Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

Mexican Wild Yam Root Ingredients & Drug Interactions

by Wonder Laboratories

Mexican Wild Yam Root label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Mexican Wild Yam Root against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Mexican Wild Yam Root is a dietary supplement by Wonder Laboratories with 2 active ingredients. Its ingredients are commonly taken for menopausal symptoms, menstrual cramps, hormone balance (popular belief).Based on those ingredients, 41 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Mexican Yam extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Mexican Wild Yam Root by Wonder Laboratories

Ask about any prescription or over-the-counter medication and we check it for interactions with Mexican Wild Yam Root by Wonder Laboratories — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Mexican Wild Yam Root by Wonder Laboratories

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 20, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product has 2 active ingredients: Mexican yam extract and adrenal concentrate. The yam extract is the ingredient we have the most information on — it's traditionally used for female hormone and reproductive health support, though the evidence for its effectiveness is mixed (see the effectiveness section below).

The inactive ingredients are gelatin, cellulose, magnesium stearate, and silica — these are common capsule fillers and binders.

Does it work?

Leans against
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Leans against

The strongest graded evidence we hold for the stated purpose leans against a benefit.

Why this rating?
  • The label markets this product for: hormone balance and menopausal symptom support.
  • We looked for evidence on: Menopausal symptoms, Postmenopausal conditions, Dysmenorrhea, Premenstrual syndrome (PMS), Hormone regulation, Estrogen balance.
  • The closest evidence on file: Wild Yam is rated "Possibly Ineffective" for Menopausal symptoms (Natural Medicines).
  • Also on file: Wild Yam is rated "Insufficient Reliable Evidence To Rate" for Postmenopausal conditions, Premenstrual syndrome (PMS), Dysmenorrhea.

The evidence for Mexican wild yam is limited and uneven. For menopausal symptoms, it's rated possibly ineffective — meaning the studies don't support the idea that it helps.

For gallbladder disease, sexual dysfunction, heavy or painful periods (dysmenorrhea), and infertility, there isn't enough reliable evidence to say whether it works or not. The data we hold doesn't show what adrenal concentrate is intended to do or how well it works.

The evidence, ingredient by ingredient Wild Yam

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Orally, wild yam is generally well tolerated. The most common side effects reported in trials are fever, headache, upset stomach, and vomiting — these tend to occur more often at higher doses.

Anaphylaxis (a severe allergic reaction) is rare but has been reported. Long-term safety hasn't been well studied, so caution is warranted if you're thinking about using it over months or years.

The safety data advises against use during pregnancy and while breastfeeding — there isn't enough data to know either way, and the safest approach is to avoid it in those situations.

Side effects, ingredient by ingredient Wild Yam

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Wild Yam.
  • The most serious interaction on file is rated Moderate.
  • For scale: 41 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start, check with your doctor or pharmacist if you take any estrogen-based medications — including birth control pills, patches, hormone replacement therapy, or other hormonal contraceptives. Wild yam extract can theoretically shift how these medications work, and that's a Moderate concern you'll want to address before combining them.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with graded evidence leaning against its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product is best for someone exploring traditional hormone support who isn't on estrogen-based medications and doesn't plan to use it long-term. If you take birth control, HRT, or any hormone therapy, check with your doctor or pharmacist first — the yam extract could interfere.

Pregnant or breastfeeding? Skip it and talk to your provider about what's safe for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 18, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Mexican Wild Yam Root, straight from the product label.

Brand Wonder Laboratories
Net contents 180 Capsule(s)
Market status On market
Date entered into DSLD Dec 18, 2021
DSLD ID 263666
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Mexican Wild Yam Root by Wonder Laboratories, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
IngredientAmount% DV
Adrenal concentrate100 mg--
Mexican Yam extract300 mg--

Other ingredients: Gelatin, Cellulose, Magnesium Stearate, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Wonder Labs Mexican Yam Root Extract is both concentrated and standardized to contain the highest quality, most potent form of Mexican Yam Root Extract containing Diosgenin, a DHEA precursor. Diosegnin may act in a way similar to soy isoflavones - as phytoestrogens in the relief of menopausal symptoms. Adrenal Concentrate is added to the formula to enhance the bioavailability of this important herb.

Conforms to USP <2091> for weight. Meets USP <2040> disintegration for maximum bioavailability.

Nutritional Support During Menopause

Gluten Free

Mfg. in an FDA Registered Facility using Good Manufacturing Practices (GMPs)

Made in USA

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take 1 capsule twice daily.

Precautions

Tamper Evident: Do not use this product if imprinted foil seal under cap is broken or missing.

Keep out of reach of children.

Storage

Keep tightly closed. Store at room temperature: 59 degrees - 86 degrees F (15 degrees to 30 degrees C).

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General Statements

Reorder #8992

Formula

Standardized 10:1 Extract

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Mexican Wild Yam Root by Wonder Laboratories label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Mexican Wild Yam Root label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Mexican Wild Yam Root by Wonder Laboratories

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Adrenal concentrate

100 mg per serving

Mexican Yam extract

Interacts with
41 drugs
300 mg per serving

Wild yam is a root traditionally used for menopausal symptoms, cramps, and as a so-called 'natural' hormone supplement, but solid human evidence for t...

Mexican Yam extract monograph & interactions

Other (inactive) ingredients: Gelatin, Cellulose, Magnesium Stearate, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Mexican Wild Yam Root by Wonder Laboratories Drug Interactions

Want to check YOUR meds against Mexican Wild Yam Root?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
41Drugs
41 Moderate

Ingredients driving the most interactions

Mexican Yam extract 41

Individual Drug Interactions

The ingredients in Mexican Wild Yam Root interact with 41 drugs. Click any drug to see the details.

1 of the 2 ingredients in Mexican Wild Yam Root interact with drugs. Each result below shows which ingredient is responsible. Mexican Yam extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Mexican Wild Yam Root with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Mexican Yam extract1 drug type · 41 drugs

Estrogens

Theoretically, wild yam might increase or decrease the effects of estrogen.
Wild yam root shows estrogenic and anti-estrogenic effects in vitro. Theoretically, wild yam might interfere with hormone therapy.

Likelihood Possible Evidence D
Mexican Yam extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Mexican Wild Yam Root, from the product label.

Wonder Laboratories

See all Wonder Laboratories products
Name
Wonder Laboratories
Street Address
115 S.C.T. Ct.
City
White House
State
TN
ZipCode
37188
Pharmacist Counseling Corner

Mexican Wild Yam Root by Wonder Laboratories: Common Questions

Does Mexican Wild Yam Root by Wonder Laboratories interact with any medications?
Yes. Based on its ingredients, Mexican Wild Yam Root has a known interaction with 41 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Mexican Wild Yam Root contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help my hot flashes or night sweats?
The evidence says wild yam is possibly ineffective for menopausal symptoms — so it's not a reliable option for hot flashes or night sweats. If you're dealing with menopause, talk with your doctor about what options do have solid backing.
What are the common side effects?
Most people tolerate it fine, but some report fever, headache, upset stomach, or vomiting — these show up more often if you take higher doses. Anaphylaxis is very rare but has occurred.
Can I take this if I'm pregnant or breastfeeding?
No — there isn't enough safety data, and the safest call is to avoid it during pregnancy and while breastfeeding. Talk with your doctor or pharmacist about what's safe for you during these times.
Is this safe to take long-term?
The data we have covers short-term use in healthy adults, and it's generally well tolerated. Long-term safety hasn't been well studied, so caution is warranted if you're thinking about taking it for months or longer.
What does the adrenal concentrate ingredient do?
We don't have effectiveness data on file for adrenal concentrate — there's no information on what it's supposed to do or how well it works in this product.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Mexican Wild Yam Root is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Mexican Wild Yam Root label
Go deeper

The Full Monographs Behind Mexican Wild Yam Root’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Wild Yam

Interacts with 41 drugs

Wild yam is a root traditionally used for menopausal symptoms, cramps, and as a so-called 'natural' hormone supplement, but solid human evidence for these uses is lacking. Despite popular cl...

Read the full Wild Yam monograph →
Sources

Sources & How We Checked

Mexican Wild Yam Root's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 7 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Wild Yam 7 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Eagon PK, Elm MS, Hunter DS, et al. Medicinal herbs: modulation of estrogen action. Era of Hope Mtg, Dept Defense; Breast Cancer Res Prog, Atlanta, GA 2000;Jun 8-11.
  3. Cheong JL, Bucknall R. Retinal vein thrombosis associated with a herbal phytoestrogen preparation in a susceptible patient. Postgrad Med J 2005;81:266-7.. PubMed
  4. Rosenberg Zand, R. S., Jenkins, D. J., and Diamandis, E. P. Effects of natural products and nutraceuticals on steroid hormone-regulated gene expression. Clin Chim.Acta 2001;312(1-2):213-219. PubMed
  5. Araghiniknam M, Chung S, Nelson-White T, and et al. Antioxidant activity of Dioscorea and dehydroepiandrosterone (DHEA) in older humans. Life Sciences 1996;59:L147-L157.
  6. Zeng M, Zhang L, Li M, et al. Estrogenic effects of the extracts from the Chinese Yam (Dioscorea opposite Thunb.) and its effective compounds in vitro and in vivo. Molecules. 2018 Jan 23;23(2). Pii: E11. PubMed
  7. Lu J, Wong RN, Zhang L, et al. Comparative analysis of proteins with stimulating activity on ovarian estradiol biosynthesis from four different Dioscorea species in vitro using both phenotypic and target-based approaches: implication for treating menopaus

See these in context on the Wild Yam monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team