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Dietary supplement

Natural Brain Enhancers PS & GPC Ingredients & Drug Interactions

by Doctor's Best

Natural Brain Enhancers PS & GPC label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Natural Brain Enhancers PS & GPC against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Natural Brain Enhancers PS & GPC is a dietary supplement by Doctor's Best with 2 active ingredients. Its ingredients are commonly taken for memory and cognitive support, age-related cognitive decline, attention and focus (adhd).Based on those ingredients, 219 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are PhosphatidylSerine, GlyceroPhosphoCholine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Natural Brain Enhancers PS & GPC by Doctor's Best

Ask about any prescription or over-the-counter medication and we check it for interactions with Natural Brain Enhancers PS & GPC by Doctor's Best — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Natural Brain Enhancers PS & GPC by Doctor's Best

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product has 2 active ingredients: phosphatidylserine and alpha-GPC (glycerophosphocholine). Both are compounds naturally found in cell membranes and are thought to support brain cell communication and cognitive function.

The capsule also contains inactive ingredients (modified cellulose, dicalcium phosphate, magnesium stearate, magnesium silicate, and silicon dioxide) that serve as fillers and binders.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: memory and cognitive function support.
  • We looked for evidence on: Age-related cognitive decline, Alzheimer disease, Attention deficit-hyperactivity disorder (ADHD), Cognitive function, Dementia, Vascular dementia — and 3 related terms.
  • The strongest evidence on file: Phosphatidylserine is rated "Possibly Effective" for Age-related cognitive decline (Natural Medicines).
  • Also on file: Phosphatidylserine is rated "Possibly Effective" for Alzheimer disease.
  • Also on file: Alpha-gpc is rated "Possibly Effective" for Alzheimer disease.

Phosphatidylserine is rated possibly effective for age-related cognitive decline and Alzheimer's disease. Alpha-GPC is rated possibly effective for Alzheimer's disease.

For other uses listed — athletic performance, ADHD, general cognitive function, dementia, brain tumors, stroke, and vascular dementia — the evidence we hold is insufficient to rate either ingredient. The data doesn't establish how well this combination works for these other purposes.

The evidence, ingredient by ingredient Phosphatidylserine Alpha-gpc

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Both ingredients are generally well tolerated in studies, though long-term safety isn't fully established. The most common side effects from phosphatidylserine are flatulence, upset stomach, headache, insomnia (especially at higher doses around 600 mg), and nausea.

Alpha-GPC rarely causes dizziness, headache, insomnia, diarrhea, heartburn, nausea, or vomiting when taken by mouth. Rarely, alpha-GPC has been associated with stroke in people who used it for at least 2 months compared with non-users.

There isn't enough safety data for either ingredient during pregnancy or breastfeeding — the safety data advises against use in both situations unless your doctor directs otherwise.

Side effects, ingredient by ingredient Phosphatidylserine Alpha-gpc

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Phosphatidylserine, Alpha-gpc.
  • The most serious interaction on file is rated Moderate.
  • For scale: 219 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before taking this product if you use anticholinergic drugs (for overactive bladder, Parkinson's, or other conditions) or cholinergic drugs (for myasthenia gravis or Alzheimer's) — both carry Moderate-severity interactions. If you use a scopolamine patch (Transderm Scop) for motion sickness, let them know as well, since alpha-GPC may reduce its effects.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product may be worth considering if you're interested in brain support for age-related cognitive changes or Alzheimer's disease, since both ingredients have some evidence for those uses. If you take anticholinergic or cholinergic medications, or use a scopolamine patch, you'll want to talk with your doctor or pharmacist first — there are documented interactions.

Same goes if you're pregnant, breastfeeding, or take any regular medications. Long-term safety data is limited, so ongoing dialogue with your healthcare provider is worth having.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Natural Brain Enhancers PS & GPC, straight from the product label.

Brand Doctor's Best
Barcode (UPC) 753950002913
Net contents 10 Veggie Cap(s)
Market status On market
Date entered into DSLD Aug 23, 2013
DSLD ID 24985
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Vegetarian, Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Natural Brain Enhancers PS & GPC by Doctor's Best, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
5
UPC/BARCODE
753950002913
IngredientAmount% DV
PhosphatidylSerine100 mg--
GlyceroPhosphoCholine300 mg--

Other ingredients: Modified Cellulose, Dicalcium Phosphate, Magnesium Stearate, Magnesium Silicate, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

Science-Based Nutrition(TM)

Formula

Contains soy

Precautions

Contains soy

Suggested/Recommended/Usage/Directions

Suggested Adult Use: Take 1 capsule twice daily between meals, not later than 4 pm. Intakes up to 6 capsules per day may be beneficial.

