Omega-3 Krill Oil Extra Strength 500 mg Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Omega-3 Krill Oil Extra Strength 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Omega-3 Krill Oil Extra Strength 500 mg is a dietary supplement by Schiff MegaRed with 5 active ingredients. Its ingredients are commonly taken for heart and cholesterol support, high triglycerides, joint pain and inflammation.Based on those ingredients, 838 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Astaxanthin, Krill Oil. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Omega-3 Krill Oil Extra Strength 500 mg by Schiff MegaRed
Ask about any prescription or over-the-counter medication and we check it for interactions with Omega-3 Krill Oil Extra Strength 500 mg by Schiff MegaRed — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Omega-3 Krill Oil Extra Strength 500 mg by Schiff MegaRed
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains 5 active ingredients. Krill oil is the main ingredient — a concentrated source of omega-3 fatty acids from Antarctic krill (tiny shrimp-like creatures).
It also contains astaxanthin, a red pigment with antioxidant properties. The product includes eicosapentaenoic acid and docosahexaenoic acid, which are the two major omega-3 fatty acids found in marine sources, plus phospholipids that help deliver these nutrients.
The softgel capsule itself is made from gelatin, glycerin, water, ethyl vanillin (for flavor), and sorbitol.
Does it work?
Insufficient evidence
Evidence for krill oil suggests it may help with dry eye, though we have insufficient reliable data to rate its effectiveness for aging skin, Alzheimer disease, cancer, high cholesterol (hyperlipidemia), or cognitive function. Astaxanthin's evidence is similarly limited — we hold insufficient data to rate it for age-related cognitive decline, age-related macular degeneration (AMD), aging skin, Alzheimer disease, athletic performance, or carpal tunnel syndrome.
How safe is it?
Well-documented data
Krill oil is generally well tolerated at doses up to 4 grams daily. The most common side effects are bloating, decreased appetite, diarrhea, fishy burps, flatulence, heartburn, nausea, and stomach discomfort — though these tend to be milder and less frequent than those from fish oil.
Headache, tiredness, and dizziness have been reported rarely. Avoid krill oil if you have a shellfish allergy and use caution if you have a bleeding disorder.
Astaxanthin is also generally well tolerated, though long-term safety data are limited. Common side effects include abdominal pain, diarrhea, and red-colored stools.
Higher doses have caused severe stomach pain in a small number of people. We don't have enough safety data to use astaxanthin during pregnancy — the facts advise against it.
We also don't have enough data for breastfeeding, so talk with your doctor or pharmacist before using it while nursing.
Meds to double-check
Moderate interaction found
Before you start this product, check with your doctor or pharmacist if you take blood thinners or antiplatelet drugs (moderate risk of increased bleeding), diabetes medications (moderate risk of low blood sugar), or any drugs metabolized through the liver enzymes CYP3A4 or CYP2B6 (moderate risk of decreased drug levels). These are theoretical concerns based on lab research, not confirmed in humans, but they're worth discussing.
The bottom line
Scorecard at a glanceFully disclosed formula with insufficient evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
This product may be worth considering if you're interested in omega-3 support and have had issues tolerating fish oil, since krill oil side effects tend to be gentler. However, if you take blood thinners or diabetes medications, you'll need to clear this with your doctor or pharmacist first — the interactions are real concerns.
Also be aware that astaxanthin shouldn't be used in pregnancy, and we don't know enough about safety while breastfeeding. Talk it over with your own healthcare provider before adding this to your routine.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 22, 2016.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Omega-3 Krill Oil Extra Strength 500 mg, straight from the product label.
