Mushroom Matcha+ Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Mushroom Matcha+ against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Mushroom Matcha+ is a dietary supplement by Everyday Dose with 25 active ingredients. Its ingredients are commonly taken for replacing fluids and electrolytes, preventing dehydration during exercise or illness, treating low blood sodium (under medical care).Based on those ingredients, 1,575 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Matcha Green Tea, Powder, L-Theanine, L-Arginine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Mushroom Matcha+ by Everyday Dose
Ask about any prescription or over-the-counter medication and we check it for interactions with Mushroom Matcha+ by Everyday Dose — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Mushroom Matcha+ by Everyday Dose
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Partial disclosure
Mushroom Matcha+ contains 24 ingredients, of which the active ones include amino acids (glycine, L-leucine, L-arginine, L-isoleucine, L-methionine, L-tyrosine, L-valine, L-proline, L-aspartic acid, L-histidine, L-glutamic acid, L-threonine, L-lysine, L-serine, L-alanine, L-phenylalanine), L-theanine from green tea, matcha green tea powder, lion's mane mushroom fruiting body extract, chaga fruiting body extract, collagen peptides, and sodium. The product also contains several amino acid derivatives including hydroxylysine and hydroxyproline.
Does it work?
Moderate evidence
The supplement's active ingredients show mixed evidence. Matcha green tea has Likely Effective evidence for human papillomavirus and Possibly Effective evidence for ovarian cancer and high cholesterol.
L-tyrosine shows Possibly Effective evidence for cognitive function and memory. L-lysine is Possibly Effective for cold sores.
L-serine and L-theanine each show Possibly Effective evidence for cognitive function. L-methionine is Possibly Effective for neural tube birth defects in pregnancy.
Most other ingredients lack established effectiveness data, ranging from Insufficient Reliable Evidence to Possibly Ineffective ratings (such as L-phenylalanine for ADHD and L-tyrosine for athletic performance).
How safe is it?
Well-documented data
Most ingredients are generally well tolerated at typical dietary amounts. Sodium is essential in small amounts, but high intake is linked to high blood pressure and heart strain; avoid supplements or very high intake without medical advice.
Glycine, L-arginine, and matcha are generally well tolerated short-term, though L-arginine can lower blood pressure and matcha contains caffeine. Rare serious adverse effects reported with sodium include worsened cardiovascular disease and kidney disease.
Matcha has caused rare anaphylaxis in sensitive individuals. L-serine at very high doses (over 25 grams) can cause seizures and reversible eye movement problems.
L-theanine may cause headaches or drowsiness. Lion's Mane and Chaga are generally well tolerated as foods, though two cases of kidney failure have been linked to excessive chaga consumption due to high oxalate content.
Pregnancy and lactation data are limited for most ingredients; several are rated Possibly Unsafe or have insufficient data, so discuss use with your doctor before pregnancy or while breastfeeding.
Meds to double-check
Major interaction found
Major interactions documented: green tea with nadolol (beta-blocker) and atorvastatin (statin)—both reduced by up to 85% and 24% respectively—and with ephedrine; L-phenylalanine and L-threonine with neurological drugs. Moderate interactions with blood pressure medications (L-arginine, L-theanine, sodium), blood thinners (L-arginine, lion's mane, chaga), diabetes drugs (L-arginine, lion's mane, chaga), thyroid hormone (L-tyrosine), Parkinson medications (L-tyrosine, L-phenylalanine), anti-seizure drugs (matcha), lithium, and immunosuppressants.
Check your exact medications with the tool below before use.
The bottom line
Scorecard at a glancePartially disclosed formula with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.
This powder blends amino acids, mushroom extracts, and matcha to support general wellness and cognitive function, though evidence for most claims is limited. If you take any blood pressure medication, blood thinner, anti-seizure drug, thyroid hormone, or medication for Parkinson disease, talk to your pharmacist before starting—the interactions here are real and can affect how your drugs work.
Pregnant or breastfeeding? Check with your doctor first, since safety data are thin for most ingredients.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 18 of 24 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 22, 2024.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Mushroom Matcha+, straight from the product label.
| Brand | Everyday Dose |
|---|---|
| Net contents | 210 Gram(s) |
| Market status | On market |
| Date entered into DSLD | Aug 22, 2024 |
| DSLD ID | 317537 |
| Product type | Other Combinations |
| Supplement form | Powder |
| Dietary claims / uses | Nutrient, All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Mushroom Matcha+ by Everyday Dose, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Calories | 20 Calorie(s) | -- |
| Total Carbohydrates | 1 Gram(s) | 1% |
| Sodium | 20 mg | 1% |
| Glycine | 1123 mg | -- |
| L-Leucine | 147 mg | -- |
| L-Arginine | 412 mg | -- |
| L-Isoleucine | 76 mg | -- |
| L-Methionine | 40 mg | -- |
| L-Tyrosine | 15 mg | -- |
| L-Valine | 122 mg | -- |
| L-Proline | 676 mg | -- |
| L-Aspartic Acid | 284 mg | -- |
| L-Histidine | 66 mg | -- |
| L-Glutamic Acid | 508 mg | -- |
| L-Threonine | 91 mg | -- |
| L-Lysine | 183 mg | -- |
| L-Serine | 167 mg | -- |
| Protein | 5 Gram(s) | -- |
| L-Theanine | 0 NP | -- |
| Hydroxylysine | 56 mg | -- |
| Bovine Collagen Peptides, Hydrolyzed | 5082 mg | -- |
| L-Alanine | 447 mg | -- |
| L-Hydroxyproline | 559 mg | -- |
| Lion's Mane Fruiting Body Extract | 0 NP | -- |
| Chaga Fruiting Body Extract | 0 NP | -- |
| Matcha Green Tea, Powder | 0 NP | -- |
| Mushrooms + Nootropics Blend | 1918 mg | -- |
| L-Phenylalanine | 110 mg | -- |
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements
Tear Me
Instagram Dose Fam Website
Formula
Matcha powered by Tenzo Mushrooms Collagen Protein Nootropics
Why dose? Everyday Dose took matcha and drastically built on its benefits with added supplements. Our next-gen matcha provides functional mushrooms, nootropics, and collagen protein to give you calmer energy and sharper focus with added gut, brain & immune support so that you feel balanced and find your flow. The taste? Better than your barista's with just a hint of caffeine (40 mg), no crash, no jitters, and no stomach problems. Welcome to the future of matcha.
Keto friendly
All mushrooms standardized to over 15% beta glucans.
