Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Neuro-PS Phosphatidylserine 200 mg Ingredients & Drug Interactions

by Puritan's Pride

Softgel Capsule Category: Fat/fatty Acid
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Neuro-PS Phosphatidylserine 200 mg is a dietary supplement by Puritan's Pride with 1 active ingredient. Its ingredients are commonly taken for memory and cognitive support, age-related cognitive decline, attention and focus (adhd).Based on those ingredients, 219 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Neuro-PS. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Neuro-PS Phosphatidylserine 200 mg by Puritan's Pride

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • “Neuro-PS” is listed as a grouped ingredient — the label gives one combined amount (2,000 mg) without saying how much of each component you get.

This softgel contains 200 mg of phosphatidylserine, a naturally occurring fat-like substance found in cell membranes. It's the only active ingredient in the formula.

The rest is inactive ingredients — medium chain triglyceride (a plant-based oil), gelatin capsule material, glycerin, and natural caramel color — which serve as the delivery system and don't add therapeutic effect.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Memory and cognitive support.
  • We looked for evidence on: Age-related cognitive decline, Cognitive function, Attention deficit-hyperactivity disorder (ADHD), Mental performance, Focus, Brain health.
  • The strongest evidence on file: Phosphatidylserine is rated "Possibly Effective" for Age-related cognitive decline (Natural Medicines).
  • Also on file: Phosphatidylserine is rated "Insufficient Reliable Evidence To Rate" for Attention deficit-hyperactivity disorder (ADHD), Cognitive function.

Phosphatidylserine shows some promise for age-related cognitive decline and Alzheimer disease — both are rated Possibly Effective based on available evidence. However, for athletic performance, ADHD, general cognitive function, and dementia, the evidence isn't strong enough to establish whether it works.

That doesn't mean it's ineffective; it means the research to date is either too limited or conflicting to say confidently either way.

The evidence, ingredient by ingredient Phosphatidylserine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Taken by mouth, phosphatidylserine is generally well tolerated. The most common side effects are flatulence, gastrointestinal upset, headache, insomnia, and nausea.

Insomnia is more likely at higher doses (around 600 mg), and stomach upset can occur even at this product's dose of 200 mg. Long-term safety hasn't been fully established in studies.

There isn't enough safety data to support use during pregnancy or while breastfeeding, so avoidance is recommended if you're pregnant or nursing. Talk with your doctor or pharmacist about your individual situation.

Side effects, ingredient by ingredient Phosphatidylserine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Phosphatidylserine.
  • The most serious interaction on file is rated Moderate.
  • For scale: 219 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check any anticholinergic drugs (like those for urinary incontinence or muscle spasms) and cholinergic drugs with your pharmacist — phosphatidylserine may interfere with how well they work. Both interactions are Moderate in severity.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Phosphatidylserine may be worth considering if you have age-related memory concerns or early Alzheimer disease, but the evidence is modest. If you take anticholinergic or cholinergic medications, check your exact drugs with the tool on this page before starting.

Stomach upset and insomnia are possible; if either bothers you, talk to your pharmacist about timing or dose adjustments.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 22, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Neuro-PS Phosphatidylserine 200 mg, straight from the product label.

Brand Puritan's Pride
Barcode (UPC) 025077165391
Net contents 60 Rapid Release Softgel(s)
Market status On market
Date entered into DSLD Jun 22, 2023
DSLD ID 286104
Product type Fat/fatty Acid
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Neuro-PS Phosphatidylserine 200 mg by Puritan's Pride, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Softgel(s)
Maximum serving Sizes:
2 Softgel(s)
Servings per container
30
UPC/BARCODE
025077165391
IngredientAmount% DV
Calories20 Calorie(s)--
Total Fat2 Gram(s)3%
Phosphatidylserine400 mg--
Neuro-PS2000 mg--

Other ingredients: Medium Chain Triglyceride, Gelatin, Glycerin, natural Caramel color

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Puritan’s Pride supplements are produced from the finest raw materials under stringent quality control standards. State-of-the-art manufacturing and packaging facilities ensure you the highest quality nutritional supplements money can buy. When it comes to your health...choose the best.

To reorder item # 16539 www.puritan.com 1-800-645-1030

Precautions

Warning: If you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Keep out of reach of children.

Do not use if seal under cap is broken or missing.

Contains soy ingredients.

Storage

Store at room temperature.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Brand IP Statement(s)

Copyright 2019 Puritan’s Pride, Inc.

Seals/Symbols

QA Quality Assured

Formulation

Double strength Aids brain function, supports a healthy mind and helps replenish PS levels

No artificial flavor or sweetener, no preservatives, no sugar, no starch, no milk, no lactose, no gluten, no wheat, no yeast, no fish. Sodium free.

Formula

Neuro-serine

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: For adults, take two (2) softgels daily, preferably with a meal.

See for yourself

Neuro-PS Phosphatidylserine 200 mg by Puritan's Pride label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Neuro-PS Phosphatidylserine 200 mg by Puritan's Pride

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Softgel(s) Dosage formSoftgel Capsule Servings per container30 Amounts shown are per serving.

Neuro-PS

Interacts with
219 drugs
2000 mg per serving Form: Phospholipid Complex

Phosphatidylserine is a natural fat-like compound found in cell membranes, especially in the brain, and it is sold mainly to support memory and thinki...

Neuro-PS monograph & interactions

Other (inactive) ingredients: Medium Chain Triglyceride, Gelatin, Glycerin, Natural Caramel color. These complete the product’s ingredient list but are not active constituents.

Interaction report

Neuro-PS Phosphatidylserine 200 mg by Puritan's Pride Drug Interactions

Want to check YOUR meds against Neuro-PS Phosphatidylserine 200 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
219Drugs
219 Moderate

Ingredients driving the most interactions

Neuro-PS 219

Each ingredient & the kinds of drugs it affects

For each ingredient in Neuro-PS Phosphatidylserine 200 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Neuro-PS2 drug types · 219 drugs

Anticholinergic Drugs

Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Phosphatidylserine is thought to increase acetylcholine levels, which could theoretically interfere with the activity of anticholinergic agents.

Likelihood Possible Evidence B
Cholinergic Drugs

Theoretically, phosphatidylserine might have additive effects with cholinergic drugs.
Phosphatidylserine is thought to increase acetylcholine levels, which could theoretically lead to additive cholinergic effects when used with cholinergic drugs.

Likelihood Possible Evidence B
The maker

Brand information

Manufacturer and brand details for Neuro-PS Phosphatidylserine 200 mg, from the product label.

Puritan's Pride

See all Puritan's Pride products
Name
Puritan's Pride, Inc.
City
Ronkonkoma
State
NY
ZipCode
11779
Phone Number
1-800-645-1030
Web Address
www.puritan.com
Pharmacist Counseling Corner

Neuro-PS Phosphatidylserine 200 mg by Puritan's Pride: Common Questions

Does Neuro-PS Phosphatidylserine 200 mg by Puritan's Pride interact with any medications?
Yes. Based on its ingredients, Neuro-PS Phosphatidylserine 200 mg has a known interaction with 219 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Neuro-PS Phosphatidylserine 200 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while pregnant or breastfeeding?
There isn't enough safety information about phosphatidylserine in pregnancy or while breastfeeding, so avoidance is recommended. Talk with your doctor or pharmacist about your personal situation and whether it's right for you.
What are the most common side effects?
The most frequent side effects are flatulence, stomach upset, headache, insomnia, and nausea. Stomach issues can happen even at this 200 mg dose. Insomnia is more likely at higher doses.
Does phosphatidylserine actually improve memory?
It's rated Possibly Effective for age-related cognitive decline and Alzheimer disease, meaning some evidence supports it but it's not conclusive. For general cognitive function, ADHD, and dementia, the evidence is too limited to say either way.
What is phosphatidylserine and what does it do?
It's a fat-like substance naturally found in cell membranes throughout your body. The theory is that it supports brain cell structure and may help with communication between nerve cells.
Is this safe to take long-term?
Phosphatidylserine is generally well tolerated in short- to medium-term studies, but long-term safety hasn't been fully established. If you're considering long-term use, check in with your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Neuro-PS Phosphatidylserine 200 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Neuro-PS Phosphatidylserine 200 mg label
Go deeper

The Full Monographs Behind Neuro-PS Phosphatidylserine 200 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Sources

Sources & How We Checked

Neuro-PS Phosphatidylserine 200 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 9 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Phosphatidylserine 9 references
  1. Crook T, Petrie W, Wells C, Massari DC. Effects of phosphatidylserine in Alzheimer's disease. Psychopharmacol Bull 1992;28:61-6.
  2. Pepping J. Phosphatidylserine. Am J Health-Syst Pharm 1999;56:2038,2043-4.
  3. Kidd PM. Phosphatidylserine; Membrane nutrient for memory. A clinical and mechanistic assessment. Altern Med Rev 1996;1:70-84.
  4. Kim HY, Akbar M, Lau A, et al. Inhibition of neuronal apoptosis by docosahexaenoic acid (22:6n-3). Role of phosphatidylserine in antiapoptotic effect. J Biol Chem 2000;275:35215-23.. PubMed
  5. Zanotti A, Valzelli L, Toffano G. Chronic phosphatidylserine treatment improves spatial memory and passive avoidance in aged rats. Psychopharmacology (Berl) 1989;99:316-21.. PubMed
  6. Schreiber S, Kampf-Sherf O, Gorfine M, et al. An open trial of plant-source derived phosphatydilserine for treatment of age-related cognitive decline. Isr J Psychiatry Relat Sci 2000;37:302-7.
  7. Pepping, J. Phosphatidylserine. Am J Health Syst.Pharm. 10-15-1999;56(20):2038, 2043-2038, 2044.
  8. Monteverde, A., Gnemmi, P., Rossi, F., Monteverde, A., and Finali, G. C. Selegiline in the treatment of mild to moderate Alzheimer-type dementia. Clin.Ther 1990;12(4):315-322.
  9. Vakhapova V, Cohen T, Richter Y, Herzog Y, Kam Y, Korczyn AD. Phosphatidylserine containing omega-3 Fatty acids may improve memory abilities in nondemented elderly individuals with memory complaints: results from an open-label extension study. Dement Geri PubMed

See these in context on the Phosphatidylserine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring