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Dietary supplement

Oil of Oregano Leaf Extract Ingredients & Drug Interactions

by Bluebonnet

Oil of Oregano Leaf Extract label
See full label image
Softgel Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Oil of Oregano Leaf Extract against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Oil of Oregano Leaf Extract is a dietary supplement by Bluebonnet with 1 active ingredient. Its ingredients are commonly taken for digestive upset, respiratory and cold symptoms, antimicrobial support.Based on those ingredients, 208 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Oil of Oregano leaf extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Oil of Oregano Leaf Extract by Bluebonnet

Ask about any prescription or over-the-counter medication and we check it for interactions with Oil of Oregano Leaf Extract by Bluebonnet — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Oil of Oregano Leaf Extract by Bluebonnet

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This softgel contains one active ingredient: oil of oregano leaf extract. The capsule itself is made from gelatin, and it's filled with extra virgin olive oil, glycerin, and purified water — all standard softgel components that help deliver the oregano oil.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Oregano's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: immune health support.
  • We looked for evidence on: Upper respiratory tract infection, Bronchitis, Cough.
  • The closest evidence on file: Oregano is rated "Insufficient Reliable Evidence To Rate" for Bronchitis (Natural Medicines).
  • Also on file: Oregano is rated "Insufficient Reliable Evidence To Rate" for Upper respiratory tract infection (URTI), Cough.

The evidence for oregano in treating acne, bronchitis, asthma, headache, or upper respiratory infection is insufficient to rate. We don't have reliable data showing it works for these uses, so we can't tell you whether it will help.

The evidence, ingredient by ingredient Oregano

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Oregano in food amounts is well tolerated. As a concentrated supplement, it's stronger and less studied than culinary oregano, so caution applies.

The most common side effect is stomach upset. Rarely, people — especially those sensitive to the Lamiaceae plant family (which includes oregano and thyme) — have had systemic allergic reactions, including anaphylaxis, after ingesting oregano.

During pregnancy, medicinal or supplement amounts should be avoided; food amounts are likely fine. While breastfeeding, normal food amounts are okay, but the safety of supplements is not established.

If you're pregnant or nursing and want to take this, talk it over with your doctor or pharmacist.

Side effects, ingredient by ingredient Oregano

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Oregano.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 208 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before taking this if you use blood thinners (anticoagulants or antiplatelet drugs like warfarin or aspirin) or diabetes medications (insulin or oral drugs). Oregano may increase bleeding risk and lower blood sugar too much when combined with these.

Altogether, these interactions span 208 individual medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This supplement is a single-ingredient oregano extract. If you take blood thinners or diabetes medications, you need to check with your own doctor or pharmacist before starting it — oregano may boost the effect of both.

It's generally well tolerated in food amounts, but allergic reactions (including severe ones) are possible in sensitive people. Anyone with a known allergy to oregano or other plants in the mint family should avoid it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 13, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Oil of Oregano Leaf Extract, straight from the product label.

Brand Bluebonnet
Barcode (UPC) 743715013827
Net contents 60 Softgel(s)
Market status On market
Date entered into DSLD Dec 13, 2022
DSLD ID 279511
Product type Botanical
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), No Allergies, Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Oil of Oregano Leaf Extract by Bluebonnet, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
Servings per container
60
UPC/BARCODE
743715013827
IngredientAmount% DV
Oil of Oregano leaf extract150 mg--

Other ingredients: Gelatin, Glycerin, Water, Purified, Extra Virgin Olive Oil

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Bluebonnet's Oil of Oregano Leaf Extract Softgels are formulated with a full spectrum 10:1 extract of oregano leaf to help support immune health.

Formulation

Sustainably wildcrafted

Free of milk, egg, fish, crustacean shellfish, tree nuts, peanuts, wheat, soybeans and sesame. Also free of corn, yeast, gluten, barley, rice, sodium and sugar.

Made in USA from domestic and imported ingredients.

Made with non GMO ingredients

Immune health

Gluten free Soy free

Precautions

Caution: For adults only.

Consult physician if pregnant/nursing, taking medication, or have a medical condition.

Keep out of reach of children.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Herbal Supplement

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take one softgel daily or as directed by a healthcare practitioner.

Storage

Store tightly closed in a cool, dry place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Oil of Oregano Leaf Extract by Bluebonnet label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Oil of Oregano Leaf Extract label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Oil of Oregano Leaf Extract by Bluebonnet

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container60 Amounts shown are per serving.

Oil of Oregano leaf extract

Interacts with
208 drugs
150 mg per serving

Oregano is a common Mediterranean cooking herb that is also sold as a concentrated oil or supplement, often standardized for a compound called carvacr...

Oil of Oregano leaf extract monograph & interactions

Other (inactive) ingredients: Gelatin, Glycerin, Water, Purified, Extra Virgin Olive Oil. These complete the product’s ingredient list but are not active constituents.

Interaction report

Oil of Oregano Leaf Extract by Bluebonnet Drug Interactions

Want to check YOUR meds against Oil of Oregano Leaf Extract?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
208Drugs
208 Moderate

Ingredients driving the most interactions

Oil of Oregano leaf extract 208

Individual Drug Interactions

The ingredients in Oil of Oregano Leaf Extract interact with 208 drugs. Click any drug to see the details.

1 of the 1 ingredient in Oil of Oregano Leaf Extract interact with drugs. Each result below shows which ingredient is responsible. Oil of Oregano leaf extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Oil of Oregano Leaf Extract with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Oil of Oregano leaf extract2 drug types · 208 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, oregano might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro research shows that aristolochic acid isolated from oregano leaves has antithrombin activity. It has also been reported that oregano oil inhibits arachidonic acid-induced, and ADP-induced, platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, oregano might increase the risk for hypoglycemia when taken with antidiabetes drugs.
In vitro and animal research shows that oregano extracts might lower blood glucose levels.

Likelihood Possible Evidence D
Oil of Oregano leaf extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Oil of Oregano Leaf Extract, from the product label.

Bluebonnet

Name
Bluebonnet Nutrition Corporation
Street Address
12915 Dairy Ashford
City
Sugar Land
State
Texas
ZipCode
77478
Web Address
www.bluebonnetnutrition.com
Pharmacist Counseling Corner

Oil of Oregano Leaf Extract by Bluebonnet: Common Questions

Does Oil of Oregano Leaf Extract by Bluebonnet interact with any medications?
Yes. Based on its ingredients, Oil of Oregano Leaf Extract has a known interaction with 208 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Oil of Oregano Leaf Extract contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is oregano oil safe to take while I'm pregnant?
Medicinal or supplement amounts should be avoided during pregnancy. Food amounts of oregano — like what you'd use in cooking — are likely fine. Talk with your doctor or pharmacist about whether this supplement is right for you.
What's the most common side effect?
Stomach upset is the most common side effect when oregano is taken orally. Serious allergic reactions are rare but have been reported, especially in people sensitive to plants in the mint family like thyme.
Does this actually work for colds or cough?
The evidence for oregano in treating upper respiratory infections, bronchitis, or asthma isn't solid enough for us to rate it. We don't have reliable data showing it works for these conditions.
Why is this supplement different from oregano I cook with?
This is a concentrated extract, so it's much stronger than the dried oregano you'd sprinkle on food. Because it's stronger, it's less studied for safety in supplement form, so we recommend caution with larger doses.
Can I take this if I'm allergic to oregano?
No — you should avoid it. People allergic to oregano or other plants in the mint family (like thyme) have had serious allergic reactions, including anaphylaxis, so skip this product if you have a known sensitivity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Oil of Oregano Leaf Extract is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Oil of Oregano Leaf Extract label
Go deeper

The Full Monographs Behind Oil of Oregano Leaf Extract’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Oregano

Interacts with 208 drugs

Oregano is a common Mediterranean cooking herb that is also sold as a concentrated oil or supplement, often standardized for a compound called carvacrol. While lab studies suggest it may hav...

Read the full Oregano monograph →
Sources

Sources & How We Checked

Oil of Oregano Leaf Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 12 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Oregano 12 references
  1. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  2. Benito M, Jorro G, Morales C, et al. Labiatae allergy: systemic reactions due to ingestion of oregano and thyme. Ann Allergy Asthma Immunol 1996;76:416-8. PubMed
  3. Chevallier A. Encyclopedia of Herbal Medicine. 2nd ed. New York, NY: DK Publ, Inc., 2000.
  4. Ciganda C, and Laborde A. Herbal infusions used for induced abortion. J Toxicol.Clin Toxicol. 2003;41:235-239. PubMed
  5. Futrell, J. M. and Rietschel, R. L. Spice allergy evaluated by results of patch tests. Cutis 1993;52(5):288-290.
  6. Tognolini, M., Barocelli, E., Ballabeni, V., Bruni, R., Bianchi, A., Chiavarini, M., and Impicciatore, M. Comparative screening of plant essential oils: phenylpropanoid moiety as basic core for antiplatelet activity. Life Sci. 2-23-2006;78(13):1419-1432. PubMed
  7. Goun, E., Cunningham, G., Solodnikov, S., Krasnykch, O., and Miles, H. Antithrombin activity of some constituents from Origanum vulgare. Fitoterapia 2002;73(7-8):692-694. PubMed
  8. Lemhadri, A., Zeggwagh, N. A., Maghrani, M., Jouad, H., and Eddouks, M. Anti-hyperglycaemic activity of the aqueous extract of Origanum vulgare growing wild in Tafilalet region. J Ethnopharmacol. 2004;92(2-3):251-256. PubMed
  9. McCue, P., Vattem, D., and Shetty, K. Inhibitory effect of clonal oregano extracts against porcine pancreatic amylase in vitro. Asia Pac.J Clin.Nutr. 2004;13(4):401-408.
  10. Ragi, J., Pappert, A., Rao, B., Havkin-Frenkel, D., and Milgraum, S. Oregano extract ointment for wound healing: a randomized, double-blind, petrolatum-controlled study evaluating efficacy. J.Drugs Dermatol. 2011;10(10):1168-1172.
  11. Singletary K. Oregano: overview of the literature on health benefits. Nutrition Today 2010;45(3):129-38.
  12. Silva MLAE, Lucarini R, Dos Santos FF, et al. Hypoglycemic effect of rosmarinic acid-rich infusion (RosCE) from Origanum vulgare in alloxan-induced diabetic rats. Nat Prod Res 2022;36(17):4525-4531.

See these in context on the Oregano monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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