Major interaction on record — check this product against your medications before combining. Based on 4 of 7 ingredients. Check your meds →
Dietary supplement

Metal Cleanse+ Ingredients & Drug Interactions

by Zemvelo

Metal Cleanse+ label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Metal Cleanse+ against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Metal Cleanse+ is a dietary supplement by Zemvelo with 7 active ingredients. Its ingredients are commonly taken for diabetic nerve pain (neuropathy), blood sugar support in diabetes, antioxidant support.Based on those ingredients, 1,261 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Gingerols, N-Acetyl L-Cysteine, Alpha-Lipoic Acid. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Metal Cleanse+ by Zemvelo

Ask about any prescription or over-the-counter medication and we check it for interactions with Metal Cleanse+ by Zemvelo — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Metal Cleanse+ by Zemvelo

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 4 of its 7 active ingredients.
  • “BioEnhance 3XC” is listed as a grouped ingredient — the label gives one combined amount (5 mg) without saying how much of each component you get.

Metal Cleanse+ contains 7 ingredients. The active ones are alpha-lipoic acid, fulvic acid (supplied as both Fulvic Acid and ActivFulvic), N-acetyl L-cysteine (NAC), asiaticosides, bladderwrack powder, and gingerols (the active compounds in ginger), plus a proprietary blend called BioEnhance 3XC.

The product also contains rice bran and hypromellose as inactive ingredients—these are fillers and capsule material. Alpha-lipoic acid is an antioxidant studied for nerve damage from diabetes, cholesterol levels, and weight.

NAC is a form of the amino acid cysteine used for respiratory health and as an antidote to acetaminophen overdose. Fulvic acid is a substance from decomposed organic matter looked at for immune support and various health conditions.

Gingerols are the pungent compounds in ginger, traditionally used for nausea, menstrual cramps, and joint discomfort. Asiaticosides and bladderwrack are botanical extracts; we hold no interaction data for asiaticosides, and the bladderwrack content is also unchecked here.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: heavy metal detoxification and immune support.
  • We looked for evidence on: heavy metal poisoning, lead toxicity, mercury toxicity, arsenic exposure.
  • The closest evidence on file: N-acetyl Cysteine (nac) is rated "Insufficient Reliable Evidence To Rate" for Lead toxicity (Natural Medicines).
  • Also on file: N-acetyl Cysteine (nac) is rated "Insufficient Reliable Evidence To Rate" for Mercury toxicity.
  • Also on file: Fulvic Acid is rated "Insufficient Reliable Evidence To Rate" for Lead toxicity.

The evidence is mixed. Alpha-lipoic acid is possibly effective for nerve damage from diabetes and for managing cholesterol and weight.

NAC is effective for acetaminophen poisoning and for clearing airways in respiratory conditions, and it's possibly effective for bronchitis. Gingerols (ginger) are possibly effective for pregnancy-related nausea, menstrual cramps, and osteoarthritis, but the research suggests they are likely ineffective for muscle soreness from exercise.

Fulvic acid and asiaticosides lack reliable evidence; the data we hold shows insufficient evidence to rate them for any condition, including respiratory infections, lead toxicity, eczema, fatigue, or allergies. There is no effectiveness rating on file for bladderwrack or BioEnhance 3XC.

The evidence, ingredient by ingredient Alpha-lipoic Acid N-acetyl Cysteine (nac) Fulvic Acid Ginger

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Alpha-lipoic acid is generally well tolerated but can lower blood sugar—use it under medical guidance, and avoid it in pregnancy and while breastfeeding (safety data is not adequate). Common side effects are headache, heartburn, nausea, and vomiting; skin rash and itching have been reported, and rare case reports mention a syndrome involving insulin antibodies.

Fulvic acid (including ActivFulvic) appears well tolerated short-term, though high-quality human safety data is limited. Common side effects are diarrhea, headache, and sore throat; avoid in pregnancy and breastfeeding.

NAC is generally well tolerated at typical doses but can cause diarrhea, dry mouth, indigestion, heartburn, loss of appetite, nausea, and vomiting—higher single doses (over 9 grams) or daily regimens over 30 grams raise the risk of side effects. Pregnancy and breastfeeding safety haven't been well studied; discuss with your doctor.

Gingerols from ginger are generally well tolerated at food and supplement amounts, with mild side effects like heartburn, diarrhea, and a pepper-like mouth irritation at typical doses; higher doses (5 grams daily or more) reduce tolerability. Ginger is often used for morning sickness but check with your doctor first and keep amounts moderate.

Avoid supplemental amounts if breastfeeding without guidance.

Side effects, ingredient by ingredient Alpha-lipoic Acid N-acetyl Cysteine (nac) Fulvic Acid Ginger

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 4 of the 4 matched ingredients can interact with medications — Alpha-lipoic Acid, Ginger, N-acetyl Cysteine (nac), Fulvic Acid.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; cancer treatments; diabetes medications.
  • For scale: 1,262 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist or doctor before taking this if you use nitroglycerin (Major risk of severe low blood pressure and headache with NAC), blood thinners or antiplatelet drugs like warfarin or aspirin (Moderate bleeding risk from multiple ingredients), thyroid hormone therapy, diabetes medications, blood pressure drugs, chemotherapy, immunosuppressants, or any medications processed by the liver. Do not take it with activated charcoal.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with no established evidence rating for its marketed use. Major medication interactions have been identified, and safety information is well characterized.

Metal Cleanse+ is designed around ingredients with some evidence for detoxification and specific health claims, but the interaction profile is significant. If you take nitroglycerin, blood thinners, thyroid medication, diabetes drugs, or blood pressure medicine, do not start this without checking with your pharmacist or doctor first.

Even if none of those apply, run your complete medication list through the tool on this page—the product touches a large number of drugs.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 7 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Metal Cleanse+, straight from the product label.

Brand Zemvelo
Barcode (UPC) 891663002629
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Sep 25, 2025
DSLD ID 333499
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Children (All), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Metal Cleanse+ by Zemvelo, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
891663002629
IngredientAmount% DV
Alpha-Lipoic Acid50 mg--
Fulvic Acid0 NP--
N-Acetyl L-Cysteine100 mg--
Asiaticosides0 NP--
Bladderwrack, Powder100 mg--
ActivFulvic100 mg--
BioEnhance 3XC5 mg--
Gingerols0 NP--

Other ingredients: Rice Bran, Hypromellose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Powerful herbal ingredients known for detoxifying properties Science-backed BioEnhance 3XC to increase nutrient absorption

Supports healthy immune system and vitality by removing heavy metal burden

Heavy metal detoxification with advanced absorption technology

Metal cleanse With 24 hour support

Vegetarian

GF (Gluten free) Non GMO

Third party tested

FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Dietary Supplement

General Statements

"Love & gratitude"

Suggested/Recommended/Usage/Directions

Directions: Adults: As a dietary supplement for heavy metal detoxification, take one (1) capsule daily, with or without food, or as directed by a healthcare professional. Children: Consult a physician.

Precautions

Children: Consult a physician.

Seals/Symbols

Manufactured in the U.S.A. with quality ingredients from around the world cGMP

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Metal Cleanse+ by Zemvelo label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Metal Cleanse+ label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Metal Cleanse+ by Zemvelo

These are the 7 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Alpha-Lipoic Acid

Interacts with
263 drugs
50 mg per serving

Alpha-lipoic acid (ALA) is an antioxidant made naturally by the body and found in small amounts in foods. It is most studied for diabetic nerve pain,...

Alpha-Lipoic Acid monograph & interactions

N-Acetyl L-Cysteine

Interacts with
294 drugs
100 mg per serving

N-acetyl cysteine (NAC) is a supplement form of the amino acid cysteine and a building block for the antioxidant glutathione. It has well-established...

