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Dietary supplement

NeuroKrill Ingredients & Drug Interactions

by Douglas Laboratories

Capsule Category: Other Combinations
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

NeuroKrill is a dietary supplement by Douglas Laboratories with 3 active ingredients. Its ingredients are commonly taken for heart and cholesterol support, high triglycerides, joint pain and inflammation.Based on those ingredients, 964 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Astaxanthin Esters, Phosphatidylserine, ultra-pure Krill Oil. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of NeuroKrill by Douglas Laboratories

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 5 of its 5 active ingredients.
  • “ultra-pure Krill Oil” is listed as a grouped ingredient — the label gives one combined amount (500 mg) without saying how much of each component you get.

NeuroKrill contains 5 active ingredients: eicosapentaenoic acid and docosahexaenoic acid (both omega-3 fatty acids from krill oil), phospholipids, phosphatidylserine, and astaxanthin esters. Phosphatidylserine is a fat-like compound your brain uses for cell communication; astaxanthin is a carotenoid pigment with antioxidant properties.

The product also contains olive oil and a capsule shell as inactive ingredients.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Moderate

Some clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Age-related cognitive decline — rated "Possibly Effective" (Phosphatidylserine) (Natural Medicines).
  • On file: Alzheimer disease — rated "Possibly Effective" (Phosphatidylserine) (Natural Medicines).

The evidence for most of these ingredients is limited. Phosphatidylserine has possibly effective evidence for age-related cognitive decline and Alzheimer disease, but not enough reliable data to rate it for ADHD, general cognitive function, athletic performance, or dementia.

Astaxanthin similarly lacks reliable evidence to rate its effectiveness for any condition we have data on — including age-related cognitive decline, macular degeneration, aging skin, Alzheimer disease, athletic performance, and carpal tunnel syndrome. The omega-3 fatty acids in krill oil were not rated in our data.

The evidence, ingredient by ingredient Krill Oil Phosphatidylserine Astaxanthin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Both phosphatidylserine and astaxanthin are generally well tolerated in studies, though long-term safety isn't fully established for either. The most common side effects of phosphatidylserine are flatulence, stomach upset, headache, insomnia (more likely at higher doses around 600 mg), and nausea, which can occur at doses of 200–300 mg per day.

Astaxanthin may cause stomach pain, diarrhea, or red-colored stools; at higher doses (around 40 mg daily), severe abdominal pain has been reported in a small number of cases. The safety data advises against use during pregnancy for both phosphatidylserine and astaxanthin esters because there isn't enough information.

The same holds for breastfeeding — avoidance is recommended due to unknown safety. Talk with your doctor or pharmacist about whether this product is right for you if you're pregnant, planning to become pregnant, or breastfeeding.

Side effects, ingredient by ingredient Krill Oil Phosphatidylserine Astaxanthin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Phosphatidylserine, Astaxanthin.
  • The most serious interaction on file is rated Moderate.
  • For scale: 800 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take NeuroKrill, check with your pharmacist or doctor if you're on any anticholinergic drugs (such as oxybutynin for bladder control), cholinergic drugs (such as donepezil for Alzheimer disease), or medications broken down by your liver's CYP3A4 or CYP2B6 enzymes — a category that includes many common prescriptions. Both phosphatidylserine and astaxanthin carry Moderate interactions with these drug types.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

NeuroKrill may be considered by someone interested in brain support, though the evidence for most of its ingredients is limited. If you take anticholinergic drugs, cholinergic drugs, or medications metabolized through your liver's CYP3A4 or CYP2B6 pathways, this product warrants a conversation with your doctor or pharmacist before you start it.

Pregnant or breastfeeding individuals should avoid it unless cleared by their healthcare provider. Check your exact medications with the search tool on this page.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 24, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about NeuroKrill, straight from the product label.

