Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Green Papaya Powder Ingredients & Drug Interactions

by Herbal Papaya

Green Papaya Powder label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Green Papaya Powder against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Green Papaya Powder is a dietary supplement by Herbal Papaya with 1 active ingredient. Its ingredients are commonly taken for digestive upset and indigestion, constipation, wound and skin care (topical).Based on those ingredients, 92 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Green Papaya fruit powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Green Papaya Powder by Herbal Papaya

Ask about any prescription or over-the-counter medication and we check it for interactions with Green Papaya Powder by Herbal Papaya — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Green Papaya Powder by Herbal Papaya

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: green papaya fruit powder. It's a whole-fruit extract in a veggie capsule with standard inactive ingredients—microcrystalline cellulose, magnesium stearate, and the capsule itself.

The green papaya fruit is rich in enzymes and compounds that have been used traditionally in herbal and culinary practices, though the science on what it actually does for health is still developing.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Papaya's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: digestive health and immune system support.
  • We looked for evidence on: Intestinal parasite infection, indigestion, constipation.
  • The closest evidence on file: Papaya is rated "Insufficient Reliable Evidence To Rate" for Intestinal parasite infection (Natural Medicines).

The evidence we hold doesn't establish that green papaya powder works for any of its proposed uses. The product facts show insufficient reliable evidence to rate it for aging skin, hair loss (androgenic alopecia), colorectal cancer, or diabetes.

That doesn't mean it's ineffective—it means the clinical data just isn't solid enough yet to know one way or the other.

The evidence, ingredient by ingredient Papaya

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Ripe papaya fruit eaten as food is generally well tolerated, and papaya leaf extract seems well tolerated too. The most common side effects from papaya leaf extract in studies were nausea and vomiting.

Rare serious reactions include severe allergic responses, and people allergic to latex are at higher risk for allergic reactions to papaya because of shared proteins. The safety notes flag that concentrated supplements and unripe papaya are less well studied than ripe fruit you'd eat—so while eating ripe papaya is likely fine, supplements are best discussed with your doctor or pharmacist first.

Side effects, ingredient by ingredient Papaya

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Papaya.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 92 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before starting, double-check your medications if you take a blood thinner like warfarin (Coumadin)—papaya may increase its effects. Also confirm with your pharmacist if you're on diabetes drugs, amiodarone for heart rhythm, or levothyroxine for thyroid replacement.

All three have moderate interactions documented with papaya.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Green papaya powder has moderate interactions with blood thinners, diabetes drugs, a heart rhythm medication, and thyroid replacement—so if you take any of those, clear it with your own doctor or pharmacist first. The clinical evidence for what it actually does for health isn't established in our data.

If you're interested despite the unknowns, know that ripe papaya as food is generally tolerated, but this concentrated supplement form is less studied.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 23, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Green Papaya Powder, straight from the product label.

Brand Herbal Papaya
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Jun 23, 2017
DSLD ID 75629
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Green Papaya Powder by Herbal Papaya, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
IngredientAmount% DV
Green Papaya fruit powder600 mg--

Other ingredients: Veggie Capsules, Magnesium Stearate, Microcrystalline Cellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Papaya - Fruit of the Angels - is native to South America and has been cultivated for centuries for its amazing health benefits.

These enzymes help break down protein, fats and carbohydrates, and support a healthy digestive and immune system.

We support farmers in communities where our products are grown and give 10% of profits to education and innovation programs for African girls.

450 mg capsules

Women owned

10% of profits go to WAAW Foundation

Promotes digestive health and immune system functions

Formula

This 100% pure product comes from unripened papaya picked while still green to retain all its natural enzymes of papain, fibrin and chymopapain.

Herbal Papaya is committed to bringing you the finest selection of products, made from the highest quality, GMO-free papaya leaves.

Green Papaya powder

Formulation

Herbal Papaya is committed to bringing you the finest selection of products, made from the highest quality, GMO-free papaya leaves.

Made with Non-GMO ingredients

Precautions

Warning: Keep out of reach of children.

Consult a physician before using this product.

If pregnant or nursing a baby or if adverse reactions occur, discontinue use and consult your doctor.