| Brand | Schiff MegaRed |
|---|---|
| Barcode (UPC) | 020525105257 |
| Net contents | 60 Softgel(s) |
| Market status | On market |
| Date entered into DSLD | Oct 22, 2016 |
| DSLD ID | 65464 |
| Product type | Fat/fatty Acid |
| Supplement form | Softgel Capsule |
| Dietary claims / uses | Nutrient, All Other, Approved Health, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Omega-3 Krill Oil Extra Strength 500 mg by Schiff MegaRed, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Calories | 5 Calorie(s) | -- |
| Krill Oil | 500 mg | -- |
| Calories from Fat | 5 Calorie(s) | -- |
| Eicosapentaenoic Acid | 64 mg | -- |
| Docosahexaenoic Acid | 30 mg | -- |
| Phospholipids | 167 mg | -- |
| Cholesterol | 5 mg | 1% |
| Total Fat | 0.5 Gram(s) | 1% |
| Total Omega-3 Fatty Acids | 115 mg | -- |
| Astaxanthin | 25 mcg | -- |
Other ingredients: Gelatin, Glycerin, Water, Ethyl Vanillin, Sorbitol
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions
WARNING: People with shellfish allergy, coagulopathy or taking anticoagulants or other medications should notify their physician and be tested prior to taking dietary supplements.
WARNING: People with shellfish allergy, coagulopathy or taking anticoagulants or other medications should notify their physician and be tested prior to taking dietary supplements. If pregnant, breastfeeding or on prescribed medication, consult your physician before using this product.
Keep out of reach of children.
Protected with a tamper evident seal. Do not use if seal under cap is broken or missing.
Contains shellfish (krill)
Storage
Store in a cool, dry place with lid tightly closed.
General Statements
Gelatin is derived from bovine sources.
May Reduce the Risk of Coronary Heart Disease
SUPPORTIVE, BUT NOT CONCLUSIVE RESEARCH SHOWS THAT CONSUMPTION OF EPA AND DHA OMEGA-3 FATTY ACIDS MAY REDUCE THE RISK OF CORONARY HEART DISEASE.
Compare to fish oil MegaRed Softgel Fish Oil Softgel 100% pure Antarctic Krill oil check Contains Omega-3 Fatty acids check check Just one small softgel per day check No fishy aftertaste check In phospholipid form for easy absorption check Contains powerful antioxidant astaxanthin check
In order for Omega-3s to be put to good use, they must first be absorbed by your body. Traditional fish oil floats on top of your stomach, giving that unpleasant fishy aftertaste.
ITS OMEGA-3s ARE CARRIED IN PHOSPHOLIPID FORM, SO IT: ~ Easily mixes in the stomach and doesn’t leave an unpleasant aftertaste. ~ Is easily recognized and utilized by your body’s cell membranes, which are also phospholipid, allowing easy absorption.
Supportive, but not conclusive research shows that consumption of EPA and DHA Omega-3 fatty acids may reduce the risk of coronary heart disease.
Actual bottle size
Eco-Friendly. Krill is one of earth’s most abundant and sustainable organisms. The harvest of krill is well below conservative international catch guidelines.
This product comes from a fishery that has been independently certified to the MSC’s standard for a well-managed and sustainable fishery. www.msc.org
GUARANTEED for purity, freshness and labeled potency.
Since 1936
Heart health
COMPARE TO FISH OIL
One Small Pill, No Fishy Aftertaste
Actual size
rb Health Hygiene Home
Formula
MegaRed contains oil from 100% pure Antarctic krill, tiny crustaceans that thrive in the frigid waters of the Antarctic. Just one small MegaRed softgel provides an optimal combination of omega-3 fatty acids and the powerful antioxidant astaxanthin to support heart health. Research has shown that omega-3s may reduce the risk of coronary heart disease.
With Phospholipid Omega-3s for easy absorption
100% Pure, High Absorption Krill Oil
Contains shellfish (krill)
Brand IP Statement(s)
MEGARED OMEGA-3 KRILL OIL IS DIFFERENT.
Just one small pill with no fishy aftertaste, that’s why MegaRed Omega-3 Krill Oil is the superior choice.
MegaRed goes a step further by only sourcing krill from the Antarctic where krill is most abundant. This helps the ecosystem maintain a healthy, sustainable krill population.
