Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Organic Papaya Leaf Tea With Mint Ingredients & Drug Interactions

by Herbal Papaya

Organic Papaya Leaf Tea With Mint label
See full label image
Other (e.g. Tea Bag) Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Organic Papaya Leaf Tea With Mint against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Organic Papaya Leaf Tea With Mint is a dietary supplement by Herbal Papaya with 2 active ingredients. Its ingredients are commonly taken for irritable bowel syndrome (ibs), indigestion and gas, nausea.Based on those ingredients, 868 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Peppermint, organic Papaya. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Organic Papaya Leaf Tea With Mint by Herbal Papaya

Ask about any prescription or over-the-counter medication and we check it for interactions with Organic Papaya Leaf Tea With Mint by Herbal Papaya — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Organic Papaya Leaf Tea With Mint by Herbal Papaya

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 2 active ingredients.
  • “Proprietary Blend (Herb/Botanical)” is a proprietary blend — the label gives one combined amount (2 Gram(s)) without saying how much of each component you get.

This tea contains 2 active ingredients: peppermint and organic papaya. Peppermint leaf is traditionally used for digestive comfort and has solid evidence backing its use for irritable bowel syndrome (IBS) and some evidence for general indigestion and nausea.

Papaya leaf is included for its traditional support, though the evidence for specific health outcomes is still being studied—most papaya claims lack strong scientific backing at this time. The tea has no inactive fillers listed.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Digestive support and calming.
  • We looked for evidence on: Abdominal pain, Dyspepsia, Irritable bowel syndrome (IBS), Intestinal parasite infection, Indigestion, Bloating — and 1 related terms.
  • The strongest evidence on file: Peppermint is rated "Likely Effective" for Irritable bowel syndrome (IBS) (Natural Medicines).
  • Also on file: Peppermint is rated "Possibly Effective" for Dyspepsia.
  • Also on file: Papaya is rated "Insufficient Reliable Evidence To Rate" for Intestinal parasite infection.

Peppermint in this tea is likely effective for IBS and possibly effective for indigestion, nausea from chemotherapy or certain medical procedures, and colonic spasm related to barium enema. Papaya leaf's effectiveness is not yet well established in the data we hold—proposed uses like supporting aging skin, hair regrowth, and blood sugar control have insufficient reliable evidence to rate, so we can't say how well it works for those purposes based on current research.

The evidence, ingredient by ingredient Peppermint Papaya

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Peppermint tea in food amounts is generally well tolerated; most people handle it fine. The most common side effects from peppermint are abdominal pain, heartburn, belching, dry mouth, diarrhea, and nausea—usually mild.

Rare cases of allergic reactions and anaphylaxis have been reported with peppermint candy, though this is uncommon. Papaya fruit eaten in normal amounts is also well tolerated, and papaya leaf extract is generally well tolerated, though nausea and vomiting have occurred in some trial participants.

Because this is a tea, concentrations are much lower than concentrated supplements or very large fruit quantities. Peppermint is likely safe in pregnancy and lactation.

There is no safety data on file for papaya in pregnancy or breastfeeding—talk with your provider or pharmacist if you're pregnant or nursing.

Side effects, ingredient by ingredient Peppermint Papaya

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Papaya, Peppermint.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 869 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this tea, check with your pharmacist if you take heart or blood pressure medications processed by your liver (especially calcium channel blockers like felodipine), blood sugar medications, amiodarone (a heart rhythm drug), warfarin or other blood thinners, or levothyroxine (thyroid medication). Peppermint's theoretical effects on these drugs are at Moderate severity, and papaya's effects on the latter four are also Moderate.

Use the medication search tool on this page to verify your specific drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This tea is a gentle, well-tolerated option for digestive comfort thanks to peppermint's solid evidence for IBS and indigestion. However, because the product's peppermint can theoretically affect how your body processes certain medications—and papaya can interact with blood sugar drugs, heart and thyroid medications, and blood thinners—you should check your exact medications with our tool before you start.

If you take any prescription drugs, a quick conversation with your pharmacist is a smart move.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Organic Papaya Leaf Tea With Mint, straight from the product label.

Brand Herbal Papaya
Barcode (UPC) 798304214147
Net contents 24 Tea Bag(s); 1.7 oz.; 48 Gram(s)
Market status On market
Date entered into DSLD Jul 25, 2017
DSLD ID 75630
Product type Botanical
Supplement form Other (e.g. Tea Bag)
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Kosher, Organic
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Organic Papaya Leaf Tea With Mint by Herbal Papaya, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tea Bag(s)
Maximum serving Sizes:
1 Tea Bag(s)
UPC/BARCODE
798304214147
IngredientAmount% DV
Peppermint0 NP--
Proprietary Blend (Herb/Botanical)2 Gram(s)--
organic Papaya0 NP--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Herbal Papaya cares about the environment. Please recycle this package where facilities accept.

Minty ~ Calming Digestion

Women owned

10% of profits go to WAAW Foundation

Individually wrapped to ensure great taste and lasting freshness.

24 .07 OZ (2G) Teabags / NET WT 1.7OZ (48G)

Get the most out of every cup

For maximum benefit, Papaya Leaf Herbal Tea must be properly prepared. These steps directly influence the amount of beneficial extracts that end up in your tea cup!

Our Papaya Leaf Tea with Mint is a gentle and natural way to maintain a healthy digestive system and support the immune system. Papaya Leaf includes antioxidants - Vitamins C, E and Beta-Carotene which help neutralize free radicals and is beneficial for promoting vitality, health and youthfulness. Peppermint aids the digestive system. This blend has an enchanting minty and calming flavor, with an assertive personality.

Herbal Papaya offers a premium selection of the highest quality papaya products with excellent five star service. We are committed to bringing you the finest, highest quality preparations. We work with nature, support the environment and give back to the farmers and communities that grow our products. Our promise to you is that we will never compromise our standards. Learn more about the benefits of Papaya Leaf and try our other Tea flavors at www.herbalpapaya.com.

We give 10% of profits to educating and empowering girls in Africa. In partnership with WAAW Foundation we help train female leaders who contribute towards technology innovation and economic growth in Africa. We also support our farmers and their livelihoods by paying fair market value for Papaya. By doing this we are building vibrant communities, and that’s who we are. So choose Herbal Papaya with confidence knowing that you are contributing directly to these causes. Thank you. visit www.waawfoundation.org to learn more.

Seals/Symbols

USDA Organic

Made with Non-GMO ingredients

KSA Kosher

Formulation

Made with Non-GMO ingredients

Caffeine free

Certified Organic by OTCO

FDA Statement of Identity

~ Herbal Tea Supplement

Suggested/Recommended/Usage/Directions

Directions: Bring 8oz water to flash boil. Pour over tea bag and steep for 5 to 8 minutes. Gently squeeze teabag to release any remaining extracts. For stronger tea, use additional teabags. Serve sweetened with sugar, honey or favorite sweetener if desired. Drink 2 to 3 cups daily.

Precautions

If pregnant, please consult your prenatal care-giver or other health care professional before drinking this tea.

Formula

Certified Kosher by KSA

FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Organic Papaya Leaf Tea With Mint by Herbal Papaya label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Organic Papaya Leaf Tea With Mint label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Organic Papaya Leaf Tea With Mint by Herbal Papaya

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tea Bag(s) Dosage formOther (e.g. Tea Bag) Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend (Herb/Botanical)

2 Gram(s) per serving
Interaction report

Organic Papaya Leaf Tea With Mint by Herbal Papaya Drug Interactions

Want to check YOUR meds against Organic Papaya Leaf Tea With Mint?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
868Drugs
803 Moderate 65 Minor

Ingredients driving the most interactions

Peppermint 796
organic Papaya 92

Individual Drug Interactions

The ingredients in Organic Papaya Leaf Tea With Mint interact with 868 drugs. Click any drug to see the details.

2 of the 2 ingredients in Organic Papaya Leaf Tea With Mint interact with drugs. Each result below shows which ingredient is responsible. Peppermint organic Papaya

Each ingredient & the kinds of drugs it affects

For each ingredient in Organic Papaya Leaf Tea With Mint with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Peppermint5 drug types · 796 drugs

Cyclosporine (Neoral, Sandimmune)

Theoretically, peppermint oil might increase the levels and adverse effects of cyclosporine.
In animal research, peppermint oil inhibits cyclosporine metabolism and increases cyclosporine levels. Inhibition of cytochrome P450 3A4 (CYP3A4) may be partially responsible for this interaction. An interaction between peppermint oil and cyclosporine has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, peppermint might increase the levels of CYP2C19 substrates.
In vitro research shows that peppermint oil inhibits CYP2C19. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, peppermint might increase the levels of CYP2C9 substrates.
In vitro research shows that peppermint oil inhibits CYP2C9. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Clinical research in healthy volunteers shows that a single dose of peppermint oil 600 mg inhibits CYP3A4 enzymes and increases the AUC of felodipine, a CYP3A4 substrate. However, in vitro research suggests that peppermint oil only inhibits CYP3A4 at very high concentrations.

Likelihood Possible Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, peppermint might increase the levels of CYP1A2 substrates.
In vitro and animal research shows that peppermint oil and peppermint leaf inhibit CYP1A2. However, in clinical research, peppermint tea did not significantly affect the metabolism of caffeine, a CYP1A2 substrate. It is possible that the 6-day duration of treatment may have been too short to identify a difference.

Likelihood Possible Evidence B
Peppermint full monograph & interactions

organic Papaya4 drug types · 92 drugs

Amiodarone (Cordarone)

Theoretically, papaya extract may increase the levels and clinical effects of amiodarone.
Animal research in rats shows that a single oral dose of papaya extract, as well as multiple doses of papaya extract daily over 14 days, prior to a single dose of amiodarone delays the time to maximum amiodarone concentration. However, only the 14-day papaya extract regimen increases systemic amiodarone exposure by 60% to 70%. This interaction has not been reported in humans.

Likelihood Probable Evidence D
Antidiabetes Drugs

Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects. It is unclear if other forms of papaya have the same effect.
A small low-quality clinical study in patients with type 2 diabetes who are taking glibenclamide shows that taking a fermented papaya preparation 3 grams daily for 2 months decreases fasting and postprandial blood glucose levels when compared to baseline. Additionally, of the 25 patients in the study, 9 required a reduction in glibenclamide dose.

Likelihood Probable Evidence B
Levothyroxine (Synthroid, Others)

Theoretically, consuming large quantities of papaya fruit can reduce the clinical effects of levothyroxine.
In one case-report, a 37-year-old male with a history of thyroidectomy who was stabilized on levothyroxine for 5 years presented with hypothyroidism after consuming 5-6 papaya fruits daily for 14 days during vacation. In a controlled re-challenge test involving 5-6 papayas daily, the patient remained euthyroid for 7 days, but developed mild hypothyroidism after 14 days. Both times, thyroid levels normalized 40-45 days after discontinuing papaya.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, concomitant use of warfarin with papain-containing papaya extract might increase the effects and side effects of warfarin.
In one case report, a patient previously stable on warfarin was found to have an international normalization ratio (INR) of 7.4, which was attributed to ingestion of a supplement containing papain from papaya extract.

Likelihood Possible Evidence D
organic Papaya full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Organic Papaya Leaf Tea With Mint, from the product label.

Herbal Papaya

See all Herbal Papaya products
Name
Herbal Papaya
Street Address
P.O. Box 1691
City
Wylie
State
TX
ZipCode
75098
Phone Number
800-820-4829
Web Address
www.herbalpapaya.com
Pharmacist Counseling Corner

Organic Papaya Leaf Tea With Mint by Herbal Papaya: Common Questions

Does Organic Papaya Leaf Tea With Mint by Herbal Papaya interact with any medications?
Yes. Based on its ingredients, Organic Papaya Leaf Tea With Mint has a known interaction with 868 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Organic Papaya Leaf Tea With Mint contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What does peppermint in this tea actually do?
Peppermint is backed by solid research for irritable bowel syndrome (IBS)—it's likely effective for that. It also has good evidence for easing general indigestion and possibly helps with nausea from chemotherapy or certain medical procedures. It's a digestive helper, which is why it's been used in herbal teas for centuries.
Is papaya leaf really effective for the things people claim?
The evidence isn't strong yet. Most of papaya's claimed uses—supporting aging skin, hair regrowth, and blood sugar—don't have reliable research backing them. So we can't say it works for those purposes based on current data. It's included in this tea for its traditional role, but benefits aren't proven.
Are there any side effects from drinking this tea?
Most people tolerate it well. The most common mild effects from peppermint are abdominal pain, heartburn, belching, dry mouth, diarrhea, and nausea. Papaya leaf extract similarly causes nausea and vomiting in a small number of trial participants. Serious allergic reactions are rare. At tea strength, these are unlikely.
Is it safe to drink this while pregnant or breastfeeding?
Peppermint is likely safe during pregnancy and lactation based on available data. However, there's no safety information on file for papaya during pregnancy or breastfeeding, so talk with your doctor or pharmacist for personalized advice before using it if you're pregnant or nursing.
Does this tea have any fillers or added ingredients?
No—there are no inactive fillers or other ingredients listed on the product facts. It's just the two active ingredients: peppermint and organic papaya.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Organic Papaya Leaf Tea With Mint is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Organic Papaya Leaf Tea With Mint label
Go deeper

The Full Monographs Behind Organic Papaya Leaf Tea With Mint’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Peppermint

Interacts with 796 drugs

Peppermint is a popular herb with the best evidence supporting enteric-coated peppermint oil for easing IBS symptoms. It is generally well tolerated for most adults, but it can cause heartbu...

Read the full Peppermint monograph → Herb & supplement monograph

Papaya

Interacts with 92 drugs

Papaya is a tropical fruit that is nutritious and generally safe to eat as food, and it contains an enzyme called papain used as a digestive aid and meat tenderizer. Papaya leaf extract is b...

Read the full Papaya monograph →
Sources

Sources & How We Checked

Organic Papaya Leaf Tea With Mint's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 55 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Peppermint 41 references
  1. Liu JH, Chen GH, Yeh HZ, et al. Enteric-coated peppermint-oil capsules in the treatment of irritable bowel syndrome: a prospective, randomized trial. J Gastroenterol 1997;32:765-8. PubMed
  2. Pittler MH, Ernst E. Peppermint oil for irritable bowel syndrome: a critical review and metaanalysis. Am J Gastroenterol 1998;93:1131-5. PubMed
  3. Kline RM, Kline JJ, Di Palma J, Barbero GJ. Enteric-coated, pH-dependent peppermint oil capsules for the treatment of irritable bowel syndrome in children. J Pediatr 2001;138:125-8. PubMed
  4. Madisch A, Heydenreich CJ, Wieland V, et al. Treatment of functional dyspepsia with a fixed peppermint oil and caraway oil combination preparation as compared to cisapride. A multicenter, reference-controlled, double-blind equivalence study. Arzneimittel
  5. May B, Kuntz HD, Kieser M, Kohler S. Efficacy of a fixed peppermint oil/caraway oil combination in non-ulcer dyspepsia. Arzneimittelforschung 1996;46:1149-53.
  6. Micklefield GH, Greving I, May B. Effects of peppermint oil and caraway oil on gastroduodenal motility. Phytother Res 2000;14:20-3. DOI
  7. Morton CA, Garioch J, Todd P, et al. Contact sensitivity to menthol and peppermint in patients with intra-oral symptoms. Contact Dermatitis 1995;32:281-4. PubMed
  8. May B, Kohler S, Schneider B. Efficacy and tolerability of a fixed combination of peppermint oil and caraway oil in patients suffering from functional dyspepsia. Aliment Pharmacol Ther 2000;14:1671-7. PubMed
  9. Nash P, Gould SR, Bernardo DE. Peppermint oil does not relieve the pain of irritable bowel syndrome. Br J Clin Pract 1986;40:292-3. DOI
  10. Rees WD, Evans BK, Rhodes J. Treating irritable bowel syndrome with peppermint oil. Br Med J 1979;2:835-6. PubMed
  11. Davies SJ, Harding LM, Baranowski AP. A novel treatment of postherpetic neuralgia using peppermint oil. Clin J Pain 2002;18:200-2. PubMed
  12. Weston CF. Anal burning and peppermint oil. Postgrad Med J 1987;63:717. PubMed
  13. Dresser GK, Wacher V, Wong S, et al. Evaluation of peppermint oil and ascorbyl palmitate as inhibitors of cytochrome P4503A4 activity in vitro and in vivo. Clin Pharmacol Ther 2002;72:247-55. PubMed
  14. Wacher VJ, Wong S, Wong HT. Peppermint oil enhances cyclosporine oral bioavailability in rats: comparison with D-alpha-tocopheryl poly(ethylene glycol 1000) succinate (TPGS) and ketoconazole. J Pharm Sci 2002;91:77-90.
  15. Lawson MJ, Knight RE, Tran K, et al. Failure of enteric-coated peppermint oil in the irritable bowel syndrome: a randomized double-blind crossover study. J Gastroenterol Hepatol 1988;3:235-8. DOI
  16. Unger M, Frank A. Simultaneous determination of the inhibitory potency of herbal extracts on the activity of six major cytochrome P450 enzymes using liquid chromatography/mass spectrometry and automated online extraction. Rapid Commun Mass Spectrom 2004;1 PubMed
  17. Maliakal PP, Wanwimolruk S. Effect of herbal teas on hepatic drug metabolizing enzymes in rats. J Pharm Pharmacol 2001;53:1323-9. PubMed
  18. Rogers SN, Pahor AL. A form of stomatitis induced by excessive peppermint consumption. Dent Update 1995;22:36-7.
  19. Cappello G, Spezzaferro M, Grossi L, et al. Peppermint oil (Mintoil) in the treatment of irritable bowel syndrome: a prospective double blind placebo-controlled randomized trial. Dig Liver Dis 2007;39:530-6. PubMed
  20. Moghadam BK, Gier R, and Thurlow T. Extensive oral mucosal ulcerations caused by misuse of a commercial mouthwash. Cutis 1999;64:131-134.
  21. Andersen, K. E. Contact allergy to toothpaste flavors. Contact Dermatitis 1978;4(4):195-198. PubMed
  22. Barnard, D. R. Repellency of essential oils to mosquitoes (Diptera: Culicidae). J Med Entomol. 1999;36(5):625-629. PubMed
  23. Tamir, S., Davidovich, Z., Attal, P., and Eliashar, R. Peppermint oil chemical burn. Otolaryngol.Head Neck Surg. 2005;133(5):801-802. PubMed
  24. Kalavala, M., Hughes, T. M., Goodwin, R. G., Anstey, A. V., and Stone, N. M. Allergic contact dermatitis to peppermint foot spray. Contact Dermatitis 2007;57(1):57-58. PubMed
  25. Vermaat, H., van Meurs, T., Rustemeyer, T., Bruynzeel, D. P., and Kirtschig, G. Vulval allergic contact dermatitis due to peppermint oil in herbal tea. Contact Dermatitis 2008;58(6):364-365. PubMed
  26. Merat, S., Khalili, S., Mostajabi, P., Ghorbani, A., Ansari, R., and Malekzadeh, R. The effect of enteric-coated, delayed-release peppermint oil on irritable bowel syndrome. Dig.Dis.Sci. 2010;55(5):1385-1390. PubMed
  27. Tran, A., Pratt, M., and DeKoven, J. Acute allergic contact dermatitis of the lips from peppermint oil in a lip balm. Dermatitis 2010;21(2):111-115. DOI
  28. Hitz, Lindenmuller, I and Lambrecht, J. T. Oral care. Curr Probl.Dermatol 2011;40:107-115.
  29. Shavakhi, A., Ardestani, S. K., Taki, M., Goli, M., and Keshteli, A. H. Premedication with peppermint oil capsules in colonoscopy: a double blind placebo-controlled randomized trial study. Acta Gastroenterol Belg 2012;75(3):349-353.
  30. Lech, Y., Olesen, K. M., Hey, H., Rask-Pedersen, E., Vilien, M., and Ostergaard, O. [Treatment of irritable bowel syndrome with peppermint oil. A double- blind study with a placebo]. Ugeskr.Laeger 10-3-1988;150(40):2388-2389.
  31. Parys, B. T. Chemical burns resulting from contact with peppermint oil mar: a case report. Burns Incl.Therm.Inj. 1983;9(5):374-375. PubMed
  32. Bayat R, Borici-Mazi R. A case of anaphylaxis to peppermint. Allergy Asthma Clin Immunol. 2014;10(1):6. PubMed
  33. Rich G, Shah A, Koloski N, et al. A randomized placebo-controlled trial on the effects of Menthacarin, a proprietary peppermint- and caraway-oil-preparation, on symptoms and quality of life in patients with functional dyspepsia. Neurogastroenterol Motil 2 PubMed
  34. Douros A, Bronder E, Andersohn F, et al. Herb-Induced Liver Injury in the Berlin Case-Control Surveillance Study. Int J Mol Sci 2016;17(1). PubMed
  35. Begas E, Tsioutsiouliti A, Kouvaras E, et al. Effects of peppermint tea consumption on the activities of CYP1A2, CYP2A6, Xanthine Oxidase, N-acetyltranferase-2 and UDP-glucuronosyltransferases-1A1/1A6 in healthy volunteers. Food Chem Toxicol 2017;100:80-9 PubMed
  36. Cash BD, Epstein MS, Shah SM. A Novel Delivery System of Peppermint Oil Is an Effective Therapy for Irritable Bowel Syndrome Symptoms. Dig Dis Sci 2016;61(2):560-71. PubMed
  37. Elsaie LT, El Mohsen AM, Ibrahim IM, Mohey-Eddin MH, Elsaie ML. Effectiveness of topical peppermint oil on symptomatic treatment of chronic pruritus. Clin Cosmet Investig Dermatol 2016;9:333-8. PubMed
  38. Wu J, Xu R, Zhan R, et al. Effective symptomatic treatment for severe and intractable pruritus associated with severe burn-induced hypertrophic scars: A prospective, multicenter, controlled trial. Burns 2016;42(5):1059-66. PubMed
  39. Weerts ZZRM, Masclee AAM, Witteman BJM, et al. Efficacy and safety of peppermint oil in a randomized, double-blind trial of patients with irritable bowel syndrome. Gastroenterology. 2020;158(1):123-136. PubMed
  40. Nee J, Ballou S, Kelley JM, et al. Peppermint Oil Treatment for Irritable Bowel Syndrome: A Randomized Placebo-Controlled Trial. Am J Gastroenterol 2021;116(11):2279-2285. PubMed
  41. Ingrosso MR, Ianiro G, Nee J, et al. Systematic review and meta-analysis: efficacy of peppermint oil in irritable bowel syndrome. Aliment Pharmacol Ther 2022;56(6):932-41. PubMed

See these in context on the Peppermint monograph →

Papaya 14 references
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  2. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
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  4. Mansfield LE, Ting S, Haverly RW, Yoo TJ. The incidence and clinical implications of hypersensitivity to papain in an allergic population, confirmed by blinded oral challenge. Ann Allergy 1985;55:541-3.
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  7. Castillo, R., Delgado, J., Quiralte, J., Blanco, C., and Carrillo, T. Food hypersensitivity among adult patients: epidemiological and clinical aspects. Allergol.Immunopathol.(Madr.) 1996;24(3):93-97.
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  12. Deiana L, Marini S, Mariotti S. Ingestion of large amounts of papaya fruit and impaired effectiveness of levothyroxine therapy. Endocr Pract 2012;18(1):98-100. PubMed
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See these in context on the Papaya monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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