Interactions on record — worth a quick check against your medications. Based on 5 of 6 ingredients. Check your meds →
Dietary supplement

MYcoMune Ingredients & Drug Interactions

by Pure Essence MyPure

MYcoMune label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking MYcoMune against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

MYcoMune is a dietary supplement by Pure Essence MyPure with 6 active ingredients. Its ingredients are commonly taken for fatigue and low energy, athletic performance and stamina, respiratory and lung support.Based on those ingredients, 662 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are organic Lion's Mane Mushroom extract, organic Chaga sclerotium extract, organic Shiitake Mushroom extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against MYcoMune by Pure Essence MyPure

Ask about any prescription or over-the-counter medication and we check it for interactions with MYcoMune by Pure Essence MyPure — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of MYcoMune by Pure Essence MyPure

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 6 of its 6 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

MYcoMune contains six active ingredients: four are mushroom extracts — cordyceps, lion's mane, maitake, and chaga — plus royal red reishi mushroom extract and shiitake mushroom extract. Cordyceps is traditionally used for athletic performance and energy, though the evidence rates it as possibly ineffective for that use.

The others are studied for various conditions like cognitive function, immune support, and general wellness, but the available evidence for most is rated insufficient to draw conclusions. The product also contains HPMC, an inactive ingredient used in the capsule.

Does it work?

Leans against
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Leans against

The strongest graded evidence we hold for the stated purpose leans against a benefit.

Why this rating?
  • The label markets this product for: Supports maximum performance and healthy immune response.
  • We looked for evidence on: Aging, Allergic rhinitis (hay fever), Asthma, Athletic performance, Common cold, Coronavirus disease 2019 (COVID-19) — and 4 related terms.
  • The closest evidence on file: Cordyceps is rated "Possibly Ineffective" for Athletic performance (Natural Medicines).
  • Also on file: Maitake Mushroom is rated "Insufficient Reliable Evidence To Rate" for Allergic rhinitis (hay fever), Chronic fatigue syndrome (CFS), Chemotherapy-related fatigue, Coronavirus disease 2019 (COVID-19).
  • Also on file: Cordyceps is rated "Insufficient Reliable Evidence To Rate" for Asthma, Cough.

For most of the uses these mushroom extracts are marketed for — Alzheimer's disease, anxiety, cancer, cognitive function, and athletic performance — the evidence we hold rates them as insufficient to establish whether they work. Cordyceps specifically is rated possibly ineffective for athletic performance.

Shiitake is rated possibly ineffective for dental plaque. The research on these mushrooms for other conditions like diabetes, cardiovascular disease, and chemotherapy side effects remains too limited in our data to rate.

If a specific health goal brought you to this product, it's worth discussing with your pharmacist whether the evidence supports its use for that purpose.

The evidence, ingredient by ingredient Cordyceps Lion's Mane Mushroom Maitake Mushroom Chaga Shiitake Mushroom

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

These mushroom extracts are generally well tolerated when used short-term, though adverse effects can occur. The most common side effects across the ingredients are gastrointestinal — abdominal discomfort, diarrhea, constipation, nausea, and bloating.

These tend to be mild and may improve if you take the product with food. Cordyceps has one case report of liver inflammation (hepatitis), though it's unclear whether cordyceps or a contaminant caused it.

Chaga carries a specific warning: excessive use can lead to kidney problems because it contains high oxalate, a compound that can accumulate in the kidneys. During pregnancy and breastfeeding, the safety data for all five checked ingredients advise against use — there simply isn't enough information to know whether they're safe.

Royal red reishi mushroom has no pregnancy or lactation data on file. Talk with your pharmacist or doctor before using this product if you're pregnant, planning to become pregnant, or breastfeeding.

Side effects, ingredient by ingredient Cordyceps Lion's Mane Mushroom Maitake Mushroom Chaga Shiitake Mushroom

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 5 of the 5 matched ingredients can interact with medications — Maitake Mushroom, Cordyceps, Shiitake Mushroom, Chaga, Lion's Mane Mushroom.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 662 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before starting MYcoMune, double-check with your pharmacist if you take blood thinners or antiplatelet drugs (warfarin, aspirin, clopidogrel) — Moderate severity across three ingredients. Blood sugar medications (metformin, insulin, sulfonylureas) also need review — Moderate severity for lion's mane and maitake, with maitake having real clinical evidence.

Immune-suppressing drugs, blood pressure medications, and drugs metabolized by the liver enzyme CYP2D6 (like some antidepressants and heart drugs) should also be checked. No interactions are documented for the royal red reishi mushroom ingredient we could check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with graded evidence leaning against its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

MYcoMune is a multi-mushroom blend best suited for people not on blood thinners, blood sugar medications, immunosuppressants, blood pressure drugs, or certain liver-metabolized medications. If you take any of those, or any prescription medication at all, check with us or your pharmacist first.

Pregnant and breastfeeding people should avoid it. Side effects are usually mild digestive upset, but kidney concerns exist with chaga if used in large amounts.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 23, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about MYcoMune, straight from the product label.

Brand Pure Essence MyPure
Barcode (UPC) 659670914010
Net contents 30 Vegi-Cap(s)
Market status On market
Date entered into DSLD Jul 23, 2020
DSLD ID 231059
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Organic, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for MYcoMune by Pure Essence MyPure, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
UPC/BARCODE
659670914010
IngredientAmount% DV
Organic Cordyceps militaris mushroom extract100 mg--
organic Lion's Mane Mushroom extract75 mg--
organic Maitake Mushroom extract75 mg--
organic Royal Red Reishi Mushroom extract100 mg--
organic Chaga sclerotium extract75 mg--
organic Shiitake Mushroom extract75 mg--

Other ingredients: HPMC

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Non GMO

Vegan

Gluten Free

Organic ingredients

100% Purity & Potency Guarantee

Supports maximum performance & healthy immune response

Does not contain: Wheat, milk, tree nuts, peanuts, soy, eggs, fish, shellfish

Every batch is lab tested for cleanliness, purity and potency. MyPure MYcoMune 4X supports: Healthy stress response Healthy immune function Brain health, memory, concentration & focus Nerve & neuron growth

General Statements

90 day Money back guarantee

1 month supply

Please recycle

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

2018 All rights reserved

Formula

MyPure MYcoMune 4X provides 500 mg of our premium blend of certified organic, fruiting body mushroom extracts to deliver the most potent mushroom nutrition you'll find.

Suggested/Recommended/Usage/Directions

Suggested Use: One capsule daily.

Storage

Storage: Keep closed in a cool, dry place.

Precautions

Caution: Keep all supplements out of children's reach.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

Made in USA

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

MYcoMune by Pure Essence MyPure label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

MYcoMune label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in MYcoMune by Pure Essence MyPure

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Organic Cordyceps militaris mushroom extract

Interacts with
249 drugs
100 mg per serving

Cordyceps is a fungus used in traditional Chinese medicine for energy, exercise performance, and lung and immune support. Human research is limited an...

Organic Cordyceps militaris mushroom extract monograph & interactions

Organic Lion's Mane Mushroom extract

Interacts with
327 drugs
75 mg per serving

Lion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and...

Organic Lion's Mane Mushroom extract monograph & interactions

Organic Maitake Mushroom extract

Interacts with
260 drugs
75 mg per serving

Maitake is an edible mushroom long used as food and in traditional Japanese medicine, and it is being studied for possible immune, blood sugar, and bl...

Organic Maitake Mushroom extract monograph & interactions

Organic Royal Red Reishi Mushroom extract

100 mg per serving

Organic Chaga sclerotium extract

Interacts with
327 drugs
75 mg per serving

Chaga is a fungus that grows mostly on birch trees and is used as a tea or supplement, mainly for immune and antioxidant support. Human evidence for i...

Organic Chaga sclerotium extract monograph & interactions

Organic Shiitake Mushroom extract

Interacts with
312 drugs
75 mg per serving

Shiitake is a popular edible mushroom that is nutritious and safe to eat as food for most people. Some of its extracts (like lentinan and AHCC) have b...

Organic Shiitake Mushroom extract monograph & interactions

Other (inactive) ingredients: HPMC. These complete the product’s ingredient list but are not active constituents.

Interaction report

MYcoMune by Pure Essence MyPure Drug Interactions

Want to check YOUR meds against MYcoMune?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
662Drugs
654 Moderate 8 Minor

Ingredients driving the most interactions

organic Lion's Mane Mushroom extract 327
organic Chaga sclerotium extract 327
organic Shiitake Mushroom extract 312
organic Maitake Mushroom extract 260
Organic Cordyceps militaris mushroom extract 249

Individual Drug Interactions

The ingredients in MYcoMune interact with 662 drugs. Click any drug to see the details.

5 of the 6 ingredients in MYcoMune interact with drugs. Each result below shows which ingredient is responsible. organic Lion's Mane Mushroom extract organic Chaga sclerotium extract organic Shiitake Mushroom extract organic Maitake Mushroom extract Organic Cordyceps militaris mushroom extract

Each ingredient & the kinds of drugs it affects

For each ingredient in MYcoMune with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

organic Lion's Mane Mushroom extract3 drug types · 327 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
In vitro research suggests that lion's mane mushroom extracts can inhibit platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, lion's mane mushroom may have additive effects when used with antidiabetes drugs.
Animal research suggests that an aqueous extract of lion's mane mushroom can reduce serum glucose and increase serum insulin.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, concurrent use of lion's mane mushroom might interfere with immunosuppressive therapy.
In animal and in vitro research, lion's mane mushroom polysaccharides stimulate the immune system.

Likelihood Possible Evidence D
organic Lion's Mane Mushroom extract full monograph & interactions

organic Chaga sclerotium extract3 drug types · 327 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, chaga may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro and animal research suggests that chaga extract can inhibit platelet aggregation. This effect has not been reported in humans.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking chaga with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research suggests that chaga might decrease blood glucose levels and increase insulin levels. This has not been reported in humans.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, chaga might interfere with immunosuppressive therapy.
In vitro research suggests that certain constituents of chaga stimulate immune function. This has not been reported in humans.

Likelihood Possible Evidence D
organic Chaga sclerotium extract full monograph & interactions

organic Shiitake Mushroom extract2 drug types · 312 drugs

Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, shiitake mushroom might decrease levels of drugs metabolized by CYP2D6.
In vitro studies suggest that the shiitake mushroom extract AHCC might induce the CYP2D6 enzyme. This effect has not been reported in humans.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, taking shiitake mushroom might decrease the effects of immunosuppressive therapy.
In vitro evidence suggests that shiitake mushroom extracts stimulate immune function.

Likelihood Possible Evidence D
organic Shiitake Mushroom extract full monograph & interactions

organic Maitake Mushroom extract3 drug types · 260 drugs

Antidiabetes Drugs

Theoretically, combining maitake mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that taking maitake mushroom polysaccharide (MMP) can lower blood glucose levels in patients with types 2 diabetes.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.
Animal research shows that maitake mushroom can lower blood pressure.

Likelihood Possible Evidence D
Warfarin (Coumadin)

There is limited evidence that maitake mushroom may increase the anticoagulant effects of warfarin.
In a case report, a patient previously stabilized on warfarin developed an elevated international normalized ratio (INR) of 5.1 after taking maitake mushroom (Grifron-Pro Maitake D-Fraction) 1 drop/kg daily in three divided doses for one week. The elevated INR resolved after holding warfarin for two days, then reducing the dose by 11%. It is thought that the beta-glucan constituent of maitake mushroom might cause warfarin dissociation from proteins, resulting in increased free warfarin levels and increased warfarin effects.

Likelihood Possible Evidence D
organic Maitake Mushroom extract full monograph & interactions

Organic Cordyceps militaris mushroom extract3 drug types · 249 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
In vitro and animal research suggests that cordyceps extract inhibits platelet aggregation and function. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, concurrent use of cordyceps might interfere with immunosuppressive therapy.
Animal and in vitro research suggests that cordyceps stimulates the immune system. However, limited clinical research suggests that taking cordyceps may lower the necessary therapeutic dose of the immunosuppressant cyclosporine, which suggests that cordyceps may have an immunosuppressive effect.

Likelihood Possible Evidence B
Testosterone

Theoretically, concurrent use of cordyceps and testosterone might have additive effects.
Animal research suggests that cordyceps can increase testosterone levels. The clinical significance of this finding is unclear.

Likelihood Possible Evidence D
Organic Cordyceps militaris mushroom extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for MYcoMune, from the product label.

Pure Essence MyPure

See all Pure Essence MyPure products
Name
Pure Essence Laboratories, Inc.
Street Address
P.O. Box 95397
City
Las Vegas
State
NV
ZipCode
89193
Web Address
www.pureessencelabs.com
Pharmacist Counseling Corner

MYcoMune by Pure Essence MyPure: Common Questions

Does MYcoMune by Pure Essence MyPure interact with any medications?
Yes. Based on its ingredients, MYcoMune has a known interaction with 662 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
MYcoMune contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on a blood thinner like warfarin?
Not without checking first. Three ingredients in this product may increase bleeding risk with blood thinners, and maitake has an actual case report of raising warfarin levels. Talk to your pharmacist before taking it alongside any blood thinner.
Will this help my brain health or memory?
The evidence for lion's mane and the other mushrooms in this product for conditions like Alzheimer's disease, cognitive function, and cognitive impairment is rated insufficient — meaning we don't have enough reliable research to say whether they work. Your pharmacist can discuss whether the current evidence supports taking it for that goal.
What side effects might I experience?
Gastrointestinal discomfort is most common — stomach upset, diarrhea, constipation, nausea, bloating, or dry mouth. These tend to be mild. Taking the product with food may help. One rare concern is chaga's high oxalate content, which in excessive amounts can stress the kidneys.
Is this safe during pregnancy?
No — not enough safety data exists for five of the six ingredients during pregnancy, so the safety data advises against use. Talk with your doctor or pharmacist about whether there's a safer option for what you're looking for.
Can I take this with my diabetes medication?
Maybe — but check first. Lion's mane and maitake may lower blood sugar further, raising the risk of low blood sugar. Maitake has shown this effect in actual patients. Your pharmacist can help you decide if it's safe for your specific drugs and dose.
Does this contain any fillers or other ingredients besides the mushrooms?
Yes — the capsule contains HPMC, which is an inactive ingredient. Otherwise the six active ingredients are cordyceps, lion's mane, maitake, royal red reishi, chaga, and shiitake mushroom extracts.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if MYcoMune is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

MYcoMune label
Go deeper

The Full Monographs Behind MYcoMune’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Cordyceps

Interacts with 249 drugs

Cordyceps is a fungus used in traditional Chinese medicine for energy, exercise performance, and lung and immune support. Human research is limited and mostly low quality, so its benefits ar...

Read the full Cordyceps monograph → Herb & supplement monograph

Lion's Mane Mushroom

Interacts with 327 drugs

Lion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and early. It is generally well tolerated as...

Read the full Lion's Mane Mushroom monograph → Herb & supplement monograph

Maitake Mushroom

Interacts with 260 drugs

Maitake is an edible mushroom long used as food and in traditional Japanese medicine, and it is being studied for possible immune, blood sugar, and blood pressure effects. The human evidence...

Read the full Maitake Mushroom monograph → Herb & supplement monograph

Chaga

Interacts with 327 drugs

Chaga is a fungus that grows mostly on birch trees and is used as a tea or supplement, mainly for immune and antioxidant support. Human evidence for its benefits is very limited, and it may...

Read the full Chaga monograph → Herb & supplement monograph

Shiitake Mushroom

Interacts with 312 drugs

Shiitake is a popular edible mushroom that is nutritious and safe to eat as food for most people. Some of its extracts (like lentinan and AHCC) have been studied as immune support, mainly al...

Read the full Shiitake Mushroom monograph →
Sources

Sources & How We Checked

MYcoMune's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 104 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Cordyceps 14 references
  1. Zhu JS, Halpern GM, Jones K. The scientific rediscovery of an ancient Chinese herbal medicine: Cordyceps sinensis: part I. J Altern Complement Med 1998;4:289-303.
  2. Zhu JS, Halpern GM, Jones K. The scientific rediscovery of a precious ancient Chinese herbal regimen: Cordyceps sinensis: part II. J Altern Complement Med 1998;4:429-57.
  3. Chen YJ, Shiao MS, Lee SS, Wang SY. Effect of Cordyceps sinensis on the proliferation and differentiation of human leukemic U937 cells. Life Sci 1997;60:2349-59. PubMed
  4. Zhao Y. [Inhibitory effects of alcoholic extract of Cordyceps sinensis on abdominal aortic thrombus formation in rabbits]. Chung Hua I Hsueh Tsa Chih (Taipei) 1991;71:612-5, 42.
  5. Chen GZ, Chen GL, Sun T, et al. Effects of Cordyceps sinensis on murine T lymphocyte subsets. Chin Med J (English) 1991;104:4-8.
  6. Zhu XY, Yu HY. [Immunosuppressive effect of cultured Cordyceps sinensis on cellular immune response]. Chung Hsi I Chieh Ho Tsa Chih 1990;10:485-7, 454.
  7. Hsu, C. C., Huang, Y. L., Tsai, S. J., Sheu, C. C., and Huang, B. M. In vivo and in vitro stimulatory effects of Cordyceps sinensis on testosterone production in mouse Leydig cells. Life Sci 9-5-2003;73(16):2127-2136. PubMed
  8. Ikumoto, T., Sasaki, S., Namba, H., Toyama, R., Moritoki, H., and Mouri, T. [Physiologically active compounds in the extracts from tochukaso and cultured mycelia of Cordyceps and Isaria]. Yakugaku Zasshi 1991;111(9):504-509. PubMed
  9. Wu, T. N., Yang, K. C., Wang, C. M., Lai, J. S., Ko, K. N., Chang, P. Y., and Liou, S. H. Lead poisoning caused by contaminated Cordyceps, a Chinese herbal medicine: two case reports. Sci.Total Environ. 4-5-1996;182(1-3):193-195. PubMed
  10. Hong T, Zhang M, Fan J. Cordyceps sinensis (a traditional Chinese medicine) for kidney transplant recipients (Review). Cochrane Database Syst Rev. 2015;(10):CD009698. doi: 10.1002/14651858.CD009698.pub2.
  11. Zhang HW, Lin ZX, Tung YS, Kwan TH, Mok CK, Leung C, Chan LS. Cordyceps sinensis (a traditional Chinese medicine) for treating chronic kidney disease (Review). Cochrane Database Syst Rev. 2014;(12):CD008353. doi: 10.1002/14651858.CD008353.pub2. PubMed
  12. Bee Yean O, Zoriah A. Efficacy of Cordyceps sinensis as an adjunctive treatment in hemodialysis patients: a systematic review and Meta-analysis. J Tradit Chin Med. 2019;39(1):1-14.
  13. Thurian D, Montani M, Stickel F. Drug-induced, mixed-type hepatitis following ingestion of Cordyceps sinensis. Int J Clin Pharmacol Ther 2022;60(2):115-120. PubMed
  14. Yu X, Mao Y, Shergis JL, et al. Effectiveness and safety of oral Cordyceps sinensis on stable COPD of GOLD stages 2-3: Systematic review and meta-analysis. Evid Based Complement Alternat Med. 2019;2019:4903671.

See these in context on the Cordyceps monograph →

Lion's Mane Mushroom 6 references
  1. Product information for <em>Niaspan</em>. Abbott Laboratories. North Chicago, IL 60064. April 2015.
  2. Liang B, Guo Z, Xie F, Zhao A. Antihyperglycemic and antihyperlipidemic activities of aqueous extract of Hericium erinaceus in experimental diabetic rats. BMC Complement Altern Med. 2013;13:253. PubMed
  3. Mori K, Inatomi S, Ouchi K, Azumi Y, Tuchida T. Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. Phytother Res. 2009;23(3):367-72.
  4. Mori K, Kikuchi H, Obara Y, et al. Inhibitory effect of hericenone B from Hericium erinaceus on collagen-induced platelet aggregation. Phytomedicine. 2010;17(14):1082-5. PubMed
  5. Li IC, Chang HH, Lin CH, et al. Prevention of early Alzheimer's disease by erinacine A-enriched Hericium erinaceus mycelia pilot double-blind placebo-controlled study. Front Aging Neurosci 2020 Jun 3;12:155. doi: 10.3389/fnagi.2020.00155. PubMed
  6. Tian B, Liu R, Xu T, et al. Modulating effects of Hericium erinaceus polysaccharides on the immune response by regulating gut microbiota in cyclophosphamide-treated mice. J Sci Food Agric 2023;103(6):3050-3064.

See these in context on the Lion's Mane Mushroom monograph →

Maitake Mushroom 8 references
  1. Kabir Y, Kimura S. Dietary mushrooms reduce blood pressure in spontaneously hypertensive rats (SHR). J Nutr Sci Vitaminol (Tokyo) 1989;35:91-4. PubMed
  2. Kabir Y, Yamaguchi M, Kimura S. Effect of shiitake (Lentinus edodes) and maitake (Grifola frondosa) mushrooms on blood pressure and plasma lipids of spontaneously hypertensive rats. J Nutr Sci Vitaminol (Tokyo) 1987;33:341-6. PubMed
  3. Konno S, Tortorelis DG, Fullerton SA, et al. A possible hypoglycaemic effect of maitake mushroom on Type 2 diabetic patients. Diabet Med 2001;18:1010. PubMed
  4. Chen JT, Tominaga K, Sato Y, et al. Maitake mushroom (Grifola frondosa) extract induces ovulation in patients with polycystic ovary syndrome: a possible monotherapy and a combination therapy after failure with first-line clomiphene citrate. J Altern Compl
  5. Hanselin MR, Vande Griend JP, Linnebur SA. INR elevation with maitake extract in combination with warfarin. Ann Pharmacother 2010;44:223-4. PubMed
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