M nammex mushrooms
Formulation
Boosts energy Elevates mood Gut health Enhances focus
Dairy free No oat filler
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
How to make 1. Add 1 tablespoon into your mug. 2. Add water (3-7 oz). 3. Froth it up for 20-30 seconds. 4. Add your favorite milk, ice, or sweetener if your sexy self desires. Ways to enjoy 1. Hot matcha 2. Iced matcha 3. Matcha latte 4. Add to smoothie 5. Put in overnight oats 6. Add to baked goods
Important Shake & mix bag before scooping Do not mix with boiling water
We recommend 1-4 servings daily for optimal results
Precautions
Do not mix with boiling water
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Mushroom Matcha+ by Everyday Dose label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Mushroom Matcha+ by Everyday Dose
These are the 25 active ingredients this product is made of. Select any to open its full monograph.
Serving size7 Gram(s) Dosage formPowder Servings per container30 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Sodium
Interacts with205 drugs
Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets g...
Sodium monograph & interactionsGlycine
Interacts with1 drug
Glycine is a non-essential amino acid your body makes on its own and that also appears in protein-rich foods. It is most studied for improving sleep q...
Glycine monograph & interactionsL-Leucine
L-Arginine
Interacts with403 drugs
L-arginine is an amino acid that the body uses to make nitric oxide, a substance that helps blood vessels relax and widen. It is popularly used for bl...
L-Arginine monograph & interactionsL-Isoleucine
L-Methionine
No knowninteractions
Methionine is an essential amino acid that your body needs for protein building and many basic chemical reactions. Most people get enough from a norma...
L-Methionine monograph & interactionsL-Tyrosine
Interacts with21 drugs
L-tyrosine is an amino acid your body uses to make brain chemicals like dopamine and norepinephrine. Some studies suggest it may help mental performan...
L-Tyrosine monograph & interactionsL-Valine
L-Proline
No knowninteractions
Proline is a non-essential amino acid that your body can make on its own and that you also get from protein-rich foods. It is a key building block of...
L-Proline monograph & interactionsL-Aspartic Acid
No knowninteractions
Aspartic acid is a common amino acid your body makes on its own and gets from protein-rich foods, so a true deficiency is rare. D-aspartic acid is hea...
L-Aspartic Acid monograph & interactionsL-Histidine
No knowninteractions
Histidine is an essential amino acid your body needs to build proteins and to make compounds like histamine and carnosine. Most people get enough from...
L-Histidine monograph & interactionsL-Glutamic Acid
L-Threonine
Interacts with3 drugs
Threonine is an essential amino acid your body needs but cannot make, so you must get it from food or supplements. Most people get plenty from a norma...
L-Threonine monograph & interactionsL-Lysine
Interacts with1 drug
Lysine is an essential amino acid your body cannot make on its own, so it must come from food or supplements. People most often take extra lysine to t...
L-Lysine monograph & interactionsL-Serine
No knowninteractions
Serine is an amino acid your body can make on its own and also gets from protein-rich foods, so most people do not need a supplement. L-serine has bee...
L-Serine monograph & interactionsProtein
Hydroxylysine
Bovine Collagen Peptides, Hydrolyzed
No knowninteractions
Collagen peptides are a well-absorbed form of protein that may modestly improve skin elasticity and joint comfort for some people, though evidence is...
Bovine Collagen Peptides, Hydrolyzed monograph & interactionsL-Alanine
No knowninteractions
Alpha-alanine (usually called alanine) is a non-essential amino acid your body can make on its own and that you also get from protein foods. Most peop...
L-Alanine monograph & interactionsL-Hydroxyproline
Mushrooms + Nootropics Blend
L-Phenylalanine
Interacts with16 drugs
Phenylalanine is an essential amino acid the body uses to make brain chemicals like dopamine and norepinephrine. Some people take it for mood, vitilig...
L-Phenylalanine monograph & interactionsMushroom Matcha+ by Everyday Dose Drug Interactions
HelloPharmacist Interaction Report
Mushroom Matcha+ by Everyday Dose contains multiple ingredients with documented medication interactions.
The most serious concern is matcha green tea, which has Major-severity interactions with the beta-blocker nadolol—green tea can reduce nadolol levels by approximately 85%, potentially undermining blood pressure control—and with the statin atorvastatin, reducing its levels by roughly 24%. Matcha also carries Major-severity risk with ephedrine due to its caffeine content, which can cause serious stimulant effects including heart attack, stroke, or seizures.
Read the full breakdown — every affected drug type, severity by severity
Several other ingredients pose Moderate-severity interactions. Sodium may reduce the effectiveness of blood pressure medications (antihypertensives) and can interact with corticosteroids, lithium, and diuretics in ways that affect drug levels or sodium balance.
L-arginine may lower blood pressure further when combined with blood pressure drugs, ACE inhibitors, or ARBs, and may increase bleeding risk with blood thinners. L-tyrosine can interfere with levodopa (a Parkinson medication) and may have additive effects with thyroid hormone.
L-phenylalanine, in high doses, can reduce levodopa effectiveness and poses risk with certain antidepressants (MAOIs). Matcha also carries Moderate interactions with several anti-seizure drugs (felbamate, valproate, ethosuximide, phenytoin), the blood thinner dipyridamole, and glycine may worsen schizophrenia symptoms in patients taking clozapine.
Lion's Mane and Chaga mushroom extracts each carry Moderate interactions with blood thinners, diabetes medications, and immunosuppressants. L-threonine has a Major interaction with NMDA antagonist medications.
L-lysine carries a Minor interaction with certain serotonergic drugs, and L-theanine has Minor interactions with CNS depressants and serotonergic drugs, plus Moderate risk with blood pressure medications.
We could not check interaction data for L-Leucine, L-Isoleucine, L-Glutamic Acid, Hydroxylysine, and L-Hydroxyproline. Altogether, these interactions span 1,576 individual medications.
If you take any prescription medication, use the interaction checker below before adding this product.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Mushroom Matcha+?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Mushroom Matcha+ interact with 1,575 drugs. Click any drug to see the details.
11 of the 25 ingredients in Mushroom Matcha+ interact with drugs. Each result below shows which ingredient is responsible. Matcha Green Tea, Powder L-Theanine L-Arginine Lion's Mane Fruiting Body Extract Chaga Fruiting Body Extract Sodium L-Tyrosine L-Phenylalanine L-Threonine Glycine L-Lysine
6-mercaptopurinePurinethol
How 6-mercaptopurine interacts with Mushroom Matcha+ — through 3 ingredients. Tap an ingredient for the detail:
Lion's Mane Fruiting Body ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, concurrent use of lion's mane mushroom might interfere with immunosuppressive therapy.
Read the full Lion's Mane Fruiting Body Extract + 6-mercaptopurine interactionChaga Fruiting Body ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, chaga might interfere with immunosuppressive therapy.
