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Dietary supplement

Nopal Cactus 650 mg Ingredients & Drug Interactions

by AN Amazing Nutrition Amazing Formulas

Nopal Cactus 650 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Nopal Cactus 650 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Nopal Cactus 650 mg is a dietary supplement by AN Amazing Nutrition Amazing Formulas with 1 active ingredient. Its ingredients are commonly taken for blood sugar control, high cholesterol, hangover symptoms.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Prickly Pear Cactus. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Nopal Cactus 650 mg by AN Amazing Nutrition Amazing Formulas

Ask about any prescription or over-the-counter medication and we check it for interactions with Nopal Cactus 650 mg by AN Amazing Nutrition Amazing Formulas — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Nopal Cactus 650 mg by AN Amazing Nutrition Amazing Formulas

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: prickly pear cactus (nopal) at 650 mg per capsule. Prickly pear is the pad and fruit of a cactus plant used traditionally in Mexican cuisine and folk medicine.

The capsule itself is filled out with inactive ingredients—gelatin, magnesium stearate, silica, and maltodextrin—which are standard binders and flow agents.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: anti-inflammatory antioxidant glucose digestive health.
  • We looked for evidence on: Diabetes, Dyspepsia, Hypercholesterolemia, Metabolic syndrome, Inflammation, Oxidative stress.
  • The strongest evidence on file: Prickly Pear Cactus is rated "Possibly Effective" for Diabetes (Natural Medicines).
  • Also on file: Prickly Pear Cactus is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia, Familial hypercholesterolemia, Hypercholesterolemia, Metabolic syndrome.

The evidence supports prickly pear cactus as possibly effective for diabetes. For other uses listed—age-related cognitive decline, benign prostatic hyperplasia, dyspepsia, and high cholesterol—the evidence isn't strong enough to rate effectiveness in the data we hold.

The evidence, ingredient by ingredient Prickly Pear Cactus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Prickly pear cactus is generally well tolerated when taken by mouth. The most common side effects are mild: abdominal fullness, dyspepsia (indigestion), mild diarrhea, and nausea.

Rarely, headache, insomnia, and dizziness have been reported. Because dried prickly pear swells significantly in your digestive tract, very large amounts—particularly the seeds from whole fruits—carry an extremely rare risk of bowel obstruction; standard supplement doses don't pose this risk.

During pregnancy and breastfeeding, there isn't enough safety data on supplement amounts of prickly pear. The safety data advises against using it in these situations—talk to your doctor or pharmacist for personalized guidance if you're pregnant, trying to conceive, or nursing.

Side effects, ingredient by ingredient Prickly Pear Cactus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Prickly Pear Cactus.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take any antidiabetes medication—including metformin, glyburide, glipizide, or chlorpropamide—double-check with your pharmacist before starting this product. The combination can lower your blood sugar more than either one alone.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Prickly pear cactus may help with blood sugar control in type 2 diabetes, but it works by lowering glucose—so if you're already on a diabetes medication, you need to monitor your levels and check with your pharmacist first. It's generally easy on the stomach.

Steer clear during pregnancy and breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Nopal Cactus 650 mg, straight from the product label.

Brand AN Amazing Nutrition Amazing Formulas
Barcode (UPC) 810180023580
Net contents 180 Capsule(s)
Market status On market
Date entered into DSLD Nov 22, 2024
DSLD ID 314686
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Nopal Cactus 650 mg by AN Amazing Nutrition Amazing Formulas, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
90
UPC/BARCODE
810180023580
IngredientAmount% DV
Prickly Pear Cactus1300 mg--

Other ingredients: Gelatin, Magnesium Stearate, Silica, Maltodextrin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

Dietary Supplement

Formulation

Anti-inflammatory & antioxidant properties Promotes healthy glucose levels Supports digestive health & food breakdown

An FDA Regulated Facility

Seals/Symbols

Made in USA GMP Good Manufacturing Practice Quality Product

Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement, adults take two (2) capsules daily with 8 ounces of water, 30 minutes before mealtime or as directed by a health care professional.

Precautions

Caution: If you are pregnant, nursing, taking any medication(s) or have any medical condition, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Keep out of reach of children.

Do not use if safety seal is damaged or missing.

General Statements

We believe that Amazing Nutrition is the key for healthy living. We are passionate about bringing you the finest selection of products which can perfectly complement a healthy diet and active lifestyle.

Shop online at: amazingnutrition.com Vitamin Angels Proud Supporter

Formula

Nopal Cactus, or more commonly known as prickly pear, is not only a staple in Mexican cuisine, it also has excellent medicinal properties. Nopal Cactus has anti-inflammatory and antioxidant properties, which helps prevent damage from inflammation and free radicals. Nopal Cactus plays a part in the breakdown of foods, which supports over-all digestive health and maintains healthy glucose levels.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Storage

Store in a cool, dry place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Nopal Cactus 650 mg by AN Amazing Nutrition Amazing Formulas label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Nopal Cactus 650 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Nopal Cactus 650 mg by AN Amazing Nutrition Amazing Formulas

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

Prickly Pear Cactus

Interacts with
86 drugs
1300 mg per serving Form: Opuntia ficus-indica

Prickly pear cactus is a desert plant whose pads and fruit are eaten as food and taken as a supplement, mainly for blood sugar, cholesterol, and hango...

