Curaphen Ingredients & Drug Interactions
by EuroMedica
What is this page for?
First and foremost: checking Curaphen against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Curaphen is a dietary supplement by EuroMedica with 4 active ingredients. Its ingredients are commonly taken for heart and circulatory health, blood clot prevention, high blood pressure.Based on those ingredients, 1,126 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Boswellia serrata Gum Resin Extract, Nattokinase. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Curaphen by EuroMedica
Ask about any prescription or over-the-counter medication and we check it for interactions with Curaphen by EuroMedica — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Curaphen by EuroMedica
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
Curaphen contains four active ingredients designed to support inflammatory response and circulation. Nattokinase is a fibrin-digesting enzyme from fermented soybeans; DL-Phenylalanine is an amino acid; Boswellia serrata gum resin extract comes from frankincense tree resin; and BCM-95 Curcugreen is a form of curcumin from turmeric.
The capsules also hold inactive ingredients — hydroxypropyl methylcellulose, magnesium stearate, and silica — which serve as binders and flow agents.
Does it work?
Moderate evidence
Boswellia serrata in this product is rated possibly effective for osteoarthritis, meaning there's some clinical support for its use in that condition. For the other indications in Boswellia's data — hay fever, Alzheimer disease, asthma, and cluster headache — evidence is insufficient to rate it.
We hold no effectiveness data in our monographs for nattokinase, DL-Phenylalanine, or BCM-95 Curcugreen.
How safe is it?
Well-documented data
Nattokinase is generally well tolerated short-term, but because of its blood-thinning effects, it carries caution for anyone with a bleeding risk or history of hemorrhage. The safety data advises against nattokinase in pregnancy and while breastfeeding.
Boswellia serrata is generally well tolerated orally; the most common side effects are abdominal pain, diarrhea, headache, heartburn, itching, and nausea. Rarely, large amounts can form a bezoar (intestinal blockage).
Like nattokinase, Boswellia is best avoided during pregnancy and breastfeeding due to insufficient safety data. Quality and dose vary widely among Boswellia products.
Meds to double-check
Moderate interaction found
Before you start Curaphen, double-check if you're on blood thinners or antiplatelet drugs (like aspirin or warfarin), blood pressure medications, or any drugs metabolized by your liver's CYP2D6, CYP2C19, CYP1A2, CYP2C9, or CYP3A4 pathways — Moderate interactions are documented with all of these. Also check if you take immunosuppressants.
Use the tool on this page to verify your exact medications.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Curaphen is designed for people interested in supporting joint and cardiovascular health with natural enzymes and plant extracts. If you take blood thinners, blood pressure medications, or drugs that rely on liver metabolism for clearance, you'll need to check with your pharmacist first — the interactions are real.
Pregnant or breastfeeding? Talk to your doctor or pharmacist before taking it.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 23, 2024.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Curaphen, straight from the product label.
| Brand | EuroMedica |
|---|---|
| Barcode (UPC) | 367703602604 |
| Net contents | 60 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Apr 23, 2024 |
| DSLD ID | 309461 |
| Product type | Other Combinations |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Halal, Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Curaphen by EuroMedica, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Calories | 5 Calorie(s) | -- |
| Nattokinase | 0 NP | -- |
| DL-Phenylalanine | 0 NP | -- |
| Proprietary Complex | 727 mg | -- |
| BCM-95 Curcugreen | 0 NP | -- |
| Boswellia serrata Gum Resin Extract | 0 NP | -- |
Other ingredients: Hydroxypropyl Methylcellulose, Magnesium Stearate, Silica
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
Curaphen is for pain relief. Occasional muscle pain due to exercise or overuse. This unique and proprietary formula supports healthy endorphin/enkephalin activity, and healthy circulation.
Professional pain formula Safe and effective All ingredients established in human studies for safety and effectiveness. Does not interfere with stomach, liver or kidney function.
Vegan
Non-GMO
No sugar, salt, yeast, wheat, gluten, corn, dairy products, artificial coloring, artificial flavoring, or artificial preservatives.
Color variations are normal.
Formula
Our clinically studied curcumin has better absorption than turmeric and a uniquely standardized boswellia features up to 10 times higher levels of beneficial AKBA than plain boswellia.
Clinically studied Curcumin and Boswellia
H Halal
CRC Kosher 328
Suggested/Recommended/Usage/Directions
Recommendations: One capsule three times daily, or as directed by your healthcare practitioner.
Precautions
If pregnant or nursing, consult a healthcare practitioner before use.
Contains Soy (less than 5 parts per million)
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
FDA Statement of Identity
Dietary Supplement
Seals/Symbols
H Halal CRC Kosher 328
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Curaphen by EuroMedica label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Curaphen by EuroMedica
These are the 4 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Proprietary Complex
- › Nattokinase
- › DL-Phenylalanine
- › BCM-95 Curcugreen
- › Boswellia serrata Gum Resin Extract
Other (inactive) ingredients: Hydroxypropyl Methylcellulose, Magnesium Stearate, Silica. These complete the product’s ingredient list but are not active constituents.
Curaphen by EuroMedica Drug Interactions
HelloPharmacist Interaction Report
Curaphen by EuroMedica contains two ingredients with documented interactions with medications.
Nattokinase, the primary concern, carries a Moderate risk with blood thinners (anticoagulant/antiplatelet drugs) like aspirin and warfarin — it has thrombolytic and anticoagulant effects of its own, and there's a case report of brain bleeding in someone who combined it with low-dose aspirin. Nattokinase also poses a Moderate risk with blood pressure medications (antihypertensive drugs), since it may lower blood pressure further.
Read the full breakdown — every affected drug type, severity by severity
Boswellia serrata gum resin interacts with several drug types through liver metabolism pathways. It may raise levels of drugs broken down by CYP2D6, CYP2C19, CYP1A2, CYP2C9, and CYP3A4 enzymes — all Moderate severity — potentially making those medications stronger.
Boswellia serrata may also theoretically alter how immunosuppressant drugs work (Moderate severity). We could not check two ingredients in this product: DL-Phenylalanine and BCM-95 Curcugreen.
Altogether, these interactions span 1,112 individual medications.
Use the medication checker on this page to look up your exact drugs before starting Curaphen.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Curaphen?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Curaphen interact with 1,126 drugs. Click any drug to see the details.
2 of the 4 ingredients in Curaphen interact with drugs. Each result below shows which ingredient is responsible. Boswellia serrata Gum Resin Extract Nattokinase
6-mercaptopurinePurinethol
How 6-mercaptopurine interacts with Curaphen — through 1 ingredient. Tap an ingredient for the detail:
Boswellia Serrata Gum Resin ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, Boswellia serrata might alter the effects of immunosuppressive drugs.
Read the full Boswellia Serrata Gum Resin Extract + 6-mercaptopurine interactionAdo-trastuzumab EmtansineKadcyla
How Ado-trastuzumab Emtansine interacts with Curaphen — through 1 ingredient. Tap an ingredient for the detail:
Boswellia Serrata Gum Resin ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase or decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Boswellia Serrata Gum Resin Extract + Ado-trastuzumab Emtansine interactionAbciximabReoPro
How Abciximab interacts with Curaphen — through 1 ingredient. Tap an ingredient for the detail:
NattokinaseAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Nattokinase might increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
Read the full Nattokinase + Abciximab interactionAbemaciclibVerzenio
How Abemaciclib interacts with Curaphen — through 1 ingredient. Tap an ingredient for the detail:
Boswellia Serrata Gum Resin ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase or decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Boswellia Serrata Gum Resin Extract + Abemaciclib interactionAbiraterone
How Abiraterone interacts with Curaphen — through 1 ingredient. Tap an ingredient for the detail:
Boswellia Serrata Gum Resin ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase or decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Boswellia Serrata Gum Resin Extract + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with Curaphen — through 1 ingredient. Tap an ingredient for the detail:
Boswellia Serrata Gum Resin ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase or decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Boswellia Serrata Gum Resin Extract + Abiraterone Acetate interactionAbrocitinibCibinqo
How Abrocitinib interacts with Curaphen — through 2 ingredients. Tap an ingredient for the detail:
Boswellia Serrata Gum Resin ExtractImmunosuppressants, Cytochrome P450 2c9 (cyp2c9) Substrates +1 Moderate
Interaction Summary
Theoretically, Boswellia serrata might alter the effects of immunosuppressive drugs.
Read the full Boswellia Serrata Gum Resin Extract + Abrocitinib interactionNattokinaseAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Nattokinase might increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
Read the full Nattokinase + Abrocitinib interactionAcalabrutinibCalquence
How Acalabrutinib interacts with Curaphen — through 1 ingredient. Tap an ingredient for the detail:
Boswellia Serrata Gum Resin ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase or decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Boswellia Serrata Gum Resin Extract + Acalabrutinib interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Curaphen — through 1 ingredient. Tap an ingredient for the detail:
NattokinaseAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, nattokinase might increase the risk of hypotension when used with antihypertensive drugs.
Read the full Nattokinase + Acebutolol interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Curaphen — through 1 ingredient. Tap an ingredient for the detail:
NattokinaseAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Nattokinase might increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
Read the full Nattokinase + Acenocoumarol interactionAcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength
How Acetaminophen interacts with Curaphen — through 1 ingredient. Tap an ingredient for the detail:
Boswellia Serrata Gum Resin ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase the levels of CYP1A2 substrates.
Read the full Boswellia Serrata Gum Resin Extract + Acetaminophen interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Curaphen — through 2 ingredients. Tap an ingredient for the detail:
Boswellia Serrata Gum Resin ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase the levels of CYP1A2 substrates.
Read the full Boswellia Serrata Gum Resin Extract + Acetaminophen, Aspirin interactionNattokinaseAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Nattokinase might increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
Read the full Nattokinase + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Curaphen — through 2 ingredients. Tap an ingredient for the detail:
NattokinaseAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Nattokinase might increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
Read the full Nattokinase + Acetaminophen, Aspirin, Caffeine interactionBoswellia Serrata Gum Resin ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase the levels of CYP1A2 substrates.
Read the full Boswellia Serrata Gum Resin Extract + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with Curaphen — through 1 ingredient. Tap an ingredient for the detail:
Boswellia Serrata Gum Resin ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase the levels of CYP1A2 substrates.
Read the full Boswellia Serrata Gum Resin Extract + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more
How Acetaminophen, Butalbital interacts with Curaphen — through 1 ingredient. Tap an ingredient for the detail:
Boswellia Serrata Gum Resin ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase the levels of CYP1A2 substrates.
Read the full Boswellia Serrata Gum Resin Extract + Acetaminophen, Butalbital interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Curaphen — through 1 ingredient. Tap an ingredient for the detail:
Boswellia Serrata Gum Resin ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase the levels of CYP1A2 substrates.
Read the full Boswellia Serrata Gum Resin Extract + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Curaphen — through 1 ingredient. Tap an ingredient for the detail:
Boswellia Serrata Gum Resin ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase or decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Boswellia Serrata Gum Resin Extract + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Curaphen — through 1 ingredient. Tap an ingredient for the detail:
Boswellia Serrata Gum Resin ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase the levels of CYP1A2 substrates.
Read the full Boswellia Serrata Gum Resin Extract + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Curaphen — through 1 ingredient. Tap an ingredient for the detail:
Boswellia Serrata Gum Resin ExtractCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase the levels of CYP2D6 substrates.
Read the full Boswellia Serrata Gum Resin Extract + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Curaphen — through 1 ingredient. Tap an ingredient for the detail:
Boswellia Serrata Gum Resin ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase the levels of CYP1A2 substrates.
Read the full Boswellia Serrata Gum Resin Extract + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Curaphen — through 1 ingredient. Tap an ingredient for the detail:
Boswellia Serrata Gum Resin ExtractCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase the levels of CYP2D6 substrates.
Read the full Boswellia Serrata Gum Resin Extract + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Curaphen — through 1 ingredient. Tap an ingredient for the detail:
Boswellia Serrata Gum Resin ExtractCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase the levels of CYP2D6 substrates.
Read the full Boswellia Serrata Gum Resin Extract + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Curaphen — through 1 ingredient. Tap an ingredient for the detail:
Boswellia Serrata Gum Resin ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase the levels of CYP1A2 substrates.
Read the full Boswellia Serrata Gum Resin Extract + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Curaphen — through 1 ingredient. Tap an ingredient for the detail:
Boswellia Serrata Gum Resin ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase or decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Boswellia Serrata Gum Resin Extract + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Curaphen — through 1 ingredient. Tap an ingredient for the detail:
Boswellia Serrata Gum Resin ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase the levels of CYP1A2 substrates.
Read the full Boswellia Serrata Gum Resin Extract + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Curaphen — through 1 ingredient. Tap an ingredient for the detail:
Boswellia Serrata Gum Resin ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase the levels of CYP1A2 substrates.
Read the full Boswellia Serrata Gum Resin Extract + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Curaphen — through 1 ingredient. Tap an ingredient for the detail:
Boswellia Serrata Gum Resin ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase the levels of CYP1A2 substrates.
Read the full Boswellia Serrata Gum Resin Extract + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Curaphen — through 1 ingredient. Tap an ingredient for the detail:
Boswellia Serrata Gum Resin ExtractCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase the levels of CYP2D6 substrates.
Read the full Boswellia Serrata Gum Resin Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with Curaphen — through 1 ingredient. Tap an ingredient for the detail:
Boswellia Serrata Gum Resin ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase or decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Boswellia Serrata Gum Resin Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with Curaphen — through 1 ingredient. Tap an ingredient for the detail:
Boswellia Serrata Gum Resin ExtractCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase the levels of CYP2D6 substrates.
Read the full Boswellia Serrata Gum Resin Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Curaphen with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Boswellia serrata Gum Resin Extract
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, Boswellia serrata might increase the levels of CYP1A2 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP1A2 enzymes.
Cytochrome P450 2C19 (Cyp2C19) Substrates
Theoretically, Boswellia serrata might increase the levels of CYP2C19 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP2C19 enzymes.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, Boswellia serrata might increase the levels of CYP2C9 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP2C9 enzymes.
Cytochrome P450 2D6 (Cyp2D6) Substrates
Theoretically, Boswellia serrata might increase the levels of CYP2D6 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP2D6 enzymes.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, Boswellia serrata might increase or decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP3A4 enzymes. Other in vitro research shows that Boswellia serrata extract inhibits CYP3A4 enzymes at most concentrations, although it may modestly induce enzyme activity at low concentrations.
Immunosuppressants
Theoretically, Boswellia serrata might alter the effects of immunosuppressive drugs.
Some in vitro research suggests that Boswellia serrata extracts might inhibit mediators of autoimmune disorders such as leukotrienes and reduce production of antibodies and cell-mediated immunity. However, other in vitro research suggests that, when coupled with calcium ions, boswellic acids containing the keto group have immunostimulant properties within specific cell signaling pathways.
Nattokinase
Anticoagulant/Antiplatelet Drugs
Nattokinase might increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
Nattokinase has thrombolytic and anticoagulant effects. There is a case report of intracranial hemorrhage in a patient who added nattokinase to aspirin therapy.
Antihypertensive Drugs
Theoretically, nattokinase might increase the risk of hypotension when used with antihypertensive drugs.
Some clinical research suggests that nattokinase may reduce systolic and diastolic blood pressure.
Brand information
Manufacturer and brand details for Curaphen, from the product label.
EuroMedica
See all EuroMedica products- Name
- EuroMedica
- Street Address
- 955 Challenger Dr
- City
- Green Bay
- State
- WI
- ZipCode
- 54311
- Phone Number
- 866-842-7256
- Web Address
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Curaphen by EuroMedica: Common Questions
Does Curaphen by EuroMedica interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Does Curaphen have nattokinase, and will it thin my blood?
Can I take Curaphen if I'm pregnant or breastfeeding?
What are the common side effects of Boswellia in this product?
Will Curaphen work for arthritis?
Why do I need to check my medications before taking Curaphen?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Curaphen’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Nattokinase
Interacts with 289 drugsNattokinase is an enzyme from the fermented soybean food natto that may have mild blood-thinning and blood-flow effects. Some small studies hint at benefits for blood pressure and circulatio...
Read the full Nattokinase monograph → Herb & supplement monographBoswellia Serrata
Interacts with 952 drugsBoswellia serrata is a tree resin used in traditional medicine, mainly for joint pain and inflammation. Some studies suggest it may help with osteoarthritis symptoms, but the overall evidenc...
Read the full Boswellia Serrata monograph →Sources & How We Checked
Curaphen's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 25 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Nattokinase 9 references
- Suzuki Y, Kondo K, Matsumoto Y, et al. Dietary supplementation of fermented soybean, natto, suppresses intimal thickening and modulates the lysis of mural thrombi after endothelial injury in rat femoral artery. Life Sci 2003;73:1289-98.. PubMed
- Sumi H, Hamada H, Nakanishi K, Hiratani H. Enchancement of fibrinolytic activity in plasma by oral administration of nattokinase. Acta Haematol 1990;84:139-43.
- Chang, Y. Y., Liu, J. S., Lai, S. L., Wu, H. S., and Lan, M. Y. Cerebellar hemorrhage provoked by combined use of nattokinase and aspirin in a patient with cerebral microbleeds. Intern Med 2008;47(5):467-469. PubMed
- Kim, J. Y., Gum, S. N., Paik, J. K., Lim, H. H., Kim, K. C., Ogasawara, K., Inoue, K., Park, S., Jang, Y., and Lee, J. H. Effects of nattokinase on blood pressure: a randomized, controlled trial. Hypertens.Res 2008;31(8):1583-1588. PubMed
- <p>Maruyama M, Sumi H (eds): Effect of natto diet on blood pressure, in Basic and Clinical Aspects of Japanese Traditional Food Natto II. Japan Technology Transfer Association (JTTAS), 1998, pp 1–3.</p>
- Kurosawa Y, Nirengi S, Homma T, et al. A single-dose of oral nattokinase potentiates thrombolysis and anti-coagulation profiles. Sci Rep 2015;5:11601. PubMed
- Ramachandran L, Aqeel A, Jafri A, Sidhu Y, Mohamed Djirdeh T. Nattokinase-associated hemoperitoneum in an elderly woman. Cureus 2021;13(12):e20074. PubMed
- Awatani-Yoshidome K, Hashimoto T, Satoh T. Anaphylaxis from nattokinase in a patient with fermented soybean (natto) allergy. Allergol Int 2022;71(1):153-4. PubMed
- Suzuki K, Nakamura M, Sato N, Futamura K, Matsunaga K, Yagami A. Nattokinase, a subtilisin family serine protease, is a novel allergen contained in the traditional Japanese fermented food natto. Allergol Int 2022.
Boswellia Serrata 16 references
- Gupta I, Gupta V, Parihar A, et al. Effects of Boswellia serrata gum resin in patients with bronchial asthma: results of a double-blind, placebo-controlled, 6-week clinical study. Eur J Med Res 1998;3:511-4.
- Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
- Kimmatkar N, Thawani V, Hingorani L, et al. Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee--a randomized double blind placebo controlled trial. Phytomedicine 2003;10:3-7. PubMed
- Liu JJ, Nilsson A, Oredsson S, et al. Boswellic acids trigger apoptosis via a pathway dependent on caspase-8 activation but independent on Fas/Fas ligand interaction in colon cancer HT-29 cells. Carcinogenesis 2002;23:2087-93. PubMed
- Wildfeuer A, Neu IS, Safayhi H, et al. Effects of boswellic acids extracted from a herbal medicine on the biosynthesis of leukotrienes and the course of experimental autoimmune encephalomyelitis. Arzneimittelforschung 1998;48:668-74.
- Gupta I, Parihar A, Malhotra P, et al. Effects of gum resin of Boswellia serrata in patients with chronic colitis. Planta Med 2001;67:391-5. PubMed
- Sengupta K, Alluri KV, Satish AR, et al. A double blind, randomized, placebo controlled study of the efficacy and safety of 5-Loxin. Arthritis Res Ther 2008;10:R85.
- Sengupta K, Krishnaraju AV, Vishal AA, et al. Comparative efficacy and tolerability of 5-Loxin and Aflapin against osteoarthritis of the knee: a double blind, randomized, placebo controlled clinical study. Int J Med Sci 2010;7:366-77.
- Ernst E. Frankincense: systematic review. BMJ 2008;337:a2813. PubMed
- Kirste S, Treier M, Wehrle SJ, et al. Boswellia serratea extract acts on cerebral edema in patients irradiated for brain tumors: a prospective, randomized, placebo-controlled, double-blind pilot trial. Cancer 2011;117:3788-95.
- Frank A, Unger M. Analysis of frankincense from various Boswellia species with inhibitory activity on human drug metabolising cytochrome P450 enzymes using liquid chromatography mass spectrometry after automated on-line extraction. J Chromatogr A 2006;111 PubMed
- Altmann A, Poeckel D, Fischer L, et al. Coupling of boswellic acid-incuded Ca2+ mobilisation and MAPK activation to lipid metabolism and peroxide formation in human leucocytes. Br J Pharmacol 2004;141:223-32.
- El Fortia, M., Badi, H., Elalem, Kh, Kadiki, O., and Topov, Y. Olibanum bezoar: complication of a traditional popular medicine. East Mediterr.Health J 2006;12(6):927-929.
- Meshkat S, Mahmoodi Baram S, Rajaei S, et al. Boswellia serrata extract shows cognitive benefits in a double-blind, randomized, placebo-controlled pilot clinical trial in individuals who suffered traumatic brain injury. Brain Inj 2022;36(4):553-559. PubMed
- Haron MH, Dale O, Martin K, et al. Evaluation of the Herb-Drug Interaction Potential of Commonly Used Botanicals on the US Market with Regard to PXR- and AhR-Mediated Influences on CYP3A4 and CYP1A2. J Diet Suppl 2022. PubMed
- Valente IVB, Garcia D, Abbott A, et al. The anti-proliferative effects of a frankincense extract in a window of opportunity phase ia clinical trial for patients with breast cancer. Breast Cancer Res Treat 2024;204(3):521-530. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC