Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

Mexican Wild Yam Root Ingredients & Drug Interactions

by Wonder Laboratories

Mexican Wild Yam Root label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Mexican Wild Yam Root against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Mexican Wild Yam Root is a dietary supplement by Wonder Laboratories with 2 active ingredients. Its ingredients are commonly taken for menopausal symptoms, menstrual cramps, hormone balance (popular belief).Based on those ingredients, 41 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Mexican Wild Yam Root Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Mexican Wild Yam Root by Wonder Laboratories

Ask about any prescription or over-the-counter medication and we check it for interactions with Mexican Wild Yam Root by Wonder Laboratories — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Mexican Wild Yam Root by Wonder Laboratories

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains 2 active ingredients. Mexican Wild Yam Root Extract is the primary one — a plant-based ingredient historically used in traditional medicine.

The product also includes Adrenal concentrate, which we don't have detailed data on. The remaining ingredients — Gelatin, Cellulose, Magnesium Stearate, and Silica — are inactive fillers and capsule materials that help hold the supplement together.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Wild Yam's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Mexican Wild Yam Root extract, highest potency.
  • We looked for evidence on: Menopausal symptoms, Dysmenorrhea, Postmenopausal conditions, Hormone balance, Menstrual health.
  • The closest evidence on file: Wild Yam is rated "Possibly Ineffective" for Menopausal symptoms (Natural Medicines).
  • Also on file: Wild Yam is rated "Insufficient Reliable Evidence To Rate" for Postmenopausal conditions, Dysmenorrhea.

The evidence for wild yam is mixed and often weak. For menopausal symptoms, it's rated possibly ineffective — meaning studies haven't shown it works well for hot flashes or other menopause-related discomfort.

For gallbladder disease, sexual dysfunction, irregular periods, and infertility, there isn't enough reliable evidence to know either way. We don't have effectiveness data on adrenal concentrate.

The evidence, ingredient by ingredient Wild Yam

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Wild yam is generally well tolerated when taken short-term by healthy adults, but long-term safety hasn't been well studied. The most common side effects are mild: headache, fever, upset stomach, and vomiting.

Serious reactions like anaphylaxis are rare. However, the safety data advises against use during pregnancy and while breastfeeding — there isn't enough information to know it's safe in those situations.

One case report described vision loss in someone taking a multi-ingredient supplement containing wild yam, though it's unclear if wild yam was the cause.

Side effects, ingredient by ingredient Wild Yam

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Wild Yam.
  • The most serious interaction on file is rated Moderate.
  • For scale: 41 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your estrogen medications before taking this product — estrogen-based therapies (birth control, hormone replacement, and similar medications) may be affected. We cannot assess interaction risk for adrenal concentrate, so mention this ingredient to your pharmacist too.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This supplement may be worth considering if you're interested in traditional remedies for menopausal or gynecological concerns, but the evidence it works is limited to weak or absent. It's safest for short-term use in otherwise healthy adults.

Talk to your pharmacist or doctor before starting, especially if you're on hormone therapy or planning to become pregnant or breastfeed.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 22, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Mexican Wild Yam Root, straight from the product label.

Brand Wonder Laboratories
Net contents 120 Capsule(s)
Market status On market
Date entered into DSLD Jan 22, 2022
DSLD ID 263663
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Mexican Wild Yam Root by Wonder Laboratories, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
IngredientAmount% DV
Adrenal concentrate100 mg--
Mexican Wild Yam Root Extract300 mg--

Other ingredients: Gelatin, Cellulose, Magnesium Stearate, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Guaranteed Maximum Potency Mexican Wild Yam Root contains the highest quality, most potent form of Mexican Yam Root Extract available. An abundant source of Diosgenin.

Standardized for 30,000 mcg Diosgenin

Formulation

Mfg. in an FDA Registered Facility using Good Manufacturing Practices (GMPs)

Conforms to USP <2091> for weight. Meets USP <2040> disintegration for maximum bioavailability.

Gluten Free

Made in USA

Precautions

Tamper Evident: Do not use this product if imprinted foil seal under cap is broken or missing.

Keep out of reach of children.

Caution: If you are pregnant or nursing, consult your physician before taking this product.

Storage

Keep tightly closed. Store at room temperature: 59 degrees - 86 degrees F (15 degrees to 30 degrees C).

General Statements

Formula 899

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take 1 capsule twice daily.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Mexican Wild Yam Root by Wonder Laboratories label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Mexican Wild Yam Root label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Mexican Wild Yam Root by Wonder Laboratories

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Adrenal concentrate

100 mg per serving

Mexican Wild Yam Root Extract

Interacts with
41 drugs
300 mg per serving Form: Diosgenin

Wild yam is a root traditionally used for menopausal symptoms, cramps, and as a so-called 'natural' hormone supplement, but solid human evidence for t...

Mexican Wild Yam Root Extract monograph & interactions

Other (inactive) ingredients: Gelatin, Cellulose, Magnesium Stearate, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Mexican Wild Yam Root by Wonder Laboratories Drug Interactions

Want to check YOUR meds against Mexican Wild Yam Root?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
41Drugs
41 Moderate

Ingredients driving the most interactions

Mexican Wild Yam Root Extract 41

Individual Drug Interactions

The ingredients in Mexican Wild Yam Root interact with 41 drugs. Click any drug to see the details.

1 of the 2 ingredients in Mexican Wild Yam Root interact with drugs. Each result below shows which ingredient is responsible. Mexican Wild Yam Root Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Mexican Wild Yam Root with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Mexican Wild Yam Root Extract1 drug type · 41 drugs

Estrogens

Theoretically, wild yam might increase or decrease the effects of estrogen.
Wild yam root shows estrogenic and anti-estrogenic effects in vitro. Theoretically, wild yam might interfere with hormone therapy.

Likelihood Possible Evidence D
Mexican Wild Yam Root Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Mexican Wild Yam Root, from the product label.

Wonder Laboratories

See all Wonder Laboratories products
Name
Wonder Laboratories
Street Address
115 S.C.T. Ct.
City
White House
State
TN
ZipCode
37188
Pharmacist Counseling Corner

Mexican Wild Yam Root by Wonder Laboratories: Common Questions

Does Mexican Wild Yam Root by Wonder Laboratories interact with any medications?
Yes. Based on its ingredients, Mexican Wild Yam Root has a known interaction with 41 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Mexican Wild Yam Root contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will wild yam help with my hot flashes?
The evidence suggests it probably won't. Wild yam is rated possibly ineffective for menopausal symptoms, so studies haven't shown it works well for hot flashes or other menopause-related discomfort. If you're looking for relief, talk to your doctor about options with stronger evidence behind them.
Can I take this while pregnant or breastfeeding?
The safety data advises against it — there isn't enough information to know it's safe during pregnancy or while breastfeeding. If you're pregnant, planning to become pregnant, or nursing, talk to your pharmacist or doctor before using this product.
What side effects might I get?
Most people tolerate wild yam well. The most common mild side effects are headache, fever, upset stomach, and vomiting. Serious reactions like anaphylaxis are very rare. At higher doses, headache and fever tend to be more likely.
What's in this besides the wild yam?
There's also an adrenal concentrate, which we don't have detailed safety or interaction data for. The rest — gelatin, cellulose, magnesium stearate, and silica — are inactive fillers that hold the capsule together.
How long can I safely take this?
Wild yam is likely fine for short-term use in healthy adults, but long-term safety hasn't been well studied. Check with your pharmacist about how long is reasonable for your situation.
Will this interfere with my birth control?
Possibly. Wild yam shows estrogenic and anti-estrogenic effects in studies, so it could theoretically affect how your birth control works. Before starting, use the medication checker on this page with your exact birth control brand, and talk to your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Mexican Wild Yam Root label
Go deeper

The Full Monographs Behind Mexican Wild Yam Root’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Wild Yam

Interacts with 41 drugs

Wild yam is a root traditionally used for menopausal symptoms, cramps, and as a so-called 'natural' hormone supplement, but solid human evidence for these uses is lacking. Despite popular cl...

Read the full Wild Yam monograph →
Sources

Sources & How We Checked

Mexican Wild Yam Root's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 7 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Wild Yam 7 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Eagon PK, Elm MS, Hunter DS, et al. Medicinal herbs: modulation of estrogen action. Era of Hope Mtg, Dept Defense; Breast Cancer Res Prog, Atlanta, GA 2000;Jun 8-11.
  3. Cheong JL, Bucknall R. Retinal vein thrombosis associated with a herbal phytoestrogen preparation in a susceptible patient. Postgrad Med J 2005;81:266-7.. PubMed
  4. Rosenberg Zand, R. S., Jenkins, D. J., and Diamandis, E. P. Effects of natural products and nutraceuticals on steroid hormone-regulated gene expression. Clin Chim.Acta 2001;312(1-2):213-219. PubMed
  5. Araghiniknam M, Chung S, Nelson-White T, and et al. Antioxidant activity of Dioscorea and dehydroepiandrosterone (DHEA) in older humans. Life Sciences 1996;59:L147-L157.
  6. Zeng M, Zhang L, Li M, et al. Estrogenic effects of the extracts from the Chinese Yam (Dioscorea opposite Thunb.) and its effective compounds in vitro and in vivo. Molecules. 2018 Jan 23;23(2). Pii: E11. PubMed
  7. Lu J, Wong RN, Zhang L, et al. Comparative analysis of proteins with stimulating activity on ovarian estradiol biosynthesis from four different Dioscorea species in vitro using both phenotypic and target-based approaches: implication for treating menopaus

See these in context on the Wild Yam monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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