Prickly Pear Cactus monograph & interactions

Other (inactive) ingredients: Gelatin, Magnesium Stearate, Silica, Maltodextrin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Nopal Cactus 650 mg by AN Amazing Nutrition Amazing Formulas Drug Interactions

Want to check YOUR meds against Nopal Cactus 650 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

Prickly Pear Cactus 86

Individual Drug Interactions

The ingredients in Nopal Cactus 650 mg interact with 86 drugs. Click any drug to see the details.

1 of the 1 ingredient in Nopal Cactus 650 mg interact with drugs. Each result below shows which ingredient is responsible. Prickly Pear Cactus

Each ingredient & the kinds of drugs it affects

For each ingredient in Nopal Cactus 650 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Prickly Pear Cactus1 drug type · 86 drugs

Antidiabetes Drugs

Combining prickly pear cactus with antidiabetes drugs might increase the risk of hypoglycemia.
Case reports show that combining prickly pear cactus with antidiabetes drugs such as chlorpropamide, glyburide, glipizide, and metformin can increase the risk of hypoglycemia in patients with type 2 diabetes. Advise patients to monitor glucose levels closely. Dose adjustments may be necessary.

Likelihood Probable Evidence D
Prickly Pear Cactus full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Nopal Cactus 650 mg, from the product label.

AN Amazing Nutrition Amazing Formulas

See all AN Amazing Nutrition Amazing Formulas products
Name
Amazing Nutrition
City
Jersey City
State
NJ
ZipCode
07310
Phone Number
1-800-526-0177
Web Address
amazingnutrition.com
Pharmacist Counseling Corner

Nopal Cactus 650 mg by AN Amazing Nutrition Amazing Formulas: Common Questions

Does Nopal Cactus 650 mg by AN Amazing Nutrition Amazing Formulas interact with any medications?
Yes. Based on its ingredients, Nopal Cactus 650 mg has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Nopal Cactus 650 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is prickly pear cactus, and why is it in this supplement?
Prickly pear (nopal) is the pad and fruit of a cactus plant. It's been used traditionally in cooking and folk medicine, and research suggests it may help with blood sugar control in type 2 diabetes.
What side effects might I experience?
Most people tolerate it well. The most common effects are mild—abdominal fullness, indigestion, mild diarrhea, and nausea. Rarely, some people report headache, insomnia, or dizziness.
Can I take this if I'm pregnant or breastfeeding?
No, the safety data advises against supplement amounts of prickly pear during pregnancy and breastfeeding. Talk to your doctor or pharmacist about what's safe for you.
Does this supplement actually help with diabetes?
The evidence shows prickly pear cactus is possibly effective for type 2 diabetes. That said, if you're on diabetes medication, this product can lower your blood sugar further, so you'll need to work with your doctor on monitoring and dosing.
Will this help with my cholesterol or other conditions listed?
The evidence for cholesterol, cognitive decline, indigestion, and prostate health isn't strong enough to rate in our data. The strongest evidence is for blood sugar control in diabetes.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Nopal Cactus 650 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Nopal Cactus 650 mg label
Go deeper

The Full Monographs Behind Nopal Cactus 650 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Prickly Pear Cactus

Interacts with 86 drugs

Prickly pear cactus is a desert plant whose pads and fruit are eaten as food and taken as a supplement, mainly for blood sugar, cholesterol, and hangover symptoms. Some small studies suggest...

Read the full Prickly Pear Cactus monograph →
Sources

Sources & How We Checked

Nopal Cactus 650 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 9 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Prickly Pear Cactus 9 references
  1. Meckes-Lozyoa M, Roman-Ramos R. Opuntia streptacantha; a coadjutor in the treatment of diabetes mellitus. Am J Chin Med 1986;14:116-8.
  2. Rayburn K, Martinez R, Escobedo M, et al. Glycemic effects of various species of nopal (Opuntia sp.) in type 2 diabetes mellitus. Texas J Rural Health 1998;26:68-76.
  3. Bush TM, Rayburn KS, Holloway SW, et al. Adverse interactions between herbal and dietary substances and prescription medications: a clinical survey. Altern Ther Health Med 2007;13:30-5.
  4. Sobieraj DM, Freyer CW. Probable hypoglycemic adverse drug reaction associated with prickly pear cactus, glipizide, and metformin in a patient with type 2 diabetes mellitus. Ann Pharmacother 2010;44:1334-7. PubMed
  5. Kleiner, O., Cohen, Z., and Mares, A. J. Low colonic obstruction due to Opuntia ficus indica seeds: the aftermath of enjoying delicious cactus fruits. Acta Paediatr. 2002;91(5):606-607.
  6. Steinberg, J. M. and Eitan, A. Prickly pear fruit bezoar presenting as rectal perforation in an elderly patient. Int J Colorectal Dis. 2003;18(4):365-367. PubMed
  7. Meckes-Lozyoa, M. and Roman-Ramos, R. Opuntia streptacantha: a coadjutor in the treatment of diabetes mellitus. Am J Chin Med 1986;14(3-4):116-118.
  8. Onakpoya IJ, O'Sullivan J, Heneghan CJ. The effect of cactus pear (Opuntia ficus-indica) on body weight and cardiovascular risk factors: a systematic review and meta-analysis of randomized clinical trials. Nutrition. 2015;31(5):640-6. PubMed
  9. Han EH, Lim MK, Lee S, et al. Efficacy of Ethanolic Extract of Opuntia ficus-indica var. saboten Stems for Improving Cognitive Function in Elderly Subjects 55-85 Years of Age: A Randomized, Double-Blind, Placebo-Controlled Study. J Med Food 2020;23(11):11

See these in context on the Prickly Pear Cactus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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