Read the full Chaga Fruiting Body Extract + 6-mercaptopurine interactionMatcha Green Tea, PowderHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Matcha Green Tea, Powder + 6-mercaptopurine interactionAbacavir Sulfate, Dolutegravir, LamivudineTriumeq
How Abacavir Sulfate, Dolutegravir, Lamivudine interacts with Mushroom Matcha+ — through 1 ingredient. Tap an ingredient for the detail:
Matcha Green Tea, PowderHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Matcha Green Tea, Powder + Abacavir Sulfate, Dolutegravir, Lamivudine interactionAbacavir, LamivudineEpzicom
How Abacavir, Lamivudine interacts with Mushroom Matcha+ — through 1 ingredient. Tap an ingredient for the detail:
Matcha Green Tea, PowderHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Matcha Green Tea, Powder + Abacavir, Lamivudine interactionAbametapirXeglyze
How Abametapir interacts with Mushroom Matcha+ — through 1 ingredient. Tap an ingredient for the detail:
Matcha Green Tea, PowderCytochrome P450 1a2 (cyp1a2) Inhibitors Moderate
Interaction Summary
Theoretically, concomitant use might increase the levels and adverse effects of caffeine.
Read the full Matcha Green Tea, Powder + Abametapir interactionAbciximabReoPro
How Abciximab interacts with Mushroom Matcha+ — through 4 ingredients. Tap an ingredient for the detail:
Chaga Fruiting Body ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, chaga may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Chaga Fruiting Body Extract + Abciximab interactionLion's Mane Fruiting Body ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
Read the full Lion's Mane Fruiting Body Extract + Abciximab interactionMatcha Green Tea, PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, green tea may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Matcha Green Tea, Powder + Abciximab interactionL-arginineAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-arginine with anticoagulant and antiplatelet drugs might have additive effects and increase the risk of bleeding.
Read the full L-arginine + Abciximab interactionAbiraterone
How Abiraterone interacts with Mushroom Matcha+ — through 1 ingredient. Tap an ingredient for the detail:
Matcha Green Tea, PowderHepatotoxic Drugs, Cytochrome P450 1a2 (cyp1a2) Inhibitors +1 Moderate
Interaction Summary
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Matcha Green Tea, Powder + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with Mushroom Matcha+ — through 1 ingredient. Tap an ingredient for the detail:
Matcha Green Tea, PowderCytochrome P450 3a4 (cyp3a4) Substrates, Hepatotoxic Drugs Moderate
Interaction Summary
Green tea is unlikely to produce clinically significant changes in the levels and clinical effects of CYP3A4 substrates.
Read the full Matcha Green Tea, Powder + Abiraterone Acetate interactionAbrocitinibCibinqo
How Abrocitinib interacts with Mushroom Matcha+ — through 4 ingredients. Tap an ingredient for the detail:
L-arginineAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-arginine with anticoagulant and antiplatelet drugs might have additive effects and increase the risk of bleeding.
Read the full L-arginine + Abrocitinib interactionLion's Mane Fruiting Body ExtractAnticoagulant/antiplatelet Drugs, Immunosuppressants Moderate
Interaction Summary
Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
Read the full Lion's Mane Fruiting Body Extract + Abrocitinib interactionChaga Fruiting Body ExtractImmunosuppressants, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, chaga might interfere with immunosuppressive therapy.
Read the full Chaga Fruiting Body Extract + Abrocitinib interactionMatcha Green Tea, PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, green tea may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Matcha Green Tea, Powder + Abrocitinib interactionAcalabrutinibCalquence
How Acalabrutinib interacts with Mushroom Matcha+ — through 1 ingredient. Tap an ingredient for the detail:
Matcha Green Tea, PowderP-glycoprotein Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Green tea might increase the levels and adverse effects of P-glycoprotein (P-gp) substrates.
Read the full Matcha Green Tea, Powder + Acalabrutinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Mushroom Matcha+ — through 4 ingredients. Tap an ingredient for the detail:
Matcha Green Tea, PowderHepatotoxic Drugs, Antidiabetes Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Matcha Green Tea, Powder + Acarbose interactionL-arginineAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-arginine might have additive effects with antidiabetes drugs.
Read the full L-arginine + Acarbose interactionLion's Mane Fruiting Body ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, lion's mane mushroom may have additive effects when used with antidiabetes drugs.
Read the full Lion's Mane Fruiting Body Extract + Acarbose interactionChaga Fruiting Body ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking chaga with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Chaga Fruiting Body Extract + Acarbose interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Mushroom Matcha+ — through 4 ingredients. Tap an ingredient for the detail:
SodiumAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium + Acebutolol interactionL-arginineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-arginine and antihypertensive drugs may increase the risk of hypotension.
Read the full L-arginine + Acebutolol interactionMatcha Green Tea, PowderHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Matcha Green Tea, Powder + Acebutolol interactionL-theanineAntihypertensive Drugs Moderate
Interaction Summary
Theanine might lower blood pressure, potentiating the effects of antihypertensive drugs.
Read the full L-theanine + Acebutolol interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Mushroom Matcha+ — through 4 ingredients. Tap an ingredient for the detail:
Matcha Green Tea, PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, green tea may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Matcha Green Tea, Powder + Acenocoumarol interactionChaga Fruiting Body ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, chaga may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Chaga Fruiting Body Extract + Acenocoumarol interactionLion's Mane Fruiting Body ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
Read the full Lion's Mane Fruiting Body Extract + Acenocoumarol interactionL-arginineAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-arginine with anticoagulant and antiplatelet drugs might have additive effects and increase the risk of bleeding.
Read the full L-arginine + Acenocoumarol interactionAcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength
How Acetaminophen interacts with Mushroom Matcha+ — through 1 ingredient. Tap an ingredient for the detail:
Matcha Green Tea, PowderHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Matcha Green Tea, Powder + Acetaminophen interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Mushroom Matcha+ — through 4 ingredients. Tap an ingredient for the detail:
Matcha Green Tea, PowderHepatotoxic Drugs, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Matcha Green Tea, Powder + Acetaminophen, Aspirin interactionL-arginineAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-arginine with anticoagulant and antiplatelet drugs might have additive effects and increase the risk of bleeding.
Read the full L-arginine + Acetaminophen, Aspirin interactionLion's Mane Fruiting Body ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
Read the full Lion's Mane Fruiting Body Extract + Acetaminophen, Aspirin interactionChaga Fruiting Body ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, chaga may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Chaga Fruiting Body Extract + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Mushroom Matcha+ — through 4 ingredients. Tap an ingredient for the detail:
Chaga Fruiting Body ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, chaga may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Chaga Fruiting Body Extract + Acetaminophen, Aspirin, Caffeine interactionLion's Mane Fruiting Body ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
Read the full Lion's Mane Fruiting Body Extract + Acetaminophen, Aspirin, Caffeine interactionMatcha Green Tea, PowderHepatotoxic Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates +2 Moderate
Interaction Summary
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Matcha Green Tea, Powder + Acetaminophen, Aspirin, Caffeine interactionL-arginineAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-arginine with anticoagulant and antiplatelet drugs might have additive effects and increase the risk of bleeding.
Read the full L-arginine + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with Mushroom Matcha+ — through 1 ingredient. Tap an ingredient for the detail:
Matcha Green Tea, PowderStimulant Drugs, Phenylpropanolamine +1 Moderate
Interaction Summary
Theoretically, concomitant use might increase stimulant adverse effects.
Read the full Matcha Green Tea, Powder + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more
How Acetaminophen, Butalbital interacts with Mushroom Matcha+ — through 1 ingredient. Tap an ingredient for the detail:
Matcha Green Tea, PowderHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Matcha Green Tea, Powder + Acetaminophen, Butalbital interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Mushroom Matcha+ — through 1 ingredient. Tap an ingredient for the detail:
Matcha Green Tea, PowderHepatotoxic Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Matcha Green Tea, Powder + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Mushroom Matcha+ — through 2 ingredients. Tap an ingredient for the detail:
Matcha Green Tea, PowderStimulant Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, concomitant use might increase stimulant adverse effects.
Read the full Matcha Green Tea, Powder + Acetaminophen, Butalbital, Caffeine, Codeine interactionL-theanineCns Depressants Minor
Interaction Summary
Theoretically, theanine might have additive sedative effects when used in conjunction with CNS depressants.
Read the full L-theanine + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Mushroom Matcha+ — through 2 ingredients. Tap an ingredient for the detail:
Matcha Green Tea, PowderHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Matcha Green Tea, Powder + Acetaminophen, Butalbital, Codeine interactionL-theanineCns Depressants Minor
Interaction Summary
Theoretically, theanine might have additive sedative effects when used in conjunction with CNS depressants.
Read the full L-theanine + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Mushroom Matcha+ — through 2 ingredients. Tap an ingredient for the detail:
Matcha Green Tea, PowderHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Matcha Green Tea, Powder + Acetaminophen, Butalbital, Codeine Phosphate interactionL-theanineCns Depressants Minor
Interaction Summary
Theoretically, theanine might have additive sedative effects when used in conjunction with CNS depressants.
Read the full L-theanine + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Mushroom Matcha+ — through 2 ingredients. Tap an ingredient for the detail:
Matcha Green Tea, PowderHepatotoxic Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Matcha Green Tea, Powder + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionL-theanineCns Depressants Minor
Interaction Summary
Theoretically, theanine might have additive sedative effects when used in conjunction with CNS depressants.
Read the full L-theanine + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Mushroom Matcha+ — through 2 ingredients. Tap an ingredient for the detail:
Matcha Green Tea, PowderStimulant Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, concomitant use might increase stimulant adverse effects.
Read the full Matcha Green Tea, Powder + Acetaminophen, Caffeine, Codeine interactionL-theanineCns Depressants Minor
Interaction Summary
Theoretically, theanine might have additive sedative effects when used in conjunction with CNS depressants.
Read the full L-theanine + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Mushroom Matcha+ — through 2 ingredients. Tap an ingredient for the detail:
Matcha Green Tea, PowderHepatotoxic Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Matcha Green Tea, Powder + Acetaminophen, Caffeine, Codeine, Salicylamide interactionL-theanineCns Depressants Minor
Interaction Summary
Theoretically, theanine might have additive sedative effects when used in conjunction with CNS depressants.
Read the full L-theanine + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Mushroom Matcha+ — through 2 ingredients. Tap an ingredient for the detail:
Matcha Green Tea, PowderStimulant Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, concomitant use might increase stimulant adverse effects.
Read the full Matcha Green Tea, Powder + Acetaminophen, Caffeine, Dihydrocodeine interactionL-theanineCns Depressants Minor
Interaction Summary
Theoretically, theanine might have additive sedative effects when used in conjunction with CNS depressants.
Read the full L-theanine + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Mushroom Matcha+ — through 1 ingredient. Tap an ingredient for the detail:
Matcha Green Tea, PowderHepatotoxic Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Matcha Green Tea, Powder + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Mushroom Matcha+ — through 1 ingredient. Tap an ingredient for the detail:
Matcha Green Tea, PowderDiuretic Drugs, Stimulant Drugs +2 Moderate
Interaction Summary
Theoretically, using green tea with diuretic drugs might increase the risk of hypokalemia.
Read the full Matcha Green Tea, Powder + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Mushroom Matcha+ — through 2 ingredients. Tap an ingredient for the detail:
Matcha Green Tea, PowderCytochrome P450 3a4 (cyp3a4) Substrates, Hepatotoxic Drugs Moderate
Interaction Summary
Green tea is unlikely to produce clinically significant changes in the levels and clinical effects of CYP3A4 substrates.
Read the full Matcha Green Tea, Powder + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionL-theanineSerotonergic Drugs Minor
Interaction Summary
Clinical studies regarding the effects of L-theanine on serotonin levels are conflicting.
Read the full L-theanine + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Mushroom Matcha+ — through 2 ingredients. Tap an ingredient for the detail:
Matcha Green Tea, PowderStimulant Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, concomitant use might increase stimulant adverse effects.
Read the full Matcha Green Tea, Powder + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionL-theanineSerotonergic Drugs, Cns Depressants Minor
Interaction Summary
Clinical studies regarding the effects of L-theanine on serotonin levels are conflicting.
Read the full L-theanine + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Mushroom Matcha+ — through 2 ingredients. Tap an ingredient for the detail:
Matcha Green Tea, PowderCytochrome P450 3a4 (cyp3a4) Substrates, Hepatotoxic Drugs Moderate
Interaction Summary
Green tea is unlikely to produce clinically significant changes in the levels and clinical effects of CYP3A4 substrates.
Read the full Matcha Green Tea, Powder + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionL-theanineSerotonergic Drugs Minor
Interaction Summary
Clinical studies regarding the effects of L-theanine on serotonin levels are conflicting.
Read the full L-theanine + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Mushroom Matcha+ with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Matcha Green Tea, Powder
Atorvastatin (Lipitor)
Green tea extract seems to reduce the levels and clinical effects of atorvastatin.
In healthy humans, taking green tea extract 300 mg or 600 mg along with atorvastatin reduces plasma levels of atorvastatin by approximately 24%. The elimination of atorvastatin is not affected. Atorvastatin is a substrate of organic anion-transporting polypeptides (OATPs). Research shows that two of the major catechins found in green tea, epicatechin gallate (ECG) and epigallocatechin gallate (EGCG), inhibit OATPs. Some OATPs are expressed in the small intestine and are responsible for the uptake of drugs and other compounds, which may have resulted in reduced plasma levels of atorvastatin. It is not clear if drinking green tea alters the absorption of atorvastatin.
Ephedrine
Theoretically, concomitant use might increase the risk for stimulant adverse effects.
Green tea contains caffeine. There is evidence that using ephedrine with caffeine might increase the risk of serious life-threatening or debilitating adverse effects such as hypertension, myocardial infarction, stroke, seizures, and death.
Nadolol (Corgard)
Green tea seems to reduce the levels and clinical effects of nadolol.
