before combining. Based on 4 of 5 ingredients. Check your meds →
Dietary supplement

Metabolic Stimulator Ingredients & Drug Interactions

by Neurobiologix

Metabolic Stimulator label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Metabolic Stimulator against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Metabolic Stimulator is a dietary supplement by Neurobiologix with 5 active ingredients. Its ingredients are commonly taken for blood sugar support in type 2 diabetes, weight loss and appetite control, insulin sensitivity.Based on those ingredients, 728 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Lithium Orotate, Phosphatidylserine, Chromium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Metabolic Stimulator by Neurobiologix

Ask about any prescription or over-the-counter medication and we check it for interactions with Metabolic Stimulator by Neurobiologix — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Metabolic Stimulator by Neurobiologix

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 5 of its 5 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Metabolic Stimulator contains five active ingredients: chromium (supports glucose metabolism), myo-inositol and D-chiro inositol (carbohydrate compounds involved in insulin action and cellular signaling), phosphatidylserine (a fat molecule in cell membranes linked to nerve and brain function), and lithium orotate (a mineral salt form of lithium). The capsule also contains inactive ingredients — hypromellose, ascorbyl palmitate, silicon dioxide, and microcrystalline cellulose — which are binders and fillers that help hold the capsule together.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: insulin signaling and metabolic support.
  • We looked for evidence on: Impaired glucose tolerance (Prediabetes), Metabolic syndrome, Polycystic ovary syndrome (PCOS), Diabetes, Antiretroviral-induced insulin resistance, insulin resistance — and 2 related terms.
  • The strongest evidence on file: Inositol is rated "Possibly Effective" for Polycystic ovary syndrome (PCOS) (Natural Medicines).
  • Also on file: Inositol is rated "Possibly Effective" for Metabolic syndrome.
  • Also on file: Chromium is rated "Possibly Effective" for Diabetes.

The evidence for these ingredients is mixed. Chromium is likely effective for chromium deficiency and possibly effective for type 2 diabetes management, though research on prediabetes shows it may not help.

Myo-inositol and D-chiro inositol are both possibly effective for polycystic ovary syndrome (PCOS) and metabolic syndrome, and possibly effective for preventing preterm labor, but show little promise for anxiety, nerve pain related to diabetes, or depression. Phosphatidylserine is possibly effective for age-related cognitive decline and Alzheimer disease, but there isn't enough reliable evidence to rate it for athletic performance, ADHD, general cognitive function, or other types of dementia.

Lithium orotate has insufficient reliable evidence for the conditions listed in the data we hold, so we can't make claims about its effectiveness.

The evidence, ingredient by ingredient Chromium Inositol Phosphatidylserine Lithium

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Chromium is generally well tolerated at typical supplement doses, though long-term or high doses may carry risks; common side effects include upset stomach, headaches, insomnia, and mood changes. Rare serious effects (kidney or liver damage, muscle breakdown) have been reported.

Inositol is generally well tolerated with mostly mild digestive side effects like diarrhea, gas, and nausea. Phosphatidylserine is generally well tolerated in short-term studies, but long-term safety isn't fully established; flatulence, upset stomach, headache, insomnia, and nausea can occur, especially at higher doses.

Lithium orotate has a narrow margin between an effective and toxic dose, and prescription lithium requires blood monitoring — supplement forms are not well studied. Common side effects include tremor, fatigue, weakness, increased thirst and urination, weight gain, and skin problems.

Pregnancy: chromium supplementation beyond small dietary amounts should be avoided unless a doctor recommends it; phosphatidylserine safety data advises against it in pregnancy; lithium can cross the placenta and has been linked to birth defects — avoid unless directed and monitored by a doctor. Breastfeeding: safety data for chromium and inositol isn't on file; phosphatidylserine safety while breastfeeding is unknown and avoidance is recommended; lithium passes into breast milk and may affect the infant — avoid unless supervised by a doctor.

