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Dietary supplement

Superior Omega-3 Krill Oil Extra Strength 500 mg Ingredients & Drug Interactions

by Schiff MegaRed

Superior Omega-3 Krill Oil Extra Strength 500 mg label
See full label image
Softgel Capsule Category: Fat/fatty Acid
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Superior Omega-3 Krill Oil Extra Strength 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Superior Omega-3 Krill Oil Extra Strength 500 mg is a dietary supplement by Schiff MegaRed with 1 active ingredient. Its ingredients are commonly taken for heart and cholesterol support, high triglycerides, joint pain and inflammation.Based on those ingredients, 838 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Krill Oil. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Superior Omega-3 Krill Oil Extra Strength 500 mg by Schiff MegaRed

Ask about any prescription or over-the-counter medication and we check it for interactions with Superior Omega-3 Krill Oil Extra Strength 500 mg by Schiff MegaRed — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Superior Omega-3 Krill Oil Extra Strength 500 mg by Schiff MegaRed

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 17, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • “Total Omega-3 Fatty Acids” is listed as a grouped ingredient — the label gives one combined amount (115 mg) without saying how much of each component you get.
  • “Krill Oil” is listed as a grouped ingredient — the label gives one combined amount (500 mg) without saying how much of each component you get.

This softgel delivers 4 active ingredients: two omega-3 fatty acids (eicosapentaenoic acid and docosahexaenoic acid), the total omega-3 blend they're part of, and astaxanthin, a carotenoid antioxidant from krill. The krill oil itself is a blend of phospholipids — fat molecules that help carry the omega-3s.

The inactive ingredients are gelatin (the capsule), glycerin, water, ethyl vanillin (for flavor), and sorbitol (a sweetener).

Does it work?

Insufficient evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Insufficient

There isn't enough reliable clinical evidence to rate this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: heart and cholesterol support.
  • We looked for evidence on: Cardiovascular disease (CVD), Hyperlipidemia, Hypertriglyceridemia, Heart failure, Hypertension, Stroke — and 4 related terms.
  • The closest evidence on file: Astaxanthin is rated "Insufficient Reliable Evidence To Rate" for Heart failure (Natural Medicines).
  • Also on file: Astaxanthin is rated "Insufficient Reliable Evidence To Rate" for Hyperlipidemia, Hypertension, Stroke.

The evidence we hold on astaxanthin — one of the active ingredients — is not strong enough to rate it for any of the conditions listed, including age-related cognitive decline, macular degeneration, aging skin, Alzheimer disease, athletic performance, or carpal tunnel syndrome. For the omega-3 components themselves, we have no effectiveness ratings on file.

The evidence, ingredient by ingredient Krill Oil Astaxanthin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Astaxanthin is generally well tolerated in studies, though long-term safety data are limited. The most common side effects reported orally are abdominal pain, diarrhea, and red fecal color — a harmless discoloration.

At typical doses (6 mg daily), a small number of trial participants experienced increased bowel movements or red stools; at much higher doses (40 mg daily), a small number reported severe stomach pain. During pregnancy and breastfeeding, there is not enough safety data on astaxanthin, so the evidence advises against use.

Talk with your doctor or pharmacist about whether this product is right for you if you're pregnant, planning to become pregnant, or breastfeeding.

Side effects, ingredient by ingredient Krill Oil Astaxanthin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Astaxanthin.
  • The most serious interaction on file is rated Moderate.
  • For scale: 672 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before taking this product if you take any medications broken down by the liver enzyme CYP3A4 (such as certain statins, some immunosuppressants, and some antiarrhythmics) or CYP2B6 (such as some antidepressants and antiretrovirals) — astaxanthin may reduce how well they work. We could not verify interactions for the omega-3 components themselves.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with insufficient evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This krill oil supplement is primarily an omega-3 source with added astaxanthin. It carries moderate interaction risks with certain prescription medications that your liver breaks down — especially those dependent on CYP3A4 and CYP2B6 enzymes.

Before taking it, confirm with your own doctor or pharmacist that it won't interfere with any drugs you're on. Avoid it during pregnancy or breastfeeding unless your healthcare provider advises otherwise.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 19, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Superior Omega-3 Krill Oil Extra Strength 500 mg, straight from the product label.

Brand Schiff MegaRed
Net contents 80 Softgel(s)
Market status On market
Date entered into DSLD May 19, 2022
DSLD ID 264035
Product type Fat/fatty Acid
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Superior Omega-3 Krill Oil Extra Strength 500 mg by Schiff MegaRed, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
Servings per container
80
IngredientAmount% DV
Calories5 Calorie(s)--
Total Carbohydrates0.5 Gram(s)1%
Eicosapentaenoic Acid64 mg--
Docosahexaenoic Acid30 mg--
Cholesterol5 mg1%
Total Omega-3 Fatty Acids115 mg--
Astaxanthin25 mcg--
Krill Oil500 mg--
Phospholipids167 mg--

Other ingredients: Gelatin, Glycerin, Water, Ethyl Vanillin, Sorbitol

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Copyright 2019 RB Health

General Statements

For information call: 1-800-526-6251 www.megared.com

Precautions

Caution: If you are pregnant, breastfeeding, allergic to seafood, have existing medical conditions, taking medications (including blood thinners) or are planning a medical or surgical procedure, consult a healthcare professional before use.