Brand Douglas Laboratories
Barcode (UPC) 310539033234
Net contents 30 Caplique(R) Capsule(s)
Market status On market
Date entered into DSLD Mar 24, 2016
DSLD ID 57704
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for NeuroKrill by Douglas Laboratories, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Caplique(R) Capsule(s)
Maximum serving Sizes:
1 Caplique(R) Capsule(s)
Servings per container
30
UPC/BARCODE
310539033234
IngredientAmount% DV
Eicosapentaenoic Acid75 mg--
Docosahexaenoic Acid40 mg--
Phospholipids195 mg--
ultra-pure Krill Oil500 mg--
Phosphatidylserine100 mg--
Astaxanthin Esters700 mcg--

Other ingredients: Capsule, Olive Oil

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

This product contains NO yeast, wheat, gluten, milk/dairy, corn, sodium, sugar, starch, artificial coloring, preservatives or flavoring.

Suggested/Recommended/Usage/Directions

Suggested Usage: As a dietary supplement, adults take 1 Caplique capsule daily, or as directed by your healthcare professional.

Brand IP Statement(s)

Sharp-PS GOLD is a registered trademark of Enzymotec Ltd. Caplique Caplique is a registered trademark used with permission

Formula

Contains: Soy

With DHA-Conjugated Phosphatidylserine

Precautions

KEEP OUT OF REACH OF CHILDREN.

Tamper resistant package, do not use if outer seal is missing.

Contains: Soy

Storage

For optimal storage conditions, store in a cool, dry place. (59(0)-77(0)F/15(0)-25(0)C) (35-65% relative humidity)

General

Formula #200241

FDA Statement of Identity

A Dietary Supplement

Seals/Symbols

Sharp-PS GOLD

Caplique

See for yourself

NeuroKrill by Douglas Laboratories label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in NeuroKrill by Douglas Laboratories

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Caplique(R) Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Ultra-pure Krill Oil

Interacts with
208 drugs
500 mg per serving Form: Shellfish

Krill oil is a source of omega-3 fatty acids (EPA and DHA) bound to phospholipids, which may help absorption. It is most studied for lowering triglyce...

Ultra-pure Krill Oil monograph & interactions
  • › Eicosapentaenoic Acid
  • › Docosahexaenoic Acid
  • › Phospholipids

Phosphatidylserine

Interacts with
219 drugs
100 mg per serving Form: DHA-Conjugated Phosphatidylserine

Phosphatidylserine is a natural fat-like compound found in cell membranes, especially in the brain, and it is sold mainly to support memory and thinki...

Phosphatidylserine monograph & interactions

Astaxanthin Esters

Interacts with
671 drugs
700 mcg per serving Form: Astaxanthin

Astaxanthin is a reddish carotenoid pigment with strong antioxidant activity in the lab, and it is widely promoted for skin, eye, heart, and exercise...

Astaxanthin Esters monograph & interactions

Other (inactive) ingredients: Capsule, Olive Oil. These complete the product’s ingredient list but are not active constituents.

Interaction report

NeuroKrill by Douglas Laboratories Drug Interactions

Want to check YOUR meds against NeuroKrill?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
964Drugs
964 Moderate

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in NeuroKrill with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Astaxanthin Esters2 drug types · 671 drugs

Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP2B6.
In vitro research shows that astaxanthin induces cytochrome CYP2B6 enzyme activity in human hepatocytes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
In vitro research shows that astaxanthin induces CYP3A4 enzyme activity in human hepatocytes. This effect has not been reported in humans.

Likelihood Possible Evidence D

Phosphatidylserine2 drug types · 219 drugs

Anticholinergic Drugs

Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Phosphatidylserine is thought to increase acetylcholine levels, which could theoretically interfere with the activity of anticholinergic agents.

Likelihood Possible Evidence B
Cholinergic Drugs

Theoretically, phosphatidylserine might have additive effects with cholinergic drugs.
Phosphatidylserine is thought to increase acetylcholine levels, which could theoretically lead to additive cholinergic effects when used with cholinergic drugs.