Side effects, ingredient by ingredient Chromium Inositol Phosphatidylserine Lithium

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 4 of the 4 matched ingredients can interact with medications — Inositol, Chromium, Phosphatidylserine, Lithium.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: seizure medications; diabetes medications.
  • For scale: 728 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Metabolic Stimulator, check with your pharmacist if you use serotonergic drugs like SSRIs (antidepressants); diuretics (water pills); skeletal muscle relaxants; NSAIDs or aspirin; antipsychotic medications; ACE inhibitors (blood pressure meds); calcium channel blockers (heart or blood pressure meds); anticonvulsants (seizure meds); anticholinergic drugs (overactive bladder, some Parkinson meds); cholinergic drugs; antidiabetes drugs or insulin; or levothyroxine (thyroid medication). These are the primary medication types to verify before you start.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This product may appeal to people managing blood sugar, PCOS, or metabolic concerns, but it's not for everyone. If you take blood pressure medication, antidepressants, diabetes drugs, thyroid medication, or NSAIDs — or if you're pregnant, breastfeeding, or have kidney disease — talk with your pharmacist or doctor before starting.

The lithium content especially needs professional oversight.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Metabolic Stimulator, straight from the product label.

Brand Neurobiologix
Barcode (UPC) 858104006431
Net contents 90 Vegetable Capsule(s)
Market status On market
Date entered into DSLD Mar 25, 2025
DSLD ID 327684
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Metabolic Stimulator by Neurobiologix, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
45
UPC/BARCODE
858104006431
IngredientAmount% DV
Chromium200 mcg571%
Myo-Inositol600 mg--
Phosphatidylserine100 mg--
D-Chiro Inositol300 mg--
Lithium Orotate3 mg--

Other ingredients: Hypromellose, Ascorbyl Palmitate, Silicon Dioxide, Microcrystalline Cellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: Adults take 2 capsules daily, preferably 1 capsule in the AM and 1 capsule in the PM.

Formula

D-Chiro-Inositol (DCI) is a sugar alcohol complex that is naturally occurring in the body. It acts as a significant secondary messenger in cells and is responsible for key biological processes including: Improving insulin signaling (glucose uptake) Increasing glycogen utilization (intercellular energy) mTOR down regulation and breakdown of fats

Formulation

Due to genetic weaknesses, the conversion of myo-inositol to DCI can be a challenge and sugar does not get disposed of quickly. This abnormality is known as insulin resistance. DCI along with essential nutrient cofactors assists with insulin signaling and cellular energy.

Natural support for glucose Regulation and insulin function

Free of: wheat, gluten, corn protein, soy, dairy products, artificial colors or preservatives. Gluten free Soy free Dairy free

Professional grade

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Storage

Storage: Keep tightly closed in a cool, dry place.

Precautions

Caution: Do not use if pregnant or breast feeding.

Professional Use Only

Children consult with a healthcare practitioner before use.

Seals/Symbols

GMP Good Manufacturing Practice Consistent Quality

General Statements

Exclusive formula

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Metabolic Stimulator by Neurobiologix label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Metabolic Stimulator label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Metabolic Stimulator by Neurobiologix

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container45 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Chromium

Interacts with
178 drugs
200 mcg per serving Form: Chromium Picolinate

Chromium is an essential trace mineral involved in how the body handles sugar and fat. Some studies suggest it may modestly help blood sugar control i...

Chromium monograph & interactions

Myo-Inositol

Interacts with
86 drugs
600 mg per serving

Inositol is a sugar alcohol made naturally in the body and found in many foods, and it is sold as a supplement (often myo-inositol) mainly for PCOS, m...

Myo-Inositol monograph & interactions

Phosphatidylserine

Interacts with
219 drugs
100 mg per serving Form: Sunflower Seed Extract

Phosphatidylserine is a natural fat-like compound found in cell membranes, especially in the brain, and it is sold mainly to support memory and thinki...

Phosphatidylserine monograph & interactions

D-Chiro Inositol

Interacts with
86 drugs
300 mg per serving

Inositol is a sugar alcohol made naturally in the body and found in many foods, and it is sold as a supplement (often myo-inositol) mainly for PCOS, m...

