Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Organic Ashwagandha Ingredients & Drug Interactions

by True Veda

Organic Ashwagandha label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Organic Ashwagandha against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Organic Ashwagandha is a dietary supplement by True Veda with 1 active ingredient. Its ingredients are commonly taken for stress and anxiety, sleep problems, fatigue and low energy.Based on those ingredients, 1,372 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are organic KSM-66 Ashwagandha full-spectrum standardized extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Organic Ashwagandha by True Veda

Ask about any prescription or over-the-counter medication and we check it for interactions with Organic Ashwagandha by True Veda — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Organic Ashwagandha by True Veda

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

True Veda's Organic Ashwagandha is a single-ingredient product: one active ingredient, an organic KSM-66 ashwagandha full-spectrum standardized extract. The capsule itself is made from plant-based hypromellose, an inactive ingredient used as the capsule material.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Ashwagandha's overall clinical evidence instead.

Moderate

Some clinical evidence supports Ashwagandha for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Anxiety — rated "Possibly Effective" (Natural Medicines).
  • On file: Generalized anxiety disorder (GAD) — rated "Possibly Effective" (Natural Medicines).
  • On file: Insomnia — rated "Possibly Effective" (Natural Medicines).
  • On file: Stress — rated "Possibly Effective" (Natural Medicines).

Ashwagandha is possibly effective for insomnia, anxiety, stress, and generalized anxiety disorder (GAD) according to the evidence we hold. For bipolar disorder, the reliability of the evidence isn't established in our data.

The evidence, ingredient by ingredient Ashwagandha

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Ashwagandha is generally well tolerated short-term in healthy adults, though quality and long-term safety data are limited. The most commonly reported side effects at typical doses are mild—diarrhea, gastrointestinal upset, nausea, and vomiting—though these don't occur often.

Drowsiness has also been reported. Rare but serious concerns include acute hepatitis and liver failure; a few case reports have raised questions about other rare effects like reversible cerebral vasoconstriction (a narrowing of blood vessels in the brain), though the link to ashwagandha alone isn't always clear.

The safety data advises against use during pregnancy—it's traditionally thought to carry a miscarriage risk. There isn't enough safety information to use it while breastfeeding, so talk with your doctor or pharmacist for personalized advice if you're nursing or pregnant.

Side effects, ingredient by ingredient Ashwagandha

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Ashwagandha.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 1,373 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this ashwagandha, double-check with your doctor or pharmacist if you're on any liver-damaging medications, sedatives or benzodiazepines, blood pressure medications, immunosuppressants, diabetes drugs, thyroid hormones, or medications processed by the CYP1A2 liver enzyme.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

True Veda's Organic Ashwagandha may be worth considering if you're looking to support sleep, anxiety, or stress and you're generally healthy without liver disease or blood pressure concerns. Be cautious if you take sedatives, blood pressure medications, immunosuppressants, diabetes drugs, or thyroid hormones—these need a closer look before you start.

Skip it if you're pregnant or breastfeeding. Check your medications with your doctor or pharmacist before adding this product.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Nov 19, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Organic Ashwagandha, straight from the product label.

Brand True Veda
Barcode (UPC) 646437300155
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Nov 19, 2021
DSLD ID 257704
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Women (not pregnant or lactating), Organic
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Organic Ashwagandha by True Veda, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
646437300155
IngredientAmount% DV
organic KSM-66 Ashwagandha full-spectrum standardized extract400 mg--

Other ingredients: Plant-Based Hypromellose Capsules

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

True Veda Organic Ashwagandha

Organic Ashwagandha Ashwagandha is an Ayurvedic herb commonly used in traditional Indian medicines. Through 14 years of careful research and development with our partners, we have perfected the way to extract the full spectrum of nutrients from the Ashwagandha root to give you the most potent and effective version of Ashwagandha on the market today.

Vegan, Vegetarian, Kosher and Gluten-free

What is Ayurveda? Ayurveda, meaning 'Knowledge of Life' is a 5000 year old holistic healing system from India that promotes longevity, balance and happiness. Ayurveda helps sustain wellbeing by applying the essential principles of nature to bring the person back into equilibrium with their pure self. Ayurveda places great emphasis on prevention of illness. By rebalancing through appropriate nutrition, exercise, relaxation and lifestyle choices, we can help you live a significantly fuller life.

Suggested/Recommended/Usage/Directions

Suggested Use: Take one capsule two times per day.

Directions: As a food supplement, take one vegetable capsule two times per day, or as directed by your health care practitioner.

Precautions

Warning: Do not take if you are pregnant or nursing.

Keep out of the reach of children.

Warning: Do not take if you are pregnant or nursing.

Keep out of the reach of children.

Do not exceed the recommended daily intake and do not use this product as a substitute for a varied diet.

Storage

Store in a cool, dry place.

Store in a cool, dry place.

General Statements

www.TrueVeda.com [email protected]

Our Story For us, it's not just about a business; it's about a healthy lifestyle. We are a small, independent family run business, whose aim is to support the world through a healthy vision. By being conscientious of the environmental effects we have on the world and how we can help, we do just that. By running our business in the most eco-friendly way possible and with a premium, researched list of products, we ensure that we are a bring added value to everyone we come into contact with. And this will never change! Get in touch with us today to help with your healthy lifestyle.

For information, guides and discounts on our products... www.TrueVeda.com [email protected]

100% Money back guarantee

X000W3LA3H

Formulation

USDA Organic

Non GMO

Benefits of True Veda Organic Ashwaganda Relieves stress and promotes relaxation Boosts the immune system and healthy aging Enhances memory, concentration and mental clarity Supports cardiovascular health

100% of the agricultural ingredients are organic

Vegan, Vegetarian, Kosher and Gluten-free

Vegan, Vegetarian, Kosher and Gluten-free No artificial ingredients or preservatives

Sourced from India and made in the UK in a GMP certified facility

Herbal Dietary Supplement to support a natural and balanced response to Stress and promote a Healthy Immune System

Certified Organic by Soil Association Certification

GB-ORG-05 EU/Non-EU Agriculture UK/Non-UK Agriculture

Certified organic by Soil Association Certification

Free of: Egg, peanut, shellfish, and soy. Gluten-Free.

Our Promise Your satisfaction is our top priority. We promise to offer 100% natural-sourced products and we follow through! This means no artificial ingredients or preservatives go near our products. Our products are made from premium ingredients, ensuring that everything we sell is of the absolute best quality. And as a bonus, by supporting us you are supporting other worthy causes. We donate a percentage of our profits to multiple charitable foundations. Let's make this world a better place to live and love!

Made in UK

Seals/Symbols

GMP Good Manufacturing Practice

USDA Organic

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Brand IP Statement(s)

Your health Our world

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Organic Ashwagandha by True Veda label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Organic Ashwagandha label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Organic Ashwagandha by True Veda

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Organic KSM-66 Ashwagandha full-spectrum standardized extract

Interacts with
1,372 drugs
400 mg per serving Form: Withaferin A, Withanolides

Ashwagandha is an Ayurvedic herb most often taken to help with stress, anxiety, and sleep, and some small studies suggest it may help, though the evid...

Organic KSM-66 Ashwagandha full-spectrum standardized extract monograph & interactions

Other (inactive) ingredients: Plant-Based Hypromellose Capsules. These complete the product’s ingredient list but are not active constituents.

Interaction report

Organic Ashwagandha by True Veda Drug Interactions

Want to check YOUR meds against Organic Ashwagandha?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,372Drugs
916 Moderate 456 Minor

Ingredients driving the most interactions

organic KSM-66 Ashwagandha full-spectrum standardized extract 1,372

Individual Drug Interactions

The ingredients in Organic Ashwagandha interact with 1,372 drugs. Click any drug to see the details.

1 of the 1 ingredient in Organic Ashwagandha interact with drugs. Each result below shows which ingredient is responsible. organic KSM-66 Ashwagandha full-spectrum standardized extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Organic Ashwagandha with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

organic KSM-66 Ashwagandha full-spectrum standardized extract10 drug types · 1,372 drugs

Antidiabetes Drugs

Theoretically, taking ashwagandha with antidiabetes drugs might increase the risk of hypoglycemia.
There is preliminary clinical evidence suggesting that ashwagandha might lower blood glucose levels. Theoretically, ashwagandha might have additive effects when used with antidiabetes drugs and increase the risk of hypoglycemia.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.
Animal research suggests that ashwagandha might lower systolic and diastolic blood pressure. Theoretically, ashwagandha might have additive effects when used with antihypertensive drugs and increase the risk of hypotension.