Preliminary clinical research shows that green tea consumption reduces plasma concentrations of nadolol. Compared to a control group, both peak levels and total drug exposure (AUC) of nadolol were reduced by approximately 85% in subjects who drank green tea daily for two weeks. Drinking green tea with nadolol also significantly reduced nadolol's systolic blood pressure lowering effect. Other clinical research shows that a single dose of green tea can affect plasma nadolol levels for at least one hour. Green tea catechins have been shown to inhibit organic anion transporting polypeptides (OATP), one of which, OATP1A2, is involved in the uptake of nadolol in the intestine The interaction is thought to be due primarily to the epigallocatechin gallate (EGCG) content of green tea.
5-Fluorouracil
Theoretically, high doses of green tea might increase the effects and side effects of 5-fluorouracil.
Animal research shows that taking green tea in amounts equivalent to about 6 cups daily in humans for 4 weeks prior to receiving a single injection of 5-fluorouracil increases the maximum plasma levels of 5-fluorouracil by about 2.5-fold and the area under the curve by 425%.
Adenosine (Adenocard)
Theoretically, green tea might decrease the vasodilatory effects of adenosine and interfere with its use prior to stress testing.
Green tea contains caffeine. Caffeine is a competitive inhibitor of adenosine at the cellular level. However, caffeine doesn't seem to affect supplemental adenosine because high interstitial levels of adenosine overcome the antagonistic effects of caffeine. It is recommended that methylxanthines and methylxanthine-containing products be stopped 24 hours prior to pharmacological stress tests. However, methylxanthines appear more likely to interfere with dipyridamole (Persantine) than adenosine-induced stress testing.
Anticoagulant/Antiplatelet Drugs
Theoretically, green tea may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Conflicting reports exist regarding the effect of green tea on bleeding risk when used with anticoagulant or antiplatelet drugs; however, most evidence suggests that drinking green tea in moderate amounts is unlikely to cause a significant interaction. Green tea contains small amounts of vitamin K, approximately 7 mcg per cup. Some case reports have associated the antagonism of warfarin with the vitamin K content of green tea. However, these reports are rare, and very large doses of green tea (about 8-16 cups daily) appear to be needed to cause these effects. Furthermore, the catechins and caffeine in green tea are reported to have antiplatelet activity.
Beta-Adrenergic Agonists
Green tea contains caffeine. Theoretically, concomitant use of large amounts of caffeine might increase cardiac inotropic effects of beta-agonists.
Bortezomib (Velcade)
Theoretically, green tea might interfere with the effects of bortezomib.
In vitro research shows that green tea polyphenols, such as epigallocatechin gallate (EGCG), interact with bortezomib and block its proteasome inhibitory action. This prevents the induction of cell death in multiple myeloma or glioblastoma cancer cell lines. Advise patients taking bortezomib, not to take green tea.
Carbamazepine (Tegretol)
Theoretically, green tea might reduce the effects of carbamazepine and increase the risk for convulsions.
Green tea contains caffeine. Animal research suggests that taking caffeine can lower the anticonvulsant effects of carbamazepine and can induce seizures when taken in doses above 400 mg/kg. Human research has shown that taking caffeine 300 mg in three divided doses along with carbamazepine 200 mg reduces the bioavailability of carbamazepine by 32% and prolongs the plasma half-life of carbamazepine 2-fold in healthy individuals.
Celiprolol (Celicard)
Theoretically, green tea might reduce the levels and clinical effects of celiprolol.
In a small human study, taking green tea daily for 4 days appears to decrease blood and urine levels of celiprolol by at least 98%. This interaction is possibly due to the inhibition of organic anion transporting polypeptide (OATP). Green tea catechins have been shown to inhibit organic anion transporting polypeptides (OATP), one of which, OATP1A2, is found in the intestine The interaction is thought to be due primarily to the epigallocatechin gallate (EGCG) content of green tea.
Cimetidine (Tagamet)
Theoretically, concomitant use might increase the effects and adverse effects of caffeine in green tea.
Green tea contains caffeine. Cimetidine can reduce caffeine clearance by 31% to 42%.
Clozapine (Clozaril)
Theoretically, green tea might increase the levels and adverse effects of clozapine and acutely exacerbate psychotic symptoms.
Animal research suggests that, although green tea extract does not affect the elimination of clozapine, it delays the time to reach peak concentration and reduces the peak plasma levels. Also, concomitant administration of green tea and clozapine might theoretically cause acute exacerbation of psychotic symptoms due to the caffeine in green tea. Caffeine can increase the effects and toxicity of clozapine. Caffeine doses of 400-1000 mg daily inhibit clozapine metabolism. Clozapine is metabolized by cytochrome P450 1A2 (CYP1A2). Researchers speculate that caffeine might inhibit CYP1A2. However, there is no reliable evidence that caffeine affects CYP1A2. There is also speculation that genetic factors might make some patients be more sensitive to the interaction between clozapine and caffeine.
Contraceptive Drugs
Theoretically, concomitant use might increase the effects and adverse effects of caffeine found in green tea.
Green tea contains caffeine. Oral contraceptives can decrease caffeine clearance by 40% to 65%.
Cytochrome P450 1A2 (Cyp1A2) Inhibitors
Theoretically, concomitant use might increase the levels and adverse effects of caffeine.
Green tea contains caffeine. Caffeine is metabolized by cytochrome P450 1A2 (CYP1A2),. Theoretically, drugs that inhibit CYP1A2 may decrease the clearance rate of caffeine from green tea and increase caffeine levels.
Dipyridamole (Persantine)
Theoretically, green tea might decrease the vasodilatory effects of dipyridamole and interfere with its use prior to stress testing.
Green tea contains caffeine. Caffeine might inhibit dipyridamole-induced vasodilation. It is recommended that methylxanthines and methylxanthine-containing products be stopped 24 hours prior to pharmacological stress tests. Methylxanthines appear more likely to interfere with dipyridamole (Persantine) than adenosine-induced stress testing.
Disulfiram (Antabuse)
Theoretically, disulfiram might increase the risk of adverse effects from caffeine.
In human research, disulfiram decreases the clearance and increases the half-life of caffeine.
Diuretic Drugs
Theoretically, using green tea with diuretic drugs might increase the risk of hypokalemia.
Green tea contains caffeine. In excessive amounts, caffeine can reduce potassium levels due to stimulation of the sodium-potassium pump. Diuretics can also cause lower potassium levels.
Estrogens
Theoretically, estrogens might increase the levels and adverse effects of caffeine.
Green tea contains caffeine. Estrogen inhibits caffeine metabolism.
Ethosuximide (Zarontin)
Theoretically, green tea might reduce the effects of ethosuximide and increase the risk for convulsions.
Green tea contains caffeine. Animal research suggests that caffeine 92.4 mg/kg can decrease the anticonvulsant activity of ethosuximide. However, this effect has not been reported in humans.
