Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Super Heart Ingredients & Drug Interactions

by Schiff MegaRed

Super Heart label
See full label image
Softgel Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Super Heart against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Super Heart is a dietary supplement by Schiff MegaRed with 3 active ingredients. Its ingredients are commonly taken for heart and cholesterol support, high triglycerides, joint pain and inflammation.Based on those ingredients, 1,008 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Vitamin D3, Krill Oil, Coenzyme Q10. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Super Heart by Schiff MegaRed

Ask about any prescription or over-the-counter medication and we check it for interactions with Super Heart by Schiff MegaRed — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Super Heart by Schiff MegaRed

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 4 of its 6 active ingredients.
  • “Krill Oil” is listed as a grouped ingredient — the label gives one combined amount (300 mg) without saying how much of each component you get.
  • “Total Omega-3 Fatty Acids” is listed as a grouped ingredient — the label gives one combined amount (66 mg) without saying how much of each component you get.
  • “EPA and DHA Blend” is a proprietary blend — the label gives one combined amount (53 mg) without saying how much of each component you get.

Super Heart contains six active ingredients. Three are components of the krill oil blend — Eicosapentaenoic Acid (EPA), Docosahexaenoic Acid (DHA), and Phospholipids — all omega-3 fatty acids and related compounds that support heart and brain health.

Vitamin D3 helps your body absorb calcium and supports bone and immune function. Astaxanthin is a carotenoid antioxidant from algae.

Coenzyme Q10 is an antioxidant your cells make naturally and use for energy production. The softgel also contains inactive ingredients — gelatin, medium chain triglycerides, and several others — that serve as the capsule and preserve the formula.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Heart and cholesterol support.
  • We looked for evidence on: Angina, Anthracycline cardiotoxicity, Atrial fibrillation, Cardiovascular disease (CVD), Coenzyme Q10 deficiency, Congestive heart failure (CHF) — and 4 related terms.
  • The strongest evidence on file: Coenzyme Q10 is rated "Likely Effective" for Coenzyme Q10 deficiency (Natural Medicines).
  • Also on file: Vitamin D is rated "Possibly Effective" for Heart failure.
  • Also on file: Coenzyme Q10 is rated "Possibly Effective" for Congestive heart failure (CHF).

Vitamin D3 is Effective for treating rickets, osteomalacia (soft bones), renal bone disease, familial hypophosphatemia, and hypoparathyroidism — conditions where your body can't regulate calcium and phosphate properly. Coenzyme Q10 is Likely Effective for CoQ10 deficiency and Possibly Effective for fibromyalgia, migraines, heart failure, and diabetic nerve damage.

Astaxanthin has Insufficient Reliable Evidence for age-related cognitive decline, macular degeneration, aging skin, Alzheimer disease, athletic performance, and carpal tunnel syndrome — meaning we don't yet have strong data to say whether it works for those uses.

The evidence, ingredient by ingredient Krill Oil Astaxanthin Vitamin D Coenzyme Q10

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin D3 is generally well tolerated at recommended doses, but very high doses over time can cause toxicity — symptoms include high blood calcium, bone loss, and eye inflammation. The safety notes advise using it during pregnancy and breastfeeding only under your doctor's guidance.

Astaxanthin is generally well tolerated in studies, but long-term safety data are limited; the safety data advise against it in pregnancy and while breastfeeding. Coenzyme Q10 is generally well tolerated; there isn't enough reliable safety data during pregnancy, and breastfeeding safety hasn't been well studied, so check with your doctor.

The most common side effects from CoQ10 are mild gastrointestinal effects like nausea and diarrhea (less than 1% of patients), and from astaxanthin are abdominal discomfort, diarrhea, and red-colored stools.

