NeuroKrill Ingredients & Drug Interactions
What is this page for?
First and foremost: checking NeuroKrill against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
NeuroKrill is a dietary supplement by Douglas Laboratories with 3 active ingredients. Its ingredients are commonly taken for heart and cholesterol support, high triglycerides, joint pain and inflammation.Based on those ingredients, 964 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Astaxanthin Esters, Phosphatidylserine, ultra-pure Krill Oil. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against NeuroKrill by Douglas Laboratories
Ask about any prescription or over-the-counter medication and we check it for interactions with NeuroKrill by Douglas Laboratories — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of NeuroKrill by Douglas Laboratories
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
NeuroKrill contains 5 active ingredients: eicosapentaenoic acid and docosahexaenoic acid (both omega-3 fatty acids from krill oil), phospholipids, phosphatidylserine, and astaxanthin esters. Phosphatidylserine is a fat-like compound your brain uses for cell communication; astaxanthin is a carotenoid pigment with antioxidant properties.
The product also contains olive oil and a capsule shell as inactive ingredients.
Does it work?
Moderate evidence
The evidence for most of these ingredients is limited. Phosphatidylserine has possibly effective evidence for age-related cognitive decline and Alzheimer disease, but not enough reliable data to rate it for ADHD, general cognitive function, athletic performance, or dementia.
Astaxanthin similarly lacks reliable evidence to rate its effectiveness for any condition we have data on — including age-related cognitive decline, macular degeneration, aging skin, Alzheimer disease, athletic performance, and carpal tunnel syndrome. The omega-3 fatty acids in krill oil were not rated in our data.
How safe is it?
Well-documented data
Both phosphatidylserine and astaxanthin are generally well tolerated in studies, though long-term safety isn't fully established for either. The most common side effects of phosphatidylserine are flatulence, stomach upset, headache, insomnia (more likely at higher doses around 600 mg), and nausea, which can occur at doses of 200–300 mg per day.
Astaxanthin may cause stomach pain, diarrhea, or red-colored stools; at higher doses (around 40 mg daily), severe abdominal pain has been reported in a small number of cases. The safety data advises against use during pregnancy for both phosphatidylserine and astaxanthin esters because there isn't enough information.
The same holds for breastfeeding — avoidance is recommended due to unknown safety. Talk with your doctor or pharmacist about whether this product is right for you if you're pregnant, planning to become pregnant, or breastfeeding.
Meds to double-check
Moderate interaction found
Before you take NeuroKrill, check with your pharmacist or doctor if you're on any anticholinergic drugs (such as oxybutynin for bladder control), cholinergic drugs (such as donepezil for Alzheimer disease), or medications broken down by your liver's CYP3A4 or CYP2B6 enzymes — a category that includes many common prescriptions. Both phosphatidylserine and astaxanthin carry Moderate interactions with these drug types.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.
NeuroKrill may be considered by someone interested in brain support, though the evidence for most of its ingredients is limited. If you take anticholinergic drugs, cholinergic drugs, or medications metabolized through your liver's CYP3A4 or CYP2B6 pathways, this product warrants a conversation with your doctor or pharmacist before you start it.
Pregnant or breastfeeding individuals should avoid it unless cleared by their healthcare provider. Check your exact medications with the search tool on this page.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 24, 2016.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about NeuroKrill, straight from the product label.
| Brand | Douglas Laboratories |
|---|---|
| Barcode (UPC) | 310539033234 |
| Net contents | 30 Caplique(R) Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Mar 24, 2016 |
| DSLD ID | 57704 |
| Product type | Other Combinations |
| Supplement form | Capsule |
| Dietary claims / uses | All Other |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for NeuroKrill by Douglas Laboratories, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Eicosapentaenoic Acid | 75 mg | -- |
| Docosahexaenoic Acid | 40 mg | -- |
| Phospholipids | 195 mg | -- |
| ultra-pure Krill Oil | 500 mg | -- |
| Phosphatidylserine | 100 mg | -- |
| Astaxanthin Esters | 700 mcg | -- |
Other ingredients: Capsule, Olive Oil
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
This product contains NO yeast, wheat, gluten, milk/dairy, corn, sodium, sugar, starch, artificial coloring, preservatives or flavoring.
Suggested/Recommended/Usage/Directions
Suggested Usage: As a dietary supplement, adults take 1 Caplique capsule daily, or as directed by your healthcare professional.
Brand IP Statement(s)
Sharp-PS GOLD is a registered trademark of Enzymotec Ltd. Caplique Caplique is a registered trademark used with permission
Formula
Contains: Soy
With DHA-Conjugated Phosphatidylserine
Precautions
KEEP OUT OF REACH OF CHILDREN.
Tamper resistant package, do not use if outer seal is missing.
Contains: Soy
Storage
For optimal storage conditions, store in a cool, dry place. (59(0)-77(0)F/15(0)-25(0)C) (35-65% relative humidity)
General
Formula #200241
FDA Statement of Identity
A Dietary Supplement
Seals/Symbols
Sharp-PS GOLD
Caplique
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
NeuroKrill by Douglas Laboratories label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in NeuroKrill by Douglas Laboratories
These are the 3 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Caplique(R) Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Ultra-pure Krill Oil
Interacts with208 drugs
Krill oil is a source of omega-3 fatty acids (EPA and DHA) bound to phospholipids, which may help absorption. It is most studied for lowering triglyce...
Ultra-pure Krill Oil monograph & interactions- › Eicosapentaenoic Acid
- › Docosahexaenoic Acid
- › Phospholipids
Phosphatidylserine
Interacts with219 drugs
Phosphatidylserine is a natural fat-like compound found in cell membranes, especially in the brain, and it is sold mainly to support memory and thinki...
Phosphatidylserine monograph & interactionsAstaxanthin Esters
Interacts with671 drugs
Astaxanthin is a reddish carotenoid pigment with strong antioxidant activity in the lab, and it is widely promoted for skin, eye, heart, and exercise...
Astaxanthin Esters monograph & interactionsOther (inactive) ingredients: Capsule, Olive Oil. These complete the product’s ingredient list but are not active constituents.
NeuroKrill by Douglas Laboratories Drug Interactions
HelloPharmacist Interaction Report
NeuroKrill by Douglas Laboratories contains phosphatidylserine and astaxanthin esters, both of which have documented interactions with medications.
The most serious concern is with astaxanthin esters and drugs metabolized by your liver's CYP3A4 and CYP2B6 enzymes — a Moderate interaction where astaxanthin may lower the blood levels of these medications, potentially reducing how well they work. Lab studies suggest astaxanthin speeds up how your liver processes these drugs, though this hasn't been confirmed in people yet.
Read the full breakdown — every affected drug type, severity by severity
Phosphatidylserine carries Moderate interactions with anticholinergic drugs (medications that block acetylcholine, often used for overactive bladder or certain nerve problems) and cholinergic drugs (those that boost acetylcholine, such as some Alzheimer's treatments). Phosphatidylserine is thought to raise acetylcholine levels, which could interfere with anticholinergics or add to the effects of cholinergics.
We could not check three other ingredients in this product — eicosapentaenoic acid, docosahexaenoic acid, and phospholipids — because we hold no interaction data for them. The krill oil itself is a blend of those components listed separately.
Altogetherh, these interactions span 800 individual medications. Use the search tool on this page to check your exact prescriptions before you start NeuroKrill.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against NeuroKrill?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in NeuroKrill interact with 964 drugs. Click any drug to see the details.
3 of the 3 ingredients in NeuroKrill interact with drugs. Each result below shows which ingredient is responsible. Astaxanthin Esters Phosphatidylserine ultra-pure Krill Oil
Ado-trastuzumab EmtansineKadcyla
How Ado-trastuzumab Emtansine interacts with NeuroKrill — through 1 ingredient. Tap an ingredient for the detail:
Astaxanthin EstersCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Astaxanthin Esters + Ado-trastuzumab Emtansine interactionAbciximabReoPro
How Abciximab interacts with NeuroKrill — through 1 ingredient. Tap an ingredient for the detail:
Ultra-pure Krill OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, krill oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Ultra-pure Krill Oil + Abciximab interactionAbemaciclibVerzenio
How Abemaciclib interacts with NeuroKrill — through 1 ingredient. Tap an ingredient for the detail:
Astaxanthin EstersCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Astaxanthin Esters + Abemaciclib interactionAbiraterone
How Abiraterone interacts with NeuroKrill — through 1 ingredient. Tap an ingredient for the detail:
Astaxanthin EstersCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Astaxanthin Esters + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with NeuroKrill — through 1 ingredient. Tap an ingredient for the detail:
Astaxanthin EstersCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Astaxanthin Esters + Abiraterone Acetate interactionAbrocitinibCibinqo
How Abrocitinib interacts with NeuroKrill — through 1 ingredient. Tap an ingredient for the detail:
Ultra-pure Krill OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, krill oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Ultra-pure Krill Oil + Abrocitinib interactionAcalabrutinibCalquence
How Acalabrutinib interacts with NeuroKrill — through 1 ingredient. Tap an ingredient for the detail:
Astaxanthin EstersCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Astaxanthin Esters + Acalabrutinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with NeuroKrill — through 1 ingredient. Tap an ingredient for the detail:
Ultra-pure Krill OilAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking krill oil with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Ultra-pure Krill Oil + Acarbose interactionAcenocoumarolSintrom
How Acenocoumarol interacts with NeuroKrill — through 1 ingredient. Tap an ingredient for the detail:
Ultra-pure Krill OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, krill oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Ultra-pure Krill Oil + Acenocoumarol interactionAcepromazineAtravet
How Acepromazine interacts with NeuroKrill — through 1 ingredient. Tap an ingredient for the detail:
PhosphatidylserineAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Read the full Phosphatidylserine + Acepromazine interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with NeuroKrill — through 1 ingredient. Tap an ingredient for the detail:
Ultra-pure Krill OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, krill oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Ultra-pure Krill Oil + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with NeuroKrill — through 2 ingredients. Tap an ingredient for the detail:
Ultra-pure Krill OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, krill oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Ultra-pure Krill Oil + Acetaminophen, Aspirin, Caffeine interactionAstaxanthin EstersCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Astaxanthin Esters + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with NeuroKrill — through 1 ingredient. Tap an ingredient for the detail:
Astaxanthin EstersCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Astaxanthin Esters + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with NeuroKrill — through 1 ingredient. Tap an ingredient for the detail:
Astaxanthin EstersCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Astaxanthin Esters + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with NeuroKrill — through 2 ingredients. Tap an ingredient for the detail:
Astaxanthin EstersCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Astaxanthin Esters + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionPhosphatidylserineAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Read the full Phosphatidylserine + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with NeuroKrill — through 1 ingredient. Tap an ingredient for the detail:
Astaxanthin EstersCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Astaxanthin Esters + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with NeuroKrill — through 1 ingredient. Tap an ingredient for the detail:
Astaxanthin EstersCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Astaxanthin Esters + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with NeuroKrill — through 1 ingredient. Tap an ingredient for the detail:
Astaxanthin EstersCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Astaxanthin Esters + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with NeuroKrill — through 1 ingredient. Tap an ingredient for the detail:
Astaxanthin EstersCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Astaxanthin Esters + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with NeuroKrill — through 2 ingredients. Tap an ingredient for the detail:
Astaxanthin EstersCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Astaxanthin Esters + Acetaminophen, Caffeine, Pyrilamine interactionPhosphatidylserineAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Read the full Phosphatidylserine + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with NeuroKrill — through 2 ingredients. Tap an ingredient for the detail:
PhosphatidylserineAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Read the full Phosphatidylserine + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAstaxanthin EstersCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Astaxanthin Esters + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with NeuroKrill — through 2 ingredients. Tap an ingredient for the detail:
Astaxanthin EstersCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Astaxanthin Esters + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionPhosphatidylserineAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Read the full Phosphatidylserine + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with NeuroKrill — through 2 ingredients. Tap an ingredient for the detail:
PhosphatidylserineAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Read the full Phosphatidylserine + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAstaxanthin EstersCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Astaxanthin Esters + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with NeuroKrill — through 2 ingredients. Tap an ingredient for the detail:
Astaxanthin EstersCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Astaxanthin Esters + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionPhosphatidylserineAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Read the full Phosphatidylserine + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with NeuroKrill — through 2 ingredients. Tap an ingredient for the detail:
PhosphatidylserineAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Read the full Phosphatidylserine + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionAstaxanthin EstersCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Astaxanthin Esters + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interacts with NeuroKrill — through 2 ingredients. Tap an ingredient for the detail:
Astaxanthin EstersCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Astaxanthin Esters + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionPhosphatidylserineAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Read the full Phosphatidylserine + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionAcetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, SalicylamideRhinogesic GG
How Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interacts with NeuroKrill — through 2 ingredients. Tap an ingredient for the detail:
PhosphatidylserineAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Read the full Phosphatidylserine + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interactionAstaxanthin EstersCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Astaxanthin Esters + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylephrineAlka-Seltzer PLUS, Histex SR, Protid
How Acetaminophen, Chlorpheniramine, Phenylephrine interacts with NeuroKrill — through 2 ingredients. Tap an ingredient for the detail:
Astaxanthin EstersCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Astaxanthin Esters + Acetaminophen, Chlorpheniramine, Phenylephrine interactionPhosphatidylserineAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Read the full Phosphatidylserine + Acetaminophen, Chlorpheniramine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, Phenylephrine, SalicylamideRhinogesic, Rhinogesic JR
How Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interacts with NeuroKrill — through 2 ingredients. Tap an ingredient for the detail:
PhosphatidylserineAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Read the full Phosphatidylserine + Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interactionAstaxanthin EstersCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Astaxanthin Esters + Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylpropanolamineAlumadrine, Conex, Sinadrin Max Strength, Sinulin
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine interacts with NeuroKrill — through 2 ingredients. Tap an ingredient for the detail:
Astaxanthin EstersCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Astaxanthin Esters + Acetaminophen, Chlorpheniramine, Phenylpropanolamine interactionPhosphatidylserineAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Read the full Phosphatidylserine + Acetaminophen, Chlorpheniramine, Phenylpropanolamine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in NeuroKrill with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Astaxanthin Esters
Cytochrome P450 2B6 (Cyp2B6) Substrates
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP2B6.