Likelihood Possible Evidence D
Benzodiazepines

Theoretically, taking ashwagandha might increase the sedative effects of benzodiazepines.
There is preliminary evidence that ashwagandha might have an additive effect with diazepam (Valium) and clonazepam (Klonopin). This may also occur with other benzodiazepines.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.
Ashwagandha seems to have sedative effects. Theoretically, this may potentiate the effects of barbiturates, other sedatives, and anxiolytics.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Ashwagandha has been linked to cases of acute hepatitis, liver failure, hepatic encephalopathy, autoimmune hepatitis, the need for liver transplantation, and death due to liver failure.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, taking ashwagandha might decrease the effects of immunosuppressants.
Ashwagandha has demonstrated immunostimulant effects in humans. Animal research has shown that ashwagandha can attenuate the immunosuppression caused by cyclophosphamide.

Likelihood Possible Evidence D
Thyroid Hormone

Ashwagandha might increase the effects and adverse effects of thyroid hormone.
Concomitant use of ashwagandha with thyroid hormones may cause additive therapeutic and adverse effects. Preliminary clinical research and animal studies suggest that ashwagandha boosts thyroid hormone synthesis and secretion. In one clinical study, ashwagandha increased triiodothyronine (T3) and thyroxine (T4) levels by 41.5% and 19.6%, respectively, and reduced serum TSH levels by 17.4% from baseline in adults with subclinical hypothyroidism.

Likelihood Probable Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that ashwagandha extract induces CYP1A2 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that ashwagandha extract induces CYP3A4 enzymes.

Likelihood Possible Evidence D
Serotonergic Drugs

Some animal studies have reported that ashwagandha can enhance serotonergic transmission by altering certain serotonin (5-HT) receptors. However, there is no evidence to suggest that ashwagandha increases the risk of serotonin-related effects, and there have been no published case reports of serotonin syndrome when combined with other serotonergic drugs. Nevertheless, due to the lack of extensive studies on the matter and the fact that ashwagandha appears to affect serotonergic pathways, it would be prudent to exercise caution when combining it with drugs that affect serotonin. [References: - Effects of Withania somnifera (Ashwaga ndha) on Stress and the Stress-Related Neuropsychiatric Disorders Anxiety, Depression, and Insomnia. Curr Neuropharmacol. 2021 Sep 14; 19: 1468–1495. - A Prospective, Randomized Double-Blind, Placebo-Controlled Study of Safety and Efficacy of a High-Concentration Full-Spectrum Extract of Ashwagandha Root in Reducing Stress and Anxiety in Adults. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573577/]

Likelihood Possible Evidence C
organic KSM-66 Ashwagandha full-spectrum standardized extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Organic Ashwagandha, from the product label.

True Veda

See all True Veda products
Name
Simply by Nature Ltd. Kemp House
Street Address
152 City Road
City
London
ZipCode
EC1C 2NX
Web Address
www.trueveda.com
Pharmacist Counseling Corner

Organic Ashwagandha by True Veda: Common Questions

Does Organic Ashwagandha by True Veda interact with any medications?
Yes. Based on its ingredients, Organic Ashwagandha has a known interaction with 1,372 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Organic Ashwagandha contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is ashwagandha safe to take if I'm pregnant or nursing?
No—the safety data advises against ashwagandha during pregnancy because it's traditionally thought to increase miscarriage risk. There isn't enough safety information for breastfeeding either. Talk with your doctor or pharmacist before considering it if you're pregnant or nursing.
What are the side effects?
At typical doses, ashwagandha is generally well tolerated. The most common side effects—when they do occur—are mild: diarrhea, gastrointestinal upset, nausea, vomiting, and drowsiness. Rare but serious side effects include liver damage; a few case reports have raised other rare concerns, though the direct link to ashwagandha isn't always certain.
Does this really help with anxiety and sleep?
Ashwagandha is possibly effective for both insomnia and anxiety, as well as stress and generalized anxiety disorder based on the evidence we hold. That said, the data is preliminary—it's not a guaranteed cure, and results vary from person to person.
What's KSM-66?
KSM-66 is a standardized extract of ashwagandha that's been used in clinical research. Standardized means the extract is concentrated to contain a consistent level of ashwagandha's active compounds, which helps ensure quality batch to batch.
Does this product have any fillers?
The capsule is made from plant-based hypromellose, which is an inactive ingredient used as the capsule material itself. The active ingredient is the ashwagandha extract.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Organic Ashwagandha is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Organic Ashwagandha label
Go deeper

The Full Monographs Behind Organic Ashwagandha’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Ashwagandha

Interacts with 1,372 drugs

Ashwagandha is an Ayurvedic herb most often taken to help with stress, anxiety, and sleep, and some small studies suggest it may help, though the evidence is still limited. It is generally w...

Read the full Ashwagandha monograph →
Sources

Sources & How We Checked

Organic Ashwagandha's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 32 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Ashwagandha 32 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Upton R, ed. Ashwagandha Root (Withania somnifera): Analytical, quality control, and therapuetic monograph. Santa Cruz, CA: American Herbal Pharmacopoeia 2000:1-25.
  3. Davis L, Kuttan G. Effect of Withania somnifera on cyclophosphamide-induced urotoxicity. Cancer Lett 2000;148:9-17. PubMed
  4. Davis L, Kuttan G. Suppressive effect of cyclophosphamide-induced toxicity by Withania somnifera extract in mice. J Ethnopharmacol 1998;62:209-14. PubMed
  5. Mishra LC, Singh BB, Dagenais S. Scientific basis for the therapeutic use of Withania somnifera (ashwagandha): a review. Altern Med Rev 2000;5:334-46. DOI
  6. Andallu B, Radhika B. Hypoglycemic, diuretic and hypocholesterolemic effect of winter cherry (Withania somnifera, Dunal) root. Indian J Exp Biol 2000;38:607-9.
  7. Kulkarni RR, Patki PS, Jog VP, et al. Treatment of osteoarthritis with a herbomineral formulation: a double-blind, placebo-controlled, cross-over study. J Ethnopharmacol 1991;33:91-5. PubMed
  8. Ahumada F, Aspee F, Wikman G, Hancke J. Withania somnifera exract. Its effects on arterial blood pressure in anaesthetized dogs. Phytother Res 1991;5:111-14.
  9. Panda S, Kar A. Withania somnifera and Bauhinia purpurea in the regulation of circulating thyroid hormone concentrations in female mice. J Ethnopharmacol 1999;67:233-39. PubMed
  10. Panda S, Kar A. Changes in thyroid hormone concentrations after administration of ashwagandha root extract to adult male mice. J Pharm Pharmacol 1998;50:1065-68. PubMed
  11. Sehgal, V. N., Verma, P., and Bhattacharya, S. N. Fixed-drug eruption caused by ashwagandha (Withania somnifera): a widely used Ayurvedic drug. Skinmed. 2012;10(1):48-49.
  12. Agnihotri AP, Sontakke SD, Thawani VR, Saoji A, Goswami VS. Effects of Withania somnifera in patients of schizophrenia: a randomized, double blind, placebo controlled pilot trial study. Indian J Pharmacol. 2013;45(4):417-8. PubMed
  13. Biswal BM, Sulaiman SA, Ismail HC, Zakaria H, Musa KI. Effect of Withania somnifera (Ashwagandha) on the development of chemotherapy-induced fatigue and quality of life in breast cancer patients. Integr Cancer Ther. 2013;12(4):312-22.
  14. Sharma AK, Basu I, Singh S. Efficacy and safety of Ashwagandha root extract in subclinical hypothyroid patients: a double-blind, randomized placebo-controlled trial. J Altern Complement Med. 2018 Mar;24(3):243-248. PubMed
  15. Durg S, Bavage S, Shivaram SB. Withania somnifera (Indian ginseng) in diabetes mellitus: A systematic review and meta-analysis of scientific evidence from experimental research to clinical application. Phytother Res. 2020;34(5):1041-1059.
  16. Björnsson HK, Björnsson ES, Avula B, et al. Ashwagandha-induced liver injury: A case series from Iceland and the US Drug-Induced Liver Injury Network. Liver Int. 2020;40(4):825-829. PubMed
  17. Tharakan A, Shukla H, Benny IR, Tharakan M, George L, Koshy S. Immunomodulatory Effect of Withania somnifera (Ashwagandha) Extract-A Randomized, Double-Blind, Placebo Controlled Trial with an Open Label Extension on Healthy Participants. J Clin Med 2021;1 PubMed
  18. Ireland PJ, Hardy T, Burt AD, Donnelly MC. Drug-induced hepatocellular injury due to herbal supplement ashwagandha. J R Coll Physicians Edinb. 2021;51(4):363-365. PubMed
  19. Kamal HI, Patel K, Brdak A, Heffernan J, Ahmad N. Ashwagandha as a unique cause of thyrotoxicosis presenting with supraventricular tachycardia. Cureus. 2022 Mar 25;14(3):e23494. PubMed
  20. Suryawanshi G, Abdallah M, Thomson M, Desai N, Chauhan A, Lim N. Ashwagandha-Associated Acute Liver Failure Requiring Liver Transplantation. Am J Ther 2023;30(1):e80-e83. PubMed
  21. Pusec CM, Wolsky R, Llerena C, Sura P. A Case of Supplement-Induced Hepatitis. Cureus 2022;14(10):e30433. PubMed
  22. Ajgaonkar A, Jain M, Debnath K. Efficacy and Safety of Ashwagandha (Withania somnifera) Root Extract for Improvement of Sexual Health in Healthy Women: A Prospective, Randomized, Placebo-Controlled Study. Cureus 2022;14(10):e30787. PubMed
  23. Haron MH, Dale O, Martin K, et al. Evaluation of the Herb-Drug Interaction Potential of Commonly Used Botanicals on the US Market with Regard to PXR- and AhR-Mediated Influences on CYP3A4 and CYP1A2. J Diet Suppl 2022. PubMed
  24. Lubarska M, Halasinski P, Hryhorowicz S, et al. Liver Dangers of Herbal Products: A Case Report of Ashwagandha-Induced Liver Injury. Int J Environ Res Public Health 2023;20(5):3921. PubMed
  25. Tóth M, Benedek AE, Longerich T, Seitz HK. Ashwagandha-induced acute liver injury: A case report. Clin Case Rep 2023;11(3):e7078.
  26. Bokan G, Glamocanin T, Mavija Z, et al. Herb-Induced Liver Injury by Ayurvedic Ashwagandha as Assessed for Causality by the Updated RUCAM: An Emerging Cause. Pharmaceuticals (Basel) 2023;16(8):1129. PubMed
  27. Patel PA, Sanborn E, Then R, Williams DM. Recurrent Reversible Cerebral Vasoconstriction Syndrome: A Report of Two Cases. Cureus 2023;15(8):e42992. PubMed
  28. Majeed M, Nagabhushanam K, Murali A, Vishwanathan DT, Mamidala RV, Mundkur L. A Standardized Withania somniferra (Linn.) Root Extract with Piperine Alleviates the Symptoms of Anxiety and Depression by Increasing Serotonin Levels: A Double-Blind, Randomize
  29. Philips CA, Valsan A, Theruvath AH, et al. Ashwagandha-induced liver injury-A case series from India and literature review. Hepatol Commun 2023;7(10):e0270. PubMed
  30. Hayashi M, Hamada H, Azuma SI, Hayashi K. Painless Thyroiditis by Withania somnifera (Ashwagandha). Cureus 2024;16(3):e55352. PubMed
  31. Vazirani S, Kothari A, Fujimoto J, Gomez M. Supplements Are Not a Synonym for Safe: Suspected Liver Injury From Ashwagandha. Fed Pract 2023;40(9):315-319. PubMed
  32. Patel M, Newell R, Hillier M, Ramalingam R. Herbal remedies as a potential cause of hypoadrenalism. Br J Hosp Med (Lond) 2024;85(6):1-4. PubMed

See these in context on the Ashwagandha monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team