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Dietary supplement

100% Organic Lion's Mane Mushroom 1 g Unflavored Ingredients & Drug Interactions

by Nutricost Organic

100% Organic Lion's Mane Mushroom 1 g Unflavored label
See full label image
Powder Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking 100% Organic Lion's Mane Mushroom 1 g Unflavored against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

100% Organic Lion's Mane Mushroom 1 g Unflavored is a dietary supplement by Nutricost Organic with 1 active ingredient. Its ingredients are commonly taken for memory and cognitive support, nerve health, mood and anxiety.Based on those ingredients, 327 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lion's Mane. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against 100% Organic Lion's Mane Mushroom 1 g Unflavored by Nutricost Organic

Ask about any prescription or over-the-counter medication and we check it for interactions with 100% Organic Lion's Mane Mushroom 1 g Unflavored by Nutricost Organic — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of 100% Organic Lion's Mane Mushroom 1 g Unflavored by Nutricost Organic

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: Lion's Mane Mushroom, a fungal extract used traditionally to support brain health. There are no other inactive ingredients listed.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Lion's Mane Mushroom's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Memory and cognitive support.
  • We looked for evidence on: Memory, Cognitive function, Cognitive impairment, Alzheimer disease, Dementia, Parkinson disease — and 3 related terms.
  • The closest evidence on file: Lion's Mane Mushroom is rated "Insufficient Reliable Evidence To Rate" for Alzheimer disease (Natural Medicines).
  • Also on file: Lion's Mane Mushroom is rated "Insufficient Reliable Evidence To Rate" for Cognitive function, Cognitive impairment, Dementia, Memory, and more.

The evidence we hold does not establish that Lion's Mane is effective for Alzheimer disease, anxiety, athletic performance, cancer, cognitive function, or cognitive impairment — all six uses show insufficient reliable evidence to rate. That doesn't mean it doesn't work; it means the data on file isn't strong enough yet to say either way.

The evidence, ingredient by ingredient Lion's Mane Mushroom

How safe is it?

Some data gaps
Safety Information · database check
Some gaps

Safety data exists for these ingredients, but with some important gaps.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 0 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lion's Mane is generally well tolerated when taken by mouth. The most common side effects reported are gastrointestinal discomfort, nausea, and skin rash.

However, long-term supplement safety hasn't been studied well, so we don't have a complete picture of extended use. There isn't enough safety data for pregnancy or breastfeeding — the facts advise against use in both cases.

Talk with your doctor or pharmacist before taking this if you're pregnant, trying to become pregnant, or nursing.

Side effects, ingredient by ingredient Lion's Mane Mushroom

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Lion's Mane Mushroom.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 327 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start, double-check if you take blood thinners or antiplatelet drugs (like warfarin or aspirin) — moderate risk of increased bleeding. Also verify any diabetes medications and immunosuppressants, which have moderate interactions documented.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and some safety-information gaps remain.

Lion's Mane is a single-ingredient powder that's generally well tolerated for short-term use. If you take blood thinners, diabetes medications, or immune-suppressing drugs, check with your pharmacist before starting.

Pregnant or breastfeeding? Skip it unless your doctor says otherwise.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jan 24, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about 100% Organic Lion's Mane Mushroom 1 g Unflavored, straight from the product label.

Brand Nutricost Organic
Barcode (UPC) 810014670492
Net contents 4 Ounce(s); 113 Gram(s)
Market status On market
Date entered into DSLD Jan 24, 2024
DSLD ID 306371
Product type Botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Organic, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for 100% Organic Lion's Mane Mushroom 1 g Unflavored by Nutricost Organic, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Gram(s)
Maximum serving Sizes:
1 Gram(s)
Servings per container
113
UPC/BARCODE
810014670492
IngredientAmount% DV
Total Carbohydrates1 Gram(s)--
Lion's Mane1 Gram(s)--

Other ingredients: None

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement, mix 1 scoop daily with 6-10 oz of water or as directed by your healthcare professional.

Formulation

Third party tested

Gluten-free

Made and quality tested in the USA with globally sourced ingredients.

Certified Organic by CCOF

Vegetarian product

Non-GMO product

Precautions

Warning: For healthy individuals 18 years and older.

Consult a healthcare professional prior to use if you are pregnant or nursing, taking medication, or have a medical condition.

Keep out of reach of children.

Do not use if safety seal is broken or missing.

Storage

Notice: Store in a cool, dry place.

General Statements

Contents are sold by weight, not volume. Some settling may occur.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Seals/Symbols

CCOF Certified Organic USDA Organic

Nutricost Quality Guaranteed GMP Compliant Facility

Formula

100% Organic Lion's Mane Mushroom 1 g per serving 4 oz per container

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

100% Organic Lion's Mane Mushroom 1 g Unflavored by Nutricost Organic label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

100% Organic Lion's Mane Mushroom 1 g Unflavored label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in 100% Organic Lion's Mane Mushroom 1 g Unflavored by Nutricost Organic

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Gram(s) Dosage formPowder Servings per container113 Amounts shown are per serving.

Lion's Mane

Interacts with
327 drugs
1 Gram(s) per serving

Lion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and...

Lion's Mane monograph & interactions

Other (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.

Interaction report

100% Organic Lion's Mane Mushroom 1 g Unflavored by Nutricost Organic Drug Interactions

Want to check YOUR meds against 100% Organic Lion's Mane Mushroom 1 g Unflavored?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
327Drugs
327 Moderate

Ingredients driving the most interactions

Lion's Mane 327

Individual Drug Interactions

The ingredients in 100% Organic Lion's Mane Mushroom 1 g Unflavored interact with 327 drugs. Click any drug to see the details.

1 of the 1 ingredient in 100% Organic Lion's Mane Mushroom 1 g Unflavored interact with drugs. Each result below shows which ingredient is responsible. Lion's Mane

Each ingredient & the kinds of drugs it affects

For each ingredient in 100% Organic Lion's Mane Mushroom 1 g Unflavored with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Lion's Mane3 drug types · 327 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
In vitro research suggests that lion's mane mushroom extracts can inhibit platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, lion's mane mushroom may have additive effects when used with antidiabetes drugs.
Animal research suggests that an aqueous extract of lion's mane mushroom can reduce serum glucose and increase serum insulin.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, concurrent use of lion's mane mushroom might interfere with immunosuppressive therapy.
In animal and in vitro research, lion's mane mushroom polysaccharides stimulate the immune system.

Likelihood Possible Evidence D
Lion's Mane full monograph & interactions
The maker

Brand information

Manufacturer and brand details for 100% Organic Lion's Mane Mushroom 1 g Unflavored, from the product label.

Nutricost Organic

See all Nutricost Organic products
Name
Nutricost
Street Address
351 E 1750 N
City
Vineyard
State
UT
ZipCode
84059
Phone Number
(866) 438-3694
Web Address
www.nutricost.com
Pharmacist Counseling Corner

100% Organic Lion's Mane Mushroom 1 g Unflavored by Nutricost Organic: Common Questions

Does 100% Organic Lion's Mane Mushroom 1 g Unflavored by Nutricost Organic interact with any medications?
Yes. Based on its ingredients, 100% Organic Lion's Mane Mushroom 1 g Unflavored has a known interaction with 327 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
100% Organic Lion's Mane Mushroom 1 g Unflavored contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What exactly is Lion's Mane Mushroom?
It's an extract from the Lion's Mane fungus, traditionally used in supplements aimed at brain health and cognitive support.
Is this safe to take every day?
Lion's Mane is generally well tolerated, but long-term safety hasn't been studied thoroughly as a supplement, so we don't have solid data on daily use over months or years. Your pharmacist can help you decide if daily use makes sense for you.
What side effects should I watch for?
The most common ones are stomach discomfort, nausea, and skin rash. Most people don't experience them, but if you do, stop and let your pharmacist know.
Can I take this while pregnant or breastfeeding?
No — there isn't enough safety data, so it's best to avoid it during pregnancy and while breastfeeding. Talk to your doctor if you have questions about what's safe for you.
Does this product actually work for memory or brain fog?
The evidence we have doesn't establish that it works for cognitive function, memory, or Alzheimer disease. That doesn't prove it doesn't; it just means we don't have reliable data yet to say it does.
Why does this interact with so many drugs?
The 322 figure includes all individual medications affected by Lion's Mane across three drug categories: blood thinners, diabetes drugs, and immune-suppressing drugs. Many medications fall into those broad groups, which is why the total is high.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if 100% Organic Lion's Mane Mushroom 1 g Unflavored is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

100% Organic Lion's Mane Mushroom 1 g Unflavored label
Go deeper

The Full Monographs Behind 100% Organic Lion's Mane Mushroom 1 g Unflavored’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lion's Mane Mushroom

Interacts with 327 drugs

Lion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and early. It is generally well tolerated as...

Read the full Lion's Mane Mushroom monograph →
Sources

Sources & How We Checked

100% Organic Lion's Mane Mushroom 1 g Unflavored's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lion's Mane Mushroom 6 references
  1. Product information for <em>Niaspan</em>. Abbott Laboratories. North Chicago, IL 60064. April 2015.
  2. Liang B, Guo Z, Xie F, Zhao A. Antihyperglycemic and antihyperlipidemic activities of aqueous extract of Hericium erinaceus in experimental diabetic rats. BMC Complement Altern Med. 2013;13:253. PubMed
  3. Mori K, Inatomi S, Ouchi K, Azumi Y, Tuchida T. Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. Phytother Res. 2009;23(3):367-72.
  4. Mori K, Kikuchi H, Obara Y, et al. Inhibitory effect of hericenone B from Hericium erinaceus on collagen-induced platelet aggregation. Phytomedicine. 2010;17(14):1082-5. PubMed
  5. Li IC, Chang HH, Lin CH, et al. Prevention of early Alzheimer's disease by erinacine A-enriched Hericium erinaceus mycelia pilot double-blind placebo-controlled study. Front Aging Neurosci 2020 Jun 3;12:155. doi: 10.3389/fnagi.2020.00155. PubMed
  6. Tian B, Liu R, Xu T, et al. Modulating effects of Hericium erinaceus polysaccharides on the immune response by regulating gut microbiota in cyclophosphamide-treated mice. J Sci Food Agric 2023;103(6):3050-3064.

See these in context on the Lion's Mane Mushroom monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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