D-Chiro Inositol monograph & interactions

Lithium Orotate

Interacts with
515 drugs
3 mg per serving Form: Lithium

Lithium is a naturally occurring metal that, in prescription form (lithium carbonate or citrate), is an FDA-approved, well-proven treatment for bipola...

Lithium Orotate monograph & interactions

Other (inactive) ingredients: Hypromellose, Ascorbyl Palmitate, Silicon Dioxide, Microcrystalline Cellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Metabolic Stimulator by Neurobiologix Drug Interactions

Want to check YOUR meds against Metabolic Stimulator?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
728Drugs
259 Major 469 Moderate

Ingredients driving the most interactions

Lithium Orotate 515
Phosphatidylserine 219
Chromium 178
Myo-Inositol 86

Individual Drug Interactions

The ingredients in Metabolic Stimulator interact with 728 drugs. Click any drug to see the details.

4 of the 5 ingredients in Metabolic Stimulator interact with drugs. Each result below shows which ingredient is responsible. Lithium Orotate Phosphatidylserine Chromium Myo-Inositol

Each ingredient & the kinds of drugs it affects

For each ingredient in Metabolic Stimulator with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Lithium Orotate11 drug types · 515 drugs

Diuretic Drugs

Theoretically, taking lithium supplements with loop diuretics might increase lithium levels and adverse effects.
Thiazide diuretics and loop diuretics might reduce lithium excretion, particularly in sodium-restricted patients. If lithium is clinically indicated and other treatment options are unavailable or inadequate in patients using diuretics, lithium treatment can be initiated with extreme caution. Serum lithium should be measured frequently and the doses used should be the lowest dose ordinarily tolerated. It is unclear if this interaction would be clinically significant with the smaller doses found in lithium supplements.

Likelihood Probable Evidence D
Serotonergic Drugs

Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.
In a case report, a 67-year-old female with depression and bipolar disorder using lithium in combination with selective serotonin reuptake inhibitors (SSRIs) and other medications developed serotonin syndrome with symptoms of deep tendon hyperreflexia, muscle rigidity, tremor, and hyperthermia. However, agitation, one classical symptom of serotonin syndrome, was lacking. This was thought to be due to masking by lithium toxicity. Lithium can increase serotonin levels, thus, combining serotonergic drugs with lithium might increase the risk of serotonergic side effects including serotonin syndrome and cerebral vasoconstrictive disorders. It is unclear if this interaction would occur with the smaller doses found in lithium supplements.

Likelihood Probable Evidence D
Ace Inhibitors (Aceis)

Theoretically, taking lithium supplements with ACEIs might increase levels and adverse effects of lithium.
Concomitant administration of ACEIs with lithium may increase lithium concentrations. It is unclear if this interaction would be clinically significant with the smaller doses found in lithium supplements.

Likelihood Possible Evidence D
Anticonvulsants

Theoretically, taking lithium supplements with anticonvulsants might increase the risk of neurotoxicity.
Drugs such as carbamazepine and phenytoin seem to increase the risk of neurotoxicity. It is unclear if this interaction would occur with the smaller doses found in lithium supplements.

Likelihood Possible Evidence D
Antipsychotic Drugs

Theoretically, taking lithium supplements with antipsychotic drugs might increase the risk of encephalopathic syndrome.
Encephalopathic syndrome has been reported in multiple patients taking prescription lithium and antipsychotics concomitantly. Symptoms have included weakness and lethargy, fever, confusion, and extrapyramidal symptoms. In some patients, resulting brain damage was irreversible. Although there is no established causal relationship between these symptoms and the combination of lithium and antipsychotic medications, there is a theoretical relationship. It is unclear if this interaction would occur with the smaller doses found in lithium supplements.

Likelihood Possible Evidence D
Calcium Channel Blockers

Theoretically, taking lithium supplements with calcium channel blockers might reduce lithium levels and might also increase the risk of certain adverse effects.
Calcium channel blockers might reduce lithium concentrations. Monitor lithium levels with concurrent use. Calcium channel blockers might also increase the adverse neurological and gastrointestinal adverse effects of lithium. It is unclear if these interactions would occur with the smaller doses found in lithium supplements.