Likelihood Possible Evidence B

ultra-pure Krill Oil2 drug types · 208 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, krill oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Taking high doses of omega-3 fatty acids from fish oil can modestly decrease platelet aggregation. Since krill oil also contains these fatty acids, taking high doses of krill oil might also inhibit platelet aggregation. Theoretically, taking high doses of krill oil with antiplatelet or anticoagulant drugs might increase the risk of bleeding. However, the omega-3 content of krill oil is much lower than that of fish oil.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking krill oil with antidiabetes drugs might increase the risk of hypoglycemia.
Some research in animals and humans shows that krill oil might lower blood glucose levels. However, a small study shows that taking krill oil does not reduce blood glucose levels in patients with type 2 diabetes, most of whom were taking antidiabetes drugs.

Likelihood Possible Evidence B
The maker

Brand information

Manufacturer and brand details for NeuroKrill, from the product label.

Douglas Laboratories

See all Douglas Laboratories products
Name
Douglas Laboratories
Street Address
600 Boyce Road
City
Pittsburgh
State
PA
ZipCode
15205
Phone Number
1.800.245.4440
Web Address
www.douglaslabs.com
Pharmacist Counseling Corner

NeuroKrill by Douglas Laboratories: Common Questions

Does NeuroKrill by Douglas Laboratories interact with any medications?
Yes. Based on its ingredients, NeuroKrill has a known interaction with 964 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
NeuroKrill contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What are phosphatidylserine and astaxanthin?
Phosphatidylserine is a fat-like compound your brain cells use to communicate with each other. Astaxanthin is a pigment with antioxidant properties, sometimes called a natural carotenoid. Both are thought to support brain health, though the solid evidence is limited.
Can I take this if I'm pregnant or breastfeeding?
No — the safety data advises against both phosphatidylserine and astaxanthin during pregnancy and while breastfeeding because there isn't enough information. Talk with your doctor or pharmacist about your specific situation.
What are the most common side effects?
From phosphatidylserine: flatulence, stomach upset, headache, insomnia (especially at higher doses), and nausea. From astaxanthin: diarrhea, stomach pain, and red-colored stools. Most people tolerate these ingredients well, but long-term safety data are limited.
Is there good evidence that this works?
Phosphatidylserine has possibly effective evidence for age-related cognitive decline and Alzheimer disease. For everything else in NeuroKrill — astaxanthin and the omega-3 fatty acids — we don't have reliable evidence to say whether they work for their intended purposes.
Does NeuroKrill contain any fillers?
It contains olive oil and a capsule shell as inactive ingredients — these are standard in most supplements and help deliver the active ingredients.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if NeuroKrill is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

NeuroKrill label
Sources

Sources & How We Checked

NeuroKrill's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 25 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Krill Oil 13 references
  1. Leaf A. On the reanalysis of the GISSI-Prevenzione. Circulation 2002;105:1874-5. PubMed
  2. Connor WE. n-3 Fatty acids from fish and fish oil: panacea or nostrum? Am J Clin Nutr 2001;74;415-6. PubMed
  3. Calder PC. N-3 polyunsaturated fatty acids, inflammation and immunity: pouring oil on troubled waters or another fishy tale? Nutr Res 2001;21:309-41. DOI
  4. Bunea R, El Farrah K, Deutsch L. Evaluation of the effects of Neptune Krill Oil on the clinical course of hyperlipidemia. Altern Med Rev 2004;9:420-8.
  5. Sampalis F, Bunea R, Pelland MF, et al. Evaluation of the effects of Neptune Krill Oil on the management of premenstrual syndrome and dysmenorrhea. Altern Med Rev 2003;8:171-9.
  6. Harris WS, Miller M, Tighe AP, et al. Omega-3 fatty acids and coronary heart disease risk: clinical and mechanistic perspectives. Atherosclerosis 2008;197:12-24. PubMed
  7. Tandy S, Chung RW, Wat E, et al. Dietary krill oil supplementation reduces hepatic steatosis, glycemia, and hypercholesterolemia in high-fat-fed mice. J Agric Food Chem 10-14-2009;57:9339-45. PubMed
  8. Maki, K. C., Reeves, M. S., Farmer, M., Griinari, M., Berge, K., Vik, H., Hubacher, R., and Rains, T. M. Krill oil supplementation increases plasma concentrations of eicosapentaenoic and docosahexaenoic acids in overweight and obese men and women. Nutr.R PubMed
  9. Albert BB, Derraik JG, Brennan CM, et al. Supplementation with a blend of krill and salmon oil is associated with increased metabolic risk in overweight men. Am J Clin Nutr 2015;102(1):49-57.
  10. Berge K, Musa-Veloso K, Harwood M, Hoem N, Burri L. Krill oil supplementation lowers serum triglycerides without increasing low-density lipoprotein cholesterol in adults with borderline high or high triglyceride levels. Nutr Res 2014;34(2):126-33. PubMed
  11. Lobraico JM, DiLello LC, Butler AD, Cordisco ME, Petrini JR, Ahmadi R. Effects of krill oil on endothelial function and other cardiovascular risk factors in participants with type 2 diabetes, a randomized controlled trial. BMJ Open Diabetes Res Care. 2015 PubMed
  12. van der Wurff ISM, von Schacky C, Bergeland T, Zeegers MP, Kirschner PA, de Groot RHM. Krill oil supplementation's effect on school grades in typically developing adolescents. Prostaglandins Leukot Essent Fatty Acids 2023;191:102553. PubMed
  13. van der Wurff ISM, von Schacky C, Bergeland T, et al. Effect of 1 year krill oil supplementation on cognitive achievement of Dutch adolescents: A double-blind randomized controlled trial. Nutrients. 2019;11(6):1230. PubMed

