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Dietary supplement

Orajel Baby Cooling Tablets for Teething Ingredients & Drug Interactions

by Orajel Baby

Tablet Or Pill Category: Vitamin
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Orajel Baby Cooling Tablets for Teething is a dietary supplement by Orajel Baby with 1 active ingredient. Its ingredients are commonly taken for bone health and osteoporosis, correcting vitamin d deficiency, immune system support.Based on those ingredients, 715 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Vitamin D. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Orajel Baby Cooling Tablets for Teething by Orajel Baby

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Orajel Baby Cooling Tablets for Teething contains one active ingredient: vitamin D. This is a fat-soluble vitamin your body uses to help absorb calcium and support bone health.

The product also contains several inactive ingredients — glucose syrup, microcrystalline cellulose, natural and artificial flavors, magnesium stearate, and chamomile extract — which are fillers and binders that give the tablet its form and taste.

Does it work?

Insufficient evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Insufficient

There isn't enough reliable clinical evidence to rate this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: soothe infants who are teething.
  • We looked for evidence on: Infant development, teething pain, tooth eruption discomfort, infant irritability.
  • The closest evidence on file: Vitamin D is rated "Insufficient Reliable Evidence To Rate" for Infant development (Natural Medicines).

Vitamin D is effective for treating rickets, osteomalacia (soft bones), renal osteodystrophy (bone disease from kidney failure), familial hypophosphatemia (a genetic condition affecting phosphate), and hypoparathyroidism (low parathyroid hormone). However, the data we hold does not establish vitamin D's effectiveness for teething relief specifically, which is the use suggested by this product's name and form.

The evidence, ingredient by ingredient Vitamin D

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin D is generally well tolerated at recommended doses. However, very high doses over time can cause vitamin D toxicity, with symptoms including high blood calcium (hypercalcemia), bone loss in adults, slowed growth in children, eye inflammation and light sensitivity, and kidney problems.

In pregnancy, vitamin D at recommended amounts is likely safe, though the safety data also suggests caution — use only under your doctor's guidance. During breastfeeding, vitamin D at recommended doses is considered likely safe; again, check with your doctor before taking higher amounts.

Side effects, ingredient by ingredient Vitamin D

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Vitamin D.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: heart-rhythm medications.
  • For scale: 716 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Orajel Baby, double-check with your doctor or pharmacist if you take thiazide diuretics (water pills), verapamil or diltiazem (heart rhythm medications), digoxin (a heart drug), atorvastatin (a cholesterol medication), calcipotriene (a psoriasis cream), or aluminum-containing products. Also mention any other medications, since vitamin D may affect how your liver breaks down many drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with insufficient evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Orajel Baby Cooling Tablets deliver vitamin D, which is essential for bone health and calcium absorption but comes with important medication interactions — particularly with heart, cholesterol, and diuretic drugs. If you're pregnant or breastfeeding, or if you take any prescription medication, talk with your own doctor or pharmacist before starting this product to make sure it's right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 22, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Orajel Baby Cooling Tablets for Teething, straight from the product label.

Brand Orajel Baby
Barcode (UPC) 310310071509
Net contents 100 Quick Dissolve Tablet(s)
Market status On market
Date entered into DSLD Jun 22, 2023
DSLD ID 286726
Product type Vitamin
Supplement form Tablet Or Pill
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Infants/Baby (0 - 1 Year), Gluten Free, Dairy Free, Children more than 1 but less than 4
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Orajel Baby Cooling Tablets for Teething by Orajel Baby, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Infants
Minimum serving Sizes:
2 Tablet(s)
Maximum serving Sizes:
2 Tablet(s)
Servings per container
50
UPC/BARCODE
310310071509
IngredientAmount% DV
Vitamin D1 mcg10%, 6%

Other ingredients: Glucose Syrup, Dried, Microcrystalline Cellulose, Natural and Artificial flavors, Magnesium Stearate, Chamomile extract

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Stage 1 0+ years

Cooling flavor technology With Vitamin D for healthy tooth support

General Statements

#1 Pediatrician recommended brand for teething among those who recommended a brand

Grow with Orajel Baby

Stage 1: age 0+ Baby tooth care Teething and tooth & gum cleansers Stage 2: ages 0-3 Learning to brush Fluoride-free training toothpaste Stage 3: ages 2-10 Independent brushing Fluoride toothpaste Questions or comment Call us at 1-800-952-5080 M-F 9am-5pm ET Or visit our website at www.orajel.com

Our Commitment Proud supporter of Arbor Day Foundation Recycle paper box Do not recycle plastic bottle how2recycle.info

Daytime

Formulation

No Benzocaine, belladonna, preservatives, or dyes

Our drug-free cooling tablets may help soothe infants who may be teething, upset, cranky, or fussy. Use at home or on the go!

Our drug-free cooling tablets may help soothe infants who may be teething, upset, cranky, or fussy. Use at home or on the go! Our teething formulas are always free from: benzocaine belladonna parabens preservatives gluten dairy artificial colors, dyes, sweeteners

Drug-free

Other information: To ensure quality and potency through expiration, this dietary supplement is manufactured with higher active ingredient levels than the indicated Amount Per Serving.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: Dissolve 2 tablets (1 at a time) under baby's tongue. Ensure dissolved tablet is swallowed. Can give 2 tablets up to 10 times per day or as recommended by a licensed healthcare professional.

Precautions

Warnings: Take only as directed. Do not exceed suggested dosage. Do not use if seal is cut or torn prior to opening. Do not remove SorbiPak desiccant in bottle.

If your child has a medical condition or is on medication, please consult a physician before using this product. Stop use and ask a doctor if symptoms persist for more than 7 days, if irritation persists, or if inflammation, fever or infection develops. In case of overdose or allergic reaction, get medical help or contact a poison control center right away. Keep out of reach of children.

Storage

Store in a dry environment.

See for yourself

Orajel Baby Cooling Tablets for Teething by Orajel Baby label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Orajel Baby Cooling Tablets for Teething by Orajel Baby

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Tablet(s) Dosage formTablet Or Pill Servings per container50 Amounts shown are per serving.

Vitamin D

Interacts with
715 drugs
1 mcg per serving Form: Cholecalciferol

Vitamin D is a fat-soluble vitamin that helps your body absorb calcium and is important for healthy bones, muscles, and immune function. Many people,...

Vitamin D monograph & interactions

Other (inactive) ingredients: Glucose Syrup, Dried, Microcrystalline Cellulose, Natural and Artificial flavors, Magnesium Stearate, Chamomile extract. These complete the product’s ingredient list but are not active constituents.

Interaction report

Orajel Baby Cooling Tablets for Teething by Orajel Baby Drug Interactions

Want to check YOUR meds against Orajel Baby Cooling Tablets for Teething?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
715Drugs
80 Moderate 635 Minor

Ingredients driving the most interactions

Vitamin D 715

Each ingredient & the kinds of drugs it affects

For each ingredient in Orajel Baby Cooling Tablets for Teething with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin D8 drug types · 715 drugs

Aluminum

Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
The protein that transports calcium across the intestinal wall can also bind and transport aluminum. This protein is stimulated by vitamin D, which may therefore increase aluminum absorption. This mechanism may contribute to increased aluminum levels and toxicity in people with renal failure, when they take vitamin D and aluminum-containing phosphate binders chronically.

Likelihood Probable Evidence B
Atorvastatin (Lipitor)

Vitamin D might reduce absorption of atorvastatin.
A small, low-quality clinical study shows that taking vitamin D reduces levels of atorvastatin and its active metabolites by up to 55%. However, while atorvastatin levels decreased, total cholesterol, low-density lipoprotein (LDL) cholesterol, and high-density lipoprotein (HDL) cholesterol levels did not substantially change. Atorvastatin is metabolized in the gut by CYP3A4 enzymes, and researchers theorized that vitamin D might induce CYP3A4, causing reduced levels of atorvastatin. However, this proposed mechanism was not specifically studied.

Likelihood Probable Evidence B
Calcipotriene (Dovonex)

Taking calcipotriene with vitamin D increases the risk for hypercalcemia.
Calcipotriene is a vitamin D analog used topically for psoriasis. It can be absorbed in sufficient amounts to cause systemic effects, including hypercalcemia. Theoretically, combining calcipotriene with vitamin D supplements might increase the risk of hypercalcemia.

Likelihood Probable Evidence D
Digoxin (Lanoxin)

Theoretically, hypercalcemia induced by high-dose vitamin D can increase the risk of arrhythmia from digoxin.
High doses of vitamin D can cause hypercalcemia. Hypercalcemia increases the risk of fatal cardiac arrhythmias with digoxin. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and digoxin concurrently.

Likelihood Possible Evidence D
Diltiazem (Cardizem, Others)

Theoretically, hypercalcemia induced by high-dose vitamin D can reduce the therapeutic effects of diltiazem for arrhythmia.
High doses of vitamin D can cause hypercalcemia. Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically this could also occur with diltiazem. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and diltiazem concurrently.

Likelihood Probable Evidence B
Thiazide Diuretics

Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Thiazide diuretics decrease urinary calcium excretion, which could lead to hypercalcemia if vitamin D supplements are taken concurrently. This has been reported in people being treated with vitamin D for hypoparathyroidism, and also in elderly people with normal parathyroid function who were taking a thiazide, vitamin D, and calcium-containing antacids daily.

Likelihood Probable Evidence D
Verapamil (Calan, Others)

Hypercalcemia induced by high-dose vitamin D can reduce the therapeutic effects of verapamil for arrhythmia.
Hypercalcemia due to high doses of vitamin D can reduce the effectiveness of verapamil in atrial fibrillation. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and verapamil concurrently.

Likelihood Probable Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
There is some concern that vitamin D might induce CYP3A4. In vitro research suggests that vitamin D induces CYP3A4 transcription. Additionally, observational research has found that increased UV light exposure and serum vitamin D levels are associated with decreased serum levels of CYP3A4 substrates such as tacrolimus and sirolimus, while no association between UV light exposure or vitamin D levels and levels of mycophenolic acid, a non-CYP3A4 substrate, was found. A small, low-quality clinical study shows that taking vitamin D reduces levels of the CYP3A4 substrate atorvastatin and its active metabolites by up to 55%; however, the clinical effects of atorvastatin were not reduced. While researchers theorized that vitamin D might induce CYP3A4, this proposed mechanism was not specifically studied.

Likelihood Possible Evidence D
The maker

Brand information

Manufacturer and brand details for Orajel Baby Cooling Tablets for Teething, from the product label.

Orajel Baby

See all Orajel Baby products
Name
Church & Dwight Co., Inc.
City
Ewing
State
NJ
ZipCode
08628
Phone Number
1-800-952-5080
Web Address
www.orajel.com
Pharmacist Counseling Corner

Orajel Baby Cooling Tablets for Teething by Orajel Baby: Common Questions

Does Orajel Baby Cooling Tablets for Teething by Orajel Baby interact with any medications?
Yes. Based on its ingredients, Orajel Baby Cooling Tablets for Teething has a known interaction with 715 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Orajel Baby Cooling Tablets for Teething contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is vitamin D safe during pregnancy?
Vitamin D at recommended doses is likely safe during pregnancy, but the data also notes caution — meaning you should use it only under your doctor's guidance, not on your own.
Can I breastfeed while taking vitamin D?
Vitamin D at recommended doses is considered likely safe during breastfeeding. If you want to take higher amounts, check with your doctor first.
What are the side effects of vitamin D?
At recommended doses, vitamin D is well tolerated. High doses over time can cause vitamin D toxicity, with symptoms like high blood calcium, bone loss, slowed growth in children, eye problems, and kidney issues.
What is vitamin D used for?
Vitamin D helps your body absorb calcium and is effective for treating rickets, soft bones, bone disease from kidney failure, certain genetic phosphate disorders, and low parathyroid hormone. Its use for teething relief is not established in our data.
Does this product have fillers?
Yes — it contains glucose syrup, microcrystalline cellulose, magnesium stearate, and chamomile extract as inactive ingredients alongside the active vitamin D.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Orajel Baby Cooling Tablets for Teething is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Orajel Baby Cooling Tablets for Teething label
Go deeper

The Full Monographs Behind Orajel Baby Cooling Tablets for Teething’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Sources

Sources & How We Checked

Orajel Baby Cooling Tablets for Teething's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 26 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin D 26 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Tatro DS, ed. Drug Interactions Facts. Facts and Comparisons Inc., St. Louis, MO. 1999.
  3. Koutkia P, Chen TC, Holick MF. Vitamin D intoxication associated with an over-the-counter supplement. N Engl J Med 2001;345:66-7. PubMed
  4. Bar-Or D, Yoel G. Calcium and calciferol antagonize effect of verapamil in atrial fibrillation. Br Med J 1981;282:1585-6.
  5. Demontis R, Leflon A, Fournier A, et al. 1 alpha(OH) vitamin D3 increases plasma aluminum in hemodialyzed patients taking AI(OH)3. Clin Nephrol 1986;26:146-9.
  6. Crowe M, Wollner L, Griffiths RA. Hypercalcemia following vitamin D and thiazide therapy in the elderly. Practitioner 1984;228:312-3.
  7. Parfitt AM. Thiazide-induced hypercalcemia in vitamin D-treated hypoparathyroidism. Ann Intern Med 1972;77:557-63. PubMed
  8. Thiazide diuretics and the risk of osteoporosis. Pharmacist's Letter/Prescriber's Letter 2003;19(11):191105.
  9. Moon J. The role of vitamin D in toxic metal absorption. J Am Coll Nutr 1994;13:559-64.
  10. Demontis R, Reissi D, Noel C, et al. Indirect clinical evidence that 1alphaOH vitamin D<SUB>3</SUB> increases the intestinal absorption of aluminum. Clin Nephrol 1989;31:123-7.
  11. Adler AJ, Berlyne GM. Duodenal aluminum absorption in the rat: effect of vitamin D. Am J Physiol 1985;249:G209-13. PubMed
  12. Schwartz JB. Effects of vitamin D supplementation in atorvastatin-treated patients: A new drug interaction with an unexpected consequence. Clin Pharmacol Ther 2009;85:198-203. PubMed
  13. Dietary reference intakes for calcium and vitamin D. Institute of Medicine, November 30, 2010. Available at: http://www.iom.edu/~/media/Files/Report%20Files/2010/Dietary-Reference-Intakes-for-Calcium-and-Vitamin-D/Vitamin%20D%20and%20Calcium%202010%20Repo
  14. Cox KA, Dunn MA. Aluminum toxicity alters the regulation of calbindin-D28k protein and mRNA expression in chick intestine. J Nutr 2001;131:2007-13. PubMed
  15. Escribano, J., Balaguer, A., Pagone, F., Feliu, A., and Roque, I. Figuls. Pharmacological interventions for preventing complications in idiopathic hypercalciuria. Cochrane.Database.Syst.Rev. 2009;(1):CD004754. PubMed
  16. Carlton, S., Clopton, D., and Cappuzzo, K. A. Vitamin D deficiency: appropriate replenishment therapies and the effects of vitamin D toxicity. Consult Pharm 2010;25(3):171-177. PubMed
  17. Wang, H., Xia, N., Yang, Y., and Peng, D. Q. Influence of vitamin D supplementation on plasma lipid profiles: a meta-analysis of randomized controlled trials. Lipids Health Dis. 2012;11:42. PubMed
  18. Turner AN, Carr Reese P, Fields KS, Anderson J, Ervin M, Davis JA, Fichorova RN, Roberts MW, Klebanoff MA, Jackson RD. A blinded, randomized controlled trial of high-dose vitamin D supplementation to reduce recurrence of bacterial vaginosis. Am J Obstet G PubMed
  19. Weiner M, Epstein FH. Signs and symptoms of electrolyte disorders. Yale J Biol Med. 1970;43(2):76-109.
  20. Lappe J, Watson P, Travers-Gustafson D, Recker R, Garland C, Gorham E, Baggerly K, McDonnell SL. Effect of Vitamin D and Calcium Supplementation on Cancer Incidence in Older Women: A Randomized Clinical Trial. JAMA. 2017 Mar 28;317(12):1234-1243. PubMed
  21. Roth DE, Leung M, Mesfin E, Qamar H, Watterworth J, Papp E. Vitamin D supplementation during pregnancy: state of the evidence from a systematic review of randomised trials. BMJ. 2017;359:j5237. PubMed
  22. Murai IH, Fernandes AL, Sales LP, et al. Effect of a single high dose of vitamin D3 on hospital length of stay in patients with moderate to severe COVID-19: A randomized clinical trial. JAMA. 2021.
  23. Wang Z, Schuetz EG, Xu Y, Thummel KE. Interplay between vitamin D and the drug metabolizing enzyme CYP3A4. J Steroid Biochem Mol Biol 2013;136:54-8. PubMed
  24. Doyle D, Browne U, Brickley A, Murphy D. Vitamin D-induced hypercalcaemia and acute kidney injury in sarcoidosis. BMJ Case Rep 2023;16(1):e250580. PubMed
  25. Williamson A, Martineau AR, Sheikh A, Jolliffe D, Griffiths CJ. Vitamin D for the management of asthma. Cochrane Database Syst Rev 2023;2(2):CD011511. PubMed
  26. Kinesya E, Santoso D, Gde Arya N, et al. Vitamin D as adjuvant therapy for diabetic foot ulcers: Systematic review and meta-analysis approach. Clin Nutr ESPEN 2023;54:137-143. PubMed

See these in context on the Vitamin D monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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