Likelihood Possible Evidence D
Methyldopa (Aldomet)

Theoretically, taking lithium supplements with methyldopa might increase the risk of lithium toxicity.
Concurrent use of methyldopa with lithium increases the risk of lithium toxicity. It is unclear if this interaction would be clinically significant with the smaller doses found in lithium supplements.

Likelihood Probable Evidence D
Methylxanthines

Theoretically, taking lithium supplements with methylxanthines might decrease lithium levels.
Xanthines such as aminophylline, caffeine, and theophylline (Theo-Dur, Theo-24, others) might increase the clearance of lithium. It is unclear if this interaction would be clinically significant with the smaller doses found in lithium supplements.

Likelihood Probable Evidence D
Nonsteroidal Anti-Inflammatory Drugs (Nsaids)

Theoretically, taking lithium supplements with NSAIDs might increase lithium levels and adverse effects.
NSAIDs can decrease the renal clearance of lithium and increase lithium levels. It is unclear if this interaction would be clinically significant with the smaller doses found in lithium supplements.

Likelihood Probable Evidence D
Phenothiazines

Theoretically, taking lithium supplements with phenothiazines might decrease the levels and clinical effects of phenothiazines.
Concomitant use of lithium with phenothiazines might reduce lithium concentrations. Lithium might also reduce phenothiazine concentrations, making the pharmacokinetic effect unpredictable. It is unclear if these interactions would occur with the smaller doses found in lithium supplements.

Likelihood Probable Evidence D
Skeletal Muscle Relaxants

Theoretically, taking lithium supplements with skeletal muscle relaxants might prolong neuromuscular blockade.
Lithium might prolong neuromuscular blockade. It is unclear if this interaction would occur with the smaller doses found in lithium supplements.

Likelihood Probable Evidence D
Lithium Orotate full monograph & interactions

Phosphatidylserine2 drug types · 219 drugs

Anticholinergic Drugs

Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Phosphatidylserine is thought to increase acetylcholine levels, which could theoretically interfere with the activity of anticholinergic agents.

Likelihood Possible Evidence B
Cholinergic Drugs

Theoretically, phosphatidylserine might have additive effects with cholinergic drugs.
Phosphatidylserine is thought to increase acetylcholine levels, which could theoretically lead to additive cholinergic effects when used with cholinergic drugs.

Likelihood Possible Evidence B
Phosphatidylserine full monograph & interactions

Chromium5 drug types · 178 drugs

Antidiabetes Drugs

Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Some research shows that taking chromium might lower blood glucose levels, especially in patients with poorly controlled type 2 diabetes.

Likelihood Possible Evidence A
Insulin

Theoretically, concomitant use of chromium and insulin might increase the risk of hypoglycemia.
In clinical research, chromium has been shown to increase insulin sensitivity,

Likelihood Possible Evidence B
Levothyroxine (Synthroid, Others)

Chromium might bind levothyroxine in the intestinal tract and decrease levothyroxine absorption.
Clinical research in healthy volunteers shows that taking chromium picolinate 1000 mcg with levothyroxine 1 mg decreases serum levels of levothyroxine by 17% when compared to taking levothyroxine alone. Advise patients to take levothyroxine at least 30 minutes before or 3-4 hours after taking chromium.

Likelihood Probable Evidence B
Aspirin

Theoretically, aspirin might increase chromium absorption.
Animal research suggests that aspirin may increase chromium absorption and chromium levels in the blood.

Likelihood Possible Evidence D
Nonsteroidal Anti-Inflammatory Drugs (Nsaids)

NSAIDs might increase chromium levels in the body.
Drugs that are prostaglandin inhibitors, such as NSAIDs, seem to increase chromium absorption and retention.

Likelihood Possible Evidence D
Chromium full monograph & interactions

Myo-Inositol1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking inositol with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that inositol lowers blood glucose levels and glycated hemoglobin (HbA1c) levels in patients with diabetes.

Likelihood Possible Evidence A
Myo-Inositol full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Metabolic Stimulator, from the product label.

Neurobiologix

See all Neurobiologix products
Name
Neurobiologix, Inc
Street Address
13376 N. Highway 183, Suite 126
City
Austin
State
TX
ZipCode
78750
Phone Number
(866) 500-5388
Web Address
www.neurobiologix.com
Pharmacist Counseling Corner

Metabolic Stimulator by Neurobiologix: Common Questions

Does Metabolic Stimulator by Neurobiologix interact with any medications?
Yes. Based on its ingredients, Metabolic Stimulator has a known interaction with 728 medications, including 259 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Metabolic Stimulator contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help my blood sugar or metabolism?
Chromium is possibly effective for type 2 diabetes, and both inositol forms are possibly effective for metabolic syndrome and PCOS. The phosphatidylserine and lithium orotate in this blend don't have strong evidence for blood sugar or metabolism in the data we hold.
Can I take this if I'm on levothyroxine (Synthroid)?
Not without checking first. Chromium in this product can bind to levothyroxine and lower your blood levels by up to 17%, which could reduce how well your thyroid medication works. Talk to your pharmacist about spacing or alternative products.
What are the most common side effects?
Upset stomach, gas, diarrhea, and nausea are most likely from the inositol and chromium. Headaches, insomnia, and mood changes can occur with chromium. Phosphatidylserine may cause flatulence or insomnia at higher doses.
Is it safe to take with my diabetes medication or insulin?
Not without checking with your doctor or pharmacist first. Chromium and both forms of inositol may lower blood sugar, and combining them with antidiabetes drugs or insulin raises the risk of low blood sugar (hypoglycemia).
Why does this contain lithium?
The product contains lithium orotate, a supplement form of lithium. The data we hold shows insufficient reliable evidence for its effectiveness for the conditions studied, and it carries significant interactions with many medications and pregnancy risks.
Can I take this while pregnant or breastfeeding?
The safety data doesn't support it. Chromium supplementation beyond diet should be avoided in pregnancy; phosphatidylserine is advised against; and lithium can harm a developing baby and passes into breast milk. Talk to your doctor before using any of these during pregnancy or while nursing.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Metabolic Stimulator label
Go deeper

The Full Monographs Behind Metabolic Stimulator’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Chromium

Interacts with 178 drugs

Chromium is an essential trace mineral involved in how the body handles sugar and fat. Some studies suggest it may modestly help blood sugar control in certain people with type 2 diabetes, b...

Read the full Chromium monograph → Herb & supplement monograph

Inositol

Interacts with 86 drugs

Inositol is a sugar alcohol made naturally in the body and found in many foods, and it is sold as a supplement (often myo-inositol) mainly for PCOS, mood, and metabolic concerns. The stronge...

Read the full Inositol monograph → Herb & supplement monograph

Phosphatidylserine

Interacts with 219 drugs

Phosphatidylserine is a natural fat-like compound found in cell membranes, especially in the brain, and it is sold mainly to support memory and thinking. Some research suggests possible bene...

Read the full Phosphatidylserine monograph → Herb & supplement monograph

Lithium

Interacts with 515 drugs

Lithium is a naturally occurring metal that, in prescription form (lithium carbonate or citrate), is an FDA-approved, well-proven treatment for bipolar disorder. Low-dose supplement forms li...

Read the full Lithium monograph →
Sources

Sources & How We Checked

Metabolic Stimulator's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 102 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Chromium 53 references
  1. Cerulli J, Grabe DW, Gauthier I, et al. Chromium picolinate toxicity. Ann Pharmacother 1998;32:428-31. PubMed
  2. Urberg M, Zemel MB. Evidence for synergism between chromium and nicotinic acid in the control of glucose tolerance in elderly humans. Metabolism 1987;36:896-9. PubMed
  3. Mohamedshah FY, Moser-Veillon PB, Yamini S, et al. Distribution of a stable isotope of chromium (53Cr) in serum, urine, and breast milk in lactating women. Am J Clin Nutr 1998;67:1250-5. PubMed
  4. Wasser WG, Feldman NS, D'Agati VD. Chronic renal failure after ingestion of over-the-counter chromium picolinate. [letter]. Ann Intern Med 1997;126:410. PubMed
  5. Mertz W. Interaction of chromium with insulin: a progress report. Nutr Rev 1998;56:174-7. PubMed
  6. Anderson RA. Chromium, glucose intolerance and diabetes. J Am Coll Nutr 1998;17:548-55. PubMed
  7. McLeod MN, Gaynes BN, Golden RN. Chromium potentiation of antidepressant pharmacotherapy for dysthymic disorder in 5 patients. J Clin Psych 1999;60:237-40. PubMed
  8. Fowler JF Jr. Systemic contact dermatitis caused by oral chromium picolinate. Cutis 2000;65:116. DOI
  9. Trent LK, Thieding-Cancel D. Effects of chromium picolinate on body composition. J Sports Med Phys Fitness 1995;35:273-80.
  10. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  11. Rabinovitz H, Friedensohn A, Leibovitz A, et al. Effect of chromium supplementation on blood glucose and lipid levels in type 2 diabetes mellitus elderly patients. Int J Vitam Nutr Res 2004;74:178-82. PubMed
  12. Lanca S, Alves A, Vieira AI, et al. Chromium-induced toxic hepatitis. Eur J Intern Med 2002;13:518-20. PubMed
  13. Kockler DR, McCarthy MW, Lawson CL. Seizure activity and unresponsiveness after hydroxycut ingestion. Pharmacotherapy 2001;21:647-51.. PubMed
  14. Davidson JR, Abraham K, Connor KM, McLeod MN. Effectiveness of chromium in atypical depression: a placebo-controlled trial. Biol Psychiatry 2003;53:261-4.. PubMed
  15. Food Standards Agency. Medicines and Healthcare products Regulatory Agency (MHRA). Expert Group on Vitamins and Minerals. Available at: http://cot.food.gov.uk/sites/default/files/vitmin2003.pdf.
  16. Mouser JF, Hak EB, Helms RA, et al. Chromium and zinc concentrations in pediatric patients receiving long-term parenteral nutrition. Am J Health Syst Pharm 1999;56:1950-6. PubMed
  17. Stevens T, Qadri A, Zein NN. Two patients with acute liver injury associated with use of the herbal weight-loss supplement hydroxycut. Ann Intern Med 2005;142:477-8. PubMed
  18. Wani S, Weskamp C, Marple J, Spry L. Acute tubular necrosis associated with chromium picolinate-containing dietary supplement. Ann Pharmacother 2006;40:563-6. PubMed
  19. Kleefstra N, Houweling ST, Jansman FG, et al. Chromium treatment has no effect in patients with poorly controlled, insulin-treated type 2 diabetes in an obese Western population: a randomized, double-blind, placebo-controlled trial. Diabetes Care 2006;29: PubMed
  20. Martin J, Wang ZQ, Zhang XH, et al. Chromium picolinate supplementation attenuates body weight gain and increases insulin sensitivity in subjects with type 2 diabetes. Diabetes Care 2006;29:1826-32. PubMed
  21. Singer GM, Geohas J. The effect of chromium picolinate and biotin supplementation on glycemic control in poorly controlled patients with type 2 diabetes mellitus: a placebo-controlled, double-blinded, randomized trial. Diabetes Technol Ther 2006;8:636-43. PubMed
  22. John-Kalarickal J, Pearlman G, Carlson HE. New medications which decrease levothyroxine absorption. Thyroid 2007;17:763-5. PubMed
  23. Yazaki Y, Faridi Z, Ma Y, et al. A pilot study of chromium picolinate for weight loss. J Altern Complement Med 2010;16:291-9. PubMed
  24. Davis ML, Seaborn CD, and Stoecker BJ. Effects of over-the-counter drugs on chromium retention and urinary excretion in rats. Nutrition Research 1995;15(2):201-210.
  25. Young P, Turiansky G, Bonner M, and et al. Acute generalized exanthematous pustulosis induced by chromium picolinate. J.Am Acad.Dermatol. 1999;41(5 Pt 2):820-823. PubMed
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