Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

Migra Profen Ingredients & Drug Interactions

by Gaia Herbs RapidRelief

Migra Profen label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Migra Profen against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Migra Profen is a dietary supplement by Gaia Herbs RapidRelief with 2 active ingredients. Its ingredients are commonly taken for migraine prevention, headache, fever (traditional).Based on those ingredients, 929 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Feverfew leaf. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Migra Profen by Gaia Herbs RapidRelief

Ask about any prescription or over-the-counter medication and we check it for interactions with Migra Profen by Gaia Herbs RapidRelief — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Migra Profen by Gaia Herbs RapidRelief

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 20, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • “TOTAL EXTRACTS” is listed as a grouped ingredient — the label gives one combined amount (486 mg) without saying how much of each component you get.

Migra Profen contains 2 active ingredients: feverfew leaf and a proprietary synergistic blend. Feverfew is a plant extract traditionally used for migraine and headache support.

The product also contains vegetable glycerin and vegetable cellulose as inactive ingredients (the capsule material and preservative).

Does it work?

Insufficient evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Insufficient

There isn't enough reliable clinical evidence to rate this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: support during tension and stress.
  • We looked for evidence on: Tension headache, migraine, headache pain, stress-related pain.
  • The closest evidence on file: Feverfew is rated "Insufficient Reliable Evidence To Rate" for Tension headache (Natural Medicines).

The evidence for feverfew in tension headaches is currently insufficient to rate — we don't have reliable data showing it works for that purpose. Feverfew has also been studied for other conditions like rheumatoid arthritis and psoriasis, but the evidence for those uses is similarly insufficient.

If migraine or headache relief is what you're after, talk with your doctor about whether this product is a reasonable choice for you.

The evidence, ingredient by ingredient Feverfew

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Feverfew is generally well tolerated when taken short-term, though some people experience stomach upset — nausea, heartburn, diarrhea, constipation, bloating, or abdominal pain are the most common side effects. Chewing fresh feverfew leaves is more likely to cause mouth sores and irritation than commercial preparations.

A small number of people may have allergic reactions or skin rash. After long-term use, stopping feverfew suddenly can trigger "post-feverfew syndrome" — anxiety, headaches, and insomnia — so if you've been taking it regularly, talk with your doctor or pharmacist about how to stop it safely.

Feverfew should be avoided during pregnancy because it may stimulate the uterus and its safety is not established. The safety data for breastfeeding is too limited, so it's best avoided while nursing.

If you're pregnant, planning pregnancy, or breastfeeding, discuss any herbal products with your doctor or pharmacist before taking them.

Side effects, ingredient by ingredient Feverfew

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Feverfew.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 930 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, double-check with your doctor or pharmacist if you take any blood thinners or antiplatelet drugs (like warfarin, clopidogrel, or aspirin) — feverfew may increase bleeding risk. Additionally, feverfew may raise levels of medications broken down by liver enzymes CYP2C19, CYP2D6, CYP1A2, CYP2C9, CYP3A4, or CYP2C8.

That covers a lot of drugs — heart medications, psychiatric medications, immunosuppressants, and many others — so use the interaction checker on this page with your complete medication list.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with insufficient evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Migra Profen is built around feverfew, a plant with a long history in herbal medicine. The current evidence doesn't show it reliably works for tension headaches, and it interacts with a large number of medications through liver enzyme effects.

If you take any prescriptions — especially blood thinners, heart meds, or psychiatric drugs — check your list before starting. Talk it over with your doctor or pharmacist to decide if it's right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 25, 2012.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Migra Profen, straight from the product label.

Brand Gaia Herbs RapidRelief
Barcode (UPC) 751063398800
Net contents 60 Vegetarian Liquid Phyto-Cap(s)(TM)
Market status On market
Date entered into DSLD Jun 25, 2012
DSLD ID 9989
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Migra Profen by Gaia Herbs RapidRelief, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
UPC/BARCODE
751063398800
IngredientAmount% DV
Calories20 {Calories}--
TOTAL EXTRACTS486 mg--
Feverfew leaf240 mg--
PROPRIETARY SYNERGISTIC BLEND246 mg--

Other ingredients: Vegetable Glycerin, Vegetable Cellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use: Take 2 capsules with a small amount of warm water at the onset of pain and repeat 2-3 times at 15 minute intervals. For intermittent use only. Maximum time of use: one month.

Use only as directed on label.

General Statements

Support during tension and stress*

BEST BY

Natural separation may occur. This does not affect product quality.

FDA Statement of Identity

DIETARY SUPPLEMENT

Precautions

Caution: US FDA advises that a potential risk of rare, but severe, liver injury may be associated with kava-containing dietary supplements. Do not take if you have or have had liver problems, drink alcohol, or take any medications. If you have a medical condition, use under the advice of a health practitioner. Stop use and see a doctor if you develop symptoms that may signal liver problems, including jaundice (yellowing of the skin or whites of the eyes) and brown urine. Other nonspecific symptoms can include nausea, vomiting, light-colored stools, unexplained tiredness, weakness, stomach or abdominal pain, and loss of appetite.

Not for use by persons under 18 years of age, or by pregnant or breastfeeding women.

Not for use with alcoholic beverages. Excessive use, or use with products that cause drowsiness, may impair your ability to operate a vehicle or heavy equipment.

Safety sealed for your protection.

Storage

Keep bottle capped at all times and store in a cool dry place.

Formula

Feverfew

Each 2 capsules contain 5,000 mg crude herb equivalent.

General

[02] 1012-0210

FDA Disclaimer Statement

*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Brand IP Statement(s)

meetyourherbs(TM) Enter ID # at GaiaHerbs.com

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Migra Profen by Gaia Herbs RapidRelief label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Migra Profen label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Migra Profen by Gaia Herbs RapidRelief

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

TOTAL EXTRACTS

486 mg per serving

Other (inactive) ingredients: Vegetable Glycerin, Vegetable Cellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Migra Profen by Gaia Herbs RapidRelief Drug Interactions

Want to check YOUR meds against Migra Profen?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
929Drugs
929 Moderate

Ingredients driving the most interactions

Feverfew leaf 929

Individual Drug Interactions

The ingredients in Migra Profen interact with 929 drugs. Click any drug to see the details.

1 of the 2 ingredients in Migra Profen interact with drugs. Each result below shows which ingredient is responsible. Feverfew leaf

Each ingredient & the kinds of drugs it affects

For each ingredient in Migra Profen with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Feverfew leaf7 drug types · 929 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, feverfew might have additive effects and increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Laboratory research suggests that feverfew may inhibit platelet aggregation. Additionally, in one case report, a 36-year-old patient taking feverfew 2400 mg daily for 3 months experienced vaginal bleeding and a prolonged menstrual cycle, with a modest increase in partial thromboplastin time (PTT) and prothrombin time (PT).

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, feverfew might increase levels of drugs metabolized by CYP1A2.
Laboratory research shows that feverfew might inhibit CYP1A2. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, feverfew might increase levels of drugs metabolized by CYP2C19.
Laboratory research shows that feverfew might inhibit CYP2C19. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C8 (Cyp2C8) Substrates

Theoretically, feverfew might increase levels of drugs metabolized by CYP2C8.
Laboratory research shows that feverfew might inhibit CYP2C8. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, feverfew might increase levels of drugs metabolized by CYP2C9.
Laboratory research shows that feverfew might inhibit CYP2C9. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, feverfew might increase levels of drugs metabolized by CYP2D6.
Laboratory research shows that feverfew might inhibit CYP2D6. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, feverfew might increase levels of drugs metabolized by CYP3A4.
Laboratory research shows that feverfew might inhibit CYP3A4. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Feverfew leaf full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Migra Profen, from the product label.

Gaia Herbs RapidRelief

See all Gaia Herbs RapidRelief products
Name
Gaia Herbs, Inc.
Street Address
101 Gaia Herbs Dr.
City
Brevard
State
NC
ZipCode
28712
Web Address
GaiaHerbs.com
Pharmacist Counseling Corner

Migra Profen by Gaia Herbs RapidRelief: Common Questions

Does Migra Profen by Gaia Herbs RapidRelief interact with any medications?
Yes. Based on its ingredients, Migra Profen has a known interaction with 929 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Migra Profen contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is feverfew and what is it supposed to do?
Feverfew is a plant extract traditionally used for migraine and headache support. It's been used in herbal medicine for a long time, though the current evidence doesn't reliably show it works for tension headaches.
What are the most common side effects?
Stomach upset is most typical — nausea, heartburn, diarrhea, constipation, bloating, or abdominal pain. Chewing fresh feverfew leaves raises the risk of mouth sores. A small number of people get skin rash or allergic reactions.
Can I take this while pregnant or breastfeeding?
No — feverfew should be avoided during pregnancy because it may stimulate the uterus and safety isn't established. It's also best avoided while breastfeeding because there isn't enough safety data. Talk with your doctor or pharmacist if you're pregnant, planning pregnancy, or nursing.
What happens if I stop taking it after a long time?
Stopping feverfew suddenly after regular long-term use can cause "post-feverfew syndrome" — anxiety, headaches, and insomnia. If you've been taking it regularly, discuss how to stop it safely with your doctor or pharmacist.
Why does this product interact with so many drugs?
Feverfew may inhibit several liver enzymes that break down many medications. When these enzymes are slowed, drugs can build up to higher levels in your body, potentially causing stronger effects or side effects. So far this hasn't been reported in actual patients, but the risk exists based on lab research.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Migra Profen label
Go deeper

The Full Monographs Behind Migra Profen’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Feverfew

Interacts with 929 drugs

Feverfew is a daisy-family herb best known for migraine prevention, where some studies suggest it may modestly lower how often migraines occur, though the evidence is mixed. It is generally...

Read the full Feverfew monograph →
Sources

Sources & How We Checked

Migra Profen's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 18 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Feverfew 18 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Awang DVC. Prescribing therapeutic feverfew (Tancetum pathrnium (L.) Schultz Bip., syn. Chrysanthemumparthenium (L.) Bernh). Int Med 1998;1:11-3.
  3. Heptinstall S, Groenewegen WA, Spangenberg P, Loesche W. Extracts of feverfew may inhibit platelet behaviour via neutralization of sulphydryl groups. J Pharm Pharmacol 1987;39:459-65. PubMed
  4. Heptinstall S, White A, Williamson L, Mitchell JR. Extracts of feverfew inhibit granule secretion in blood platelets and polymorphonuclear leucocytes. Lancet 1985;1:1071-4. PubMed
  5. Makheja AN, Bailey JM. A platelet phospholipase inhibitor from the medicinal herb feverfew (Tanacetum parthenium). Prostaglandins Leukot Med 1982;8:653-60.
  6. Groenewegen WA, Heptinstall S. A comparison of the effects of an extract of feverfew and parthenolide, a component of feverfew, on human platelet activity in-vitro. J Pharm Pharmacol 1990;42:553-7. PubMed
  7. Heptinstall S, Groenewegen WA, Spangenberg P, Losche W. Inhibition of platelet behaviour by feverfew: a mechanism of action involving sulphydryl groups. Folia Haematol Int Mag Klin Morphol Blutforsch 1988;115:447-9.
  8. Biggs MJ, Johnson ES, Persaud NP, Ratcliffe DM. Platelet aggregation in patients using feverfew for migraine. Lancet 1982;2:776. PubMed
  9. Lamminpaa A, Estlander T, Jolanki R, Kanerva L. Occupational allergic contact dermatitis caused by decorative plants. Contact Dermatitis 1996;34:330-5. PubMed
  10. Johnson ES, Kadam NP, Hylands DM, Hylands PJ. Efficacy of feverfew as prophylactic treatment of migraine. Br Med J (Clin Res Ed) 1985;291:569-73. PubMed
  11. Pittler MH, Ernst E. Feverfew for preventing migraine. Cochrane Database Syst Rev 2004;(1):CD002286. PubMed
  12. Ernst E, Pittler MH. The efficacy and safety of feverfew (Tanacetum parthenium L.): an update of a systematic review. Public Health Nutr 2000;3:509-14.
  13. Unger M, Frank A. Simultaneous determination of the inhibitory potency of herbal extracts on the activity of six major cytochrome P450 enzymes using liquid chromatography/mass spectrometry and automated online extraction. Rapid Commun Mass Spectrom 2004;1 PubMed
  14. Sil'vestrov VP, Kinitin AV, and Chesnokova, IV. [Immunological and metabolic disorders and the means for their correction in patients with chronic bronchitis]. Ter.Arkh. 1991;63:7-11.
  15. Cady RK, Goldstein J, Nett R, et al. A double-blind placebo-controlled pilot study of sublingual feverfew and ginger (LipiGesic M) in the treatment of migraine. Headache 2011;51:1078-86.
  16. Jovanovic, M. and Poljacki, M. [Compositae dermatitis]. Med Pregl. 2003;56(1-2):43-49. PubMed
  17. Burry, J. N. Compositae dermatitis in South Australia: contact dermatitis from Chrysanthemum parthenium. Contact Dermatitis 1980;6(6):445.
  18. Alenzi KA, Alharbi FH, Tawhari FM, Fradees GS. Alteration of Coagulation Test Results and Vaginal Bleeding Associated With the Use of Feverfew (Tanacetum parthenium). J Med Cases 2021;12(1):9-12.

See these in context on the Feverfew monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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