In vitro research shows that astaxanthin induces cytochrome CYP2B6 enzyme activity in human hepatocytes. This effect has not been reported in humans.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
In vitro research shows that astaxanthin induces CYP3A4 enzyme activity in human hepatocytes. This effect has not been reported in humans.
Phosphatidylserine
Anticholinergic Drugs
Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Phosphatidylserine is thought to increase acetylcholine levels, which could theoretically interfere with the activity of anticholinergic agents.
Cholinergic Drugs
Theoretically, phosphatidylserine might have additive effects with cholinergic drugs.
Phosphatidylserine is thought to increase acetylcholine levels, which could theoretically lead to additive cholinergic effects when used with cholinergic drugs.
ultra-pure Krill Oil
Anticoagulant/Antiplatelet Drugs
Theoretically, krill oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Taking high doses of omega-3 fatty acids from fish oil can modestly decrease platelet aggregation. Since krill oil also contains these fatty acids, taking high doses of krill oil might also inhibit platelet aggregation. Theoretically, taking high doses of krill oil with antiplatelet or anticoagulant drugs might increase the risk of bleeding. However, the omega-3 content of krill oil is much lower than that of fish oil.
Antidiabetes Drugs
Theoretically, taking krill oil with antidiabetes drugs might increase the risk of hypoglycemia.
Some research in animals and humans shows that krill oil might lower blood glucose levels. However, a small study shows that taking krill oil does not reduce blood glucose levels in patients with type 2 diabetes, most of whom were taking antidiabetes drugs.
Brand information
Manufacturer and brand details for NeuroKrill, from the product label.
Douglas Laboratories
See all Douglas Laboratories products- Name
- Douglas Laboratories
- Street Address
- 600 Boyce Road
- City
- Pittsburgh
- State
- PA
- ZipCode
- 15205
- Phone Number
- 1.800.245.4440
- Web Address
- www.douglaslabs.com
NeuroKrill by Douglas Laboratories: Common Questions
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind NeuroKrill’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Krill Oil
Interacts with 208 drugsKrill oil is a source of omega-3 fatty acids (EPA and DHA) bound to phospholipids, which may help absorption. It is most studied for lowering triglycerides and supporting heart health, but t...
Read the full Krill Oil monograph → Herb & supplement monographPhosphatidylserine
Interacts with 219 drugsPhosphatidylserine is a natural fat-like compound found in cell membranes, especially in the brain, and it is sold mainly to support memory and thinking. Some research suggests possible bene...
Read the full Phosphatidylserine monograph → Herb & supplement monographAstaxanthin
Interacts with 671 drugsAstaxanthin is a reddish carotenoid pigment with strong antioxidant activity in the lab, and it is widely promoted for skin, eye, heart, and exercise benefits. Early human studies are promis...
Read the full Astaxanthin monograph →Sources & How We Checked
NeuroKrill's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 25 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Krill Oil 13 references
- Leaf A. On the reanalysis of the GISSI-Prevenzione. Circulation 2002;105:1874-5. PubMed
- Connor WE. n-3 Fatty acids from fish and fish oil: panacea or nostrum? Am J Clin Nutr 2001;74;415-6. PubMed
- Calder PC. N-3 polyunsaturated fatty acids, inflammation and immunity: pouring oil on troubled waters or another fishy tale? Nutr Res 2001;21:309-41. DOI
- Bunea R, El Farrah K, Deutsch L. Evaluation of the effects of Neptune Krill Oil on the clinical course of hyperlipidemia. Altern Med Rev 2004;9:420-8.
- Sampalis F, Bunea R, Pelland MF, et al. Evaluation of the effects of Neptune Krill Oil on the management of premenstrual syndrome and dysmenorrhea. Altern Med Rev 2003;8:171-9.
- Harris WS, Miller M, Tighe AP, et al. Omega-3 fatty acids and coronary heart disease risk: clinical and mechanistic perspectives. Atherosclerosis 2008;197:12-24. PubMed
- Tandy S, Chung RW, Wat E, et al. Dietary krill oil supplementation reduces hepatic steatosis, glycemia, and hypercholesterolemia in high-fat-fed mice. J Agric Food Chem 10-14-2009;57:9339-45. PubMed
- Maki, K. C., Reeves, M. S., Farmer, M., Griinari, M., Berge, K., Vik, H., Hubacher, R., and Rains, T. M. Krill oil supplementation increases plasma concentrations of eicosapentaenoic and docosahexaenoic acids in overweight and obese men and women. Nutr.R PubMed
- Albert BB, Derraik JG, Brennan CM, et al. Supplementation with a blend of krill and salmon oil is associated with increased metabolic risk in overweight men. Am J Clin Nutr 2015;102(1):49-57.
- Berge K, Musa-Veloso K, Harwood M, Hoem N, Burri L. Krill oil supplementation lowers serum triglycerides without increasing low-density lipoprotein cholesterol in adults with borderline high or high triglyceride levels. Nutr Res 2014;34(2):126-33. PubMed
- Lobraico JM, DiLello LC, Butler AD, Cordisco ME, Petrini JR, Ahmadi R. Effects of krill oil on endothelial function and other cardiovascular risk factors in participants with type 2 diabetes, a randomized controlled trial. BMJ Open Diabetes Res Care. 2015 PubMed
- van der Wurff ISM, von Schacky C, Bergeland T, Zeegers MP, Kirschner PA, de Groot RHM. Krill oil supplementation's effect on school grades in typically developing adolescents. Prostaglandins Leukot Essent Fatty Acids 2023;191:102553. PubMed
- van der Wurff ISM, von Schacky C, Bergeland T, et al. Effect of 1 year krill oil supplementation on cognitive achievement of Dutch adolescents: A double-blind randomized controlled trial. Nutrients. 2019;11(6):1230. PubMed
Phosphatidylserine 9 references
- Crook T, Petrie W, Wells C, Massari DC. Effects of phosphatidylserine in Alzheimer's disease. Psychopharmacol Bull 1992;28:61-6.
- Pepping J. Phosphatidylserine. Am J Health-Syst Pharm 1999;56:2038,2043-4.
- Kidd PM. Phosphatidylserine; Membrane nutrient for memory. A clinical and mechanistic assessment. Altern Med Rev 1996;1:70-84.
- Kim HY, Akbar M, Lau A, et al. Inhibition of neuronal apoptosis by docosahexaenoic acid (22:6n-3). Role of phosphatidylserine in antiapoptotic effect. J Biol Chem 2000;275:35215-23.. PubMed
- Zanotti A, Valzelli L, Toffano G. Chronic phosphatidylserine treatment improves spatial memory and passive avoidance in aged rats. Psychopharmacology (Berl) 1989;99:316-21.. PubMed
- Schreiber S, Kampf-Sherf O, Gorfine M, et al. An open trial of plant-source derived phosphatydilserine for treatment of age-related cognitive decline. Isr J Psychiatry Relat Sci 2000;37:302-7.
- Pepping, J. Phosphatidylserine. Am J Health Syst.Pharm. 10-15-1999;56(20):2038, 2043-2038, 2044.
- Monteverde, A., Gnemmi, P., Rossi, F., Monteverde, A., and Finali, G. C. Selegiline in the treatment of mild to moderate Alzheimer-type dementia. Clin.Ther 1990;12(4):315-322.
- Vakhapova V, Cohen T, Richter Y, Herzog Y, Kam Y, Korczyn AD. Phosphatidylserine containing omega-3 Fatty acids may improve memory abilities in nondemented elderly individuals with memory complaints: results from an open-label extension study. Dement Geri PubMed
Astaxanthin 3 references
- Kupcinskas L, Lafolie P, Lignell A, et al. Efficacy of the natural antioxidant astaxanthin in the treatment of functional dyspepsia in patients with or without Helicobacter pylori infection: A prospective, randomized, double blind, and placebo-controlled
- Kistler, A., Liechti, H., Pichard, L., Wolz, E., Oesterhelt, G., Hayes, A., and Maurel, P. Metabolism and CYP-inducer properties of astaxanthin in man and primary human hepatocytes. Arch.Toxicol. 2002;75(11-12):665-675. PubMed
- Choi HD, Youn YK, Shin WG. Positive effects of astaxanthin on lipid profiles and oxidative stress in overweight subjects. Plant Foods Hum Nutr. 2011;66:363-369. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC