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Dietary supplement

Nattozimes 65 mg Ingredients & Drug Interactions

by Swanson

Nattozimes 65 mg label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Nattozimes 65 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Nattozimes 65 mg is a dietary supplement by Swanson with 1 active ingredient. Its ingredients are commonly taken for heart and circulatory health, blood clot prevention, high blood pressure.Based on those ingredients, 289 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Nattozimes. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Nattozimes 65 mg by Swanson

Ask about any prescription or over-the-counter medication and we check it for interactions with Nattozimes 65 mg by Swanson — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Nattozimes 65 mg by Swanson

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Nattozimes contains one active ingredient: nattokinase, a fibrinolytic enzyme—a protein that breaks down clots—derived from natto (fermented soybean). It comes in a capsule with inactive ingredients including rice bran, hypromellose, dextrin, maltodextrin, and medium chain triglyceride powder.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Nattokinase's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Promotes healthy circulation and cardiovascular health.
  • We looked for evidence on: Cardiovascular disease (CVD), Hypertension, Hyperlipidemia, Atherosclerosis, Peripheral arterial disease (PAD), Venous insufficiency — and 4 related terms.
  • The closest evidence on file: Nattokinase is rated "Insufficient Reliable Evidence To Rate" for Angina (Natural Medicines).
  • Also on file: Nattokinase is rated "Insufficient Reliable Evidence To Rate" for Atherosclerosis, Cardiovascular disease (CVD), Hyperlipidemia, Hypertension, and more.

The evidence for nattokinase is not established in the data we hold. We don't have reliable evidence to rate its effectiveness for angina, atherosclerosis, cancer, cardiovascular disease, or chronic fatigue syndrome.

If you're considering it for a specific condition, talk with us about what the current research actually shows.

The evidence, ingredient by ingredient Nattokinase

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Nattokinase is generally well tolerated in short-term use, but its blood-thinning effect means you need to be careful if you have any bleeding risk—including if you're already on blood thinners or aspirin. Rare cases of severe bleeding, including brain hemorrhage, have been reported.

Some people may also have hypersensitivity reactions to natto or nattokinase itself, with symptoms like throat or larynx swelling occurring within two hours of taking it. The safety data advises against nattokinase during pregnancy.

Safety while breastfeeding is unknown, so avoid it while nursing. If you're pregnant, planning to become pregnant, or nursing, talk with your pharmacist or doctor before considering this supplement.

Side effects, ingredient by ingredient Nattokinase

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Nattokinase.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 289 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take Nattozimes, check with us if you're on blood thinners or antiplatelet drugs (like warfarin, apixaban, dabigatran, rivaroxaban, clopidogrel, or aspirin)—nattokinase raises bleeding risk with these. Also check if you take blood pressure medications (antihypertensives), as nattokinase may lower your pressure further.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Nattokinase is intended for people interested in cardiovascular support, but the evidence backing that isn't clear. If you take any blood thinner, antiplatelet drug like aspirin, or blood pressure medication, this product requires careful checking first—the bleeding risk is real.

Anyone with a bleeding disorder or sensitivity to soy should also check with us before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Nattozimes 65 mg, straight from the product label.

Brand Swanson
Barcode (UPC) 087614022581
Net contents 90 Veggie Capsule(s)
Market status On market
Date entered into DSLD Nov 22, 2024
DSLD ID 322738
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Nattozimes 65 mg by Swanson, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Veggie Capsule(s)
Maximum serving Sizes:
1 Veggie Capsule(s)
Servings per container
90
UPC/BARCODE
087614022581
IngredientAmount% DV
Nattozimes65 mg--

Other ingredients: Rice Bran, Hypromellose, Dextrin, Maltodextrin, Medium Chain Triglyceride, Powder

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Promotes healthy circulation function Supports cardiovascular health Science-backed quality since 1969

Cardiovascular health

General Statements

Inspired by the popular Japanese food, natto

Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement, take one veggie capsule one to two times per day with water on an empty stomach at least two hours before or after a meal. Start with one veggie capsule per day for the first 10 days. Take two veggie capsules per day thereafter.

Precautions

Do not exceed three veggie capsules per day.

Warning: For adults only.

Do not use if you have a blood coagulation disorder and/or if you are taking any drug that affects blood coagulation such as prescription vitamin k, heparin or warfarin (coumadin). Consult your healthcare provider before use if you are taking prescription medications or if you are pregnant or nursing.

Keep out of reach of children.

Do not use if seal is broken.

Brand IP Statement(s)

Nattozimes is a registered trademark of Deerland Probiotics & Enzymes, Inc.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formula

Nattozimes 65 mg per capsule 2,275 FU

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Nattozimes 65 mg by Swanson label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Nattozimes 65 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Nattozimes 65 mg by Swanson

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Veggie Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

Nattozimes

Interacts with
289 drugs
65 mg per serving Form: Endoprotease, Exoprotease

Nattokinase is an enzyme from the fermented soybean food natto that may have mild blood-thinning and blood-flow effects. Some small studies hint at be...

Nattozimes monograph & interactions

Other (inactive) ingredients: Rice Bran, Hypromellose, Dextrin, Maltodextrin, Medium Chain Triglyceride, Powder. These complete the product’s ingredient list but are not active constituents.

Interaction report

Nattozimes 65 mg by Swanson Drug Interactions

Want to check YOUR meds against Nattozimes 65 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
289Drugs
289 Moderate

Ingredients driving the most interactions

Nattozimes 289

Individual Drug Interactions

The ingredients in Nattozimes 65 mg interact with 289 drugs. Click any drug to see the details.

1 of the 1 ingredient in Nattozimes 65 mg interact with drugs. Each result below shows which ingredient is responsible. Nattozimes

Each ingredient & the kinds of drugs it affects

For each ingredient in Nattozimes 65 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Nattozimes2 drug types · 289 drugs

Anticoagulant/Antiplatelet Drugs

Nattokinase might increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
Nattokinase has thrombolytic and anticoagulant effects. There is a case report of intracranial hemorrhage in a patient who added nattokinase to aspirin therapy.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, nattokinase might increase the risk of hypotension when used with antihypertensive drugs.
Some clinical research suggests that nattokinase may reduce systolic and diastolic blood pressure.

Likelihood Possible Evidence D
Nattozimes full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Nattozimes 65 mg, from the product label.

Swanson

See all Swanson products
Name
Swanson Health Products
City
Fargo
State
ND
ZipCode
58104
Phone Number
1-800-437-4148
Web Address
swanson.com
Pharmacist Counseling Corner

Nattozimes 65 mg by Swanson: Common Questions

Does Nattozimes 65 mg by Swanson interact with any medications?
Yes. Based on its ingredients, Nattozimes 65 mg has a known interaction with 289 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Nattozimes 65 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on aspirin?
No, not without checking with your pharmacist first. There's a documented case of serious brain bleeding when someone combined nattokinase with aspirin. Both thin the blood, and together they may increase bleeding risk too much.
Is nattokinase safe during pregnancy?
No. The safety data advises against it during pregnancy. If you're pregnant or planning to become pregnant, talk with your doctor or pharmacist before considering this product.
What is nattokinase and where does it come from?
Nattokinase is an enzyme extracted from natto, a traditional Japanese fermented soybean food. It works as a fibrinolytic—it can break down blood clots.
Can I take this while breastfeeding?
Safety while breastfeeding is unknown, so it's best to avoid it while nursing. Talk with your pharmacist or doctor for personalized advice.
What side effects should I watch for?
Nattokinase is generally well tolerated short-term, but rare cases of bleeding—including severe brain bleeding—have been reported. Some people also have hypersensitivity reactions to natto, with throat or throat swelling within two hours of taking it. If you have a history of bleeding or sensitivity to soy, mention that to us.
Does nattokinase actually work for heart health?
The evidence we have isn't clear enough to say. We don't have reliable data on nattokinase for angina, atherosclerosis, cardiovascular disease, or other conditions. If you're curious about what research does exist, ask us about it.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Nattozimes 65 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Nattozimes 65 mg label
Go deeper

The Full Monographs Behind Nattozimes 65 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Nattokinase

Interacts with 289 drugs

Nattokinase is an enzyme from the fermented soybean food natto that may have mild blood-thinning and blood-flow effects. Some small studies hint at benefits for blood pressure and circulatio...

Read the full Nattokinase monograph →
Sources

Sources & How We Checked

Nattozimes 65 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 9 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Nattokinase 9 references
  1. Suzuki Y, Kondo K, Matsumoto Y, et al. Dietary supplementation of fermented soybean, natto, suppresses intimal thickening and modulates the lysis of mural thrombi after endothelial injury in rat femoral artery. Life Sci 2003;73:1289-98.. PubMed
  2. Sumi H, Hamada H, Nakanishi K, Hiratani H. Enchancement of fibrinolytic activity in plasma by oral administration of nattokinase. Acta Haematol 1990;84:139-43.
  3. Chang, Y. Y., Liu, J. S., Lai, S. L., Wu, H. S., and Lan, M. Y. Cerebellar hemorrhage provoked by combined use of nattokinase and aspirin in a patient with cerebral microbleeds. Intern Med 2008;47(5):467-469. PubMed
  4. Kim, J. Y., Gum, S. N., Paik, J. K., Lim, H. H., Kim, K. C., Ogasawara, K., Inoue, K., Park, S., Jang, Y., and Lee, J. H. Effects of nattokinase on blood pressure: a randomized, controlled trial. Hypertens.Res 2008;31(8):1583-1588. PubMed
  5. <p>Maruyama M, Sumi H (eds): Effect of natto diet on blood pressure, in Basic and Clinical Aspects of Japanese Traditional Food Natto II. Japan Technology Transfer Association (JTTAS), 1998, pp 1–3.</p>
  6. Kurosawa Y, Nirengi S, Homma T, et al. A single-dose of oral nattokinase potentiates thrombolysis and anti-coagulation profiles. Sci Rep 2015;5:11601. PubMed
  7. Ramachandran L, Aqeel A, Jafri A, Sidhu Y, Mohamed Djirdeh T. Nattokinase-associated hemoperitoneum in an elderly woman. Cureus 2021;13(12):e20074. PubMed
  8. Awatani-Yoshidome K, Hashimoto T, Satoh T. Anaphylaxis from nattokinase in a patient with fermented soybean (natto) allergy. Allergol Int 2022;71(1):153-4. PubMed
  9. Suzuki K, Nakamura M, Sato N, Futamura K, Matsunaga K, Yagami A. Nattokinase, a subtilisin family serine protease, is a novel allergen contained in the traditional Japanese fermented food natto. Allergol Int 2022.

See these in context on the Nattokinase monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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