Felbamate (Felbatol)
Theoretically, green tea might reduce the effects of felbamate and increase the risk for convulsions.
Green tea contains caffeine. Animal research suggests that a high dose of caffeine 161.7 mg/kg can decreases the anticonvulsant activity of felbamate. However, this effect has not been reported in humans.
Fexofenadine (Allegra)
Green tea can decrease blood levels of fexofenadine.
Clinical research shows that green tea can significantly decrease blood levels and excretion of fexofenadine. Taking green tea extract with a dose of fexofenadine decreased bioavailability of fexofenadine by about 30%. In vitro, green tea inhibits the cellular accumulation of fexofenadine by inhibiting the organic anion transporting polypeptide (OATP) drug transporter. Research shows that two of the major catechins found in green tea, epicatechin gallate (ECG) and epigallocatechin gallate (EGCG), inhibit OATPs, specifically OATP1A2, OATP1B1, and OATP2B1. In addition, green tea has been shown to reduce the absorption of some drugs that are OATP substrates.
Flutamide (Eulexin)
Theoretically, green tea might increase the levels and adverse effects of flutamide.
Green tea contains caffeine. In vitro evidence suggests that caffeine can inhibit the metabolism of flutamide. Theoretically, concomitant use of caffeine and flutamide might increase serum concentrations of flutamide and increase the risk adverse effects.
Fluvoxamine (Luvox)
Theoretically, fluvoxamine might increase the levels and adverse effects of caffeine.
Green tea contains caffeine. Fluvoxamine reduces caffeine metabolism.
Hepatotoxic Drugs
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Green tea extract supplements have been linked to several cases of hepatotoxicity and might have additive hepatotoxic effects with other drugs..
Imatinib (Gleevec)
Theoretically, green tea might reduce the levels and clinical effects of imatinib.
In animal research, a single dose of green tea extract reduces the area under the curve (AUC) of imatinib by up to approximately 64% and its main metabolite N-desmethyl imatinib by up to approximately 81%. This interaction has not been shown in humans. The mechanism of action is unclear but may involve multiple pathways.
L-Theanine
Antihypertensive Drugs
Theanine might lower blood pressure, potentiating the effects of antihypertensive drugs.
Animal research shows that theanine can lower blood pressure in spontaneously hypertensive animals. Theoretically, concomitant use of theanine and antihypertensive drugs might potentiate the antihypertensive activity.
Cns Depressants
Theoretically, theanine might have additive sedative effects when used in conjunction with CNS depressants. However, it is unclear if this concern is clinically relevant.
Theoretically, theanine may compete with glutamate and/or increase plasma gamma-aminobutyric acid (GABA) levels, which could cause CNS depression. In one clinical study, some subjects taking oral theanine reported drowsiness.
Serotonergic Drugs
Clinical studies regarding the effects of L-theanine on serotonin levels are conflicting. Some studies suggest it can increase serotonin levels in the brain while others report that it may decrease them. Nevertheless, there have been no reports of l-theanine being a causative agent in serotonergic-related side effects or serotonin syndrome.
L-Arginine
Ace Inhibitors (Aceis)
Theoretically, concomitant use of L-arginine and ACE inhibitors may increase the risk for hypotension and hyperkalemia.
Combining L-arginine with some antihypertensive drugs, especially ACE inhibitors, seems to have additive vasodilating and blood pressure-lowering effects. Furthermore, ACE inhibitors can increase potassium levels. Use of L-arginine has been associated with hyperkalemia in some patients. Theoretically, concomitant use of ACE inhibitors with L-arginine may increases the risk of hyperkalemia.
Angiotensin Receptor Blockers (Arbs)
Theoretically, concomitant use of L-arginine and ARBs may increase the risk of hypotension and hyperkalemia.
L-arginine increases nitric oxide, which causes vasodilation. Combining L-arginine with ARBs seems to increase L-arginine-induced vasodilation. Furthermore, ARBs can increase potassium levels. Use of L-arginine has been associated with hyperkalemia in some patients. Theoretically, concomitant use of ARBs with L-arginine may increases the risk of hyperkalemia.
Anticoagulant/Antiplatelet Drugs
Theoretically, concomitant use of L-arginine with anticoagulant and antiplatelet drugs might have additive effects and increase the risk of bleeding.
Preliminary research suggests that L-arginine infusions reduce platelet aggregation in humans. The clinical significance of this effect is unclear.
Antidiabetes Drugs
Theoretically, concomitant use of L-arginine might have additive effects with antidiabetes drugs.
Preliminary clinical research shows that L-arginine decreases blood glucose levels in patients with type 2 diabetes.
Antihypertensive Drugs
Theoretically, concomitant use of L-arginine and antihypertensive drugs may increase the risk of hypotension.
L-arginine increases nitric oxide, which causes vasodilation. Clinical evidence shows that L-arginine can reduce blood pressure in some individuals with hypertension. Furthermore, combining L-arginine with some antihypertensive drugs seems to have additive vasodilating and blood pressure-lowering effects.
Isoproterenol (Isuprel)
Theoretically, concurrent use of isoproterenol and L-arginine might result in additive effects and hypotension.
Preliminary clinical evidence suggests that L-arginine enhances isoproterenol-induced vasodilation in patients with essential hypertension or a family history of essential hypertension.
Potassium-Sparing Diuretics
Theoretically concomitant use of potassium-sparing diuretics with L-arginine may increases the risk of hyperkalemia.
Potassium-sparing diuretics can increase potassium levels. Use of L-arginine has been associated with hyperkalemia in some patients.
Sildenafil (Viagra)
Theoretically, concurrent use of sildenafil and L-arginine might increase the risk for hypotension.
In vivo, concurrent use of L-arginine and sildenafil has resulted in increased vasodilation. Theoretically, concurrent use might have additive vasodilatory and hypotensive effects. However, in studies evaluating the combined use of L-arginine and sildenafil for erectile dysfunction, hypotension was not reported.
Testosterone
Theoretically, concomitant use of L-arginine and testosterone might have additive effects.
In clinical research, L-arginine increases the level of testosterone in male patients with erectile dysfunction. The clinical significance of this finding is unclear.
Lion's Mane Fruiting Body Extract
Anticoagulant/Antiplatelet Drugs
Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
In vitro research suggests that lion's mane mushroom extracts can inhibit platelet aggregation.
Antidiabetes Drugs
Theoretically, lion's mane mushroom may have additive effects when used with antidiabetes drugs.
Animal research suggests that an aqueous extract of lion's mane mushroom can reduce serum glucose and increase serum insulin.
Immunosuppressants
Theoretically, concurrent use of lion's mane mushroom might interfere with immunosuppressive therapy.
In animal and in vitro research, lion's mane mushroom polysaccharides stimulate the immune system.
