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Dietary supplement

Nettle Root Extract 1500 mg Ingredients & Drug Interactions

by SuperSmart

Nettle Root Extract 1500 mg label
See full label image
Tablet Or Pill Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Nettle Root Extract 1500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Nettle Root Extract 1500 mg is a dietary supplement by SuperSmart with 1 active ingredient. Its ingredients are commonly taken for enlarged prostate (bph) symptoms, seasonal allergies, joint pain and arthritis.Based on those ingredients, 164 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Nettle Root Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Nettle Root Extract 1500 mg by SuperSmart

Ask about any prescription or over-the-counter medication and we check it for interactions with Nettle Root Extract 1500 mg by SuperSmart — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Nettle Root Extract 1500 mg by SuperSmart

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: nettle root extract at 1500 mg per tablet. Nettle root has been used traditionally for a range of conditions affecting the urinary and reproductive systems.

The tablet also contains acacia gum as an inactive ingredient to help hold the tablet together.

Does it work?

Insufficient evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Insufficient

There isn't enough reliable clinical evidence to rate this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Supports prostate health.
  • We looked for evidence on: Benign prostatic hyperplasia (BPH), Prostate symptoms, Urinary flow.
  • The closest evidence on file: Stinging Nettle is rated "Insufficient Reliable Evidence To Rate" for Benign prostatic hyperplasia (BPH) (Natural Medicines).

Clinical research suggests nettle root is possibly effective for diabetes, with some evidence that it may help lower blood glucose levels in people with diabetes. For allergic rhinitis (hay fever), anemia, asthma, benign prostatic hyperplasia (enlarged prostate), and gingivitis, the evidence isn't established well enough for us to rate it—the data we hold is insufficient.

If you're considering this product for one of those other uses, talk with your doctor about whether the evidence supports it for your situation.

The evidence, ingredient by ingredient Stinging Nettle

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Nettle root is generally well tolerated by most adults when used as directed, though the quality and evidence vary between products. The most common side effects are constipation and diarrhea when taken by mouth.

Rare case reports describe liver injury (hepatitis-like damage) in people taking herbal products containing nettle along with other ingredients, though cause and effect aren't certain. Pregnancy safety data advises against use—traditional concerns about effects on the uterus mean it's best avoided if you're pregnant or trying to become pregnant.

Safety during breastfeeding has not been established, so talk with your doctor or pharmacist before taking this product while nursing.

Side effects, ingredient by ingredient Stinging Nettle

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Stinging Nettle.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; lithium.
  • For scale: 164 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your doctor or pharmacist if you take warfarin or other blood thinners, antidiabetes drugs, diuretics (water pills), or lithium. All four carry moderate interaction risk with nettle root.

If you're on any of these, your dose or monitoring may need adjustment.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with insufficient evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Nettle root extract may help with blood sugar if you have diabetes, but it interacts with common medications including blood thinners, diuretics, and antidiabetes drugs—so check with your own doctor or pharmacist before starting. It's not recommended in pregnancy or while breastfeeding.

If you're on lithium or warfarin especially, this product needs your doctor's approval.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 24, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Nettle Root Extract 1500 mg, straight from the product label.

Brand SuperSmart
Barcode (UPC) 5453003825678
Net contents 90 Tablet(s)
Market status On market
Date entered into DSLD May 24, 2023
DSLD ID 285343
Product type Botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Nettle Root Extract 1500 mg by SuperSmart, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Tablet(s)
Maximum serving Sizes:
3 Tablet(s)
Servings per container
30
UPC/BARCODE
5453003825678
IngredientAmount% DV
Nettle Root Extract1500 mg--

Other ingredients: Acacia Gum

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Supports prostate health

FDA Statement of Identity

Dietary Supplement

Formula

Nettle root extract 1500 mg per day

Each tablet provides 500 mg of nettle root extract (16:1).

Suggested/Recommended/Usage/Directions

Recommended use: Adults. Take 2 to 3 tablets a day.

Precautions

Precautions: Do not exceed the recommended daily dose. This product is a nutritional supplement and should not replace a varied, balanced diet.

Keep out of children's reach.

As with any nutritional supplement, you should consult a health professional before taking this product if you are pregnant, breastfeeding or have a health problem.

Storage

Store away from direct light, heat and humidity.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Nettle Root Extract 1500 mg by SuperSmart label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Nettle Root Extract 1500 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Nettle Root Extract 1500 mg by SuperSmart

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Tablet(s) Dosage formTablet Or Pill Servings per container30 Amounts shown are per serving.

Nettle Root Extract

Interacts with
164 drugs
1500 mg per serving

Stinging nettle is a common plant used as food and in traditional medicine, most often for prostate symptoms, allergies, and joint pain. The evidence...

Nettle Root Extract monograph & interactions

Other (inactive) ingredients: Acacia Gum. These complete the product’s ingredient list but are not active constituents.

Interaction report

Nettle Root Extract 1500 mg by SuperSmart Drug Interactions

Want to check YOUR meds against Nettle Root Extract 1500 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
164Drugs
164 Moderate

Ingredients driving the most interactions

Nettle Root Extract 164

Individual Drug Interactions

The ingredients in Nettle Root Extract 1500 mg interact with 164 drugs. Click any drug to see the details.

1 of the 1 ingredient in Nettle Root Extract 1500 mg interact with drugs. Each result below shows which ingredient is responsible. Nettle Root Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Nettle Root Extract 1500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Nettle Root Extract4 drug types · 164 drugs

Antidiabetes Drugs

Theoretically, stinging nettle might have additive effects with antidiabetes drugs.
Clinical research shows that stinging nettle might decrease blood glucose levels in patients with diabetes.

Likelihood Possible Evidence B
Diuretic Drugs

Theoretically, combining stinging nettle with diuretic drugs may have additive effects.
Animal research suggests that the above ground parts and roots of stinging nettle may have a diuretic effect.

Likelihood Possible Evidence D
Lithium

Theoretically, stinging nettle might reduce excretion and increase levels of lithium.
Animal research suggests that stinging nettle has diuretic and natriuretic properties, which could alter the excretion of lithium. The dose of lithium might need to be decreased.

Likelihood Possible Evidence D
Warfarin (Coumadin)

There is some concern that stinging nettle might decrease the effects of anticoagulant drugs such as warfarin.
Stinging nettle contains a significant amount of vitamin K. When taken in large quantities, this might interfere with the activity of warfarin.

Likelihood Possible Evidence D
Nettle Root Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Nettle Root Extract 1500 mg, from the product label.

SuperSmart

See all SuperSmart products
Name
SN Worldwide Unipessoal, Lda
Street Address
Avenida Do Infante 66, Edificio Quinta Avenida 1 C
City
Funchal
ZipCode
9000-015
Pharmacist Counseling Corner

Nettle Root Extract 1500 mg by SuperSmart: Common Questions

Does Nettle Root Extract 1500 mg by SuperSmart interact with any medications?
Yes. Based on its ingredients, Nettle Root Extract 1500 mg has a known interaction with 164 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Nettle Root Extract 1500 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant?
No—the safety data advises against it. Traditional concerns about nettle's effects on the uterus mean it's best avoided in pregnancy. Talk with your doctor before taking it if you're pregnant or planning to become pregnant.
Can I take this while breastfeeding?
Safety during breastfeeding has not been established, so there isn't enough data to know either way. Talk with your doctor or pharmacist before using this product while nursing.
What are the most common side effects?
By mouth, the most common are constipation and diarrhea. These are usually mild. If you handle the raw fresh plant, you may get itching, rash, or a stinging sensation on your skin.
Does nettle root really work for diabetes?
Clinical research suggests it's possibly effective—some studies show nettle may help lower blood glucose levels in people with diabetes. But talk with your doctor before using it as part of your diabetes care, especially since it can interact with your medications.
Why is this product high in vitamin K?
Nettle naturally contains significant amounts of vitamin K as part of its plant composition. This matters mainly if you take warfarin or other blood thinners, because vitamin K can reduce their effectiveness.
How many active ingredients are in this product?
One: nettle root extract at 1500 mg per tablet. The only other ingredient is acacia gum, which is inactive—it's a binder used to hold the tablet together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Nettle Root Extract 1500 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Nettle Root Extract 1500 mg label
Go deeper

The Full Monographs Behind Nettle Root Extract 1500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Stinging Nettle

Interacts with 164 drugs

Stinging nettle is a common plant used as food and in traditional medicine, most often for prostate symptoms, allergies, and joint pain. The evidence is mixed and mostly preliminary, so it i...

Read the full Stinging Nettle monograph →
Sources

Sources & How We Checked

Nettle Root Extract 1500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 23 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Stinging Nettle 23 references
  1. Monographs on the medicinal uses of plant drugs. Exeter, UK: European Scientific Co-op Phytother, 1997.
  2. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  3. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  4. Schulz V, Hansel R, Tyler VE. Rational Phytotherapy: A Physician's Guide to Herbal Medicine. Terry C. Telger, transl. 3rd ed. Berlin, GER: Springer, 1998.
  5. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  6. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  7. Mittman P. Randomized, double-blind study of freeze-dried Urtica dioica in the treatment of allergic rhinitis. Planta Med 1990;56:44-7.
  8. Vontobel HP, Herzog R, Rutishauser G, Kres H. [Results of a double-blind study on the effectiveness of ERU (extractum radicis Urticae) capsules in conservative treatment of benign prostatic hyperplasia]. (Abstract). Urologe A 1985;24:49-51.
  9. Randall C, Randall H, Dobbs F, et al. Randomized controlled trial of nettle sting for treatment of base-of-thumb pain. J R Soc Med 2000;93:305-9. PubMed
  10. Caliskaner Z, Karaayvaz M, Ozturk S. Misuse of a herb: stinging nettle (Urtica urens) induced severe tongue oedema. Complement Ther Med 2004;12:57-8. PubMed
  11. Krzeski, T., Kazon, M., Borkowski, A., Witeska, A., and Kuczera, J. Combined extracts of Urtica dioica and Pygeum africanum in the treatment of benign prostatic hyperplasia: double-blind comparison of two doses. Clin Ther 1993;15(6):1011-1020.
  12. Randall, C., Meethan, K., Randall, H., and Dobbs, F. Nettle sting of Urtica dioica for joint pain--an exploratory study of this complementary therapy. Complement Ther Med 1999;7(3):126-131. PubMed
  13. Tahri, A., Yamani, S., Legssyer, A., Aziz, M., Mekhfi, H., Bnouham, M., and Ziyyat, A. Acute diuretic, natriuretic and hypotensive effects of a continuous perfusion of aqueous extract of Urtica dioica in the rat. J Ethnopharmacol 2000;73(1-2):95-100. PubMed
  14. Sahin, M., Yilmaz, H., Gursoy, A., Demirel, A. N., Tutuncu, N. B., and Guvener, N. D. Gynaecomastia in a man and hyperoestrogenism in a woman due to ingestion of nettle (Urtica dioica). N.Z.Med.J. 2007;120(1265):U2803.
  15. Randall, C., Dickens, A., White, A., Sanders, H., Fox, M., and Campbell, J. Nettle sting for chronic knee pain: a randomised controlled pilot study. Complement Ther.Med. 2008;16(2):66-72. PubMed
  16. Rayburn, K., Fleischbein, E., Song, J., Allen, B., Kundert, M., Leiter, C., and Bush, T. Stinging nettle cream for osteoarthritis. Altern.Ther.Health Med. 2009;15(4):60-61.
  17. Oliver, F., Amon, E. U., Breathnach, A., Francis, D. M., Sarathchandra, P., Black, A. K., and Greaves, M. W. Contact urticaria due to the common stinging nettle (Urtica dioica)-- histological, ultrastructural and pharmacological studies. Clin Exp Dermato PubMed
  18. Kulze, A. and Greaves, M. Contact urticaria caused by stinging nettles. Br.J Dermatol. 1988;119(2):269-270. PubMed
  19. Patten G. Medicinal plant review: Urtica. Aust J Med Herbalism 1993;5(1):5-13.
  20. Maor D, Little M. Skin contact with a stinging tree requiring intensive care unit admission. Contact Dermatitis. 2017 Nov;77(5):335-37. PubMed
  21. Easton L, Vaid S, Nagel AK, Venci JV, Fortuna RJ. Stinging Nettle (Urtica dioica): An Unusual Case of Galactorrhea. Am J Case Rep 2021;22:e933999. PubMed
  22. Niazi B, Ahmed K, Ahmed M, Ali S, Song K, Elias S. Drug-Induced Liver Injury from Herbal Liver Detoxification Tea. Case Rep Gastroenterol 2022;16(3):612-617. PubMed
  23. Nnamani I, Tolu-Akinnawo O, Dufera RR, Akintunde A, Maliakkal B. Tinospora cordifolia (Guduchi/Giloy)-Induced Liver Injury: A Case Review. Cureus 2023;15(5):e39793. PubMed

See these in context on the Stinging Nettle monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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