Interactions on record — worth a quick check against your medications. Based on 1 of 4 ingredients. Check your meds →
Dietary supplement

Microbiome Protect w/IgG Ingredients & Drug Interactions

by Douglas Laboratories

Microbiome Protect w/IgG label
See full label image
Powder Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Microbiome Protect w/IgG against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Microbiome Protect w/IgG is a dietary supplement by Douglas Laboratories with 4 active ingredients. Its ingredients are commonly taken for constipation, irritable bowel syndrome (ibs), diarrhea.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are LactoSpore Bacillus coagulans. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Microbiome Protect w/IgG by Douglas Laboratories

Ask about any prescription or over-the-counter medication and we check it for interactions with Microbiome Protect w/IgG by Douglas Laboratories — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Microbiome Protect w/IgG by Douglas Laboratories

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 20, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • “ImmunoLin” is listed as a grouped ingredient — the label gives one combined amount (1.25 Gram(s)) without saying how much of each component you get.

This powder contains three active ingredients: Bacillus coagulans (sold as LactoSpore), Immunoglobulin G, and two others — ImmunoLin and BioEcolians A-Glucooligosaccharide. Bacillus coagulans is a probiotic — a live organism meant to support digestive health.

The other ingredients are designed to support immune function, though we don't hold detailed interaction or effectiveness data for Immunoglobulin G and BioEcolians. There are no inactive fillers or binders listed for this product.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: microbiome and digestive health support.
  • We looked for evidence on: Antibiotic-associated diarrhea, Clostridioides difficile infection, Constipation, Diarrhea, Dyspepsia, Flatulence — and 4 related terms.
  • The strongest evidence on file: Bacillus Coagulans is rated "Possibly Effective" for Constipation (Natural Medicines).
  • Also on file: Bacillus Coagulans is rated "Possibly Effective" for Irritable bowel syndrome (IBS).
  • Also on file: Bacillus Coagulans is rated "Insufficient Reliable Evidence To Rate" for Antibiotic-associated diarrhea, Diarrhea, Dyspepsia, Flatulence, and more.

Bacillus coagulans has some evidence behind it: it's rated possibly effective for constipation and for irritable bowel syndrome (IBS). For antibiotic-associated diarrhea, athletic performance, cancer, and nonalcoholic fatty liver disease, the evidence we hold is insufficient to say whether it works.

We don't have effectiveness ratings on file for the other active ingredients in this product.

The evidence, ingredient by ingredient Bacillus Coagulans

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Bacillus coagulans is generally well tolerated in healthy adults, but the strength and quality of probiotic products vary, and we don't have enough solid safety data to make a firm call. One concern: because this product contains live microorganisms, there's a theoretical risk of infection in people with central lines or catheters, severe illness, or weakened immune systems — including premature infants.

Healthy people with normal immune systems appear to be at very low risk. We don't have specific pregnancy or breastfeeding data on file for this product.

Talk with your doctor or pharmacist before starting, especially if you have a catheter, are severely ill, or have a weakened immune system.

Side effects, ingredient by ingredient Bacillus Coagulans

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Bacillus Coagulans.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antibiotics, don't take them at the same time as this product — space out your doses. The live organisms in Bacillus coagulans can be killed by antibiotics, which would reduce how well the probiotic works.

Check your other medications and any catheters or devices with your doctor or pharmacist before starting.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Microbiome Protect w/IgG may be worth considering if you have constipation or IBS and want to try a probiotic approach. If you take antibiotics, separate your doses from this supplement so the antibiotics don't kill off the live organisms.

Anyone with a central line, severe illness, or a compromised immune system should check with their doctor first. Run your full medication list through the search tool on this page before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 11, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Microbiome Protect w/IgG, straight from the product label.

Brand Douglas Laboratories
Barcode (UPC) 310539979990
Net contents 70.5 Gram(s); 2.5 Ounce(s)
Market status On market
Date entered into DSLD Apr 11, 2022
DSLD ID 261756
Product type Other Combinations
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Microbiome Protect w/IgG by Douglas Laboratories, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2.35 Gram(s), 4.7 Gram(s)
Maximum serving Sizes:
2.35 Gram(s), 4.7 Gram(s)
Servings per container
15
UPC/BARCODE
310539979990
IngredientAmount% DV
Calories10 Calorie(s)--
LactoSpore Bacillus coagulans70 mg--
Protein1 Gram(s)2%
Immunoglobulin G0.6 Gram(s)--
ImmunoLin1.25 Gram(s)--
BioEcolians A-Glucooligosaccharide1 Gram(s)--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested usage: Adults and children age 4+ take 1-2 scoops daily blended in 4 oz. of cool to room temperature liquid or food, or as directed by a healthcare professional. For best results, start with 2 scoops daily for the first 4 to 12 weeks, then continue with 1 scoop daily for maintenance.

Precautions

Warning: If you are pregnant or lactating, have any health condition or are taking any medication, consult your health professional before use.

Caution: If you are immunocompromised, consult your healthcare professional before using probiotic-containing products.

Keep out of the reach of children.

Use only if safety seal is intact.

Brand IP Statement(s)

ImmunoLin is a registered trademark of Enterahealth, LLC. LactoSpore is a registered trademark of Sabinsa Corporation. BioEcolians is a registered trademark of Solabia.

Storage

Store in a cool, dry place.

Formulation

Gluten-free, dairy-free, non-GMO

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General Statements

Packaged by weight, not volume. Settling may occur. Scan to learn about our manufacturing excellence.

FDA Statement of Identity

Dietary supplement

Formula

ImmunoLin immunoglobulins, prebiotic and spore probiotic for intestinal health

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Microbiome Protect w/IgG by Douglas Laboratories label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Microbiome Protect w/IgG label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Microbiome Protect w/IgG by Douglas Laboratories

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size2.35 Gram(s) Dosage formPowder Servings per container15 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

LactoSpore Bacillus coagulans

Interacts with
182 drugs
70 mg per serving

Bacillus coagulans is a spore-forming probiotic that survives stomach acid well and may help with some digestive problems such as IBS, constipation, a...

LactoSpore Bacillus coagulans monograph & interactions

Protein

1 Gram(s) per serving

ImmunoLin

1.25 Gram(s) per serving Form: Immunoglobulin Concentrate
  • › Immunoglobulin G

BioEcolians A-Glucooligosaccharide

1 Gram(s) per serving
Interaction report

Microbiome Protect w/IgG by Douglas Laboratories Drug Interactions

Want to check YOUR meds against Microbiome Protect w/IgG?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

LactoSpore Bacillus coagulans 182

Individual Drug Interactions

The ingredients in Microbiome Protect w/IgG interact with 182 drugs. Click any drug to see the details.

1 of the 4 ingredients in Microbiome Protect w/IgG interact with drugs. Each result below shows which ingredient is responsible. LactoSpore Bacillus coagulans

Each ingredient & the kinds of drugs it affects

For each ingredient in Microbiome Protect w/IgG with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

LactoSpore Bacillus coagulans1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking antibiotics with Bacillus coagulans might decrease the effectiveness of B. coagulans.
B. coagulans preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. coagulans preparations by at least two hours.

Likelihood Probable Evidence D
LactoSpore Bacillus coagulans full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Microbiome Protect w/IgG, from the product label.

Douglas Laboratories

See all Douglas Laboratories products
Name
Douglas Laboratories
Street Address
600 Boyce Road
City
Pittsburgh
State
PA
ZipCode
15205
Phone Number
1.800.245.4440
Web Address
www.douglaslabs.com
Pharmacist Counseling Corner

Microbiome Protect w/IgG by Douglas Laboratories: Common Questions

Does Microbiome Protect w/IgG by Douglas Laboratories interact with any medications?
Yes. Based on its ingredients, Microbiome Protect w/IgG has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Microbiome Protect w/IgG contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help with my diarrhea after I take antibiotics?
The evidence for Bacillus coagulans in antibiotic-associated diarrhea isn't strong enough for us to say whether it works. What we do know is that if you take this product and antibiotics together, the antibiotics may kill the live organisms in it, so you'd want to space them out. Talk to your doctor about whether a probiotic makes sense for your situation.
Is this safe if I have a weak immune system?
Not without checking first. Because this product contains live microorganisms, there's a documented risk of infection in people who are severely ill or immunocompromised. Healthy people with normal immune systems are at very low risk, but if that's not you, talk with your doctor or pharmacist before using it.
Can I take this while pregnant or breastfeeding?
We don't have specific safety data on file for this product during pregnancy or breastfeeding. Talk with your doctor or pharmacist to get personalized advice for your situation.
What exactly is Bacillus coagulans and why is it in here?
It's a live probiotic organism — a beneficial microbe meant to support digestive health. It's rated possibly effective for constipation and IBS. This product includes it under the brand name LactoSpore.
What are the other ingredients doing?
Immunoglobulin G and the other components (ImmunoLin and BioEcolians) are included for immune support, but we don't have detailed effectiveness data on file for them in this product.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Microbiome Protect w/IgG is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Microbiome Protect w/IgG label
Go deeper

The Full Monographs Behind Microbiome Protect w/IgG’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bacillus Coagulans

Interacts with 182 drugs

Bacillus coagulans is a spore-forming probiotic that survives stomach acid well and may help with some digestive problems such as IBS, constipation, and certain types of diarrhea. The eviden...

Read the full Bacillus Coagulans monograph →
Sources

Sources & How We Checked

Microbiome Protect w/IgG's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 20 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bacillus Coagulans 20 references
  1. Saxelin M, Chuang NH, Chassy B, et al. Lactobacilli and bacteremia in southern Finland 1989-1992. Clin Infect Dis 1996;22:564-6. PubMed
  2. Tynkkynen S, Singh KV, Varmanen P. Vancomycin resistance factor of Lactobacillus rhamnosus GG in relation to enterococcal vancomycin resistance (van) genes. Int J Food Microbiol 1998;41:195-204. PubMed
  3. Klein G, Zill E, Schindler R, et al. Peritonitis associated with vancomycin-resistant Lactobacillus rhamnosus in a continuous ambulatory peritoneal dialysis patient; organism identification, antibiotic therapy, and case report. J Clin Microbiol 1998;36:
  4. Kalima P, Masterton RG, Roddie PH, et al. Lactobacillus rhamnosus infection in a child following bone marrow transplant. J Infect 1996;32:165-7. PubMed
  5. Goldin BR. Health Benefits of probiotics. Br J Nutr 1998;80:S203-7. DOI
  6. Rautio M, Jousimies-Somer H, Kauma H, et al. Liver abscess due to Lactobacillus rhamnosus strain indistinguishable from L. rhamnosus strain GG. Clin Infect Dis 1999;28:1159-60.
  7. MacGregor G, Smith AJ, Thakker B, Kinsella J. Yoghurt biotherapy: contraindicated in immunosuppressed patients? Postgrad Med J 2002;78:366-7. PubMed
  8. Land MH, Rouster-Stevens K, Woods CR, et al. Lactobacillus sepsis associated with probiotic therapy. Pediatrics 2005;115:178-81.
  9. De Groote MA, Frank DN, Dowell E, et al. Lactobacillus rhamnosus GG bacteremia associated with probiotic use in a child with short gut syndrome. Pediatr Infect Dis J 2005;24:278-80. PubMed
  10. Vahabnezhad E, Mochon AB, Wozniak LJ, Ziring DA. Lactobacillus bacteremia associated with probiotic use in a pediatric patient with ulcerative colitis. J Clin Gastroenterol. 2013;47(5):437-9. PubMed
  11. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  12. Sendil S, Shrimanker I, Mansoora Q, Goldman J, Nookala VK. Lactobacillus rhamnosus bacteremia in an immunocompromised renal transplant patient. Cureus. 2020;12(2):e6887. PubMed
  13. Albarillo FS, Shah U, Joyce C, Slade D. Lactobacillus rhamnosus Infection: A single-center 4-year descriptive analysis. J Glob Infect Dis. 2020;12(3):119-123. PubMed
  14. Pasala S, Singer L, Arshad T, Roach K. Lactobacillus endocarditis in a healthy patient with probiotic use. IDCases. 2020;22:e00915. PubMed
  15. Agrawal S, Tuchman ES, Bruce MJ, Theodorou ME. Fatal Lactobacillus endocarditis in a patient with transcatheter aortic valve replacement. BMJ Case Rep. 2020;13(11):e236835.
  16. Antoun M, Hattab Y, Akhrass FA, Hamilton LD. Uncommon pathogen, Lactobacillus, causing infective endocarditis: Case report and review. Case Rep Infect Dis. 2020;2020:8833948. PubMed
  17. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  18. Franko B, Vaillant M, Recule C, Vautrin E, et al. Lactobacillus paracasei endocarditis in a consumer of probiotics. Med Mal Infect. 2013;43(4):171-3. PubMed
  19. Campbell RE, Miller A, Afroze A. Native valve endocarditis secondary to Lactobacillus paracasei bacteremia. Consultant. 2020;60(9):27-8. DOI
  20. Kato K, Funabashi N, Takaoka H, et al. Lactobacillus paracasei endocarditis in a consumer of probiotics with advanced and severe bicuspid aortic valve stenosis complicated with diffuse left ventricular mid-layer fibrosis. Int J Cardiol. 2016;224:157-161. PubMed

See these in context on the Bacillus Coagulans monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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