Side effects, ingredient by ingredient Krill Oil Astaxanthin Vitamin D Coenzyme Q10

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — Vitamin D, Coenzyme Q10, Astaxanthin.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; heart-rhythm medications.
  • For scale: 851 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, double-check any thiazide diuretics, verapamil or diltiazem, warfarin, atorvastatin, digoxin, calcipotriene, blood pressure medicines, and any drugs metabolized by your liver through CYP3A4 or CYP2B6 — the interactions are documented as Moderate risk. We could not check Eicosapentaenoic Acid, Docosahexaenoic Acid, or Phospholipids, so if you take a lot of medications, run the full list through the interaction checker on this page.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Super Heart may be worth considering if you're looking for omega-3s, vitamin D, and antioxidant support — especially Coenzyme Q10 for migraine or heart health. But if you take a thiazide diuretic, blood pressure medication, warfarin, atorvastatin, heart rhythm medicine, or any drug your liver breaks down via CYP3A4 or CYP2B6, you'll need to check with your pharmacist first.

Pregnant or breastfeeding? Talk to your doctor before starting, particularly about the astaxanthin.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 22, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Super Heart, straight from the product label.

Brand Schiff MegaRed
Barcode (UPC) 020525930507
Net contents 48 Softgel(s)
Market status On market
Date entered into DSLD Oct 22, 2016
DSLD ID 65450
Product type Other Combinations
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Super Heart by Schiff MegaRed, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
UPC/BARCODE
020525930507
IngredientAmount% DV
Calories5 Calorie(s)--
Krill Oil300 mg--
Eicosapentaenoic Acid0 NP--
Docosahexaenoic Acid0 NP--
Phospholipids120 mg--
Cholesterol5 mg2%
Total Fat0.5 Gram(s)1%
Vitamin D3400 IU100%
Total Omega-3 Fatty Acids66 mg--
Astaxanthin24 mcg--
Coenzyme Q10100 mg--
EPA and DHA Blend53 mg--

Other ingredients: Gelatin, Medium Chain Triglycerides, Polysorbate 80, Glycerin, Ascorbic Acid, Water, Red 40, Titanium Dioxide, Ethyl Vanillin, Blue 1

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Actual bottle size

Eco-Friendly. Krill is one of earth’s most abundant and sustainable organisms. The harvest of krill is well below conservative international catch guidelines.

This product comes from a fishery that has been independently certified to the MSC’s standard for a well-managed and sustainable fishery. www.msc.org

GUARANTEED for purity, freshness and labeled potency.

Since 1936

Heart health

+20% free

KEY HEART HEALTH INGREDIENTS 3 in 1

rb Health Hygiene Home

3x Action Heart Health Support ~ Blood Pressure1 ~ Triglycerides2 ~ Omega-3 Index3

Why is Heart Health Important? Staying healthy means continuing to do what you want and love – today and for years to come. A healthy and active life begins with a healthy heart. Eating healthy, staying active and taking supplements can help support your heart health.

The triple action formula helps support 3 markers of heart health – triglycerides, blood pressure and Omega-3 Index

Omega 3 Krill Oil Supports healthy triglyceride levels and omega-3 index CoQ10 Helps support energy production in the heart Vitamin D Helps support healthy blood pressure All in 1 pill

1 Research has shown that Vitamin D deficiency has been associated with increased blood pressure, and this product provides 100% of the Daily Value for Vitamin D. 2 Based on 15 randomized controlled trials assessing the impact of omega-3 fatty acid intake on serum triglyceride levels. 3 Proprietary controlled human clinical study of 300mg MegaRed for improving Omega-3 Index.

Brand IP Statement(s)

MegaRed goes a step further by only sourcing krill from the Antarctic where krill is most abundant. This helps the ecosystem maintain a healthy, sustainable krill population.

Schiff SURE DISSOLVE softgels are formulated to disintegrate within one hour.

Superba is a registered trademark of the Aker Group.

2015 RB

How Can MegaRed Super Heart Help? MegaRed Super Heart – 3x Action for Heart Health.

Sure Dissolve

Seals/Symbols

C-SCS-0123 Certified Sustainable Seafood MSC www.msc.org

Schiff Quality Guarantee

Formulation

GUARANTEED: No added sugar (sucrose, fructose, lactose), salt (sodium chloride), yeast, wheat, or milk. No preservatives.

Formula

With Phospholipid Omega-3s for easy absorption

Omega-3 Krill Oil + CoQ10 + Vitamin D

Contains shellfish (krill)

This unique formulation combines three clinically proven ingredients for heart health support: high absorption 100% pure krill oil, CoQ10 and Vitamin D.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

DIRECTIONS: Adults take one (1) softgel daily.

Precautions

Contains shellfish (krill)

WARNING: People with shellfish allergy, coagulopathy or taking anticoagulants or other medications should notify their physician and be tested prior to taking dietary supplements.

WARNING: People with shellfish allergy, coagulopathy or taking anticoagulants or other medications should notify their physician and be tested prior to taking dietary supplements. Note: If pregnant, lactating or on prescribed medication, consult your physician before using this product.

Protected with a tamper evident seal. Do not use if seal under cap is broken or missing.

Keep out of reach of children.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Storage

Store in a cool, dry place with lid tightly closed and protected from light.

General

042415 8208537

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Super Heart by Schiff MegaRed label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Super Heart label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Super Heart by Schiff MegaRed

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Krill Oil

Interacts with
208 drugs
300 mg per serving

Krill oil is a source of omega-3 fatty acids (EPA and DHA) bound to phospholipids, which may help absorption. It is most studied for lowering triglyce...

Krill Oil monograph & interactions
  • › Phospholipids
  • › Total Omega-3 Fatty Acids
  • › Astaxanthin

Vitamin D3

Interacts with
715 drugs
400 IU per serving Form: Cholecalciferol

Vitamin D is a fat-soluble vitamin that helps your body absorb calcium and is important for healthy bones, muscles, and immune function. Many people,...

Vitamin D3 monograph & interactions

Coenzyme Q10

Interacts with
198 drugs
100 mg per serving

CoQ10 is a vitamin-like substance your body makes naturally that helps cells produce energy and acts as an antioxidant. It is generally well tolerated...

Coenzyme Q10 monograph & interactions

Other (inactive) ingredients: Gelatin, Medium Chain Triglycerides, Polysorbate 80, Glycerin, Ascorbic Acid, Water, Red 40, Titanium Dioxide, Ethyl Vanillin, Blue 1. These complete the product’s ingredient list but are not active constituents.

Interaction report

Super Heart by Schiff MegaRed Drug Interactions

Want to check YOUR meds against Super Heart?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,008Drugs
924 Moderate 84 Minor

Ingredients driving the most interactions

Vitamin D3 715
Krill Oil 208
Coenzyme Q10 198

Individual Drug Interactions

The ingredients in Super Heart interact with 1,008 drugs. Click any drug to see the details.

3 of the 3 ingredients in Super Heart interact with drugs. Each result below shows which ingredient is responsible. Vitamin D3 Krill Oil Coenzyme Q10

Each ingredient & the kinds of drugs it affects

For each ingredient in Super Heart with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin D38 drug types · 715 drugs

Aluminum

Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
The protein that transports calcium across the intestinal wall can also bind and transport aluminum. This protein is stimulated by vitamin D, which may therefore increase aluminum absorption. This mechanism may contribute to increased aluminum levels and toxicity in people with renal failure, when they take vitamin D and aluminum-containing phosphate binders chronically.

Likelihood Probable Evidence B
Atorvastatin (Lipitor)

Vitamin D might reduce absorption of atorvastatin.
A small, low-quality clinical study shows that taking vitamin D reduces levels of atorvastatin and its active metabolites by up to 55%. However, while atorvastatin levels decreased, total cholesterol, low-density lipoprotein (LDL) cholesterol, and high-density lipoprotein (HDL) cholesterol levels did not substantially change. Atorvastatin is metabolized in the gut by CYP3A4 enzymes, and researchers theorized that vitamin D might induce CYP3A4, causing reduced levels of atorvastatin. However, this proposed mechanism was not specifically studied.

Likelihood Probable Evidence B
Calcipotriene (Dovonex)

Taking calcipotriene with vitamin D increases the risk for hypercalcemia.
Calcipotriene is a vitamin D analog used topically for psoriasis. It can be absorbed in sufficient amounts to cause systemic effects, including hypercalcemia. Theoretically, combining calcipotriene with vitamin D supplements might increase the risk of hypercalcemia.

Likelihood Probable Evidence D
Digoxin (Lanoxin)

Theoretically, hypercalcemia induced by high-dose vitamin D can increase the risk of arrhythmia from digoxin.
High doses of vitamin D can cause hypercalcemia. Hypercalcemia increases the risk of fatal cardiac arrhythmias with digoxin. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and digoxin concurrently.

Likelihood Possible Evidence D
Diltiazem (Cardizem, Others)

Theoretically, hypercalcemia induced by high-dose vitamin D can reduce the therapeutic effects of diltiazem for arrhythmia.
High doses of vitamin D can cause hypercalcemia. Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically this could also occur with diltiazem. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and diltiazem concurrently.

Likelihood Probable Evidence B
Thiazide Diuretics

Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Thiazide diuretics decrease urinary calcium excretion, which could lead to hypercalcemia if vitamin D supplements are taken concurrently. This has been reported in people being treated with vitamin D for hypoparathyroidism, and also in elderly people with normal parathyroid function who were taking a thiazide, vitamin D, and calcium-containing antacids daily.

Likelihood Probable Evidence D
Verapamil (Calan, Others)

Hypercalcemia induced by high-dose vitamin D can reduce the therapeutic effects of verapamil for arrhythmia.
Hypercalcemia due to high doses of vitamin D can reduce the effectiveness of verapamil in atrial fibrillation. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and verapamil concurrently.

Likelihood Probable Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
There is some concern that vitamin D might induce CYP3A4. In vitro research suggests that vitamin D induces CYP3A4 transcription. Additionally, observational research has found that increased UV light exposure and serum vitamin D levels are associated with decreased serum levels of CYP3A4 substrates such as tacrolimus and sirolimus, while no association between UV light exposure or vitamin D levels and levels of mycophenolic acid, a non-CYP3A4 substrate, was found. A small, low-quality clinical study shows that taking vitamin D reduces levels of the CYP3A4 substrate atorvastatin and its active metabolites by up to 55%; however, the clinical effects of atorvastatin were not reduced. While researchers theorized that vitamin D might induce CYP3A4, this proposed mechanism was not specifically studied.

Likelihood Possible Evidence D
Vitamin D3 full monograph & interactions

Krill Oil2 drug types · 208 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, krill oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Taking high doses of omega-3 fatty acids from fish oil can modestly decrease platelet aggregation. Since krill oil also contains these fatty acids, taking high doses of krill oil might also inhibit platelet aggregation. Theoretically, taking high doses of krill oil with antiplatelet or anticoagulant drugs might increase the risk of bleeding. However, the omega-3 content of krill oil is much lower than that of fish oil.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking krill oil with antidiabetes drugs might increase the risk of hypoglycemia.
Some research in animals and humans shows that krill oil might lower blood glucose levels. However, a small study shows that taking krill oil does not reduce blood glucose levels in patients with type 2 diabetes, most of whom were taking antidiabetes drugs.