Caution: If you are pregnant, breastfeeding, allergic to seafood, have existing medical conditions, taking medications (including blood thinners) or are planning a medical or surgical procedure, consult a healthcare professional before use.

Keep out of reach of children.

Protected with a tamper evident seal. Do not use if seal under cap is broken or missing.

Contains Shellfish (Krill). This product contains sulfites.

Storage

Store in a cool, dry place with lid tightly closed. Do not remove freshness pack from bottle.

Formula

Gelatin is derived from bovine sources.

3x more pure than regular krill oil

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: Adults take one (1) softgel daily. Consult your healthcare professional for the proper amount for you.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Superior Omega-3 Krill Oil Extra Strength 500 mg by Schiff MegaRed label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Superior Omega-3 Krill Oil Extra Strength 500 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Superior Omega-3 Krill Oil Extra Strength 500 mg by Schiff MegaRed

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container80 Amounts shown are per serving.

Krill Oil

Interacts with
208 drugs
500 mg per serving

Krill oil is a source of omega-3 fatty acids (EPA and DHA) bound to phospholipids, which may help absorption. It is most studied for lowering triglyce...

Krill Oil monograph & interactions
  • › Total Omega-3 Fatty Acids
  • › Astaxanthin
  • › Phospholipids

Other (inactive) ingredients: Gelatin, Glycerin, Water, Ethyl Vanillin, Sorbitol. These complete the product’s ingredient list but are not active constituents.

Interaction report

Superior Omega-3 Krill Oil Extra Strength 500 mg by Schiff MegaRed Drug Interactions

Want to check YOUR meds against Superior Omega-3 Krill Oil Extra Strength 500 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
838Drugs
838 Moderate

Ingredients driving the most interactions

Krill Oil 208

Individual Drug Interactions

The ingredients in Superior Omega-3 Krill Oil Extra Strength 500 mg interact with 838 drugs. Click any drug to see the details.

1 of the 1 ingredient in Superior Omega-3 Krill Oil Extra Strength 500 mg interact with drugs. Each result below shows which ingredient is responsible. Krill Oil

Each ingredient & the kinds of drugs it affects

For each ingredient in Superior Omega-3 Krill Oil Extra Strength 500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Krill Oil2 drug types · 208 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, krill oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Taking high doses of omega-3 fatty acids from fish oil can modestly decrease platelet aggregation. Since krill oil also contains these fatty acids, taking high doses of krill oil might also inhibit platelet aggregation. Theoretically, taking high doses of krill oil with antiplatelet or anticoagulant drugs might increase the risk of bleeding. However, the omega-3 content of krill oil is much lower than that of fish oil.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking krill oil with antidiabetes drugs might increase the risk of hypoglycemia.
Some research in animals and humans shows that krill oil might lower blood glucose levels. However, a small study shows that taking krill oil does not reduce blood glucose levels in patients with type 2 diabetes, most of whom were taking antidiabetes drugs.

Likelihood Possible Evidence B
Krill Oil full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Superior Omega-3 Krill Oil Extra Strength 500 mg, from the product label.

Schiff MegaRed

See all Schiff MegaRed products
Name
RB Health (US) LLC
City
Parsippany
State
NJ
ZipCode
07054-0224
Phone Number
1-800-526-6251
Web Address
www.megared.com
Pharmacist Counseling Corner

Superior Omega-3 Krill Oil Extra Strength 500 mg by Schiff MegaRed: Common Questions

Does Superior Omega-3 Krill Oil Extra Strength 500 mg by Schiff MegaRed interact with any medications?
Yes. Based on its ingredients, Superior Omega-3 Krill Oil Extra Strength 500 mg has a known interaction with 838 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Superior Omega-3 Krill Oil Extra Strength 500 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What are the omega-3 fatty acids in this supplement?
The two main omega-3s are eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), both sourced from krill oil. They're carried in phospholipids, which are fat molecules found naturally in krill.
What is astaxanthin, and why is it in here?
Astaxanthin is a carotenoid pigment — a type of antioxidant — found in krill. It's added to support the product's antioxidant profile, though the evidence we hold is not strong enough to rate it for specific health conditions.
Can I take this if I'm pregnant or breastfeeding?
There is not enough safety data on astaxanthin during pregnancy or breastfeeding, so it's best to avoid it unless your doctor or pharmacist tells you otherwise. Talk with them about whether this product is right for you.
What side effects might I notice?
Astaxanthin is usually well tolerated, but some people experience abdominal pain, diarrhea, or red-colored stools. At typical doses these are uncommon; at much higher doses, severe stomach pain has been reported in a small number of people.
Does this product have fillers?
Yes — the inactive ingredients are gelatin (capsule material), glycerin, water, ethyl vanillin, and sorbitol. These are standard excipients that help form and flavor the softgel.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Superior Omega-3 Krill Oil Extra Strength 500 mg label
Go deeper

The Full Monographs Behind Superior Omega-3 Krill Oil Extra Strength 500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Krill Oil

Interacts with 208 drugs

Krill oil is a source of omega-3 fatty acids (EPA and DHA) bound to phospholipids, which may help absorption. It is most studied for lowering triglycerides and supporting heart health, but t...

Read the full Krill Oil monograph → Herb & supplement monograph

Astaxanthin

Interacts with 671 drugs

Astaxanthin is a reddish carotenoid pigment with strong antioxidant activity in the lab, and it is widely promoted for skin, eye, heart, and exercise benefits. Early human studies are promis...

Read the full Astaxanthin monograph →
Sources

Sources & How We Checked

Superior Omega-3 Krill Oil Extra Strength 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 16 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Astaxanthin 3 references
  1. Kupcinskas L, Lafolie P, Lignell A, et al. Efficacy of the natural antioxidant astaxanthin in the treatment of functional dyspepsia in patients with or without Helicobacter pylori infection: A prospective, randomized, double blind, and placebo-controlled
  2. Kistler, A., Liechti, H., Pichard, L., Wolz, E., Oesterhelt, G., Hayes, A., and Maurel, P. Metabolism and CYP-inducer properties of astaxanthin in man and primary human hepatocytes. Arch.Toxicol. 2002;75(11-12):665-675. PubMed
  3. Choi HD, Youn YK, Shin WG. Positive effects of astaxanthin on lipid profiles and oxidative stress in overweight subjects. Plant Foods Hum Nutr. 2011;66:363-369. PubMed

See these in context on the Astaxanthin monograph →

Krill Oil 13 references
  1. Leaf A. On the reanalysis of the GISSI-Prevenzione. Circulation 2002;105:1874-5. PubMed
  2. Connor WE. n-3 Fatty acids from fish and fish oil: panacea or nostrum? Am J Clin Nutr 2001;74;415-6. PubMed
  3. Calder PC. N-3 polyunsaturated fatty acids, inflammation and immunity: pouring oil on troubled waters or another fishy tale? Nutr Res 2001;21:309-41. DOI
  4. Bunea R, El Farrah K, Deutsch L. Evaluation of the effects of Neptune Krill Oil on the clinical course of hyperlipidemia. Altern Med Rev 2004;9:420-8.
  5. Sampalis F, Bunea R, Pelland MF, et al. Evaluation of the effects of Neptune Krill Oil on the management of premenstrual syndrome and dysmenorrhea. Altern Med Rev 2003;8:171-9.
  6. Harris WS, Miller M, Tighe AP, et al. Omega-3 fatty acids and coronary heart disease risk: clinical and mechanistic perspectives. Atherosclerosis 2008;197:12-24. PubMed
  7. Tandy S, Chung RW, Wat E, et al. Dietary krill oil supplementation reduces hepatic steatosis, glycemia, and hypercholesterolemia in high-fat-fed mice. J Agric Food Chem 10-14-2009;57:9339-45. PubMed
  8. Maki, K. C., Reeves, M. S., Farmer, M., Griinari, M., Berge, K., Vik, H., Hubacher, R., and Rains, T. M. Krill oil supplementation increases plasma concentrations of eicosapentaenoic and docosahexaenoic acids in overweight and obese men and women. Nutr.R PubMed
  9. Albert BB, Derraik JG, Brennan CM, et al. Supplementation with a blend of krill and salmon oil is associated with increased metabolic risk in overweight men. Am J Clin Nutr 2015;102(1):49-57.
  10. Berge K, Musa-Veloso K, Harwood M, Hoem N, Burri L. Krill oil supplementation lowers serum triglycerides without increasing low-density lipoprotein cholesterol in adults with borderline high or high triglyceride levels. Nutr Res 2014;34(2):126-33. PubMed
  11. Lobraico JM, DiLello LC, Butler AD, Cordisco ME, Petrini JR, Ahmadi R. Effects of krill oil on endothelial function and other cardiovascular risk factors in participants with type 2 diabetes, a randomized controlled trial. BMJ Open Diabetes Res Care. 2015 PubMed
  12. van der Wurff ISM, von Schacky C, Bergeland T, Zeegers MP, Kirschner PA, de Groot RHM. Krill oil supplementation's effect on school grades in typically developing adolescents. Prostaglandins Leukot Essent Fatty Acids 2023;191:102553. PubMed
  13. van der Wurff ISM, von Schacky C, Bergeland T, et al. Effect of 1 year krill oil supplementation on cognitive achievement of Dutch adolescents: A double-blind randomized controlled trial. Nutrients. 2019;11(6):1230. PubMed

See these in context on the Krill Oil monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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