Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Microbiome Cleanse Ingredients & Drug Interactions

by Gaia Herbs

Microbiome Cleanse label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Microbiome Cleanse against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Microbiome Cleanse is a dietary supplement by Gaia Herbs with 7 active ingredients. Its ingredients are commonly taken for common cold and flu symptoms, upper respiratory infections, sore throat.Based on those ingredients, 1,450 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Oregon Grape extract, organic Sweet Wormwood extract, organic Peppermint leaf essential oil. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Microbiome Cleanse by Gaia Herbs

Ask about any prescription or over-the-counter medication and we check it for interactions with Microbiome Cleanse by Gaia Herbs — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Microbiome Cleanse by Gaia Herbs

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 20, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 7 active ingredients.
  • “Proprietary Extract Blend” is a proprietary blend — the label gives one combined amount (438 mg) without saying how much of each component you get.

Microbiome Cleanse contains 7 active ingredients. Andrographis aerial parts extract is included for its anti-inflammatory properties.

Cinnamon bark extract (a supercritical CO2 extract of the organic version) is a concentrated form of cinnamon. Oregon grape extract and black walnut green hulls extract are plant extracts, as is sweet wormwood extract (also called Sweet Annie).

Oregano extract and peppermint leaf essential oil round out the blend. There's also a proprietary extract blend listed, which contains additional component ingredients detailed separately.

The capsule itself is vegan, and the other inactive ingredients are vegetable glycerin, sunflower lecithin, and water.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: digestive support and GI tract health.
  • We looked for evidence on: Abdominal pain, Diarrhea, Dyspepsia, Gastritis, Gastroesophageal reflux disease (GERD), Intestinal parasite infection — and 4 related terms.
  • The strongest evidence on file: Peppermint is rated "Likely Effective" for Irritable bowel syndrome (IBS) (Natural Medicines).
  • Also on file: Peppermint is rated "Possibly Effective" for Chemotherapy-induced nausea and vomiting (CINV), Dyspepsia.
  • Also on file: Oregon Grape is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia, Peptic ulcers.

For andrographis, the evidence supports possibly effective use for ulcerative colitis, tonsillopharyngitis (sore throat from bacterial or viral infection), and osteoarthritis. Oregon grape is possibly effective for psoriasis.

Peppermint is likely effective for irritable bowel syndrome and possibly effective for indigestion (dyspepsia), chemotherapy-related nausea and vomiting, and spasm relief during procedures. The effectiveness of cinnamon, black walnut, sweet wormwood, and oregano for their traditional uses is not established in our data—the evidence is insufficient to rate them.

The evidence, ingredient by ingredient Andrographis Cassia Cinnamon Oregon Grape Black Walnut Sweet Annie Oregano Peppermint

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 7 of the 7 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 7 of 7.
  • General safety write-ups exist for 7 of 7.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Andrographis is generally well tolerated short-term, but long-term safety and product quality are not well established. The most common side effects are abdominal discomfort, altered taste, diarrhea, dizziness, fatigue, headache, nausea, vomiting, itching, rash, and hives.

Rare serious effects include severe allergic reactions and anaphylaxis. Avoid it during pregnancy because of theoretical concerns and animal-study evidence of possible reproductive harm, and do not use it while breastfeeding.

Cinnamon is generally safe in food amounts; supplement doses high in coumarin (a compound in cassia cinnamon) may harm the liver over extended use. Oregon grape is generally well tolerated topically but is less well studied orally.

Avoid it in pregnancy and while breastfeeding. Black walnut extract may be acceptable short-term but has limited human safety data; avoid in pregnancy and breastfeeding.

Sweet wormwood is generally well tolerated, but rare hepatotoxicity (liver damage) has been reported; avoid in pregnancy and breastfeeding. Oregano is well tolerated in food amounts; concentrated supplement forms are less studied.

Oregano extract should be avoided in pregnancy; safety while breastfeeding is not established. Peppermint tea and culinary use are generally safe; concentrated oil should be used carefully and avoided in pregnancy and breastfeeding without provider approval.

Side effects, ingredient by ingredient Andrographis Cassia Cinnamon Oregon Grape Black Walnut Sweet Annie Oregano Peppermint

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 6 of the 7 matched ingredients can interact with medications — Oregon Grape, Oregano, Peppermint, Sweet Annie, Andrographis, among others.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 1,451 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Microbiome Cleanse, check with your doctor or pharmacist if you take blood pressure medications, blood thinners, diabetes medications, immune suppressants (particularly cyclosporine), drugs metabolized by CYP3A4, CYP2C9, CYP2C19, or CYP2D6, or any drug that can harm the liver. These are Moderate-severity interactions.