See these in context on the Krill Oil monograph →

Phosphatidylserine 9 references
  1. Crook T, Petrie W, Wells C, Massari DC. Effects of phosphatidylserine in Alzheimer's disease. Psychopharmacol Bull 1992;28:61-6.
  2. Pepping J. Phosphatidylserine. Am J Health-Syst Pharm 1999;56:2038,2043-4.
  3. Kidd PM. Phosphatidylserine; Membrane nutrient for memory. A clinical and mechanistic assessment. Altern Med Rev 1996;1:70-84.
  4. Kim HY, Akbar M, Lau A, et al. Inhibition of neuronal apoptosis by docosahexaenoic acid (22:6n-3). Role of phosphatidylserine in antiapoptotic effect. J Biol Chem 2000;275:35215-23.. PubMed
  5. Zanotti A, Valzelli L, Toffano G. Chronic phosphatidylserine treatment improves spatial memory and passive avoidance in aged rats. Psychopharmacology (Berl) 1989;99:316-21.. PubMed
  6. Schreiber S, Kampf-Sherf O, Gorfine M, et al. An open trial of plant-source derived phosphatydilserine for treatment of age-related cognitive decline. Isr J Psychiatry Relat Sci 2000;37:302-7.
  7. Pepping, J. Phosphatidylserine. Am J Health Syst.Pharm. 10-15-1999;56(20):2038, 2043-2038, 2044.
  8. Monteverde, A., Gnemmi, P., Rossi, F., Monteverde, A., and Finali, G. C. Selegiline in the treatment of mild to moderate Alzheimer-type dementia. Clin.Ther 1990;12(4):315-322.
  9. Vakhapova V, Cohen T, Richter Y, Herzog Y, Kam Y, Korczyn AD. Phosphatidylserine containing omega-3 Fatty acids may improve memory abilities in nondemented elderly individuals with memory complaints: results from an open-label extension study. Dement Geri PubMed

See these in context on the Phosphatidylserine monograph →

Astaxanthin 3 references
  1. Kupcinskas L, Lafolie P, Lignell A, et al. Efficacy of the natural antioxidant astaxanthin in the treatment of functional dyspepsia in patients with or without Helicobacter pylori infection: A prospective, randomized, double blind, and placebo-controlled
  2. Kistler, A., Liechti, H., Pichard, L., Wolz, E., Oesterhelt, G., Hayes, A., and Maurel, P. Metabolism and CYP-inducer properties of astaxanthin in man and primary human hepatocytes. Arch.Toxicol. 2002;75(11-12):665-675. PubMed
  3. Choi HD, Youn YK, Shin WG. Positive effects of astaxanthin on lipid profiles and oxidative stress in overweight subjects. Plant Foods Hum Nutr. 2011;66:363-369. PubMed

See these in context on the Astaxanthin monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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