Chaga Fruiting Body Extract
Anticoagulant/Antiplatelet Drugs
Theoretically, chaga may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro and animal research suggests that chaga extract can inhibit platelet aggregation. This effect has not been reported in humans.
Antidiabetes Drugs
Theoretically, taking chaga with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research suggests that chaga might decrease blood glucose levels and increase insulin levels. This has not been reported in humans.
Immunosuppressants
Theoretically, chaga might interfere with immunosuppressive therapy.
In vitro research suggests that certain constituents of chaga stimulate immune function. This has not been reported in humans.
Sodium
Antihypertensive Drugs
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.
Corticosteroids
Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.
Didanosine (Videx)
Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.
Lithium
Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.
Sodium Phosphates
Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.
Sodium-Containing Drugs
Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.
Tolvaptan (Samsca)
Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.
L-Tyrosine
Levodopa
Theoretically, tyrosine might decrease the effectiveness of levodopa.
Tyrosine and levodopa compete for absorption in the proximal duodenum by the large neutral amino acid (LNAA) transport system. Advise patients to separate doses of tyrosine and levodopa by at least 2 hours.
Thyroid Hormone
Theoretically, tyrosine might have additive effects with thyroid hormone medications.
Tyrosine is a precursor to thyroxine and might increase levels of thyroid hormones.
L-Phenylalanine
Levodopa
Phenylalanine, especially in high doses, can reduce the effectiveness of levodopa.
Phenylalanine competes with levodopa for carrier-mediated transport into the brain. The resulting reduction in levels of levodopa in the brain can exacerbate tremor, rigidity, and the "on-off" phenomenon in patients with Parkinson disease.
Baclofen
Concomitant intake of phenylalanine may reduce the intestinal absorption of baclofen.
Phenylalanine and baclofen share the same intestinal carrier for absorption; phenylalanine competitively inhibits the absorption of baclofen, reducing its plasma levels.
Monoamine Oxidase Inhibitors (Maois)
Theoretically, concomitant use of L-phenylalanine and non-selective MAOIs might increase the risk of hypertensive crisis.
L-phenylalanine is metabolized to tyrosine. Some evidence suggests that L-phenylalanine, given with the non-selective MAOI pargyline, might prevent the elimination of tyramine, increasing the risk of hypertensive crisis. However, this was not reported in a small number of patients when using L-phenylalanine with the partially selective MAO-B inhibitor, selegiline.
L-Threonine
Nmda Antagonists
Theoretically, threonine might decrease the effects of NMDA antagonists.
Threonine increases central nervous system (CNS) glycine levels. Glycine seems to bind a site on NMDA receptors and enhance the activity of the receptors.
Glycine
Clozapine (Clozaril)
Theoretically, glycine might decrease the effectiveness of clozapine.
One small clinical study in patients with schizophrenia shows that adding glycine to clozapine therapy worsens symptoms of schizophrenia when compared with clozapine alone. The mechanism of this interaction is unclear.
L-Lysine
5-Ht4 Agonists
Theoretically, lysine may reduce the effects of 5-HT4 agonists.
Animal research suggests that L-lysine is a partial serotonin receptor 4 (5-HT4) antagonist and inhibits diarrhea induced by the 5-HT4 agonist, 5-hydroxytryptophane.
Brand information
Manufacturer and brand details for Mushroom Matcha+, from the product label.
Everyday Dose
See all Everyday Dose products- Name
- Everyday Dose, Inc
- Street Address
- 8015 Burleson Rd Suite 100
- City
- Austin
- State
- TX
- ZipCode
- 78744
- Web Address
- everydaydose.com
Mushroom Matcha+ by Everyday Dose: Common Questions
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Mushroom Matcha+’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sodium
Interacts with 205 drugsSodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets get more than enough—often too much—from...
Read the full Sodium monograph → Herb & supplement monographGlycine
Interacts with 1 drugGlycine is a non-essential amino acid your body makes on its own and that also appears in protein-rich foods. It is most studied for improving sleep quality, where early research is promisin...
Read the full Glycine monograph → Herb & supplement monographL-arginine
Interacts with 403 drugsL-arginine is an amino acid that the body uses to make nitric oxide, a substance that helps blood vessels relax and widen. It is popularly used for blood pressure, erectile dysfunction, and...
Read the full L-arginine monograph → Herb & supplement monographMethionine
Methionine is an essential amino acid that your body needs for protein building and many basic chemical reactions. Most people get enough from a normal diet, and supplements are generally no...
Read the full Methionine monograph → Herb & supplement monographTyrosine
Interacts with 21 drugsL-tyrosine is an amino acid your body uses to make brain chemicals like dopamine and norepinephrine. Some studies suggest it may help mental performance during short-term stress, sleep loss,...
Read the full Tyrosine monograph → Herb & supplement monographProline
Proline is a non-essential amino acid that your body can make on its own and that you also get from protein-rich foods. It is a key building block of collagen, but strong human evidence that...
Read the full Proline monograph → Herb & supplement monographAspartic Acid
Aspartic acid is a common amino acid your body makes on its own and gets from protein-rich foods, so a true deficiency is rare. D-aspartic acid is heavily marketed for boosting testosterone...
Read the full Aspartic Acid monograph → Herb & supplement monographHistidine
Histidine is an essential amino acid your body needs to build proteins and to make compounds like histamine and carnosine. Most people get enough from a normal diet, and good-quality researc...
Read the full Histidine monograph → Herb & supplement monographThreonine
Interacts with 3 drugsThreonine is an essential amino acid your body needs but cannot make, so you must get it from food or supplements. Most people get plenty from a normal diet, and high-quality evidence for ta...
Read the full Threonine monograph → Herb & supplement monographLysine
Interacts with 1 drugLysine is an essential amino acid your body cannot make on its own, so it must come from food or supplements. People most often take extra lysine to try to prevent or shorten cold sores, but...
Read the full Lysine monograph → Herb & supplement monographSerine
Serine is an amino acid your body can make on its own and also gets from protein-rich foods, so most people do not need a supplement. L-serine has been studied for certain neurological condi...
Read the full Serine monograph → Herb & supplement monographCollagen Peptides
Collagen peptides are a well-absorbed form of protein that may modestly improve skin elasticity and joint comfort for some people, though evidence is still developing and results vary. They...
Read the full Collagen Peptides monograph → Herb & supplement monographAlpha-alanine
Alpha-alanine (usually called alanine) is a non-essential amino acid your body can make on its own and that you also get from protein foods. Most people do not need a supplement, and strong...
Read the full Alpha-alanine monograph → Herb & supplement monographTheanine
Interacts with 565 drugsTheanine (usually L-theanine) is an amino acid found naturally in tea leaves that many people take to feel calmer and less stressed without strong drowsiness. Early research suggests it may...
Read the full Theanine monograph → Herb & supplement monographLion's Mane Mushroom
Interacts with 327 drugsLion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and early. It is generally well tolerated as...