Do not use if inner seal or tamper evident wrap is broken.

Storage

Store in a cool dry place, tightly closed.

Seals/Symbols

Made with Non-GMO ingredients

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: Take two capsules with food twice a day.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Green Papaya Powder by Herbal Papaya label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Green Papaya Powder label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Green Papaya Powder by Herbal Papaya

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Green Papaya fruit powder

Interacts with
92 drugs
600 mg per serving

Papaya is a tropical fruit that is nutritious and generally safe to eat as food, and it contains an enzyme called papain used as a digestive aid and m...

Green Papaya fruit powder monograph & interactions

Other (inactive) ingredients: Veggie Capsules, Magnesium Stearate, Microcrystalline Cellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Green Papaya Powder by Herbal Papaya Drug Interactions

Want to check YOUR meds against Green Papaya Powder?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
92Drugs
92 Moderate

Ingredients driving the most interactions

Green Papaya fruit powder 92

Individual Drug Interactions

The ingredients in Green Papaya Powder interact with 92 drugs. Click any drug to see the details.

1 of the 1 ingredient in Green Papaya Powder interact with drugs. Each result below shows which ingredient is responsible. Green Papaya fruit powder

Each ingredient & the kinds of drugs it affects

For each ingredient in Green Papaya Powder with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Green Papaya fruit powder4 drug types · 92 drugs

Amiodarone (Cordarone)

Theoretically, papaya extract may increase the levels and clinical effects of amiodarone.
Animal research in rats shows that a single oral dose of papaya extract, as well as multiple doses of papaya extract daily over 14 days, prior to a single dose of amiodarone delays the time to maximum amiodarone concentration. However, only the 14-day papaya extract regimen increases systemic amiodarone exposure by 60% to 70%. This interaction has not been reported in humans.

Likelihood Probable Evidence D
Antidiabetes Drugs

Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects. It is unclear if other forms of papaya have the same effect.
A small low-quality clinical study in patients with type 2 diabetes who are taking glibenclamide shows that taking a fermented papaya preparation 3 grams daily for 2 months decreases fasting and postprandial blood glucose levels when compared to baseline. Additionally, of the 25 patients in the study, 9 required a reduction in glibenclamide dose.

Likelihood Probable Evidence B
Levothyroxine (Synthroid, Others)

Theoretically, consuming large quantities of papaya fruit can reduce the clinical effects of levothyroxine.
In one case-report, a 37-year-old male with a history of thyroidectomy who was stabilized on levothyroxine for 5 years presented with hypothyroidism after consuming 5-6 papaya fruits daily for 14 days during vacation. In a controlled re-challenge test involving 5-6 papayas daily, the patient remained euthyroid for 7 days, but developed mild hypothyroidism after 14 days. Both times, thyroid levels normalized 40-45 days after discontinuing papaya.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, concomitant use of warfarin with papain-containing papaya extract might increase the effects and side effects of warfarin.
In one case report, a patient previously stable on warfarin was found to have an international normalization ratio (INR) of 7.4, which was attributed to ingestion of a supplement containing papain from papaya extract.

Likelihood Possible Evidence D
Green Papaya fruit powder full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Green Papaya Powder, from the product label.

Herbal Papaya

See all Herbal Papaya products
Name
Herbal Papaya
Street Address
P.O. Box 1691
City
Wylie
State
TX
ZipCode
75098
Phone Number
800-820-4829
Web Address
www.herbalpapaya.com
Pharmacist Counseling Corner

Green Papaya Powder by Herbal Papaya: Common Questions

Does Green Papaya Powder by Herbal Papaya interact with any medications?
Yes. Based on its ingredients, Green Papaya Powder has a known interaction with 92 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Green Papaya Powder contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe if I'm on warfarin or another blood thinner?
No—papaya has a moderate interaction with blood thinners like warfarin. It may increase their effects and side effects, and one case report tied papaya ingestion to an unsafe blood-thinning level. Talk with your own doctor or pharmacist before taking this if you're on a blood thinner.
Will this help my blood sugar if I have diabetes?
The evidence we hold is insufficient to say it works for diabetes. One small clinical study hints that fermented papaya might add to diabetes drug effects, which could be a risk rather than a benefit. You'd need to discuss this with your own doctor before trying it.
What are the side effects?
Papaya fruit eaten as food is generally well tolerated. Papaya leaf extract in studies most commonly caused nausea and vomiting. Rare serious reactions include severe allergic responses, especially in people allergic to latex, since papaya and latex share proteins.
Is this okay during pregnancy?
The data we hold is mixed—one source rates it likely safe, another rates it possibly unsafe. There isn't enough consistent information to know either way, so talk with your doctor or pharmacist if you're pregnant or planning to be.
Is green papaya powder the same as eating ripe papaya?
No. Ripe papaya eaten as food is generally well tolerated. This is a concentrated supplement form, and concentrated supplements are less studied for safety than ripe fruit you'd eat. The product facts note this difference.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Green Papaya Powder is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Green Papaya Powder label
Go deeper

The Full Monographs Behind Green Papaya Powder’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Papaya

Interacts with 92 drugs

Papaya is a tropical fruit that is nutritious and generally safe to eat as food, and it contains an enzyme called papain used as a digestive aid and meat tenderizer. Papaya leaf extract is b...

Read the full Papaya monograph →
Sources

Sources & How We Checked

Green Papaya Powder's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 14 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Papaya 14 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  3. Shaw D, Leon C, Kolev S, Murray V. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). Drug Saf 1997;17:342-56.
  4. Mansfield LE, Ting S, Haverly RW, Yoo TJ. The incidence and clinical implications of hypersensitivity to papain in an allergic population, confirmed by blinded oral challenge. Ann Allergy 1985;55:541-3.
  5. Blanco C, Diaz-Perales A, Collada C, et al. Class I chitinases as potential panallergens involved in the latex-fruit syndrome. J Allergy Clin Immunol 1999;103(3 Pt 1):507-13. PubMed
  6. Diaz-Perales A, Collada C, Blanco C, et al. Cross-reactions in the latex-fruit syndrome: A relevant role of chitinases but not of complex asparagine-linked glycans. J Allergy Clin Immunol 1999;104:681-7. PubMed
  7. Castillo, R., Delgado, J., Quiralte, J., Blanco, C., and Carrillo, T. Food hypersensitivity among adult patients: epidemiological and clinical aspects. Allergol.Immunopathol.(Madr.) 1996;24(3):93-97.
  8. Oderinde, O., Noronha, C., Oremosu, A., Kusemiju, T., and Okanlawon, O. A. Abortifacient properties of aqueous extract of Carica papaya (Linn) seeds on female Sprague-Dawley rats. Niger.Postgrad.Med J 2002;9(2):95-98. DOI
  9. Danese, C., Esposito, D., D'Alfonso, V., Cirene, M., Ambrosino, M., and Colotto, M. Plasma glucose level decreases as collateral effect of fermented papaya preparation use. Clin Ter. 2006;157(3):195-198.
  10. Iliev, D. and Elsner, P. Generalized drug reaction due to papaya juice in throat lozenges. Dermatology 1997;194(4):364-366. PubMed
  11. Andersen HA, Bernatz PE, Grindlay JH. Perforation of the esophagus after use of a digestant agent: report of case and experimental study. Ann Otol Rhinol Laryngol 1959;68:890-6. PubMed
  12. Deiana L, Marini S, Mariotti S. Ingestion of large amounts of papaya fruit and impaired effectiveness of levothyroxine therapy. Endocr Pract 2012;18(1):98-100. PubMed
  13. Rodrigues M, Alves G, Francisco J, Fortuna A, Falcão A. Herb-drug pharmacokinetic interaction between Carica papaya extract and amiodarone in rats. J Pharm Pharm Sci 2014;17(3):302-15. PubMed
  14. Rajapakse S, de Silva NL, Weeratunga P, Rodrigo C, Sigera C, Fernando SD. Carica papaya extract in dengue: a systematic review and meta-analysis. BMC Complement Altern Med. 2019;19(1):265. PubMed

See these in context on the Papaya monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team