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Dietary supplement

Nettle 300 mg Ingredients & Drug Interactions

by Solaray

Nettle 300 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Nettle 300 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Nettle 300 mg is a dietary supplement by Solaray with 2 active ingredients. Its ingredients are commonly taken for enlarged prostate (bph) symptoms, seasonal allergies, joint pain and arthritis.Based on those ingredients, 164 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Nettle. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Nettle 300 mg by Solaray

Ask about any prescription or over-the-counter medication and we check it for interactions with Nettle 300 mg by Solaray — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Nettle 300 mg by Solaray

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • “Nettle Root Extract” is listed as a grouped ingredient — the label gives one combined amount (300 mg) without saying how much of each component you get.

This supplement has 3 active ingredients: stinging nettle (the main herb), beta-sitosterol (a plant compound), and Total Amino Acids. Stinging nettle has been used traditionally for various conditions, while beta-sitosterol is often added for potential benefits related to cholesterol and prostate health.

The capsule also contains inactive ingredients like cellulose, maltodextrin, and silica to hold everything together.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Herbal support.
  • We looked for evidence on: Allergic rhinitis (hay fever), Benign prostatic hyperplasia (BPH), Osteoarthritis, Urinary tract infections (UTIs), Joint inflammation, Urinary health — and 1 related terms.
  • The strongest evidence on file: Beta-sitosterol is rated "Likely Effective" for Benign prostatic hyperplasia (BPH) (Natural Medicines).
  • Also on file: Stinging Nettle is rated "Insufficient Reliable Evidence To Rate" for Allergic rhinitis (hay fever), Benign prostatic hyperplasia (BPH), Osteoarthritis, Urinary tract infections (UTIs).
  • Also on file: Beta-sitosterol is rated "Insufficient Reliable Evidence To Rate" for Allergic rhinitis (hay fever).

The evidence for stinging nettle in this product is mixed. It's considered possibly effective for diabetes, but for hay fever, anemia, asthma, prostate health, and gum inflammation, we don't have strong enough evidence to say whether it works or not.

Beta-sitosterol is likely effective for benign prostatic hyperplasia (enlarged prostate) and possibly effective for high cholesterol and heart disease. The effectiveness of Total Amino Acids isn't rated in our data for any specific use.

The evidence, ingredient by ingredient Stinging Nettle Beta-sitosterol

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Stinging nettle is generally well tolerated when used as directed, though constipation and diarrhea are the most common side effects. Beta-sitosterol is also generally well tolerated, with occasional constipation, diarrhea, gas, indigestion, or nausea.

Rare case reports mention liver injury with nettle-containing products and acute pancreatitis with beta-sitosterol, though these are uncommon. During pregnancy, there isn't enough safety data for stinging nettle — traditional concerns about effects on the uterus mean it's best avoided.

Breastfeeding safety for nettle hasn't been established either. Beta-sitosterol should also be avoided during pregnancy and breastfeeding due to insufficient safety data.

Side effects, ingredient by ingredient Stinging Nettle Beta-sitosterol

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Stinging Nettle.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; lithium.
  • For scale: 164 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start, check with your pharmacist if you take blood thinners like warfarin — stinging nettle's vitamin K content may reduce their effectiveness. Also flag diabetes medications, diuretics (water pills), and lithium, as nettle may combine with their effects.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product may help with prostate health and cholesterol, but the evidence for nettle alone is limited. If you take blood thinners, diabetes drugs, diuretics, or lithium, you need to check with us or your pharmacist first.

It's not recommended in pregnancy or while breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Nettle 300 mg, straight from the product label.