Read the full Lion's Mane Mushroom monograph → Herb & supplement monographChaga
Interacts with 327 drugsChaga is a fungus that grows mostly on birch trees and is used as a tea or supplement, mainly for immune and antioxidant support. Human evidence for its benefits is very limited, and it may...
Read the full Chaga monograph → Herb & supplement monographGreen Tea
Interacts with 1,293 drugsGreen tea is a popular beverage rich in antioxidants called catechins, and drinking it in normal amounts is considered safe for most people. Concentrated green tea extracts are a different s...
Read the full Green Tea monograph → Herb & supplement monographPhenylalanine
Interacts with 16 drugsPhenylalanine is an essential amino acid the body uses to make brain chemicals like dopamine and norepinephrine. Some people take it for mood, vitiligo, or pain, but the evidence is mostly l...
Read the full Phenylalanine monograph →Sources & How We Checked
Mushroom Matcha+'s label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 414 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Sodium 38 references
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- Messerli FH, Hofstetter L, Syrogiannouli L, et al. Sodium intake, life expectancy, and all-cause mortality. Eur Heart J 2021;42(21):2103-2112. PubMed
- Graudal NA, Hubeck-Graudal T, Jurgens G. Effects of low sodium diet versus high sodium diet on blood pressure, renin, aldosterone, catecholamines, cholesterol, and triglyceride. Cochrane Database Syst Rev 2020;12(12):CD004022. PubMed
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- Nan X, Lu H, Wu J, et al. The interactive association between sodium intake, alcohol consumption and hypertension among elderly in northern China: a cross-sectional study. BMC Geriatr 2021;21(1):135. PubMed
- Kyozuka H, Fukusda T, Murata T, et al. Impact of preconception sodium intake on hypertensive disorders of pregnancy: The Japan Environment and Children's study. Pregnancy Hypertens 2021;23:66-72. PubMed
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- Ma Y, He FJ, Sun Q, et al. 24-Hour urinary sodium and potassium excretion and cardiovascular risk. N Engl J Med 2022;386(3):252-263. PubMed
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Glycine 5 references
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L-arginine 66 references
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- Brittenden J, Park KGM, Heys SD, et al. L-Arginine stimulates host defenses in patients with breast cancer. Surgery 1994;115:205-12.
- Korting GE, Smith SD, Wheeler MA, et al. A randomized double-blind trial of oral L-arginine for treatment of interstitial cystitis. J Urol 1999;161:558-65. DOI
- Rector TS, Bank AJ, Mullen KA, et al. Randomized, double-blind, placebo-controlled study of supplemental oral L-arginine in patients with heart failure. Circulation 1996;93:2135-41.
- Siani A, Pagano E, Iacone R, et al. Blood pressure and metabolic changes during dietary L-arginine supplementation in humans. Am J Hypertens 2000;13:547-51. PubMed
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- Wallace AW, Tom WL. Interaction of L-arginine and phosphodiesterase inhibitors in vasodilation of the porcine internal mammary artery. Anesth Analg 2000;90:840-6. DOI
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- Staff AC, Berge L, Haugen G, et al. Dietary supplementation with L-arginine or placebo in women with pre-eclampsia. Acta Obstet Gynecol Scand 2004;83:103-7.
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- Anon. Arginine hydrochloride injection (marketed as R-Gene 10). FDA Drug Safety Newsletter 2009;2(2):16-18. Available at: www.fda.gov/Drugs/DrugSafety/DrugSafetyNewsletter/default.htm.
- Higashi Y, Oshima T, Sasaki S, et. al. Angiotensin-converting enzyme inhibition, but not calcium antagonism, improves a response of the renal vasculature to L-arginine in patients with essential hypertension. Hypertension. 1998 Jul;32(1):16-24.
- Facchinetti, F., Longo, M., Piccinini, F., Neri, I., and Volpe, A. L-arginine infusion reduces blood pressure in preeclamptic women through nitric oxide release. J Soc Gynecol.Investig. 1999;6(4):202-207. DOI
- de Gouw, H. W., Verbruggen, M. B., Twiss, I. M., and Sterk, P. J. Effect of oral L-arginine on airway hyperresponsiveness to histamine in asthma. Thorax 1999;54(11):1033-1035. PubMed
- Komers, R., Komersova, K., Kazdova, L., Ruzickova, J., and Pelikanova, T. Effect of ACE inhibition and angiotensin AT1 receptor blockade on renal and blood pressure response to L-arginine in humans. J Hypertens. 2000;18(1):51-59. PubMed
- Cartledge, J. J., Davies, A. M., and Eardley, I. A randomized double-blind placebo-controlled crossover trial of the efficacy of L-arginine in the treatment of interstitial cystitis. BJU.Int. 2000;85(4):421-426.
- Sozykin, A. V., Noeva, E. A., Balakhonova, T. V., Pogorelova, O. A., and Men'shikov, M. I. [Effect of L-arginine on platelet aggregation, endothelial function adn exercise tolerance in patients with stable angina pectoris]. Ter.Arkh. 2000;72(8):24-27.
- Nagaya, N., Uematsu, M., Oya, H., Sato, N., Sakamaki, F., Kyotani, S., Ueno, K., Nakanishi, N., Yamagishi, M., and Miyatake, K. Short-term oral administration of L-arginine improves hemodynamics and exercise capacity in patients with precapillary pulmona
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- Park, K. G., Heys, S. D., Blessing, K., Kelly, P., McNurlan, M. A., Eremin, O., and Garlick, P. J. Stimulation of human breast cancers by dietary L-arginine. Clin.Sci.(Lond) 1992;82(4):413-417.
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- Schlaich, M. P., Ahlers, B. A., Parnell, M. M., and Kaye, D. M. beta-Adrenoceptor-mediated, nitric-oxide-dependent vasodilatation is abnormal in early hypertension: restoration by L-arginine. J Hypertens. 2004;22(10):1917-1925. PubMed
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- Neri, I., Jasonni, V. M., Gori, G. F., Blasi, I., and Facchinetti, F. Effect of L-arginine on blood pressure in pregnancy-induced hypertension: a randomized placebo-controlled trial. J Matern.Fetal Neonatal Med. 2006;19(5):277-281.
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- Abu El-Hamd M, Hegazy EM. Comparison of the clinical efficacy of daily use of L-arginine, tadalafil and combined L-arginine with tadalafil in the treatment of elderly patients with erectile dysfunction. Andrologia. 2020;52(7):e13640. PubMed
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- Xu Z, Liu C, Liu S, Zhou Z. Comparison of efficacy and safety of daily oral L-arginine and PDE5Is alone or combination in treating erectile dysfunction: A systematic review and meta-analysis of randomised controlled trials. Andrologia. 2021:e14007. PubMed
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Methionine 12 references
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See these in context on the Lion's Mane Mushroom monograph →
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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