Formulation

Suitable for Vegetarians

General Statements

CONTAINS NOTHING OTHER THAN LISTED INGREDIENTS

General

R 12/12

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Natural Brain Enhancers PS & GPC by Doctor's Best label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Natural Brain Enhancers PS & GPC label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Natural Brain Enhancers PS & GPC by Doctor's Best

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container5 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

PhosphatidylSerine

Interacts with
219 drugs
100 mg per serving

Phosphatidylserine is a natural fat-like compound found in cell membranes, especially in the brain, and it is sold mainly to support memory and thinki...

PhosphatidylSerine monograph & interactions

GlyceroPhosphoCholine

Interacts with
16 drugs
300 mg per serving

Alpha-GPC is a choline-containing compound used mainly for memory, brain health, and as a choline source. There is some evidence it may help cognition...

GlyceroPhosphoCholine monograph & interactions

Other (inactive) ingredients: Modified Cellulose, Dicalcium Phosphate, Magnesium Stearate, Magnesium Silicate, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Natural Brain Enhancers PS & GPC by Doctor's Best Drug Interactions

Want to check YOUR meds against Natural Brain Enhancers PS & GPC?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
219Drugs
219 Moderate

Ingredients driving the most interactions

PhosphatidylSerine 219
GlyceroPhosphoCholine 16

Individual Drug Interactions

The ingredients in Natural Brain Enhancers PS & GPC interact with 219 drugs. Click any drug to see the details.

2 of the 2 ingredients in Natural Brain Enhancers PS & GPC interact with drugs. Each result below shows which ingredient is responsible. PhosphatidylSerine GlyceroPhosphoCholine

Each ingredient & the kinds of drugs it affects

For each ingredient in Natural Brain Enhancers PS & GPC with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

PhosphatidylSerine2 drug types · 219 drugs

Anticholinergic Drugs

Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Phosphatidylserine is thought to increase acetylcholine levels, which could theoretically interfere with the activity of anticholinergic agents.

Likelihood Possible Evidence B
Cholinergic Drugs

Theoretically, phosphatidylserine might have additive effects with cholinergic drugs.
Phosphatidylserine is thought to increase acetylcholine levels, which could theoretically lead to additive cholinergic effects when used with cholinergic drugs.

Likelihood Possible Evidence B
PhosphatidylSerine full monograph & interactions

GlyceroPhosphoCholine1 drug type · 16 drugs

Scopolamine (Transderm Scop)

Theoretically, alpha-GPC might decrease the effects of scopolamine.
A small clinical study shows that alpha-GPC can partially counteract the attention and memory impairment effects caused by scopolamine given intramuscularly. Whether alpha-GPC can decrease the beneficial anti-motion sickness effects of the scopolamine patch (Transderm Scop) is unclear.

Likelihood Possible Evidence B
GlyceroPhosphoCholine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Natural Brain Enhancers PS & GPC, from the product label.

Doctor's Best

See all Doctor's Best products
Name
Doctor's Best, Inc.
City
San Clemente
State
CA
ZipCode
92673
Phone Number
(800) 777-2474
Web Address
www.drbvitamins.com
Pharmacist Counseling Corner

Natural Brain Enhancers PS & GPC by Doctor's Best: Common Questions

Does Natural Brain Enhancers PS & GPC by Doctor's Best interact with any medications?
Yes. Based on its ingredients, Natural Brain Enhancers PS & GPC has a known interaction with 219 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Natural Brain Enhancers PS & GPC contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while pregnant or breastfeeding?
There isn't enough safety information for either phosphatidylserine or alpha-GPC during pregnancy or breastfeeding, so the safety data advises against use unless your doctor directs otherwise. Talk with your doctor or pharmacist about your specific situation.
What are the most common side effects?
From phosphatidylserine, you may notice flatulence, upset stomach, headache, or nausea — insomnia is more likely at higher doses. Alpha-GPC rarely causes dizziness, headache, insomnia, or digestive upset like diarrhea or nausea.
Does this actually work for memory and thinking?
Phosphatidylserine and alpha-GPC are both possibly effective for age-related cognitive decline and Alzheimer's disease based on the data we have. For other uses like ADHD or general cognitive function, the evidence is too limited for us to rate.
Are there any fillers or inactive ingredients I should know about?
Yes, the capsule contains modified cellulose, dicalcium phosphate, magnesium stearate, magnesium silicate, and silicon dioxide — these are standard binders and fillers used to hold the capsule together.
Is it safe to use this long-term?
Both ingredients are generally well tolerated in the studies we have, but long-term safety hasn't been fully established. If you're thinking about taking it regularly, it's a good idea to check in with your doctor or pharmacist first.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Natural Brain Enhancers PS & GPC label
Go deeper

The Full Monographs Behind Natural Brain Enhancers PS & GPC’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Phosphatidylserine

Interacts with 219 drugs

Phosphatidylserine is a natural fat-like compound found in cell membranes, especially in the brain, and it is sold mainly to support memory and thinking. Some research suggests possible bene...

Read the full Phosphatidylserine monograph → Herb & supplement monograph

Alpha-gpc

Interacts with 16 drugs

Alpha-GPC is a choline-containing compound used mainly for memory, brain health, and as a choline source. There is some evidence it may help cognition in people with dementia, but evidence i...

Read the full Alpha-gpc monograph →
Sources

Sources & How We Checked

Natural Brain Enhancers PS & GPC's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 13 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Phosphatidylserine 9 references
  1. Crook T, Petrie W, Wells C, Massari DC. Effects of phosphatidylserine in Alzheimer's disease. Psychopharmacol Bull 1992;28:61-6.
  2. Pepping J. Phosphatidylserine. Am J Health-Syst Pharm 1999;56:2038,2043-4.
  3. Kidd PM. Phosphatidylserine; Membrane nutrient for memory. A clinical and mechanistic assessment. Altern Med Rev 1996;1:70-84.
  4. Kim HY, Akbar M, Lau A, et al. Inhibition of neuronal apoptosis by docosahexaenoic acid (22:6n-3). Role of phosphatidylserine in antiapoptotic effect. J Biol Chem 2000;275:35215-23.. PubMed
  5. Zanotti A, Valzelli L, Toffano G. Chronic phosphatidylserine treatment improves spatial memory and passive avoidance in aged rats. Psychopharmacology (Berl) 1989;99:316-21.. PubMed
  6. Schreiber S, Kampf-Sherf O, Gorfine M, et al. An open trial of plant-source derived phosphatydilserine for treatment of age-related cognitive decline. Isr J Psychiatry Relat Sci 2000;37:302-7.
  7. Pepping, J. Phosphatidylserine. Am J Health Syst.Pharm. 10-15-1999;56(20):2038, 2043-2038, 2044.
  8. Monteverde, A., Gnemmi, P., Rossi, F., Monteverde, A., and Finali, G. C. Selegiline in the treatment of mild to moderate Alzheimer-type dementia. Clin.Ther 1990;12(4):315-322.
  9. Vakhapova V, Cohen T, Richter Y, Herzog Y, Kam Y, Korczyn AD. Phosphatidylserine containing omega-3 Fatty acids may improve memory abilities in nondemented elderly individuals with memory complaints: results from an open-label extension study. Dement Geri PubMed

See these in context on the Phosphatidylserine monograph →

Alpha-gpc 4 references
  1. Di Perri R, Coppola G, Ambrosio LA, et al. A multicentre trial to the evaluate the efficacy and tolerability of alpha-glycerylphosphorylcholine versus cytosine diphosphocholine in patients with vascular dementia. J Int Med Res 1991;19:330-41.
  2. Barbagallo Sangiorgi G, Barbagallo M, Giordano M, et al. Alpha-glycerophosphocholine in the mental recovery of cerebral ischemic attacks: An Italian multicenter clinical trial. Ann N Y Acad Sci 1994;717:253-69. PubMed
  3. Canal N, Franceschi M, Alberoni M, et al. Effect of L-alpha-glyceryl-phosphorylcholine on amnesia caused by scopolamine. Int J Clin Pharmacol Ther Toxicol 1991;29:103-7.
  4. Lee G, Choi S, Chang J, et al. Association of L-a glycerylphosphorylcholine with subsequent stroke risk after 10 Years. JAMA Netw Open 2021;4(11):e2136008.

See these in context on the Alpha-gpc monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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