Additionally, if you take the diabetes drug glipizide (Glucotrol) or the pain reliever etoricoxib (Arcoxia) or celecoxib (Celebrex), check with your provider—minor interactions with andrographis are possible.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Microbiome Cleanse is a multi-ingredient botanical blend most suited to someone looking for herbal support for digestion or mild inflammation who is not taking blood pressure medications, blood thinners, diabetes drugs, or immune suppressants. If you do take any of those medication types—or any prescription at all—check your exact drugs with the tool on this page before starting.

Talk with your doctor or pharmacist before taking it, especially if you're pregnant, breastfeeding, or have liver concerns.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 7 of 7 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 23, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Microbiome Cleanse, straight from the product label.

Brand Gaia Herbs
Net contents 60 Vegan Liquid Phyto-Cap(s)(R)
Market status On market
Date entered into DSLD Jan 23, 2023
DSLD ID 273194
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Microbiome Cleanse by Gaia Herbs, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
IngredientAmount% DV
Total Carbohydrates1 Gram(s)1%
Andrographis Aerial Parts Extract0 NP--
organic Cinnamon bark supercritical CO2 extract0 NP--
Oregon Grape extract0 NP--
Proprietary Extract Blend438 mg--
Black Walnut green hulls extract0 NP--
organic Sweet Wormwood extract0 NP--
organic Oregano extract0 NP--
organic Peppermint leaf essential oil37 mg--

Other ingredients: Vegetable Glycerin, Sunflower Lecithin, Water, vegan Capsule

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Digestive support Promotes health & function of the GI tract

Natural separation may occur. This does not affect product quality.

Vegan

Gluten-free Soy-free

Formula

With Black walnut, sweet wormwood & peppermint

FDA Statement of Identity

Herbal Supplement

Precautions

Contains tree nuts (black walnut).

Not for use during pregnancy or lactation. If you have a medical condition or take medications, please consult with your doctor before use.

Store away from children.

Use only as directed on label. Safety-sealed for your protection.

Suggested/Recommended/Usage/Directions

Suggested Use Adults take 1 capsule 2 times daily between meals. Maximum time of use is 6 weeks or as recommended by your doctor.

Storage

Keep bottle capped at all times and store in a cool, dry place.

General Statements

meetyourherbs.com Gaia Herbs delivers unprecedented traceability by screening every product and sharing the results online. See for yourself, and learn more about your herbs, by entering the unique ID # below at meetyourherbs.com

Purity - Keep it clean All products are screened for pesticides, microbes & heavy metals. Integrity - Keep it real See the proof at meetyourherbs.com, the world's first herb traceability platform. Potency - Keep it strong Concentrated plant extracts are delivered in our patented Phyto-Caps technology. Discover our guiding truths at: Facebook Instagram @gaiaherbs

Seals/Symbols

Certified B Corporation

EST 1987 USA Integrity Purity Potency

Brand IP Statement(s)

Gaia Herbs Connecting Plants & People Since 1987

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Microbiome Cleanse by Gaia Herbs label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Microbiome Cleanse label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Microbiome Cleanse by Gaia Herbs

These are the 7 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Organic Peppermint leaf essential oil

Interacts with
796 drugs
37 mg per serving

Peppermint is a popular herb with the best evidence supporting enteric-coated peppermint oil for easing IBS symptoms. It is generally well tolerated f...

Organic Peppermint leaf essential oil monograph & interactions

Other (inactive) ingredients: Vegetable Glycerin, Sunflower Lecithin, Water, Vegan Capsule. These complete the product’s ingredient list but are not active constituents.

Interaction report

Microbiome Cleanse by Gaia Herbs Drug Interactions

Want to check YOUR meds against Microbiome Cleanse?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,450Drugs
1,437 Moderate 13 Minor

Ingredients driving the most interactions

Oregon Grape extract 1,218
organic Sweet Wormwood extract 889
organic Peppermint leaf essential oil 796
organic Cinnamon bark supercritical CO2 extract 442
Andrographis Aerial Parts Extract 413

Individual Drug Interactions

The ingredients in Microbiome Cleanse interact with 1,450 drugs. Click any drug to see the details.

6 of the 7 ingredients in Microbiome Cleanse interact with drugs. Each result below shows which ingredient is responsible. Oregon Grape extract organic Sweet Wormwood extract organic Peppermint leaf essential oil organic Cinnamon bark supercritical CO2 extract Andrographis Aerial Parts Extract organic Oregano extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Microbiome Cleanse with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Oregon Grape extract9 drug types · 1,218 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, Oregon grape might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro and in vivo research suggests that berberine, a constituent of Oregon grape, can inhibit platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, Oregon grape might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Clinical research suggests that berberine, a constituent of Oregon grape, can lower blood glucose levels.

Likelihood Possible Evidence A
Antihypertensive Drugs

Theoretically, Oregon grape might increase the risk of hypotension when taken with antihypertensive drugs.
Animal research suggests that berberine, a constituent of Oregon grape, can have hypotensive effects. Also, an analysis of clinical evidence suggests that taking berberine in combination with amlodipine (Norvasc) can lower systolic and diastolic blood pressure when compared with taking amlodipine alone.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, Oregon grape might increase the sedative effects of CNS depressants.
Animal research suggests that berberine, a constituent of Oregon grape, can have sedative effects.

Likelihood Possible Evidence D
Cyclosporine (Neoral, Sandimmune)

Theoretically, Oregon grape might increase the effects and adverse effects of cyclosporine.
Berberine, a constituent of Oregon grape, can reduce metabolism of cyclosporine and increase serum levels. It might inhibit cytochrome P450 3A4 (CYP3A4), which metabolizes cyclosporine.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, Oregon grape might increase serum levels of drugs metabolized by CYP2C9.
Preliminary clinical evidence suggests that berberine, a constituent of Oregon grape, can inhibit cytochrome P450 2C9 (CYP2C9).

Likelihood Possible Evidence B
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, Oregon grape might increase serum levels of drugs metabolized by CYP2D6.
In vitro research and preliminary clinical evidence suggest that berberine, a constituent of Oregon grape, can inhibit cytochrome P450 2D6 (CYP2D6).

Likelihood Possible Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, Oregon grape might increase serum levels of drugs metabolized by CYP3A4.
In vitro research and preliminary clinical evidence suggest that berberine, a constituent of Oregon grape, moderately inhibits cytochrome P450 3A4 (CYP3A4).

Likelihood Possible Evidence D
P-Glycoprotein Substrates

Theoretically, Oregon grape might increase serum levels of drugs that are P-glycoprotein (P-gp) substrates.
In vitro research suggests that Oregon grape extracts inhibit P-gp efflux.

Likelihood Possible Evidence D
Oregon Grape extract full monograph & interactions

organic Sweet Wormwood extract3 drug types · 889 drugs

Cytochrome P450 2B6 (Cyp2B6) Substrates

Sweet Annie may alter plasma levels and clinical effects of drugs metabolized by CYP2B6.
In vitro research shows that the Sweet Annie constituent artemisinin induces CYP2B6, possibly increasing CYP2B6 activity by 1.6-fold. However, Sweet Annie extract seems to inhibit the activity of CYP2B6 in vitro, suggesting that other constituents of Sweet Annie play a role in its effects on the overall activity of this enzyme. More information is needed to determine whether taking Sweet Annie extract affects the metabolism of CYP2B6 substrates.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Sweet Annie may alter plasma levels and clinical effects of drugs metabolized by CYP3A4.
In vitro research shows that the Sweet Annie constituent artemisinin induces CYP3A4, possibly increasing CYP3A4 activity by 1.9-fold. However, Sweet Annie extract seems to inhibit the activity of CYP3A4 in vitro, suggesting that other constituents of Sweet Annie play a role in its effects on the overall activity of this enzyme. More information is needed to determine whether taking Sweet Annie extract affects the metabolism of CYP3A4 substrates.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, concomitant use might have additive adverse hepatotoxic effects.
There is some concern that Sweet Annie can adversely affect the liver.

Likelihood Possible Evidence D
organic Sweet Wormwood extract full monograph & interactions

organic Peppermint leaf essential oil5 drug types · 796 drugs

Cyclosporine (Neoral, Sandimmune)

Theoretically, peppermint oil might increase the levels and adverse effects of cyclosporine.
In animal research, peppermint oil inhibits cyclosporine metabolism and increases cyclosporine levels. Inhibition of cytochrome P450 3A4 (CYP3A4) may be partially responsible for this interaction. An interaction between peppermint oil and cyclosporine has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, peppermint might increase the levels of CYP2C19 substrates.
In vitro research shows that peppermint oil inhibits CYP2C19. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, peppermint might increase the levels of CYP2C9 substrates.
In vitro research shows that peppermint oil inhibits CYP2C9. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Clinical research in healthy volunteers shows that a single dose of peppermint oil 600 mg inhibits CYP3A4 enzymes and increases the AUC of felodipine, a CYP3A4 substrate. However, in vitro research suggests that peppermint oil only inhibits CYP3A4 at very high concentrations.

Likelihood Possible Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, peppermint might increase the levels of CYP1A2 substrates.
In vitro and animal research shows that peppermint oil and peppermint leaf inhibit CYP1A2. However, in clinical research, peppermint tea did not significantly affect the metabolism of caffeine, a CYP1A2 substrate. It is possible that the 6-day duration of treatment may have been too short to identify a difference.

Likelihood Possible Evidence B
organic Peppermint leaf essential oil full monograph & interactions

organic Cinnamon bark supercritical CO2 extract2 drug types · 442 drugs

Antidiabetes Drugs

Theoretically, cassia cinnamon may have additive effects with antidiabetes drugs.
Cassia cinnamon may lower blood glucose levels, and have additive effects in patients treated with antidiabetic agents. Dose adjustments to diabetes medications might be necessary.

Likelihood Possible Evidence B
Hepatotoxic Drugs

Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
There is some concern that ingesting large amounts of cassia cinnamon for an extended duration might cause hepatotoxicity in some people. Cassia cinnamon contains coumarin, which can cause hepatotoxicity in animal models. In humans, very high doses of coumarin from 50-7000 mg/day can result in hepatotoxicity that resolves when coumarin use is discontinued. Lower amounts might also cause liver problems in sensitive people, such as those with liver disease or those taking potentially hepatotoxic agents.

Likelihood Possible Evidence D
organic Cinnamon bark supercritical CO2 extract full monograph & interactions

Andrographis Aerial Parts Extract6 drug types · 413 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, andrographis might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Animal and laboratory studies suggest that andrographis has antiplatelet effects.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, andrographis might increase the risk of hypotension when used with antihypertensive drugs.
Animal research suggests that andrographis has hypotensive effects.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, andrographis might interfere with the effects of immunosuppressive drugs.
Laboratory research suggests that andrographolide has immunostimulant activity.

Likelihood Possible Evidence D
Celecoxib (Celebrex)

Theoretically, andrographis extract might increase the maximum concentration and time to peak concentration of celecoxib. The clinical significance of these changes is unclear.
Animal research suggests that andrographis extract taken orally increases the maximum concentration and time to peak concentration of celecoxib but does not appear to impact the area under the curve.

Likelihood Possible Evidence D
Etoricoxib (Arcoxia)

Theoretically, andrographis might decrease the absorption of etoricoxib, although the clinical significance is unclear.
Animal research shows that andrographis extract, or the constituent andrographolide, taken orally with etoricoxib decreases the bioavailability of etoricoxib. However, this reduced bioavailability is not correlated with a reduction in the anti-inflammatory effects of etoricoxib in arthritic mice models. The clinical significance of this interaction is unclear.

Likelihood Possible Evidence D
Glipizide (Glucotrol)

Theoretically, andrographis extract might increase the maximum concentration and area under the curve of glipizide; however, opposite effects are seen with the constituent, andrographolide. The clinical significance of this interaction is unclear.
Animal research suggests that andrographis extract taken orally with glipizide in diabetes-induced rats increases the maximum concentration and area under the curve of glipizide. However, the opposite effect is seen with the constituent, andrographolide, in which the maximum concentration and area under the curve are decreased when taken with glipizide.

Likelihood Possible Evidence D
Andrographis Aerial Parts Extract full monograph & interactions

organic Oregano extract2 drug types · 208 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, oregano might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro research shows that aristolochic acid isolated from oregano leaves has antithrombin activity. It has also been reported that oregano oil inhibits arachidonic acid-induced, and ADP-induced, platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, oregano might increase the risk for hypoglycemia when taken with antidiabetes drugs.
In vitro and animal research shows that oregano extracts might lower blood glucose levels.

Likelihood Possible Evidence D
organic Oregano extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Microbiome Cleanse, from the product label.

Gaia Herbs

See all Gaia Herbs products
Name
Gaia Herbs, Inc.
Street Address
101 Gaia Herbs Drive
City
Brevard
State
NC
ZipCode
28712
Web Address
www.gaiaherbs.com
Pharmacist Counseling Corner

Microbiome Cleanse by Gaia Herbs: Common Questions

Does Microbiome Cleanse by Gaia Herbs interact with any medications?
Yes. Based on its ingredients, Microbiome Cleanse has a known interaction with 1,450 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Microbiome Cleanse contains 7 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
No—there isn't enough safety data. Andrographis, Oregon grape, sweet wormwood, and oregano extract should be avoided in pregnancy because of theoretical or animal-study concerns. Most ingredients also lack adequate breastfeeding safety data. Talk with your doctor or pharmacist about whether this product is right for you.
What does peppermint in this formula do?
Peppermint is included as peppermint leaf essential oil. It's likely effective for irritable bowel syndrome and possibly effective for indigestion, nausea and vomiting from chemotherapy, and reducing spasm during medical procedures. Most common side effects are mild—belly pain, burning near the anus, belching, diarrhea, dry mouth, and heartburn.
Can this help with a microbiome problem?
The name suggests a microbiome focus, but the effectiveness data in our facts don't speak directly to 'microbiome health' as a target. The individual ingredients have evidence for other uses—peppermint for IBS, andrographis for sore throat and ulcerative colitis, Oregon grape for psoriasis—but we don't hold data on whether this blend affects the gut microbiota itself.
Is this safe to use long-term?
Most ingredients are intended for short-term use, and the product label and facts note that long-term safety is not well established. Black walnut, andrographis, and cinnamon all have limited long-term safety data in humans. If you're thinking of using it regularly, discuss that with your doctor or pharmacist.
What are the most common side effects?
Andrographis most commonly causes belly discomfort, nausea, diarrhea, dizziness, fatigue, headache, and rash. Cinnamon can occasionally cause rash. Black walnut may cause stomach upset. Peppermint often causes belly pain, belching, diarrhea, and heartburn. Serious allergic reactions are rare but possible with any herbal product.
Does this contain any common allergens?
Black walnut is a tree nut and is classified as a major food allergen in the United States. If you have a tree nut allergy, avoid this product. Additionally, oregano and peppermint can trigger allergic reactions in sensitive individuals, including anaphylaxis in rare cases.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Microbiome Cleanse label
Go deeper

The Full Monographs Behind Microbiome Cleanse’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Andrographis

Interacts with 413 drugs

Andrographis is a bitter Asian herb traditionally used for colds, flu, and infections, and some studies suggest it may ease cold symptoms and shorten how long they last. The evidence is limi...

Read the full Andrographis monograph → Herb & supplement monograph

Cassia Cinnamon

Interacts with 442 drugs

Cassia cinnamon is the common, inexpensive cinnamon used in cooking, and it is also taken as a supplement, most often for blood sugar support. The evidence for its health benefits is mixed a...

Read the full Cassia Cinnamon monograph → Herb & supplement monograph

Oregon Grape

Interacts with 1,218 drugs

Oregon grape is a shrub whose root contains berberine and related compounds. The strongest (though still modest) evidence is for topical creams that may slightly ease psoriasis; evidence for...

Read the full Oregon Grape monograph → Herb & supplement monograph

Black Walnut

Black walnut is a tree whose green hulls are traditionally used as a natural antiparasitic and digestive remedy, but solid human evidence for these uses is lacking. It contains a compound ca...

Read the full Black Walnut monograph → Herb & supplement monograph

Sweet Annie

Interacts with 889 drugs

Sweet Annie (Artemisia annua) is the source of artemisinin, a compound used in prescription antimalarial drugs. While the purified drug is well studied for malaria, the herb itself as a supp...

Read the full Sweet Annie monograph → Herb & supplement monograph

Oregano

Interacts with 208 drugs

Oregano is a common Mediterranean cooking herb that is also sold as a concentrated oil or supplement, often standardized for a compound called carvacrol. While lab studies suggest it may hav...

Read the full Oregano monograph → Herb & supplement monograph

Peppermint

Interacts with 796 drugs

Peppermint is a popular herb with the best evidence supporting enteric-coated peppermint oil for easing IBS symptoms. It is generally well tolerated for most adults, but it can cause heartbu...

Read the full Peppermint monograph →
Sources

Sources & How We Checked

Microbiome Cleanse's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 134 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Andrographis 26 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
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Cassia Cinnamon 20 references
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Oregon Grape 21 references
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Black Walnut 3 references
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  41. Ingrosso MR, Ianiro G, Nee J, et al. Systematic review and meta-analysis: efficacy of peppermint oil in irritable bowel syndrome. Aliment Pharmacol Ther 2022;56(6):932-41. PubMed

See these in context on the Peppermint monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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