Interactions on record — worth a quick check against your medications. Based on 1 of 5 ingredients. Check your meds →
Dietary supplement

Natura 401 Ingredients & Drug Interactions

by AN American Nutriceuticals

Natura 401 label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Natura 401 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Natura 401 is a dietary supplement by AN American Nutriceuticals with 5 active ingredients. Its ingredients are commonly taken for cough and chest congestion, constipation, diabetes (traditional use).Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Tian Hua Fen. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Natura 401 by AN American Nutriceuticals

Ask about any prescription or over-the-counter medication and we check it for interactions with Natura 401 by AN American Nutriceuticals — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Natura 401 by AN American Nutriceuticals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 5 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (250 mg) without saying how much of each component you get.

Natura 401 contains 5 ingredients, one of which is a proprietary blend. The checked ingredient we can name is Tian Hua Fen, also known as Chinese cucumber.

The other ingredients — Lu Xian Cao, Huang Yao Zi, Ku Shen, and Tu Fu Ling — are traditional herbs in this formula. The capsule itself is made from vegetable cellulose.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Chinese Cucumber product and its label doesn't state a use — see Chinese Cucumber's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The only effectiveness data we hold is for Tian Hua Fen (Chinese cucumber) and osteoarthritis, where the evidence is insufficient to establish a reliable rating. For the other ingredients in this product and any other potential uses, effectiveness isn't established in our data.

The evidence, ingredient by ingredient Chinese Cucumber

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Tian Hua Fen can cause mild diarrhea and stomach discomfort when taken by mouth. If you take unprocessed seed or root, the side effects are more serious — nausea, vomiting, and pain are possible.

The safety notes are clear: this ingredient must be avoided in pregnancy because it can cause miscarriage, and there isn't enough safety information to recommend it while breastfeeding. We have no safety data on file for the other ingredients in this blend.

Side effects, ingredient by ingredient Chinese Cucumber

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Chinese Cucumber.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take any antidiabetes drugs — insulin, metformin, sulfonylureas, or others that lower blood sugar — check with your pharmacist or doctor before starting this product. The Tian Hua Fen in it may strengthen that effect and cause your blood sugar to drop too far.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This is a traditional herbal blend with limited evidence on whether it works. If you take diabetes medication, you'll need to talk with your pharmacist or doctor first because one ingredient may lower your blood sugar.

Pregnant or breastfeeding? Skip this one — at least the Chinese cucumber component isn't safe.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 22, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Natura 401, straight from the product label.

Brand AN American Nutriceuticals
Barcode (UPC) 859658002344
Net contents 120 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD May 22, 2020
DSLD ID 219220
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Natura 401 by AN American Nutriceuticals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
120
UPC/BARCODE
859658002344
IngredientAmount% DV
Proprietary Blend250 mg--
Lu Xian Cao0 NP--
Tian Hua Fen0 NP--
Huang Yao Zi0 NP--
Ku Shen0 NP--
Tu Fu Ling0 NP--

Other ingredients: Vegetable Cellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use: Take 1 or more capsules daily on an empty stomach or as directed by your health care professional.

Precautions

Warning: Keep this food supplement out of children's reach.

Not intended for pregnant or nursing women.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General Statements

Please recycle

Professional series

Formulation

(no) BPA

Clinical strength

GMO-free, vegan, vegetarian

GMO-free, vegan, vegetarian

FDA Statement of Identity

Herbal Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Natura 401 by AN American Nutriceuticals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Natura 401 label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Natura 401 by AN American Nutriceuticals

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container120 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

250 mg per serving
  • › Lu Xian Cao
  • › Tian Hua Fen
  • › Huang Yao Zi
  • › Ku Shen
  • › Tu Fu Ling

Other (inactive) ingredients: Vegetable Cellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Natura 401 by AN American Nutriceuticals Drug Interactions

Want to check YOUR meds against Natura 401?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

Tian Hua Fen 86

Individual Drug Interactions

The ingredients in Natura 401 interact with 86 drugs. Click any drug to see the details.

1 of the 5 ingredients in Natura 401 interact with drugs. Each result below shows which ingredient is responsible. Tian Hua Fen

Each ingredient & the kinds of drugs it affects

For each ingredient in Natura 401 with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Tian Hua Fen1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, concomitant use of Chinese cucumber with antidiabetic drugs may have additive effects and adverse effects. Monitor blood glucose levels closely, dose adjustment may be needed.

Likelihood Possible Evidence D
Tian Hua Fen full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Natura 401, from the product label.

AN American Nutriceuticals

See all AN American Nutriceuticals products
Name
American Nutriceuticals
City
Vancouver
State
WA
ZipCode
98682
Phone Number
888-848-2548
Web Address
www.888vitality.com
Pharmacist Counseling Corner

Natura 401 by AN American Nutriceuticals: Common Questions

Does Natura 401 by AN American Nutriceuticals interact with any medications?
Yes. Based on its ingredients, Natura 401 has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Natura 401 contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or nursing?
No — Tian Hua Fen (Chinese cucumber), one of the main ingredients, can cause miscarriage and must be avoided in pregnancy. There isn't enough safety data to recommend it while breastfeeding either.
What does Chinese cucumber do in this formula?
We have insufficient evidence to say that it reliably helps with osteoarthritis or any other condition. It's a traditional ingredient, but the science on it is incomplete.
What side effects might I feel?
Mild diarrhea and stomach discomfort are possible from the Chinese cucumber. If the formula contains unprocessed seed or root (which we can't determine from the label), nausea, vomiting, and stomach pain are more likely.
What are Lu Xian Cao, Huang Yao Zi, and the others?
They're traditional herbs used in Chinese medicine, but we hold no interaction or safety data for them, so we can't tell you how they work or what to watch for.
Will this interact with my other supplements?
We only have data on this product's interactions with prescription and over-the-counter drugs, not other supplements. Run your exact medications and supplements through the checker on this page to be sure.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Natura 401 is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Natura 401 label
Go deeper

The Full Monographs Behind Natura 401’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Chinese Cucumber

Interacts with 86 drugs

Chinese cucumber (Trichosanthes kirilowii) is a plant used in traditional Chinese medicine, and a protein from its root called trichosanthin (Compound Q) has been studied as an injectable dr...

Read the full Chinese Cucumber monograph →
Sources

Sources & How We Checked

Natura 401's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 4 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Chinese Cucumber 4 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  3. Hikino H, Yoshizawa M, Suzuki Y, et al. Isolation and hypoglycemic activity of trichosans A, B, C, D, and E: glycans of Trichosanthes kirilowii roots. Planta Med 1989;55:349-50.
  4. Jung YB, Roh KJ, Jung JA, et al. Effect of SKI 306X, a new herbal anti-arthritic agent, in patients with osteoarthritis of the knee: a double-blind placebo controlled study. Am J Chin Med. 2001;29(3-4):485-91. PubMed

See these in context on the Chinese Cucumber monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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