Likelihood Possible Evidence B
Krill Oil full monograph & interactions

Coenzyme Q103 drug types · 198 drugs

Alkylating Agents

Coenzyme Q10 has antioxidant effects. Theoretically, this may reduce the activity of chemotherapy drugs that generate free radicals.
Theoretically, antioxidants such as coenzyme Q10 might protect tumor cells from chemotherapeutic agents that work by inducing oxidative stress, such as alkylating agents (e.g., cyclophosphamide) and radiation therapy. The clinical importance of this interaction is unknown.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Coenzyme Q10 is chemically similar to menaquinone and might have vitamin K-like procoagulant effects, which could decrease the effects of warfarin.
Concomitant use of coenzyme Q10 and warfarin might reduce the anticoagulant effects of warfarin. Four cases of decreased warfarin efficacy thought to be due to coenzyme Q10 have been reported. However, there is some preliminary clinical research that suggests coenzyme Q10 might not significantly decrease the effects of warfarin in patients who have a stable INR.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.
Some clinical research shows that coenzyme Q10 can significantly lower blood pressure, although other studies have shown conflicting results.

Likelihood Possible Evidence B
Coenzyme Q10 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Super Heart, from the product label.

Schiff MegaRed

See all Schiff MegaRed products
Name
Reckitt Benckiser
City
Parsippany
State
NJ
ZipCode
07054-0224
Phone Number
1-800-526-6251
Web Address
www.megared.com
Pharmacist Counseling Corner

Super Heart by Schiff MegaRed: Common Questions

Does Super Heart by Schiff MegaRed interact with any medications?
Yes. Based on its ingredients, Super Heart has a known interaction with 1,008 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Super Heart contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does Coenzyme Q10 in this product interact with warfarin?
Yes — there's a Moderate interaction. Coenzyme Q10 may reduce how well warfarin (a blood thinner) works by making your blood more prone to clotting. Four cases of reduced warfarin effectiveness have been reported. Your doctor or pharmacist will need to monitor you if you take both.
Is it safe to take Super Heart while pregnant?
There isn't enough safety data for astaxanthin during pregnancy, so the data advise against it. Vitamin D is often used during pregnancy, but only at recommended doses and under your doctor's guidance. Coenzyme Q10 safety hasn't been well studied in pregnancy. Talk to your doctor before starting.
What does Coenzyme Q10 do?
Coenzyme Q10 is an antioxidant your cells make naturally to produce energy. It's Likely Effective for CoQ10 deficiency and Possibly Effective for fibromyalgia, migraines, heart failure, and diabetic nerve damage.
Can I take this if I'm on a cholesterol medication like atorvastatin?
Not without checking first — the Vitamin D3 in this product may reduce how well atorvastatin is absorbed by your body, cutting its levels by up to 55% in a small study. Your doctor may need to adjust your dose or monitor your cholesterol levels.
What are the common side effects of this product?
Most common are mild gastrointestinal effects from Coenzyme Q10 — like nausea or diarrhea (affecting less than 1% of people) — and from astaxanthin, abdominal discomfort and red-colored stools. At recommended doses, Vitamin D3 is well tolerated.
Why does this product have so many drug interactions?
The Vitamin D3, Astaxanthin, and Coenzyme Q10 together interact with a large number of individual medications — 839 total. Most are Moderate risk with your liver's drug-processing enzymes, heart medications, and blood-regulating drugs. Check your specific medications with the tool on this page.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Super Heart label
Go deeper

The Full Monographs Behind Super Heart’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Krill Oil

Interacts with 208 drugs

Krill oil is a source of omega-3 fatty acids (EPA and DHA) bound to phospholipids, which may help absorption. It is most studied for lowering triglycerides and supporting heart health, but t...

Read the full Krill Oil monograph → Herb & supplement monograph

Astaxanthin

Interacts with 671 drugs

Astaxanthin is a reddish carotenoid pigment with strong antioxidant activity in the lab, and it is widely promoted for skin, eye, heart, and exercise benefits. Early human studies are promis...

Read the full Astaxanthin monograph → Herb & supplement monograph

Vitamin D

Interacts with 715 drugs

Vitamin D is a fat-soluble vitamin that helps your body absorb calcium and is important for healthy bones, muscles, and immune function. Many people, especially those with low sun exposure,...

Read the full Vitamin D monograph → Herb & supplement monograph

Coenzyme Q10

Interacts with 198 drugs

CoQ10 is a vitamin-like substance your body makes naturally that helps cells produce energy and acts as an antioxidant. It is generally well tolerated and is most studied for heart condition...

Read the full Coenzyme Q10 monograph →
Sources

Sources & How We Checked

Super Heart's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 82 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Krill Oil 13 references
  1. Leaf A. On the reanalysis of the GISSI-Prevenzione. Circulation 2002;105:1874-5. PubMed
  2. Connor WE. n-3 Fatty acids from fish and fish oil: panacea or nostrum? Am J Clin Nutr 2001;74;415-6. PubMed
  3. Calder PC. N-3 polyunsaturated fatty acids, inflammation and immunity: pouring oil on troubled waters or another fishy tale? Nutr Res 2001;21:309-41. DOI
  4. Bunea R, El Farrah K, Deutsch L. Evaluation of the effects of Neptune Krill Oil on the clinical course of hyperlipidemia. Altern Med Rev 2004;9:420-8.
  5. Sampalis F, Bunea R, Pelland MF, et al. Evaluation of the effects of Neptune Krill Oil on the management of premenstrual syndrome and dysmenorrhea. Altern Med Rev 2003;8:171-9.
  6. Harris WS, Miller M, Tighe AP, et al. Omega-3 fatty acids and coronary heart disease risk: clinical and mechanistic perspectives. Atherosclerosis 2008;197:12-24. PubMed
  7. Tandy S, Chung RW, Wat E, et al. Dietary krill oil supplementation reduces hepatic steatosis, glycemia, and hypercholesterolemia in high-fat-fed mice. J Agric Food Chem 10-14-2009;57:9339-45. PubMed
  8. Maki, K. C., Reeves, M. S., Farmer, M., Griinari, M., Berge, K., Vik, H., Hubacher, R., and Rains, T. M. Krill oil supplementation increases plasma concentrations of eicosapentaenoic and docosahexaenoic acids in overweight and obese men and women. Nutr.R PubMed
  9. Albert BB, Derraik JG, Brennan CM, et al. Supplementation with a blend of krill and salmon oil is associated with increased metabolic risk in overweight men. Am J Clin Nutr 2015;102(1):49-57.
  10. Berge K, Musa-Veloso K, Harwood M, Hoem N, Burri L. Krill oil supplementation lowers serum triglycerides without increasing low-density lipoprotein cholesterol in adults with borderline high or high triglyceride levels. Nutr Res 2014;34(2):126-33. PubMed
  11. Lobraico JM, DiLello LC, Butler AD, Cordisco ME, Petrini JR, Ahmadi R. Effects of krill oil on endothelial function and other cardiovascular risk factors in participants with type 2 diabetes, a randomized controlled trial. BMJ Open Diabetes Res Care. 2015 PubMed
  12. van der Wurff ISM, von Schacky C, Bergeland T, Zeegers MP, Kirschner PA, de Groot RHM. Krill oil supplementation's effect on school grades in typically developing adolescents. Prostaglandins Leukot Essent Fatty Acids 2023;191:102553. PubMed
  13. van der Wurff ISM, von Schacky C, Bergeland T, et al. Effect of 1 year krill oil supplementation on cognitive achievement of Dutch adolescents: A double-blind randomized controlled trial. Nutrients. 2019;11(6):1230. PubMed

See these in context on the Krill Oil monograph →

Vitamin D 26 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Tatro DS, ed. Drug Interactions Facts. Facts and Comparisons Inc., St. Louis, MO. 1999.
  3. Koutkia P, Chen TC, Holick MF. Vitamin D intoxication associated with an over-the-counter supplement. N Engl J Med 2001;345:66-7. PubMed
  4. Bar-Or D, Yoel G. Calcium and calciferol antagonize effect of verapamil in atrial fibrillation. Br Med J 1981;282:1585-6.
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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