N-Acetyl L-Cysteine monograph & interactions

Bladderwrack, Powder

100 mg per serving

ActivFulvic

Interacts with
257 drugs
100 mg per serving Form: Fulvic Acid

Fulvic acid is a natural compound formed when plants and microbes break down in soil, and it is sold as a supplement for energy, gut, and overall well...

ActivFulvic monograph & interactions

BioEnhance 3XC

5 mg per serving

Other (inactive) ingredients: Rice Bran, Hypromellose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Metal Cleanse+ by Zemvelo Drug Interactions

Want to check YOUR meds against Metal Cleanse+?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,261Drugs
1 Major 1,143 Moderate 117 Minor

Ingredients driving the most interactions

Gingerols 1,007
N-Acetyl L-Cysteine 294
Alpha-Lipoic Acid 263
ActivFulvic 257

Individual Drug Interactions

The ingredients in Metal Cleanse+ interact with 1,261 drugs. Click any drug to see the details.

4 of the 7 ingredients in Metal Cleanse+ interact with drugs. Each result below shows which ingredient is responsible. Gingerols N-Acetyl L-Cysteine Alpha-Lipoic Acid ActivFulvic

Each ingredient & the kinds of drugs it affects

For each ingredient in Metal Cleanse+ with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Gingerols14 drug types · 1,007 drugs

Anticoagulant/Antiplatelet Drugs

Ginger may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs. However, research is conflicting.
Laboratory research suggests that ginger inhibits thromboxane synthetase and decreases platelet aggregation. However, this has not been demonstrated unequivocally in humans, with mixed results from clinical trials. Theoretically, excessive amounts of ginger might increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.

Likelihood Possible Evidence B
Antidiabetes Drugs

Theoretically, taking ginger with antidiabetes drugs might increase the risk of hypoglycemia.
Animal and human research suggests that ginger might increase insulin levels and/or decrease blood glucose levels.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Ginger might increase or decrease the levels of CYP3A4 substrates.
In vitro research and some case reports suggest that ginger inhibits CYP3A4 activity. Three case reports from the World Health Organization (WHO) adverse drug reaction database describe increased toxicity in patients taking ginger and cancer medications that are CYP3A4 substrates (imatinib, dabrafenib, and crizotinib). However, the causality of this interaction is unclear due to the presence of multiple interacting drugs and routes of administration.
Conversely, other in vitro research suggests that ginger induces CYP3A4 activity, leading to reduced levels of CYP3A4 substrates. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Losartan (Cozaar)

Theoretically, ginger might increase levels of losartan and the risk of hypotension.
In animal research, ginger increased the levels and hypotensive effects of a single dose of losartan. It is not clear if ginger alters the concentration or effects of losartan when taken continuously. Additionally, this interaction has not been shown in humans.

Likelihood Possible Evidence D
Nifedipine (Procardia)

Ginger may have antiplatelet effects and increase the risk of bleeding if used with nifedipine.
Clinical research shows that combined treatment with ginger 1 gram plus nifedipine 10 mg significantly inhibits platelet aggregation when compared to nifedipine or ginger alone.

Likelihood Possible Evidence B
P-Glycoprotein Substrates

Ginger might increase the absorption and blood levels of P-glycoprotein (P-gp) substrates.
In vitro research and case reports suggest that ginger inhibits drug efflux by P-gp, potentially increasing absorption and serum levels of P-gp substrates. Two case reports from the World Health Organization (WHO) adverse drug reaction database describe increased toxicity in patients taking ginger and cancer medications that are P-gp substrates (trametinib, crizotinib). However, the causality of this interaction is unclear due to the presence of multiple interacting drugs and routes of administration.

Likelihood Possible Evidence D
Phenprocoumon (Marcoumar, Others)

Ginger might increase the risk of bleeding with phenprocoumon.
Phenprocoumon, a warfarin-related anticoagulant, might increase the international normalized ratio (INR) when taken with ginger. There is one case report of a 76-year-old woman with a stable INR on phenprocoumon that increased to greater than 10 when she began consuming dried ginger and ginger tea.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Ginger might increase the risk of bleeding with warfarin.
Laboratory research suggests that ginger might inhibit thromboxane synthetase and decrease platelet aggregation. In one case report, ginger increased the INR when taken with phenprocoumon, which has similar pharmacological effects as warfarin. In another case report, ginger increased the INR when taken with a combination of warfarin, hydrochlorothiazide, and acetaminophen. A longitudinal analysis suggests that taking ginger increases the risk of bleeding in patients taking warfarin for at least 4 months. However, research in healthy people suggests that ginger has no effect on INR, or the pharmacokinetics or pharmacodynamics of warfarin. Until more is known, monitor INRs closely in patients taking large amounts of ginger.

Likelihood Possible Evidence B
Calcium Channel Blockers

Theoretically, taking ginger with calcium channel blockers might increase the risk of hypotension.
Some animal and in vitro research suggests that ginger has hypotensive and calcium channel-blocking effects. Another animal study shows that concomitant administration of ginger and the calcium channel blocker amlodipine leads to greater reductions in blood pressure when compared with amlodipine alone.

Likelihood Unlikely Evidence D
Cyclosporine (Neoral, Sandimmune)

Theoretically, when taken prior to cyclosporine, ginger might decrease cyclosporine levels.
In an animal model, ginger juice taken 2 hours prior to cyclosporine administration reduced the maximum concentration and area under the curve of cyclosporine by 51% and 40%, respectively. This effect was not observed when ginger juice and cyclosporine were administered at the same time.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, ginger might increase the levels of CYP1A2 substrates.
In vitro research shows that ginger inhibits CYP1A2 activity. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, ginger might increase the levels of CYP2B6 substrates.
In vitro research shows that ginger inhibits CYP2B6 activity. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, ginger might increase the levels of CYP2C9 substrates.
In vitro research shows that ginger inhibits CYP2C9 activity. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Metronidazole (Flagyl)

Theoretically, ginger might increase levels of metronidazole.
In an animal model, ginger increased the absorption and plasma half-life of metronidazole. In addition, the elimination rate and clearance of metronidazole was significantly reduced.

Likelihood Possible Evidence D
Gingerols full monograph & interactions

N-Acetyl L-Cysteine5 drug types · 294 drugs

Nitroglycerin

N-acetyl cysteine can increase the risk for hypotension and headaches when taken with intravenous or transdermal nitroglycerin.
Clinical research shows that concomitant administration of N-acetyl cysteine and intravenous or transdermal nitroglycerin can cause severe hypotension and intolerable headaches. Furthermore, in vitro research suggests that N-acetyl cysteine increases the anticoagulant activity of nitroglycerin.

Likelihood Probable Evidence B
Activated Charcoal

N-acetyl cysteine might reduce the effects of activated charcoal, while activated charcoal might reduce the absorption of N-acetyl cysteine.
N-acetyl cysteine appears to reduce the capacity of activated charcoal to adsorb acetaminophen and salicylic acid. Conversely, although clinical research suggests that although activated charcoal can reduce the absorption of N-acetyl cysteine by up to 40%, it does not seem to reduce its clinical effects. Other clinical evidence suggests that activated charcoal does not affect the absorption of N-acetyl cysteine.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, N-acetyl cysteine might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Clinical research suggests that intravenous N-acetyl cysteine decreases prothrombin time, prolongs coagulation time, decreases platelet aggregation, and increases blood loss in surgical patients. Furthermore, in vitro research suggests that N-acetyl cysteine increases the anticoagulant activity of nitroglycerin.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, N-acetyl cysteine might increase the risk of hypotension when taken with antihypertensive drugs.
Animal research suggests that N-acetyl cysteine potentiates the hypotensive effects of the angiotensin-converting enzyme inhibitors (ACEIs) captopril and enalaprilat. Theoretically, combining N-acetyl cysteine with other antihypertensive drugs might increase the risk of hypotension.

Likelihood Possible Evidence D
Chloroquine (Aralen)

Theoretically, N-acetyl cysteine might interfere with the antimalarial effects of chloroquine.
Animal research suggests that N-acetyl cysteine might reduce the antimalarial effects of chloroquine by increasing cellular levels of glutathione.

Likelihood Possible Evidence D
N-Acetyl L-Cysteine full monograph & interactions

Alpha-Lipoic Acid5 drug types · 263 drugs

Alkylating Agents

Theoretically, the antioxidant effects of alpha-lipoic acid might alter the effectiveness of alkylating agents.
The use of antioxidants like alpha-lipoic acid during chemotherapy is controversial. There are concerns that antioxidants could reduce the activity of chemotherapy drugs that generate free radicals. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as alpha-lipoic acid have on chemotherapy. Advise patients to consult their oncologist before using alpha-lipoic acid.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, alpha-lipoic acid may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro, alpha-lipoic acid inhibits platelet aggregation.

Likelihood Possible Evidence D
Antitumor Antibiotics

Theoretically, the antioxidant effects of alpha-lipoic acid might alter the effectiveness of antitumor antibiotics.
The use of antioxidants like alpha-lipoic acid during chemotherapy is controversial. There are concerns that antioxidants could reduce the activity of antitumor antibiotic drugs, which work by generating free radicals. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as alpha-lipoic acid have on chemotherapy involving antitumor antibiotics. Advise patients to consult their oncologist before using alpha-lipoic acid.

Likelihood Possible Evidence D
Thyroid Hormone

Theoretically, alpha-lipoic acid might decrease the effects of thyroid hormone drugs.
Animal research suggests that co-administration of thyroxine with alpha-lipoic acid reduces conversion into the active T3 form.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking alpha-lipoic acid with antidiabetes drugs might increase the risk of hypoglycemia.
Although some small clinical studies have suggested that alpha-lipoic acid can lower blood glucose levels, larger clinical studies in patients with diabetes have shown no clinically meaningful effect. Additionally, co-administration of single doses of alpha-lipoic acid and glyburide or acarbose did not cause detectable drug interactions in healthy volunteers.

Likelihood Unlikely Evidence B
Alpha-Lipoic Acid full monograph & interactions

ActivFulvic3 drug types · 257 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, taking fulvic acid may decrease the effectiveness of anticoagulant and antiplatelet drugs.
In vitro evidence shows that fulvic acid, formed from the oxidation and polymerization of protocatechuic acid, can shorten prothrombin time in human plasma, increasing the risk of clot formation.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, taking fulvic acid might decrease the effects of immunosuppressive therapy.
Animal research shows that fulvic acid stimulates immune function.

Likelihood Possible Evidence D
Thyroid Hormone

Theoretically, taking fulvic acid with thyroid hormone therapy might interfere with the ability to normalize thyroid function.
Animal research shows that fulvic acid increases the plasma level of thyroid-stimulating hormone (TSH) and decreases the thyroxine (T4):triiodothyronine (T3) ratio.

Likelihood Possible Evidence D
ActivFulvic full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Metal Cleanse+, from the product label.

Zemvelo

See all Zemvelo products
Name
Zemvelo by Mineralife
Phone Number
800.303.1376
Web Address
zemvelo.com
Pharmacist Counseling Corner

Metal Cleanse+ by Zemvelo: Common Questions

Does Metal Cleanse+ by Zemvelo interact with any medications?
Yes. Based on its ingredients, Metal Cleanse+ has a known interaction with 1,261 medications, including 1 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Metal Cleanse+ contains 7 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Metal Cleanse+ if I'm pregnant or breastfeeding?
The safety data isn't adequate for pregnancy or breastfeeding. Alpha-lipoic acid, fulvic acid, and the fulvic acid blend all advise against use during pregnancy and while breastfeeding. NAC's pregnancy safety hasn't been well studied, so discuss it with your doctor. Ginger is often used for morning sickness, but keep amounts moderate and check with your doctor first. Talk to your pharmacist or OB/GYN for personalized advice.
What does alpha-lipoic acid do in this product?
Alpha-lipoic acid is an antioxidant studied for diabetic nerve damage, cholesterol levels, and weight management. Research suggests it's possibly effective for those uses. However, it can lower blood sugar, so it's best used under medical guidance if you have diabetes or take diabetes medication.
Will N-acetyl cysteine help me breathe better or clear my lungs?
NAC is effective for clearing airways and is possibly effective for bronchitis. It's also the proven antidote for acetaminophen overdose. At typical doses in a supplement like this, it's generally well tolerated, though heartburn, nausea, and diarrhea can occur.
Does ginger in this product help with nausea or joint pain?
The ginger (gingerols) in this product is possibly effective for pregnancy-related nausea and menstrual cramps, and for osteoarthritis. However, research suggests it's likely ineffective for muscle soreness from exercise. Ginger is generally well tolerated at typical amounts, though heartburn, diarrhea, and a peppery mouth irritation can happen.
What is fulvic acid supposed to do?
Fulvic acid is promoted for immune support and conditions like respiratory infections, fatigue, and allergies. However, the evidence we have isn't strong enough to rate it for any of these uses. Short-term use appears well tolerated, but human safety data is limited.
What if I'm on thyroid medication—is this product safe?
No. Both alpha-lipoic acid and fulvic acid (which appear twice in this product as Fulvic Acid and ActivFulvic) can interfere with thyroid hormone therapy and your ability to normalize thyroid function. Do not take Metal Cleanse+ with thyroid drugs without checking with your doctor or pharmacist first.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Metal Cleanse+ label
Go deeper

The Full Monographs Behind Metal Cleanse+’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Alpha-lipoic Acid

Interacts with 263 drugs

Alpha-lipoic acid (ALA) is an antioxidant made naturally by the body and found in small amounts in foods. It is most studied for diabetic nerve pain, where some evidence suggests it may help...

Read the full Alpha-lipoic Acid monograph → Herb & supplement monograph

N-acetyl Cysteine (nac)

Interacts with 294 drugs

N-acetyl cysteine (NAC) is a supplement form of the amino acid cysteine and a building block for the antioxidant glutathione. It has well-established prescription uses for acetaminophen over...

Read the full N-acetyl Cysteine (nac) monograph → Herb & supplement monograph

Fulvic Acid

Interacts with 257 drugs

Fulvic acid is a natural compound formed when plants and microbes break down in soil, and it is sold as a supplement for energy, gut, and overall wellness. Human research is very limited, so...

Read the full Fulvic Acid monograph → Herb & supplement monograph

Ginger

Interacts with 1,007 drugs

Ginger is a widely used culinary spice with a long history in traditional medicine, and it has the strongest evidence for helping with nausea and vomiting, including from motion sickness, pr...

Read the full Ginger monograph →
Sources

Sources & How We Checked

Metal Cleanse+'s label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 201 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Alpha-lipoic Acid 48 references
  1. Labriola D, Livingston R. Possible interactions between dietary antioxidants and chemotherapy. Oncology 1999;13:1003-8.
  2. Anon. Alpha-lipoic acid. Altern Med Rev 1998;3:308-10.
  3. Konrad T, Vicini P, Kusterer K, et al. Alpha-lipoic acid treatment decreases serum lactate and pyruvate concentrations and improves glucose effectiveness in lean and obese patients with Type 2 diabetes. Diabetes Care 1999;22:280-7. PubMed
  4. Ziegler D, Hanefeld M, Ruhnau KJ, et al. Treatment of symptomatic diabetic peripheral neuropathy with the antioxidant alpha-lipoic acid: A 3-week, multicentre randomized controlled trial (ALADIN Study). Diabetologia 1995;38:1425-33.
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See these in context on the N-acetyl Cysteine (nac) monograph →

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See these in context on the Ginger monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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