Brand Solaray
Barcode (UPC) 076280037524
Net contents 60 VegCap(s)
Market status On market
Date entered into DSLD Sep 25, 2025
DSLD ID 338500
Product type Botanical
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Nettle 300 mg by Solaray, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 VegCap(s)
Maximum serving Sizes:
1 VegCap(s)
Servings per container
60
UPC/BARCODE
076280037524
IngredientAmount% DV
Total Amino Acids15 mg--
Beta-Sitosterol2.4 mg--
Nettle150 mg--
Nettle Root Extract300 mg--

Other ingredients: Cellulose, Maltodextrin, Agave Inulin, Silica, Magnesium Stearate, Rice extract Blend

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Solaray Est. 1973 A brighter way 1973

General Statements

Vital extracts

Since 1973, we've scoured the globe for the highest quality ingredients, connecting you with the most efficacious supplements that help you live brighter & embrace the moments that matter most.

100% PCR Bottles

Formula

0.8% Beta-Sitosterol 5% Amino acids

Formulation

Herbal support

Vegan

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

Lab Verified Vegan

Precautions

Warning: Do not use if safety seal is broken or missing. Keep your licensed health care practitioner informed when using this product. Directions: Use only as directed.

Keep out of reach of children.

California Residents Only Warning: Reproductive harm - www.P65Warnings.ca.gov

Suggested/Recommended/Usage/Directions

Directions: Use only as directed. Take 1 VegCap daily with a meal or glass of water.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Nettle 300 mg by Solaray label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Nettle 300 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Nettle 300 mg by Solaray

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 VegCap(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Nettle

Interacts with
164 drugs
150 mg per serving

Stinging nettle is a common plant used as food and in traditional medicine, most often for prostate symptoms, allergies, and joint pain. The evidence...

Nettle monograph & interactions

Nettle Root Extract

Interacts with
164 drugs
300 mg per serving

Stinging nettle is a common plant used as food and in traditional medicine, most often for prostate symptoms, allergies, and joint pain. The evidence...

Nettle Root Extract monograph & interactions

Other (inactive) ingredients: Cellulose, Maltodextrin, Agave Inulin, Silica, Magnesium Stearate, Rice extract Blend. These complete the product’s ingredient list but are not active constituents.

Interaction report

Nettle 300 mg by Solaray Drug Interactions

Want to check YOUR meds against Nettle 300 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
164Drugs
164 Moderate

Ingredients driving the most interactions

Nettle 164

Individual Drug Interactions

The ingredients in Nettle 300 mg interact with 164 drugs. Click any drug to see the details.

1 of the 2 ingredients in Nettle 300 mg interact with drugs. Each result below shows which ingredient is responsible. Nettle

Each ingredient & the kinds of drugs it affects

For each ingredient in Nettle 300 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Nettle4 drug types · 164 drugs

Antidiabetes Drugs

Theoretically, stinging nettle might have additive effects with antidiabetes drugs.
Clinical research shows that stinging nettle might decrease blood glucose levels in patients with diabetes.

Likelihood Possible Evidence B
Diuretic Drugs

Theoretically, combining stinging nettle with diuretic drugs may have additive effects.
Animal research suggests that the above ground parts and roots of stinging nettle may have a diuretic effect.

Likelihood Possible Evidence D
Lithium

Theoretically, stinging nettle might reduce excretion and increase levels of lithium.
Animal research suggests that stinging nettle has diuretic and natriuretic properties, which could alter the excretion of lithium. The dose of lithium might need to be decreased.

Likelihood Possible Evidence D
Warfarin (Coumadin)

There is some concern that stinging nettle might decrease the effects of anticoagulant drugs such as warfarin.
Stinging nettle contains a significant amount of vitamin K. When taken in large quantities, this might interfere with the activity of warfarin.

Likelihood Possible Evidence D
Nettle full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Nettle 300 mg, from the product label.

