Organic Cranberry Concentrate Ingredients & Drug Interactions
by PureCo
What is this page for?
First and foremost: checking Organic Cranberry Concentrate against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Organic Cranberry Concentrate is a dietary supplement by PureCo with 1 active ingredient. Its ingredients are commonly taken for urinary tract infection prevention, bladder health, antioxidant support.Based on those ingredients, 712 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are organic Cranberry concentrate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Organic Cranberry Concentrate by PureCo
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AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Organic Cranberry Concentrate by PureCo
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
PureCo Organic Cranberry Concentrate is a single-ingredient powder: organic cranberry concentrate. There are no inactive ingredients listed.
You're getting the cranberry in concentrated form rather than fresh juice, so the dose per serving is more potent than what you'd get from a glass of juice.
Does it work?
Moderate evidence
The data we hold shows cranberry is possibly effective for urinary tract infections (UTIs). For other conditions—age-related cognitive decline, benign prostatic hyperplasia, cancer, nonalcoholic fatty liver disease, and chronic fatigue syndrome—the evidence isn't established well enough to say whether it works.
If UTI prevention is why you're interested, cranberry has supporting evidence; for anything else, talk with your doctor about whether the science backs it up.
How safe is it?
Well-documented data
Cranberry is generally well tolerated when you take it by mouth. The most common side effects are diarrhea and stomach discomfort.
Because this is a concentrated supplement rather than the diluted juice you'd drink, concentrated doses haven't been studied as thoroughly as food amounts—so check with your provider before starting, especially if you're taking it long-term. Cranberry is not a substitute for treating an actual infection; if you think you have a UTI, see your doctor for diagnosis and treatment.
Meds to double-check
Moderate interaction found
Before you take this product, check with your pharmacist or doctor if you're on warfarin or another blood thinner, atorvastatin or another statin, nifedipine or another blood pressure medication, or any other drug your liver metabolizes through the CYP3A4 or CYP2C9 pathways. Cranberry may raise levels of these drugs and cause stronger effects than intended.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
If you're looking to help prevent urinary tract infections, cranberry has some evidence behind it. But because this is a concentrate and because it can raise levels of several important medications—blood thinners, statins, and blood pressure drugs especially—you'll want to talk with your doctor or pharmacist first.
Check your exact medications using the tool on this page before you buy.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2021.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Organic Cranberry Concentrate, straight from the product label.
| Brand | PureCo |
|---|---|
| Barcode (UPC) | X001TW9YA1 |
| Net contents | 50 grams; 1.76 Ounce(s) |
| Market status | On market |
| Date entered into DSLD | Mar 25, 2021 |
| DSLD ID | 242891 |
| Product type | Botanical |
| Supplement form | Powder |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Organic, Gluten Free, Dairy Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Organic Cranberry Concentrate by PureCo, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| organic Cranberry concentrate | 500 mg | -- |
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)
Natural Herbals
Formula
Pure organic herbal powder Powerful 50:1 concentrate Herbal equivalent to 25,000mg Fresh Cranberries
A powerful berry blast Cranberries are a superfood naturally rich in PACs and antioxidants, including vitamin C, and also contain vitamin K, vitamin E, fiber and manganese. We use fresh organic cranberries grown in the USA and Canada and concentrate them to give you the herbal equivalent of eating 25,000mg in each 500mg scoop.
Seals/Symbols
USDA Organic
Manufactured in a GMP Certified facility
Certified Organic By: Organic Certifiers Manufactured in USA
Formulation
USDA Organic
Non GMO Product No Fillers
Pure Co A company founded on one core principle to bring you the purest dietary supplement possible. We are committed to using organic and non-GMO ingredients whenever possible and manufacture all of our products right here in the USA.
This product does not contain: Yeast, wheat, gluten, dairy, corn, soy, eggs, sugar, tree nuts, peanuts, fish, shellfish or hydrogenated oils.
Certified Organic By: Organic Certifiers
General Statements
Scoop included
Satisfaction Guarantee 90 days money back guarantee We offer a full refund on the purchase price of your order within 90 days of purchase. Restrictions apply. For details please visit www.mypure.co/refunds
Were here to help! For any questions, concerns, refunds: [email protected] Connect with us to catch our latest deals and product news: Facebook mypureco Instagram mypure.co
Have a Pure Day!
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Suggested Use: Mix one scoop per day into your favorite yogurt, add to a healthy smoothie or simply stir into a glass of water.
Precautions
Discontinue use if side effects appear.
If you are pregnant, nursing, under 18, taking medications or have any medical condition please discuss use with your healthcare practitioner.
If you are pregnant, nursing, under 18, taking medications or have any medical condition please discuss use with your healthcare practitioner.
Keep out of reach of children.
Do not use if safety seal is broken.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Organic Cranberry Concentrate by PureCo label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Organic Cranberry Concentrate by PureCo
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Scoop(s) Dosage formPowder Servings per container100 Amounts shown are per serving.
Organic Cranberry concentrate
Interacts with712 drugs
Cranberry is best known for helping to prevent repeated urinary tract infections (UTIs) in some people, and the evidence here is moderate but mixed. I...
Organic Cranberry concentrate monograph & interactionsOrganic Cranberry Concentrate by PureCo Drug Interactions
HelloPharmacist Interaction Report
PureCo Organic Cranberry Concentrate interacts with several medication types, most seriously through its cranberry content affecting blood thinners and cholesterol medications.
Cranberry may increase levels of warfarin (a blood thinner), atorvastatin (a statin), and nifedipine (a blood pressure medication), each rated Moderate severity—meaning the risk of stronger effects and unwanted side effects is real enough to need checking before you start.
Read the full breakdown — every affected drug type, severity by severity
Cranberry also affects a broad class of drugs your liver processes through the CYP3A4 pathway; if you take any medication metabolized this way, cranberry may raise its level in your bloodstream. Additionally, cranberry has Minor interactions with CYP2C9 substrates and diclofenac, though the evidence here is mixed—some lab work suggests an effect, but real-world data don't always confirm it.
Altogether, these interactions span 713 individual medications. Use the medication checker on this page to look up your exact prescriptions before you begin, and talk with your pharmacist or doctor about whether this product is right for you.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Organic Cranberry Concentrate?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Organic Cranberry Concentrate interact with 712 drugs. Click any drug to see the details.
1 of the 1 ingredient in Organic Cranberry Concentrate interact with drugs. Each result below shows which ingredient is responsible. organic Cranberry concentrate
Buproprion, DextromethorphanAuvelity
How Buproprion, Dextromethorphan interacts with Organic Cranberry Concentrate — through 1 ingredient. Tap an ingredient for the detail:
Organic Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Organic Cranberry Concentrate + Buproprion, Dextromethorphan interactionBuspironeBuSpar
How Buspirone interacts with Organic Cranberry Concentrate — through 1 ingredient. Tap an ingredient for the detail:
Organic Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Organic Cranberry Concentrate + Buspirone interactionBusulfanBusulfex, Myleran
How Busulfan interacts with Organic Cranberry Concentrate — through 1 ingredient. Tap an ingredient for the detail:
Organic Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Organic Cranberry Concentrate + Busulfan interactionCabazitaxelCabazitaxel, Jetvana
How Cabazitaxel interacts with Organic Cranberry Concentrate — through 1 ingredient. Tap an ingredient for the detail:
Organic Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Organic Cranberry Concentrate + Cabazitaxel interactionCabotegravir, RilpivirineCabenuva
How Cabotegravir, Rilpivirine interacts with Organic Cranberry Concentrate — through 1 ingredient. Tap an ingredient for the detail:
Organic Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Organic Cranberry Concentrate + Cabotegravir, Rilpivirine interactionCabozantinibCometriq
How Cabozantinib interacts with Organic Cranberry Concentrate — through 1 ingredient. Tap an ingredient for the detail:
Organic Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Organic Cranberry Concentrate + Cabozantinib interactionCabozantinib S-malateCabometyx
How Cabozantinib S-malate interacts with Organic Cranberry Concentrate — through 1 ingredient. Tap an ingredient for the detail:
Organic Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Organic Cranberry Concentrate + Cabozantinib S-malate interactionCaffeine (otc Drug)Molie, Overtime, Vivarin
How Caffeine (otc Drug) interacts with Organic Cranberry Concentrate — through 1 ingredient. Tap an ingredient for the detail:
Organic Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Organic Cranberry Concentrate + Caffeine (otc Drug) interactionCaffeine (prescription Drug)Caffeine, Dextrophin
How Caffeine (prescription Drug) interacts with Organic Cranberry Concentrate — through 1 ingredient. Tap an ingredient for the detail:
Organic Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Organic Cranberry Concentrate + Caffeine (prescription Drug) interactionCaffeine , Sodium BenzoateCaffeine and Sodium Benzoate
How Caffeine , Sodium Benzoate interacts with Organic Cranberry Concentrate — through 1 ingredient. Tap an ingredient for the detail:
Organic Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Organic Cranberry Concentrate + Caffeine , Sodium Benzoate interactionCaffeine, Diphenhydramine, Ergotamine (prescription Drug)Ergodryl
How Caffeine, Diphenhydramine, Ergotamine (prescription Drug) interacts with Organic Cranberry Concentrate — through 1 ingredient. Tap an ingredient for the detail:
Organic Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Organic Cranberry Concentrate + Caffeine, Diphenhydramine, Ergotamine (prescription Drug) interactionCaffeine, Ergotamine (prescription Drug)Migergot
How Caffeine, Ergotamine (prescription Drug) interacts with Organic Cranberry Concentrate — through 1 ingredient. Tap an ingredient for the detail:
Organic Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Organic Cranberry Concentrate + Caffeine, Ergotamine (prescription Drug) interactionCaffeine, Ergotamine Tartrate (prescription Drug)Cafergot, Wigraine
How Caffeine, Ergotamine Tartrate (prescription Drug) interacts with Organic Cranberry Concentrate — through 1 ingredient. Tap an ingredient for the detail:
Organic Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Organic Cranberry Concentrate + Caffeine, Ergotamine Tartrate (prescription Drug) interactionCaffeine, Potassium Salicylate, SalicylamideTrim-Elim
How Caffeine, Potassium Salicylate, Salicylamide interacts with Organic Cranberry Concentrate — through 1 ingredient. Tap an ingredient for the detail:
Organic Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Organic Cranberry Concentrate + Caffeine, Potassium Salicylate, Salicylamide interactionCalcifediolRayaldee
How Calcifediol interacts with Organic Cranberry Concentrate — through 1 ingredient. Tap an ingredient for the detail:
Organic Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Organic Cranberry Concentrate + Calcifediol interactionCannabidiol (prescription Drug)Epidiolex
How Cannabidiol (prescription Drug) interacts with Organic Cranberry Concentrate — through 1 ingredient. Tap an ingredient for the detail:
Organic Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Organic Cranberry Concentrate + Cannabidiol (prescription Drug) interactionCapivasertibTruqap
How Capivasertib interacts with Organic Cranberry Concentrate — through 1 ingredient. Tap an ingredient for the detail:
Organic Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Organic Cranberry Concentrate + Capivasertib interactionCapmatinib HydrochlorideTabrecta
How Capmatinib Hydrochloride interacts with Organic Cranberry Concentrate — through 1 ingredient. Tap an ingredient for the detail:
Organic Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Organic Cranberry Concentrate + Capmatinib Hydrochloride interactionCarbamazepineCarbatrol, Carnexiv, Equetro, Tegretol, Tegretol XR
How Carbamazepine interacts with Organic Cranberry Concentrate — through 1 ingredient. Tap an ingredient for the detail:
Organic Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Organic Cranberry Concentrate + Carbamazepine interactionCarbetapentane Tannate, Chlorpheniramine TannateTussi-12
How Carbetapentane Tannate, Chlorpheniramine Tannate interacts with Organic Cranberry Concentrate — through 1 ingredient. Tap an ingredient for the detail:
Organic Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Organic Cranberry Concentrate + Carbetapentane Tannate, Chlorpheniramine Tannate interactionCarbetapentane Tannate, Chlorpheniramine Tannate, Ephedrine Tannate, Phenylephrine TannateQuadratuss, Ry Tuss, Rynatuss, Tri Tannate Plus
How Carbetapentane Tannate, Chlorpheniramine Tannate, Ephedrine Tannate, Phenylephrine Tannate interacts with Organic Cranberry Concentrate — through 1 ingredient. Tap an ingredient for the detail:
Organic Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Organic Cranberry Concentrate + Carbetapentane Tannate, Chlorpheniramine Tannate, Ephedrine Tannate, Phenylephrine Tannate interactionCarbetapentane, Chlorpheniramine, PhenylephrineRicotuss
How Carbetapentane, Chlorpheniramine, Phenylephrine interacts with Organic Cranberry Concentrate — through 1 ingredient. Tap an ingredient for the detail:
Organic Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Organic Cranberry Concentrate + Carbetapentane, Chlorpheniramine, Phenylephrine interactionCarbetapentane, Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Potassium GuaiacolsulfonateCophene-X
How Carbetapentane, Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Potassium Guaiacolsulfonate interacts with Organic Cranberry Concentrate — through 1 ingredient. Tap an ingredient for the detail:
Organic Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Organic Cranberry Concentrate + Carbetapentane, Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Potassium Guaiacolsulfonate interactionCariprazine HydrochlorideVraylar
How Cariprazine Hydrochloride interacts with Organic Cranberry Concentrate — through 1 ingredient. Tap an ingredient for the detail:
Organic Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Organic Cranberry Concentrate + Cariprazine Hydrochloride interactionCelecoxib, TramadolSeglentis
How Celecoxib, Tramadol interacts with Organic Cranberry Concentrate — through 1 ingredient. Tap an ingredient for the detail:
Organic Cranberry ConcentrateCytochrome P450 2c9 (cyp2c9) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Organic Cranberry Concentrate + Celecoxib, Tramadol interactionCevimelineEvoxac
How Cevimeline interacts with Organic Cranberry Concentrate — through 1 ingredient. Tap an ingredient for the detail:
Organic Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Organic Cranberry Concentrate + Cevimeline interactionChlorpheniramineChlor-Trimeton, Teldrin
How Chlorpheniramine interacts with Organic Cranberry Concentrate — through 1 ingredient. Tap an ingredient for the detail:
Organic Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Organic Cranberry Concentrate + Chlorpheniramine interactionChlorpheniramine Maleate, Dextromethorphan HydrobromideCoricidin HBP Cough & Cold, Coricidin II Cough & Cold, Pediatric Vicks Formula 44m Cough & Cold Relief
How Chlorpheniramine Maleate, Dextromethorphan Hydrobromide interacts with Organic Cranberry Concentrate — through 1 ingredient. Tap an ingredient for the detail:
Organic Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Organic Cranberry Concentrate + Chlorpheniramine Maleate, Dextromethorphan Hydrobromide interactionChlorpheniramine Maleate, Hydrocodone BitartrateVituz
How Chlorpheniramine Maleate, Hydrocodone Bitartrate interacts with Organic Cranberry Concentrate — through 1 ingredient. Tap an ingredient for the detail:
Organic Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Organic Cranberry Concentrate + Chlorpheniramine Maleate, Hydrocodone Bitartrate interactionChlorpheniramine Polistirex, Codeine PolistirexTuzistra XR
How Chlorpheniramine Polistirex, Codeine Polistirex interacts with Organic Cranberry Concentrate — through 1 ingredient. Tap an ingredient for the detail:
Organic Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Organic Cranberry Concentrate + Chlorpheniramine Polistirex, Codeine Polistirex interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Organic Cranberry Concentrate with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
organic Cranberry concentrate
Atorvastatin (Lipitor)
Theoretically, cranberry might increase levels and adverse effects of atorvastatin.
In one case report, a patient taking atorvastatin experienced upper back pain, rhabdomyolysis, and abnormal liver function after drinking cranberry juice 16 ounces daily for 2 weeks. Theoretically, this may have been caused by inhibition of cytochrome P450 3A4 (CYP3A4) enzymes by cranberry juice, as atorvastatin is a CYP3A4 substrate. Creatinine kinase and liver enzymes normalized within 2 weeks of stopping cranberry juice. Patients taking atorvastatin should avoid large quantities of cranberry juice.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
A case of upper back pain, rhabdomyolysis, and abnormal liver function has been reported for a patient taking atorvastatin, a CYP3A4 substrate, in combination with cranberry juice 16 ounces daily for 2 weeks. Creatinine kinase and liver enzymes normalized within 2 weeks of stopping cranberry juice. Also, animal research suggests that cranberry juice, administered intraduodenally 30 minutes prior to nifedipine, a CYP3A4 substrate, inhibits nifedipine metabolism and increases the area under the concentration-time curve by 1.6-fold compared to control.
Nifedipine (Procardia)
Theoretically, cranberry might increase the levels and adverse effects of nifedipine.
Animal research suggests that cranberry juice, administered intraduodenally 30 minutes prior to nifedipine treatment, inhibits nifedipine metabolism and increases the area under the concentration-time curve by 1.6-fold compared to control. This interaction has not been reported in humans.
Warfarin (Coumadin)
Theoretically, cranberry might increase the levels and adverse effects of warfarin. However, research is conflicting.
There is contradictory evidence about the effect of cranberry juice on warfarin. Case reports have linked cranberry juice consumption to increases in the international normalized ratio (INR) in patients taking warfarin, resulting in severe spontaneous bleeding and excessive postoperative bleeding. Daily consumption of cranberry sauce for one week has also been linked to an increase in INR in one case report. In a small study in healthy young males, taking a high dose of 3 grams of cranberry juice concentrate capsules, equivalent to 57 grams of fruit daily, for 2 weeks produced a 30% increase in the area under the INR-time curve after a single 25-mg dose of warfarin. However, 3 very small clinical studies in patients stabilized on warfarin reported that cranberry juice 250 mL once or twice daily for 7 days (27% cranberry juice or pure cranberry juice) or 240 mL once daily for 14 days does not significantly increase INR or affect plasma warfarin levels. The reasons for these discrepant findings are unclear. It is possible that the form and dose of cranberry may play a role, as cranberry extracts and juices contain different constituents. Additionally, an in vitro study evaluating 5 different cranberry juices found varying effects, with only a cranberry concentrate, and not diluted cranberry juices, inhibiting CYP2C9. However, this concentrate did not inhibit CYP2C9 activity in humans.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates. However, research is conflicting.
There is contradictory evidence about the effect of cranberry on CYP2C9 enzymes. In vitro evidence suggests that flavonoids in cranberry inhibit CYP2C9 enzymes. However, clinical research shows that cranberry juice does not significantly affect the levels, metabolism, or elimination of the CYP2C9 substrates flurbiprofen or diclofenac. Also, in patients stabilized on warfarin, drinking cranberry juice 250 mL daily for 7 days does not significantly increase the anticoagulant activity of warfarin, a CYP2C9 substrate. Additional pharmacokinetic research shows that cranberry juice does not increase peak plasma concentrations or area under the concentration-time curve of warfarin.
Diclofenac (Voltaren, Others)
Theoretically, cranberry might modestly increase the levels and adverse effects of diclofenac.
In vitro evidence suggests that cranberry juice inhibits diclofenac metabolism by human liver microsomes. However, drinking cranberry juice does not seem to affect diclofenac metabolism in humans.
Brand information
Manufacturer and brand details for Organic Cranberry Concentrate, from the product label.
PureCo
See all PureCo products- Name
- Pure Co, USA Supplements LLC
- Street Address
- 31 N. Gould St. Ste. 6594
- City
- Sheridan
- State
- WY
- ZipCode
- 82801
- Web Address
- www.mypure.co
Organic Cranberry Concentrate by PureCo: Common Questions
Does Organic Cranberry Concentrate by PureCo interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Does cranberry actually work to prevent UTIs?
What are the side effects I might notice?
Is it safe to take while pregnant or breastfeeding?
Why do I need to check my medications before taking this?
Can I take this as a substitute for treating a UTI?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Organic Cranberry Concentrate is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Organic Cranberry Concentrate’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Organic Cranberry Concentrate's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
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The 33 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Cranberry 33 references
- Anon. Possible interaction between warfarin and cranberry juice. Current Problems in Pharmacovigilance 2003;29:8. PubMed
- Greenblatt DJ, von Moltke LL, Perloff ES, et al. Interaction of flurbiprofen with cranberry juice, grape juice, tea, and fluconazole: in vitro and clinical studies. Clin Pharmacol Ther 2006;79:125-33. PubMed
- Hodek P, Trefil P, Stiborova M. Flavonoids-potent and versatile biologically active compounds interacting with cytochromes P450. Chem Biol Interact 2002;139:1-21.. PubMed
- Grant P. Warfarin and cranberry juice: An interaction? J Heart Valve Dis 2004;13:25-6.
- Suvarna R, Pirmohamed M, Henderson L. Possible interaction between warfarin and cranberry juice. BMJ 2003;327:1454. PubMed
- Li Z, Seeram NP, Carpenter CL, et al. Cranberry does not affect prothrombin time in male subjects on warfarin. J Am Diet Assoc 2006;106:2057-61. PubMed
- Lilja JJ, Backman JT, Neuvonen PJ. Effects of daily ingestion of cranberry juice on the pharmacokinetics of warfarin, tizanidine, and midazolam - probes of CYP2C9, CYP1A2 and CYP3A4. Clin Pharmacol The 2007:81:833-9. PubMed
- Wing DA, Rumney PJ, Preslicka CW, Chung JH. Daily cranberry juice for the prevention of asymptomatic bacteriuria in pregnancy: a randomized, controlled pilot study. J Urol 2008;180:1367-72. PubMed
- Mohammed Abdul MI, Jiang X, Williams KM, et al. Pharmacodynamic interaction of warfarin with cranberry but not with garlic in healthy subjects. Br J Pharmacol 2008;154:1691-700. PubMed
- McMurdo MET, Argo I, Phillips G, et al. Cranberry or trimethoprim for the prevention of recurrently urinary tract infections? A randomized controlled trial in older women. J Antimicrob Chemother 2009;63:389-95.
- Mergenhagen KA, Sherman O. Elevated International Normalized Ratio after concurrent ingestion of cranberry sauce and warfarin. Am J Health-Syst Pharm 2008;65:2113-6. PubMed
- Ansell J, McDonough M, Zhao Y, et al. The absence of an interaction between warfarin and cranberry juice: a randomized, double-blind trial. J Clin Pharmacol 2009;49:824-30. PubMed
- Haber SL, Cauthon KA, Raney EC. Cranberry and warfarin interaction: a case report and review of the literature. Consult Pharm 2012;27:58-65. PubMed
- Hamann GL, Campbell JD, George CM. Warfarin-cranberry juice interaction. Ann Pharmacother 2011;45:e17. PubMed
- Roberts D, Flanagan P. Case report: Cranberry juice and warfarin. Home Healthc Nurse 2011;29:92-7.
- Garcia-Calatayud, S., Larreina Cordoba, J. J., and Lozano De La Torre MJ. [Severe cranberry juice poisoning]. An.Esp.Pediatr. 2002;56(1):72-73.
- Patel, D. A., Gillespie, B., Sobel, J. D., Leaman, D., Nyirjesy, P., Weitz, M. V., and Foxman, B. Risk factors for recurrent vulvovaginal candidiasis in women receiving maintenance antifungal therapy: results of a prospective cohort study. Am J Obstet.Gy PubMed
- Isele, H. [Fatal bleeding under warfarin plus cranberry juice. Is it due to salicylic acid?]. MMW.Fortschr.Med 3-11-2004;146(11):13.
- Linsenmeyer, T. A., Harrison, B., Oakley, A., Kirshblum, S., Stock, J. A., and Millis, S. R. Evaluation of cranberry supplement for reduction of urinary tract infections in individuals with neurogenic bladders secondary to spinal cord injury. A prospecti
- McMurdo, M. E., Bissett, L. Y., Price, R. J., Phillips, G., and Crombie, I. K. Does ingestion of cranberry juice reduce symptomatic urinary tract infections in older people in hospital? A double-blind, placebo-controlled trial. Age Ageing 2005;34(3):256- PubMed
- Sylvan, L. and Justice, N. P. Possible interaction between warfarin and cranberry juice. Am Fam.Physician 9-15-2005;72(6):1000.
- Niklasson, A. and Andren, L. [Interaction between Waran and cranberry juice]. Lakartidningen 3-15-2006;103(11):853-854.
- Rindone, J. P. and Murphy, T. W. Warfarin-cranberry juice interaction resulting in profound hypoprothrombinemia and bleeding. Am J Ther 2006;13(3):283-284. PubMed
- Uesawa, Y. and Mohri, K. Effects of cranberry juice on nifedipine pharmacokinetics in rats. J Pharm Pharmacol 2006;58(8):1067-1072. PubMed
- Valentova, K., Stejskal, D., Bednar, P., Vostalova, J., Cihalik, C., Vecerova, R., Koukalova, D., Kolar, M., Reichenbach, R., Sknouril, L., Ulrichova, J., and Simanek, V. Biosafety, antioxidant status, and metabolites in urine after consumption of dried
- Royer, D. J., George, J. N., and Terrell, D. R. Thrombocytopenia as an adverse effect of complementary and alternative medicines, herbal remedies, nutritional supplements, foods, and beverages. Eur J Haematol 2010;84(5):421-429. PubMed
- Stapleton, A. E., Dziura, J., Hooton, T. M., Cox, M. E., Yarova-Yarovaya, Y., Chen, S., and Gupta, K. Recurrent urinary tract infection and urinary Escherichia coli in women ingesting cranberry juice daily: a randomized controlled trial. Mayo.Clin.Proc. PubMed
- Doad GJ, Kabange W. Cranberry juice, atorvastatin and back pain. J Med Assoc Ga 2014;103(1):14.
- Griffiths AP, Beddall A, Pegler S. Fatal haemopericardium and gastrointestinal haemorrhage due to possible interaction of cranberry juice with warfarin. J R Soc Promot Health 2008;128(6):324-6. PubMed
- Mellen CK, Ford M, Rindone JP. Effect of high-dose cranberry juice on the pharmacodynamics of warfarin in patients. Br J Clin Pharmacol 2010;70(1):139-42. PubMed
- Ushijima K, Tsuruoka S, Tsuda H, Hasegawa G, Obi Y, Kaneda T, Takahashi M, Maekawa T, Sasaki T, Koshimizu TA, Fujimura A. Cranberry juice suppressed the diclofenac metabolism by human liver microsomes, but not in healthy human subjects. Br J Clin Pharmaco PubMed
- Ngo N, Brantley SJ, Carrizosa DR, et al. The warfarin-cranberry juice interaction revisited: A systematic in vitro-in vivo evaluation. J Exp Pharmacol. 2010;2010(2):83-91.
- Williams G, Stothart CI, Hahn D, Stephens JH, Craig JC, Hodson EM. Cranberries for preventing urinary tract infections. Cochrane Database Syst Rev 2023;11(11):CD001321. PubMed
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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