Schiff SURE DISSOLVE softgels are formulated to disintegrate within one hour.
Superba is a registered trademark of the Aker Group.
2015 RB
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
General
072915 8219679
Seals/Symbols
C-SCS-0123 Certified Sustainable Seafood MSC www.msc.org
Schiff Quality Guarantee
Formulation
GUARANTEED: No added sugar (sucrose, fructose, lactose), salt (sodium chloride), yeast, wheat, gluten or milk. No preservatives or artificial colors.
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
DIRECTIONS: Adults take one (1) softgel daily.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Omega-3 Krill Oil Extra Strength 500 mg by Schiff MegaRed label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Omega-3 Krill Oil Extra Strength 500 mg by Schiff MegaRed
These are the 5 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Softgel(s) Dosage formSoftgel Capsule Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Krill Oil
Interacts with208 drugs
Krill oil is a source of omega-3 fatty acids (EPA and DHA) bound to phospholipids, which may help absorption. It is most studied for lowering triglyce...
Krill Oil monograph & interactionsPhospholipids
Total Omega-3 Fatty Acids
- › Eicosapentaenoic Acid
- › Docosahexaenoic Acid
Astaxanthin
Interacts with671 drugs
Astaxanthin is a reddish carotenoid pigment with strong antioxidant activity in the lab, and it is widely promoted for skin, eye, heart, and exercise...
Astaxanthin monograph & interactionsOther (inactive) ingredients: Gelatin, Glycerin, Water, Ethyl Vanillin, Sorbitol. These complete the product’s ingredient list but are not active constituents.
Omega-3 Krill Oil Extra Strength 500 mg by Schiff MegaRed Drug Interactions
HelloPharmacist Interaction Report
Schiff MegaRed Omega-3 Krill Oil Extra Strength contains krill oil and astaxanthin, both of which have documented interactions with medications.
The most serious concern is a moderate-severity interaction between krill oil and blood thinners (anticoagulant or antiplatelet drugs): krill oil's omega-3 fatty acids may inhibit platelet aggregation, which theoretically increases bleeding risk when combined with these medications.
Read the full breakdown — every affected drug type, severity by severity
Krill oil also interacts with diabetes medications (antidiabetes drugs) at moderate severity — some research suggests krill oil might lower blood glucose levels, which could theoretically increase the risk of low blood sugar (hypoglycemia) if you're taking diabetes medication, though one small study in type 2 diabetes patients showed no effect.
Astaxanthin, the other active ingredient, may theoretically decrease levels of certain medications metabolized by the liver through two enzyme systems: CYP3A4 substrates and CYP2B6 substrates. Both interactions carry moderate severity.
This effect hasn't been confirmed in humans yet, but if you take medications processed through these pathways, it's worth flagging.
We could not check three other ingredients — eicosapentaenoic acid, docosahexaenoic acid, and phospholipids — because we hold no interaction data for them. Altogether, these interactions span 839 individual medications.
Use the search tool below to look up your exact medications before starting this product.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Omega-3 Krill Oil Extra Strength 500 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Omega-3 Krill Oil Extra Strength 500 mg interact with 838 drugs. Click any drug to see the details.