Solaray

See all Solaray products
Name
Solaray
City
Salt Lake City
State
UT
ZipCode
84101
Phone Number
800-538-5888
Web Address
www.solaray.com
Pharmacist Counseling Corner

Nettle 300 mg by Solaray: Common Questions

Does Nettle 300 mg by Solaray interact with any medications?
Yes. Based on its ingredients, Nettle 300 mg has a known interaction with 164 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Nettle 300 mg contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
No, not without talking to your doctor first. Stinging nettle should be avoided during pregnancy due to traditional concerns about effects on the uterus, and breastfeeding safety hasn't been established. Beta-sitosterol also lacks enough safety data in pregnancy and breastfeeding, so both ingredients make this product one to skip until you've checked with your healthcare provider.
What side effects might I get from this nettle supplement?
The most common are constipation and diarrhea from both nettle and beta-sitosterol. You might also experience gas, indigestion, or nausea. Rarely, case reports describe liver injury or pancreatitis, though these are uncommon. If you notice abdominal pain or other unusual symptoms, stop and talk to your pharmacist right away.
Will this help my enlarged prostate?
Beta-sitosterol in this product is likely effective for benign prostatic hyperplasia (enlarged prostate), so that ingredient has solid evidence. Stinging nettle for prostate health doesn't have enough reliable evidence yet, so we can't say it works for that purpose.
Is this safe to take long-term?
The data we hold shows nettle and beta-sitosterol are generally well tolerated short-term, but evidence and quality vary by product. There's no long-term safety information in our data, so check with your pharmacist about how long you plan to use it.
Why can't you check interactions for Total Amino Acids?
We don't hold any data on that ingredient, so we can't verify whether it interacts with medications. Your pharmacist can help you look that up or advise whether it's a concern for your specific drugs.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Nettle 300 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Nettle 300 mg label
Go deeper

The Full Monographs Behind Nettle 300 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Stinging Nettle

Interacts with 164 drugs

Stinging nettle is a common plant used as food and in traditional medicine, most often for prostate symptoms, allergies, and joint pain. The evidence is mixed and mostly preliminary, so it i...

Read the full Stinging Nettle monograph → Herb & supplement monograph

Beta-sitosterol

Beta-sitosterol is a plant sterol that may modestly lower LDL ('bad') cholesterol and may help ease urinary symptoms from an enlarged prostate. Evidence is moderate for these uses and weaker...

Read the full Beta-sitosterol monograph →
Sources

Sources & How We Checked

Nettle 300 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 30 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Beta-sitosterol 7 references
  1. Berges RR, Windeler J, Trampisch HJ, et al. Randomised, placebo-controlled, double-blind clinical trial of beta-sitosterol in patients with benign prostatic hyperplasia. Beta-sitosterol Study Group. Lancet 1995;345:1529-32.
  2. Klippel KF, Hiltl DM, Schipp B. A multicentric, placebo-controlled, double-blind clinical trial of beta-sitosterol (phytosterol) for the treatment of benign prostatic hyperplasia. Br J Urol 1997;80:427-32.
  3. Wilt TJ, MacDonald R, Ishani A. beta-sitosterol for the treatment of benign prostatic hyperplasia: a systematic review. BJU Int 1999;83:976-83. PubMed
  4. Oster P, Schlierf G, Heuck CC, et al. [Sitosterol in familial hyperlipoproteinemia type II. A randomized, double-blind, cross-over study]. Dtsch Med Wochenschr 1976;101:1308-11.
  5. Becker M, Staab D, Von Bergman K. Long-term treatment of severe familial hypercholesterolemia in children: effect of sitosterol and bezafibrate. Pediatrics 1992;89:138-42. DOI
  6. Prager N, Bickett K, French N, Marcovici G. A randomized, double-blind, placebo-controlled trial to determine the effectiveness of botanically derived inhibitors of 5-alpha-reductase in the treatment of androgenetic alopecia. J Altern Complement Med 2002
  7. Lorenze A, Hsueh W, Nasr J. Beta-sitosterol-induced acute pancreatitis: A case report and review of the literature. Cureus. 2020;12(3):e7407. PubMed

See these in context on the Beta-sitosterol monograph →

Stinging Nettle 23 references
  1. Monographs on the medicinal uses of plant drugs. Exeter, UK: European Scientific Co-op Phytother, 1997.
  2. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  3. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  4. Schulz V, Hansel R, Tyler VE. Rational Phytotherapy: A Physician's Guide to Herbal Medicine. Terry C. Telger, transl. 3rd ed. Berlin, GER: Springer, 1998.
  5. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  6. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  7. Mittman P. Randomized, double-blind study of freeze-dried Urtica dioica in the treatment of allergic rhinitis. Planta Med 1990;56:44-7.
  8. Vontobel HP, Herzog R, Rutishauser G, Kres H. [Results of a double-blind study on the effectiveness of ERU (extractum radicis Urticae) capsules in conservative treatment of benign prostatic hyperplasia]. (Abstract). Urologe A 1985;24:49-51.
  9. Randall C, Randall H, Dobbs F, et al. Randomized controlled trial of nettle sting for treatment of base-of-thumb pain. J R Soc Med 2000;93:305-9. PubMed
  10. Caliskaner Z, Karaayvaz M, Ozturk S. Misuse of a herb: stinging nettle (Urtica urens) induced severe tongue oedema. Complement Ther Med 2004;12:57-8. PubMed
  11. Krzeski, T., Kazon, M., Borkowski, A., Witeska, A., and Kuczera, J. Combined extracts of Urtica dioica and Pygeum africanum in the treatment of benign prostatic hyperplasia: double-blind comparison of two doses. Clin Ther 1993;15(6):1011-1020.
  12. Randall, C., Meethan, K., Randall, H., and Dobbs, F. Nettle sting of Urtica dioica for joint pain--an exploratory study of this complementary therapy. Complement Ther Med 1999;7(3):126-131. PubMed
  13. Tahri, A., Yamani, S., Legssyer, A., Aziz, M., Mekhfi, H., Bnouham, M., and Ziyyat, A. Acute diuretic, natriuretic and hypotensive effects of a continuous perfusion of aqueous extract of Urtica dioica in the rat. J Ethnopharmacol 2000;73(1-2):95-100. PubMed
  14. Sahin, M., Yilmaz, H., Gursoy, A., Demirel, A. N., Tutuncu, N. B., and Guvener, N. D. Gynaecomastia in a man and hyperoestrogenism in a woman due to ingestion of nettle (Urtica dioica). N.Z.Med.J. 2007;120(1265):U2803.
  15. Randall, C., Dickens, A., White, A., Sanders, H., Fox, M., and Campbell, J. Nettle sting for chronic knee pain: a randomised controlled pilot study. Complement Ther.Med. 2008;16(2):66-72. PubMed
  16. Rayburn, K., Fleischbein, E., Song, J., Allen, B., Kundert, M., Leiter, C., and Bush, T. Stinging nettle cream for osteoarthritis. Altern.Ther.Health Med. 2009;15(4):60-61.
  17. Oliver, F., Amon, E. U., Breathnach, A., Francis, D. M., Sarathchandra, P., Black, A. K., and Greaves, M. W. Contact urticaria due to the common stinging nettle (Urtica dioica)-- histological, ultrastructural and pharmacological studies. Clin Exp Dermato PubMed
  18. Kulze, A. and Greaves, M. Contact urticaria caused by stinging nettles. Br.J Dermatol. 1988;119(2):269-270. PubMed
  19. Patten G. Medicinal plant review: Urtica. Aust J Med Herbalism 1993;5(1):5-13.
  20. Maor D, Little M. Skin contact with a stinging tree requiring intensive care unit admission. Contact Dermatitis. 2017 Nov;77(5):335-37. PubMed
  21. Easton L, Vaid S, Nagel AK, Venci JV, Fortuna RJ. Stinging Nettle (Urtica dioica): An Unusual Case of Galactorrhea. Am J Case Rep 2021;22:e933999. PubMed
  22. Niazi B, Ahmed K, Ahmed M, Ali S, Song K, Elias S. Drug-Induced Liver Injury from Herbal Liver Detoxification Tea. Case Rep Gastroenterol 2022;16(3):612-617. PubMed
  23. Nnamani I, Tolu-Akinnawo O, Dufera RR, Akintunde A, Maliakkal B. Tinospora cordifolia (Guduchi/Giloy)-Induced Liver Injury: A Case Review. Cureus 2023;15(5):e39793. PubMed

See these in context on the Stinging Nettle monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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