2 of the 5 ingredients in Omega-3 Krill Oil Extra Strength 500 mg interact with drugs. Each result below shows which ingredient is responsible. Astaxanthin Krill Oil
Ado-trastuzumab EmtansineKadcyla
How Ado-trastuzumab Emtansine interacts with Omega-3 Krill Oil Extra Strength 500 mg — through 1 ingredient. Tap an ingredient for the detail:
AstaxanthinCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Astaxanthin + Ado-trastuzumab Emtansine interactionAbciximabReoPro
How Abciximab interacts with Omega-3 Krill Oil Extra Strength 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Krill OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, krill oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Krill Oil + Abciximab interactionAbemaciclibVerzenio
How Abemaciclib interacts with Omega-3 Krill Oil Extra Strength 500 mg — through 1 ingredient. Tap an ingredient for the detail:
AstaxanthinCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Astaxanthin + Abemaciclib interactionAbiraterone
How Abiraterone interacts with Omega-3 Krill Oil Extra Strength 500 mg — through 1 ingredient. Tap an ingredient for the detail:
AstaxanthinCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Astaxanthin + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with Omega-3 Krill Oil Extra Strength 500 mg — through 1 ingredient. Tap an ingredient for the detail:
AstaxanthinCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Astaxanthin + Abiraterone Acetate interactionAbrocitinibCibinqo
How Abrocitinib interacts with Omega-3 Krill Oil Extra Strength 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Krill OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, krill oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Krill Oil + Abrocitinib interactionAcalabrutinibCalquence
How Acalabrutinib interacts with Omega-3 Krill Oil Extra Strength 500 mg — through 1 ingredient. Tap an ingredient for the detail:
AstaxanthinCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Astaxanthin + Acalabrutinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Omega-3 Krill Oil Extra Strength 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Krill OilAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking krill oil with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Krill Oil + Acarbose interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Omega-3 Krill Oil Extra Strength 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Krill OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, krill oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Krill Oil + Acenocoumarol interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Omega-3 Krill Oil Extra Strength 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Krill OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, krill oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Krill Oil + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Omega-3 Krill Oil Extra Strength 500 mg — through 2 ingredients. Tap an ingredient for the detail:
Krill OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, krill oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Krill Oil + Acetaminophen, Aspirin, Caffeine interactionAstaxanthinCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Astaxanthin + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Omega-3 Krill Oil Extra Strength 500 mg — through 1 ingredient. Tap an ingredient for the detail:
AstaxanthinCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Astaxanthin + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Omega-3 Krill Oil Extra Strength 500 mg — through 1 ingredient. Tap an ingredient for the detail:
AstaxanthinCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Astaxanthin + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Omega-3 Krill Oil Extra Strength 500 mg — through 1 ingredient. Tap an ingredient for the detail:
AstaxanthinCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Astaxanthin + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Omega-3 Krill Oil Extra Strength 500 mg — through 1 ingredient. Tap an ingredient for the detail:
AstaxanthinCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Astaxanthin + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Omega-3 Krill Oil Extra Strength 500 mg — through 1 ingredient. Tap an ingredient for the detail:
AstaxanthinCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Astaxanthin + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Omega-3 Krill Oil Extra Strength 500 mg — through 1 ingredient. Tap an ingredient for the detail:
AstaxanthinCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Astaxanthin + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Omega-3 Krill Oil Extra Strength 500 mg — through 1 ingredient. Tap an ingredient for the detail:
AstaxanthinCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Astaxanthin + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Omega-3 Krill Oil Extra Strength 500 mg — through 1 ingredient. Tap an ingredient for the detail:
AstaxanthinCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Astaxanthin + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Omega-3 Krill Oil Extra Strength 500 mg — through 1 ingredient. Tap an ingredient for the detail:
AstaxanthinCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Astaxanthin + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Omega-3 Krill Oil Extra Strength 500 mg — through 1 ingredient. Tap an ingredient for the detail:
AstaxanthinCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Astaxanthin + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Omega-3 Krill Oil Extra Strength 500 mg — through 1 ingredient. Tap an ingredient for the detail:
AstaxanthinCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Astaxanthin + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with Omega-3 Krill Oil Extra Strength 500 mg — through 1 ingredient. Tap an ingredient for the detail:
AstaxanthinCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Astaxanthin + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with Omega-3 Krill Oil Extra Strength 500 mg — through 1 ingredient. Tap an ingredient for the detail:
AstaxanthinCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Astaxanthin + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interacts with Omega-3 Krill Oil Extra Strength 500 mg — through 1 ingredient. Tap an ingredient for the detail:
AstaxanthinCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Astaxanthin + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionAcetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, SalicylamideRhinogesic GG
How Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interacts with Omega-3 Krill Oil Extra Strength 500 mg — through 1 ingredient. Tap an ingredient for the detail:
AstaxanthinCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Astaxanthin + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylephrineAlka-Seltzer PLUS, Histex SR, Protid
How Acetaminophen, Chlorpheniramine, Phenylephrine interacts with Omega-3 Krill Oil Extra Strength 500 mg — through 1 ingredient. Tap an ingredient for the detail:
AstaxanthinCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Astaxanthin + Acetaminophen, Chlorpheniramine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, Phenylephrine, SalicylamideRhinogesic, Rhinogesic JR
How Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interacts with Omega-3 Krill Oil Extra Strength 500 mg — through 1 ingredient. Tap an ingredient for the detail:
AstaxanthinCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Astaxanthin + Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylpropanolamineAlumadrine, Conex, Sinadrin Max Strength, Sinulin
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine interacts with Omega-3 Krill Oil Extra Strength 500 mg — through 1 ingredient. Tap an ingredient for the detail:
AstaxanthinCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Astaxanthin + Acetaminophen, Chlorpheniramine, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, OpiumHista-Derfule
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interacts with Omega-3 Krill Oil Extra Strength 500 mg — through 1 ingredient. Tap an ingredient for the detail:
AstaxanthinCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Astaxanthin + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Omega-3 Krill Oil Extra Strength 500 mg with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Astaxanthin
Cytochrome P450 2B6 (Cyp2B6) Substrates
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP2B6.
In vitro research shows that astaxanthin induces cytochrome CYP2B6 enzyme activity in human hepatocytes. This effect has not been reported in humans.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
In vitro research shows that astaxanthin induces CYP3A4 enzyme activity in human hepatocytes. This effect has not been reported in humans.
Krill Oil
Anticoagulant/Antiplatelet Drugs
Theoretically, krill oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Taking high doses of omega-3 fatty acids from fish oil can modestly decrease platelet aggregation. Since krill oil also contains these fatty acids, taking high doses of krill oil might also inhibit platelet aggregation. Theoretically, taking high doses of krill oil with antiplatelet or anticoagulant drugs might increase the risk of bleeding. However, the omega-3 content of krill oil is much lower than that of fish oil.
Antidiabetes Drugs
Theoretically, taking krill oil with antidiabetes drugs might increase the risk of hypoglycemia.
Some research in animals and humans shows that krill oil might lower blood glucose levels. However, a small study shows that taking krill oil does not reduce blood glucose levels in patients with type 2 diabetes, most of whom were taking antidiabetes drugs.
Brand information
Manufacturer and brand details for Omega-3 Krill Oil Extra Strength 500 mg, from the product label.
Schiff MegaRed
See all Schiff MegaRed products- Name
- Reckitt Benckiser
- City
- Parsippany
- State
- NJ
- ZipCode
- 07054-0224
- Phone Number
- 1-800-526-6251
- Web Address
- www.megared.com
Omega-3 Krill Oil Extra Strength 500 mg by Schiff MegaRed: Common Questions
Does Omega-3 Krill Oil Extra Strength 500 mg by Schiff MegaRed interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Does krill oil really cause fewer stomach problems than fish oil?
Can I take this if I'm pregnant or breastfeeding?
What is astaxanthin and why is it in here?
Is this safe if I have a shellfish allergy?
I'm on a blood thinner. Can I take this?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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The Full Monographs Behind Omega-3 Krill Oil Extra Strength 500 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Krill Oil
Interacts with 208 drugsKrill oil is a source of omega-3 fatty acids (EPA and DHA) bound to phospholipids, which may help absorption. It is most studied for lowering triglycerides and supporting heart health, but t...
Read the full Krill Oil monograph → Herb & supplement monographAstaxanthin
Interacts with 671 drugsAstaxanthin is a reddish carotenoid pigment with strong antioxidant activity in the lab, and it is widely promoted for skin, eye, heart, and exercise benefits. Early human studies are promis...
Read the full Astaxanthin monograph →Sources & How We Checked
Omega-3 Krill Oil Extra Strength 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 16 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Krill Oil 13 references
- Leaf A. On the reanalysis of the GISSI-Prevenzione. Circulation 2002;105:1874-5. PubMed
- Connor WE. n-3 Fatty acids from fish and fish oil: panacea or nostrum? Am J Clin Nutr 2001;74;415-6. PubMed
- Calder PC. N-3 polyunsaturated fatty acids, inflammation and immunity: pouring oil on troubled waters or another fishy tale? Nutr Res 2001;21:309-41. DOI
- Bunea R, El Farrah K, Deutsch L. Evaluation of the effects of Neptune Krill Oil on the clinical course of hyperlipidemia. Altern Med Rev 2004;9:420-8.
- Sampalis F, Bunea R, Pelland MF, et al. Evaluation of the effects of Neptune Krill Oil on the management of premenstrual syndrome and dysmenorrhea. Altern Med Rev 2003;8:171-9.
- Harris WS, Miller M, Tighe AP, et al. Omega-3 fatty acids and coronary heart disease risk: clinical and mechanistic perspectives. Atherosclerosis 2008;197:12-24. PubMed
- Tandy S, Chung RW, Wat E, et al. Dietary krill oil supplementation reduces hepatic steatosis, glycemia, and hypercholesterolemia in high-fat-fed mice. J Agric Food Chem 10-14-2009;57:9339-45. PubMed
- Maki, K. C., Reeves, M. S., Farmer, M., Griinari, M., Berge, K., Vik, H., Hubacher, R., and Rains, T. M. Krill oil supplementation increases plasma concentrations of eicosapentaenoic and docosahexaenoic acids in overweight and obese men and women. Nutr.R PubMed
- Albert BB, Derraik JG, Brennan CM, et al. Supplementation with a blend of krill and salmon oil is associated with increased metabolic risk in overweight men. Am J Clin Nutr 2015;102(1):49-57.
- Berge K, Musa-Veloso K, Harwood M, Hoem N, Burri L. Krill oil supplementation lowers serum triglycerides without increasing low-density lipoprotein cholesterol in adults with borderline high or high triglyceride levels. Nutr Res 2014;34(2):126-33. PubMed
- Lobraico JM, DiLello LC, Butler AD, Cordisco ME, Petrini JR, Ahmadi R. Effects of krill oil on endothelial function and other cardiovascular risk factors in participants with type 2 diabetes, a randomized controlled trial. BMJ Open Diabetes Res Care. 2015 PubMed
- van der Wurff ISM, von Schacky C, Bergeland T, Zeegers MP, Kirschner PA, de Groot RHM. Krill oil supplementation's effect on school grades in typically developing adolescents. Prostaglandins Leukot Essent Fatty Acids 2023;191:102553. PubMed
- van der Wurff ISM, von Schacky C, Bergeland T, et al. Effect of 1 year krill oil supplementation on cognitive achievement of Dutch adolescents: A double-blind randomized controlled trial. Nutrients. 2019;11(6):1230. PubMed
Astaxanthin 3 references
- Kupcinskas L, Lafolie P, Lignell A, et al. Efficacy of the natural antioxidant astaxanthin in the treatment of functional dyspepsia in patients with or without Helicobacter pylori infection: A prospective, randomized, double blind, and placebo-controlled
- Kistler, A., Liechti, H., Pichard, L., Wolz, E., Oesterhelt, G., Hayes, A., and Maurel, P. Metabolism and CYP-inducer properties of astaxanthin in man and primary human hepatocytes. Arch.Toxicol. 2002;75(11-12):665-675. PubMed
- Choi HD, Youn YK, Shin WG. Positive effects of astaxanthin on lipid profiles and oxidative stress in overweight subjects. Plant Foods Hum Nutr. 2011;66:363-369. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC